Standout Papers
Citation Impact
Citing Papers
Activation of Drosophila Toll During Fungal Infection by a Blood Serine Protease
2002 StandoutScienceNobel
Assay of locus-specific genetic load implicates rare Toll-like receptor 4 mutations in meningococcal susceptibility
2003 StandoutNobel
Heparin, sulfated heparinoids, and lipoteichoic acids bind to the 70-kDa peptidoglycan/lipopolysaccharide receptor protein on lymphocytes.
1994
LPS induction of gene expression in human monocytes
2001 Standout
CD14 Is a pattern recognition receptor
1994
CD47 Is Upregulated on Circulating Hematopoietic Stem Cells and Leukemia Cells to Avoid Phagocytosis
2009
Innate immune sensing and its roots: the story of endotoxin
2003 StandoutNobel
Leukocyte-endothelial cell recognition: Three (or more) steps to specificity and diversity
1991 Standout
Recognition of Gram-negative bacteria and endotoxin by the innate immune system
1999
Identification of the Gene Encoding the Escherichia coli Lipid A 4′-Kinase
1997
Peptidoglycan- and Lipoteichoic Acid-induced Cell Activation Is Mediated by Toll-like Receptor 2
1999 Standout
Analysis of Tlr4-Mediated LPS Signal Transduction in Macrophages by Mutational Modification of the Receptor
1999 StandoutNobel
Digestion of Streptococcus pneumoniae Cell Walls with Its Major Peptidoglycan Hydrolase Releases Branched Stem Peptides Carrying Proinflammatory Activity
1999
A Pattern Recognition Protein for Peptidoglycan
1999
The Mediator complex: a central integrator of transcription
2015
Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide
1999 StandoutNatureNobel
CD14 is required for MyD88-independent LPS signaling
2005 StandoutNobel
Binding of Bacterial Peptidoglycan to CD14
1998
Innate Immunity
2000
Catalytic Properties of Lipopolysaccharide (LPS) Binding Protein
1996
Lipopolysaccharide Is in Close Proximity to Each of the Proteins in Its Membrane Receptor Complex
2001
Eater, a Transmembrane Protein Mediating Phagocytosis of Bacterial Pathogens in Drosophila
2005 StandoutNobel
Innate recognition systems in insect immunity and development: new approaches in
2000
Spleen Tyrosine Kinase Syk Is Necessary for E-Selectin-Induced αLβ2 Integrin-Mediated Rolling on Intercellular Adhesion Molecule-1
2007
Microbial Stimulation Fully Differentiates Monocytes to DC-SIGN/CD209+ Dendritic Cells for Immune T Cell Areas
2010 StandoutNobel
Unresponsiveness of MyD88-Deficient Mice to Endotoxin
1999 Standout
Lipopolysaccharide (LPS)-induced IL-6 production by embryonic fibroblasts isolated and cloned from LPS-responsive and LPS-hyporesponsive mice
1997
Toll-like receptors in the induction of the innate immune response
2000 StandoutNature
Increased Circulating Soluble Cd14 Is Associated With High Mortality In Gram-Negative Septic Shock
1995
TAK1 mediates an activation signal from toll‐like receptor(s) to nuclear factor‐κB in lipopolysaccharide‐stimulated macrophages
2000
Lipopolysaccharide-binding protein is required to combat a murine Gram-negative bacterial infection
1997 Nature
CD36 is a sensor of diacylglycerides
2005 StandoutNatureNobel
Toll-like Receptor 2 Functions as a Pattern Recognition Receptor for Diverse Bacterial Products
1999
Lipopolysaccharide (LPS) recognition in macrophages. Participation of LPS-binding protein and CD14 in LPS-induced adaptation in rabbit peritoneal exudate macrophages.
1993
PU.1 and Interferon Consensus Sequence-binding Protein Regulate the Myeloid Expression of the Human Toll-like Receptor 4 Gene
2000 StandoutNobel
Salmonella typhi uses CFTR to enter intestinal epithelial cells
1998 StandoutNatureNobel
A novel Escherichia coli lipid A mutant that produces an antiinflammatory lipopolysaccharide.
1996
The immune response of Drosophila
2003 StandoutNatureNobel
Endotoxin, Toll-like receptor 4, and the afferent limb of innate immunity
2000 StandoutNobel
Enzymatically Deacylated Lipopolysaccharide (LPS) Can Antagonize LPS at Multiple Sites in the LPS Recognition Pathway
1995
Differential Roles of TLR2 and TLR4 in Recognition of Gram-Negative and Gram-Positive Bacterial Cell Wall Components
1999 Standout
Receptor-Dependent Mechanisms of Cell Stimulation by Bacterial Endotoxin
1995
Innate immunity: impact on the adaptive immune response
1997
Complete Identification of E-Selectin Ligands on Neutrophils Reveals Distinct Functions of PSGL-1, ESL-1, and CD44
2007
Atherosclerosis — An Inflammatory Disease
1999 Standout
Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks
2020 StandoutNobel
<I>Lps2</I>: a new locus required for responses to lipopolysaccharide, revealed by germline mutagenesis and phenotypic screening
2003 StandoutNobel
Antibodies against CD14 protect primates from endotoxin-induced shock.
1996
Mammalian Peptidoglycan Recognition Protein Binds Peptidoglycan with High Affinity, Is Expressed in Neutrophils, and Inhibits Bacterial Growth
2000
CD14 Is a Cell-activating Receptor for Bacterial Peptidoglycan
1996
Identification of Lps2 as a key transducer of MyD88-independent TIR signalling
2003 StandoutNatureNobel
Lipoteichoic Acid (LTA) of Streptococcus pneumoniaeand Staphylococcus aureus Activates Immune Cells via Toll-like Receptor (TLR)-2, Lipopolysaccharide-binding Protein (LBP), and CD14, whereas TLR-4 and MD-2 Are Not Involved
2003
Getting to the site of inflammation: the leukocyte adhesion cascade updated
2007 Standout
Lipopolysaccharide binding protein and soluble CD14 catalyze exchange of phospholipids.
1997
Lipid A diversity and the innate host response to bacterial infection
1998
Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus
2000
Inferences, questions and possibilities in Toll-like receptor signalling
2004 StandoutNatureNobel
Human CD14 mediates recognition and phagocytosis of apoptotic cells
1998 Nature
Soluble CD36 Ectodomain Binds Negatively Charged Diacylglycerol Ligands and Acts as a Co-Receptor for TLR2
2009 StandoutNobel
Lipopolysaccharide‐binding protein mediates CD14‐independent intercalation of lipopolysaccharide into phospholipid membranes
1996
The immunopathogenesis of sepsis
2002 StandoutNature
Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein
2001 StandoutNatureNobel
MIF is a pituitary-derived cytokine that potentiates lethal endotoxaemia
1993 StandoutNature
Toll-like receptors and innate immunity
2001 Standout
Involvement of CD14 and Complement Receptors CR3 and CR4 in Nuclear Factor-κB Activation and TNF Production Induced by Lipopolysaccharide and Group B Streptococcal Cell Walls
1998
Physical contact between lipopolysaccharide and Toll-like receptor 4 revealed by genetic complementation
2000 StandoutNobel
Peptidoglycan and Lipoteichoic Acid fromStaphylococcus aureusInduce Tumor Necrosis Factor Alpha, Interleukin 6 (IL-6), and IL-10 Production in Both T Cells and Monocytes in a Human Whole Blood Model
2000
The Charge of Endotoxin Molecules Influences Their Conformation and IL-6-Inducing Capacity
1998
Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene
1998 StandoutScienceNobel
CD14 enhances cellular responses to endotoxin without imparting ligand-specific recognition.
1995
Bacterial modulins: a novel class of virulence factors which cause host tissue pathology by inducing cytokine synthesis
1996
Differentiation of Monocytes into Dendritic Cells in a Model of Transendothelial Trafficking
1998 StandoutScienceNobel
Human Toll-Like Receptor 2 Mediates Monocyte Activation byListeria monocytogenes, But Not by Group B Streptococci or Lipopolysaccharide
2000
Gram-positive cell walls stimulate synthesis of tumor necrosis factor alpha and interleukin-6 by human monocytes
1994
Genetics of O-Antigen Biosynthesis inPseudomonas aeruginosa
1999
Constitutive Activation of Toll-Mediated Antifungal Defense in Serpin-Deficient Drosophila
1999 StandoutScienceNobel
Bacterial lipopolysaccharides and innate immunity.
2001
Specific binding of soluble peptidoglycan and muramyldipeptide to CD14 on human monocytes
1997
Soluble CD14 acts as a shuttle in the neutralization of lipopolysaccharide (LPS) by LPS-binding protein and reconstituted high density lipoprotein.
1995
Structure and Function of Lipopolysaccharide Binding Protein
1990 StandoutScience
Lipopolysaccharide (LPS)-binding protein accelerates the binding of LPS to CD14.
1994
Cutting Edge: Inflammatory Signaling by Borrelia burgdorferi Lipoproteins Is Mediated by Toll-Like Receptor 2
1999 Standout
Bacterial endotoxins: extraordinary lipids that activate eucaryotic signal transduction
1993
Phosphatidylinositol 3-Kinase-dependent Activation of Protein Kinase C-ζ in Bacterial Lipopolysaccharide-treated Human Monocytes
1997
The phytopathogenic bacteria Erwinia carotovora infects Drosophila and activates an immune response
2000 StandoutNobel
Targeted Deletion of the Lipopolysaccharide (LPS)-binding Protein Gene Leads to Profound Suppression of LPS Responses Ex Vivo, whereas In Vivo Responses Remain Intact
1997
Inhibition of endotoxin-induced interleukin-6 production by synthetic lipid A partial structures in human peripheral blood mononuclear cells
1991
PECAM-1 is required for transendothelial migration of leukocytes.
1993
A genome-wide analysis of immune responses in Drosophila
2001 StandoutNobel
Distinct Phenotype of E-Selectin–Deficient Mice
1996
Transport of Bacterial Lipopolysaccharide to the Golgi Apparatus
1999
An opsonic function of the neutrophil bactericidal/permeability-increasing protein depends on both its N- and C-terminal domains
1997
Platelet‐ and macrophage‐derived endogenous cannabinoids are involved in endotoxin‐induced hypotension
1998
Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2
1997 StandoutNobel
Dual Activation of the Drosophila Toll Pathway by Two Pattern Recognition Receptors
2003 StandoutScienceNobel
Lipopolysaccharide Signals Activation of Tumor Necrosis Factor Biosynthesis Through the Ras/Raf-1/MEK/MAPK Pathway
1994 StandoutNobel
Signaling Events Induced by Lipopolysaccharide-Activated Toll-Like Receptor 2
1999
Neutrophil Tethering on E-Selectin Activates β2 Integrin Binding to ICAM-1 Through a Mitogen-Activated Protein Kinase Signal Transduction Pathway
2000
Endotoxin induces rapid protein tyrosine phosphorylation in 70Z/3 cells expressing CD14.
1993
Nuclear Translocation of NF-κB in Lipopolysaccharide-Treated Macrophages Fails To Correspond to Endotoxicity: Evidence Suggesting a Requirement for a Gamma Interferon-Like Signal
1998
TLRs and innate immunity
2008 StandoutNobel
Toll-related receptors and the control of antimicrobial peptide expression inDrosophila
2000 StandoutNobel
Purification and molecular cloning of an inducible gram-negative bacteria-binding protein from the silkworm, Bombyx mori.
1996
Cutting Edge: Cells That Carry A Null Allele for Toll-Like Receptor 2 Are Capable of Responding to Endotoxin
1999
Stimulation of toll-like receptor 4 expression in human mononuclear phagocytes by interferon-γ: a molecular basis for priming and synergism with bacterial lipopolysaccharide
2002
A physiologic function for p-glycoprotein (MDR-1) during the migration of dendritic cells from skin via afferent lymphatic vessels
1998 StandoutNobel
Lps2: a new locus required for responses to lipopolysaccharide, revealed by germline mutagenesis and phenotypic screening
2003 StandoutNobel
Lipopolysaccharide Endotoxins
2002 Standout
Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection
2004 StandoutNobel
Cellular trafficking of lipoteichoic acid and Toll-like receptor 2 in relation to signaling; role of CD14 and CD36
2008
Dendritic Cells: Unique Leukocyte Populations Which Control the Primary Immune Response
1997
Constitutive expression of a complement-like protein in Toll and JAK gain-of-function mutants ofDrosophila
2000 StandoutNobel
Role of lipopolysaccharide in signaling to subepithelial polymorphonuclear leukocytes
1997
Involvement of CD14 and complement receptors CR3 and CR4 in nuclear factor-kappaB activation and TNF production induced by lipopolysaccharide and group B streptococcal cell walls.
1998
A peptidoglycan recognition protein in innate immunity conserved from insects to humans
1998
Resistance to Endotoxin Shock and Reduced Dissemination of Gram-Negative Bacteria in CD14-Deficient Mice
1996
GENETIC ANALYSIS OF HOST RESISTANCE: Toll-Like Receptor Signaling and Immunity at Large
2006 StandoutNobel
Monocyte-selective transendothelial migration: dissection of the binding and transmigration phases by an in vitro assay.
1992
HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells
2015 StandoutNobel
Phylogenetic Perspectives in Innate Immunity
1999 StandoutScienceNobel
Adjuvant-Enhanced Antibody Responses in the Absence of Toll-Like Receptor Signaling
2006 StandoutScienceNobel
Plant and Animal Sensors of Conserved Microbial Signatures
2010 StandoutScienceNobel
Regulation of Lipid A Modifications by Salmonella typhimurium Virulence Genes phoP-phoQ
1997 Science
Lipopolysaccharide (LPS) partial structures inhibit responses to LPS in a human macrophage cell line without inhibiting LPS uptake by a CD14-mediated pathway.
1992
LPS-binding proteins and receptors
1998
Soluble CD14 participates in the response of cells to lipopolysaccharide.
1992
Works of Robert Ramos being referenced
CDK8 regulates E2F1 transcriptional activity through S375 phosphorylation
2012
Endothelial-leukocyte adhesion molecule 1 stimulates the adhesive activity of leukocyte integrin CR3 (CD11b/CD18, Mac-1, alpha m beta 2) on human neutrophils.
1991
Septin: a factor in plasma that opsonizes lipopolysaccharide-bearing particles for recognition by CD14 on phagocytes.
1992
CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding Protein
1990 StandoutScience
Activation of the adhesive capacity of CR3 on neutrophils by endotoxin: dependence on lipopolysaccharide binding protein and CD14.
1991
Lipopolysaccharide (LPS) binding protein opsonizes LPS-bearing particles for recognition by a novel receptor on macrophages.
1989