Citation Impact
Citing Papers
Hereditary Anemias of the Mouse: A Review for Geneticists
1979
Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4
1993
The SCID-hu Mouse: Murine Model for the Analysis of Human Hematolymphoid Differentiation and Function
1988 Science
Differential Regulation of Retinoblastoma Protein Function by Specific Cdk Phosphorylation Sites
1996
Essential role of mouse telomerase in highly proliferative organs
1998 StandoutNatureNobel
Transplantation of Normal and Leukemic Human Bone Marrow into Immune‐Deficient Mice: Development of Animal Models for Human Hematopoiesis
1991
Role for the p53 homologue p73 in E2F-1-induced apoptosis
2000 StandoutNatureNobel
Telomerase Mutations in Families with Idiopathic Pulmonary Fibrosis
2007 StandoutNobel
RAG-1-deficient mice have no mature B and T lymphocytes
1992 StandoutNobel
The SCID Mouse Mutant: Definition, Characterization, and Potential Uses
1991
A cell initiating human acute myeloid leukaemia after transplantation into SCID mice
1994 StandoutNature
Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
1998 StandoutNatureNobel
Targeted Disruption of the Catalytic Subunit of the DNA-PK Gene in Mice Confers Severe Combined Immunodeficiency and Radiosensitivity
1998
Molecular and cellular origins of B lymphocyte diversity
1991
V(D)J Recombination: Molecular Biology and Regulation
1992
Detection and characterization of functional T cells in mice with severe combined immune deficiency
1988
The AID enzyme induces class switch recombination in fibroblasts
2002 StandoutNatureNobel
Mouse embryonic hematopoiesis
1995
The regulation of E2F by pRB-family proteins
1998 Standout
The cell cycle and the retinoblastoma protein family
1994
Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice
1999 StandoutNobel
Identification of cellular proteins that can interact specifically with the T/ElA-binding region of the retinoblastoma gene product
1991 StandoutNobel
The scid mutation in mice causes a general defect in DNA repair
1990 Nature
In situ class switching and differentiation to IgA-producing cells in the gut lamina propria
2001 StandoutNatureNobel
A Multigene Family Encoding a Diverse Array of Putative Pheromone Receptors in Mammals
1997 StandoutNobel
E2F-1 Functions in Mice to Promote Apoptosis and Suppress Proliferation
1996 StandoutNobel
Virus-induced autoantibody response to a transgenic viral antigen
1990 StandoutNatureNobel
p73 is a human p53-related protein that can induce apoptosis
1997 StandoutNatureNobel
Inhibition of DNA synthesis by RB: effects on G1/S transition and S-phase progression
1998
The scid defect affects the final step of the immunoglobulin VDJ recombinase mechanism
1988
Antigen-induced apoptotic death of Ly-1 B cells responsible for autoimmune disease in transgenic mice
1992 StandoutNatureNobel
DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis
2020 StandoutNatureNobel
RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement
1992 Standout
A common E2F-1 and p73 pathway mediates cell death induced by TCR activation
2000 StandoutNatureNobel
TGFα deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice
1993 StandoutNobel
The role of the bcl-2/ced-9 gene family in cancer and general implications of defects in cell death control for tumourigenesis and resistance to chemotherapy
1997
The mechanism of antigen receptor gene assembly
1989
Recent advances in the growth and isolation of primitive human haemopoietic progenitor cells
1992
Kaposi's Sarcoma
2000 Standout
Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme
2000 StandoutNobel
Extrathymic positive selection of αβ T-cell precursors in nude mice
1992 StandoutNatureNobel
AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching
2001 StandoutNatureNobel
The defect in murine severe combined immune deficiency: Joining of signal sequences but not coding segments in V(D)J recombination
1988
T-lymphocyte development in scid mice is arrested shortly after the initiation of T-cell receptor delta gene recombination.
1991
Genes required for cytotoxicity against virus-infected target cells in K and D regions of H-2 complex
1975 StandoutNatureNobel
Generation of Lymphohematopoietic Cells from Embryonic Stem Cells in Culture
1994 StandoutScienceNobel
T‐T Cell Interactions during Cytotoxic T Lymphocyte (CTL) Responses: T Cell Derived Helper Factor (Interleukin 2) as a Probe to Analyze CTL Responsiveness and Thymic Maturation of CTL Progenitors
1980
Functional Inactivation of the Retinoblastoma Protein Requires Sequential Modification by at Least Two Distinct Cyclin-cdk Complexes
1998
Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency
1986
Enhanced immunological surveillance in mice heterozygous at the H-2 gene complex
1975 StandoutNatureNobel
Genetics and cancer
1980
In Vitro Development of Primitive and Definitive Erythrocytes from Different Precursors
1996 StandoutScienceNobel
T-cell mitogens cause early changes in cytoplasmic free Ca2+ and membrane potential in lymphocytes
1982 StandoutNatureNobel
A link between double-strand break-related repair and V(D)J recombination: the scid mutation.
1991
A Nondeletional Mechanism of Thymic Self Tolerance
1989 StandoutScienceNobel
G1 cyclins control the retinoblastoma gene product growth regulation activity via upstream mechanisms.
1995
T-cell receptor gene rearrangements in functional T-cell clones from severe combined immune deficient (scid) mice: reversion of the scid phenotype in individual lymphocyte progenitors.
1990
A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene
1983 StandoutNobel
Developmental potential and dynamic behavior of hematopoietic stem cells
1986
Expression in transgenic mice of class I histocompatibility antigens controlled by the metallothionein promoter.
1989 StandoutNobel
Direct Transcriptional Repression by pRB and Its Reversal by Specific Cyclins
1995
A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites.
1995 StandoutNobel
Developmental regulation of T-cell receptor gene expression
1985 StandoutNatureNobel
Clonal Deletion Versus Clonal Anergy: The Role of the Thymus in Inducing Self Tolerance
1990 StandoutScienceNobel
Isolation of two early B lymphocyte progenitors from mouse marrow: A committed Pre-Pre-B cell and a clonogenic Thy-1lo hematopoietic stem cell
1986
Epstein–Barr virus transforms precursor B cells even before immunoglobulin gene rearrangements
1984 StandoutNatureNobel
Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination
1997
Two rare populations of mouse Thy-1lo bone marrow cells repopulate the thymus.
1988
In a radiation chimaera, host H–2 antigens determine immune responsiveness of donor cytotoxic cells
1977 Nature
Engraftment of Immune-Deficient Mice with Human Hematopoietic Stem Cells
1988 Science
Evidence of functional lymphocytes in some (leaky) scid mice.
1988
Identification and nucleotide sequence of a diversity DNA segment (D) of immunoglobulin heavy-chain genes
1981 StandoutNatureNobel
Muscle Regeneration by Bone Marrow-Derived Myogenic Progenitors
1998 StandoutScience
The Transcription Factor E2F-1 Is a Downstream Target of RB Action
1995 StandoutNobel
Long-term culture of B lymphocytes and their precursors from murine bone marrow.
1982
Germ-line transmission of genes introduced into cultured pluripotential cells by retroviral vector
1986 StandoutNatureNobel
A third rearranged and expressed gene in a clone of cytotoxic T lymphocytes
1984 StandoutNatureNobel
Induction of cytotoxic T lymphocytes by primary in vitro stimulation with peptides.
1988
Specific suppressor cells in graft–host tolerance of HLA-identical marrow transplantation
1981 StandoutNatureNobel
Transcriptional repression of the E2-containing promoters EIIaE, c-myc, and RB1 by the product of the RB1 gene.
1992
Cell-Mediated Cytotoxicity, Allograft Rejection, and Tumor Immunity
1974 Standout
Retinoblastoma: Clues to Human Oncogenesis
1984 Science
Retinoblastoma Protein Contains a C-terminal Motif That Targets It for Phosphorylation by Cyclin-cdk Complexes
1999 StandoutNobel
Bone marrow stromal cell lines with lymphopoietic activity express high levels of a pre-B neoplasia-associated molecule
1987
Cyclin E-induced S phase without activation of the pRb/E2F pathway.
1997
Signal Sequence Trap: a Cloning Strategy for Secreted Proteins and Type I Membrane Proteins
1993 StandoutScienceNobel
Normal Development of Mice Deficient in β 2 M, MCClass I Proteins, and CD8 + T Cells
1990 StandoutScienceNobel
Synthesis of immunoglobulin mu chain gene products precedes synthesis of light chains during B-lymphocyte development.
1981 Nobel
Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age.
1994
A Model of Human Acute Lymphoblastic Leukemia in Immune-Deficient SCID Mice
1989 Science
Analysis of Lymphoid Population in Scid Mice; Detection of a Potential B Lymphocyte Progenitor Population Present at Normal Levels in Scid Mice by Three Color Flow Cytometry With B220 and S7
1989
The Molecular Genetics of Cancer
1987 StandoutScienceNobel
DNA-Dependent Kinase (p350) as a Candidate Gene for the Murine SCID Defect
1995 Science
Wild-type V(D)J recombination in scid pre-B cells.
1990
λ5, a new light-chain-related locus selectively expressed in pre-B lymphocytes
1986 Nature
Molecular Characterization of the Lymphoid V(D) J Recombination Activity
1989
The RNA Component of Human Telomerase
1995 StandoutScienceNobel
Immunoglobulin‐bearing B cells reconstitute and maintain the murine Ly‐1 B cell lineage
1986
Collaboration of G1 cyclins in the functional inactivation of the retinoblastoma protein.
1994
Ku70 Is Required for Late B Cell Development and Immunoglobulin Heavy Chain Class Switching
1998
pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes.
1997
Cell‐mediated cytotoxicity to trinitrophenyl‐modified syngeneic lymphocytes
1974
A one-receptor view of T-cell behaviour
1981 Nature
scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair.
1991
Hematopoietic development of embryonic stem cells in vitro: cytokine and receptor gene expression.
1991
Immunoglobulin Gene Rearrangement in Immature B Cells
1980 StandoutScienceNobel
Isolation of murine pluripotent hemopoietic stem cells.
1984
The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2.
1996
Dual Mechanisms for the Inhibition of E2F Binding to RB by Cyclin-Dependent Kinase-Mediated RB Phosphorylation
1997
B cell ontogeny in murine embryo studied by a culture system with the monolayer of a stromal cell clone, ST2: B cell progenitor develops first in the embryonal body rather than in the yolk sac.
1988
Purification and Characterization of Mouse Hematopoietic Stem Cells
1988 StandoutScience
Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation.
1997
Regulation of the Ets-Related Transcription Factor Elf-1 by Binding to the Retinoblastoma Protein
1993 StandoutScienceNobel
The Basis for the Immunoregulatory Role of Macrophages and Other Accessory Cells
1987 Science
Immunoglobulin synthesis by lymphoid cells transformed in vitro by Abelson murine leukemia virus
1979 Nobel
Mouse pre-B cells synthesize and secrete heavy chains but not light chains
1980
H‐2 antigen‐specific cytotoxic T cells induced by concanavalin A: estimation of their relative frequency
1976
Introduction of a selectable gene into primitive stem cells capable of long-term reconstitution of the hemopoietic system of W/W mice
1985
Another p53 Doppelgänger?
1998 StandoutScienceNobel
Normal recombination substrate VH to DJH rearrangements in pre-B cell lines from scid mice.
1990
Cytokine Stimulation of Multilineage Hematopoiesis from Immature Human Cells Engrafted in SCID Mice
1992 Science
Works of Robert Phillips being referenced
Randomized cross-over comparison of liposomal daunorubicin versus observation for early Kaposiʼs sarcoma
1996
Early B-cell precursors in scid mice: Normal numbers of cells transformable with abelson murine leukemia virus (A-MuLV)
1988
Regions controlling hyperphosphorylation and conformation of the retinoblastoma gene product are independent of domains required for transcriptional repression.
1992
Quantitative Studies on the Precursors of Cytotoxic Lymphocytes
1978
Allograft Immunity in the Mouse
1973
The identification in adult bone marrow of pluripotent and restricted stem cells of the myeloid and lymphoid systems
1977
Quantitative studies on the precursors of cytotoxic lymphocytes. IV. Specificity and cross-reactivity of cytotoxic clones.
1978
Use of scid mice to identify and quantitate lymphoid-restricted stem cells in long-term bone marrow cultures
1989
Expression patterns of the E2F family of transcription factors during murine epithelial development.
1997
Bone marrow from children in relapse with pre-B acute lymphoblastic leukemia proliferates and disseminates rapidly in scid mice
1991
Isolation of scid pre-B cells that rearrange kappa light chain genes: formation of normal signal and abnormal coding joins.
1989
Failure of RB1 to reverse the malignant phenotype of human tumor cell lines.
1992
Potentials for lymphoid differentiation by cells from long term cultures of bone marrow.
1980
The Immune Response in Mice of Genotypes W/Wv and Sl/Sld1
1969
Multiple manifestations of the retinoblastoma gene.
1982
Dynamics and localization of early B-lymphocyte precursor cells (pro-B cells) in the bone marrow of scid mice
1992
Dynamics and localization of early B-lymphocyte precursor cells (pro-B cells) in the bone marrow of scid mice
1992
Growth of Human Tumors in Immune-Deficient scid Mice and nude Mice
1989
Quantitative studies on the precursors of cytotoxic lymphocytes. V. The cellular basis for the cross-reactivity of TNP-specific clones.
1978
Ontogeny of Murine B Lymphocytes: Development of Ig Synthesis and of Reactivities to Mitogens and to Anti-Ig-Antibodies
1977
Allograft immunity in the mouse. II. Physical studies of the development of cytotoxic effector cells from their immediate progenitors.
1973
Allograft Immunity in the Mouse
1973
Comparison of different assays for multipotent hematopoietic stem cells.
1984
Full reconstitution of the immune deficiency in scid mice with normal stem cells requires low-dose irradiation of the recipients.
1986
Characterization of early B lymphocyte precursors present in long-term bone marrow cultures.
1983
Functional status of cells from lymphoid and myeloid tissues in mice with severe combined immunodeficiency disease.
1984
The function of antigen-presenting cells in mice with severe combined immunodeficiency.
1985
Characterization of the human RB1 promoter and of elements involved in transcriptional regulation.
1994
Allograft immunity in the mouse. 1. Quantitation and specificity of cytotoxic effector cells after in vitro sensitization.
1973
Quantitative Studies on the Precursors of Cytotoxic Lymphocytes
1978
Quantitative studies on the precursors of cytotoxic lymphocytes. I. Characterization of a clonal assay and determination of the size of clones derived from single precursors.
1977