Citation Impact
Citing Papers
CTLA-4 Control over Foxp3 + Regulatory T Cell Function
2008 StandoutScienceNobel
Control of Regulatory T Cell Development by the Transcription Factor Foxp3
2003 StandoutScienceNobel
Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma
2003 StandoutNobel
A Sulfilimine Bond Identified in Collagen IV
2009 StandoutScienceNobel
Inducible costimulator is required for type 2 antibody isotype switching but not T helper cell type 2 responses in chronic nematode infection
2005 StandoutNobel
Systemic CTLA-4 Blockade Ameliorates Glioma-Induced Changes to the CD4+ T Cell Compartment without Affecting Regulatory T-Cell Function
2007 StandoutNobel
CTLA-4-Mediated Inhibition of Early Events of T Cell Proliferation
1999 StandoutNobel
Cytolytic T Lymphocyte-Associated Antigen-4 and the TCRζ/CD3 Complex, But Not CD28, Interact with Clathrin Adaptor Complexes AP-1 and AP-2
1999
The Role of CD80, CD86, and CTLA4 in Alloimmune Responses and the Induction of Long-Term Allograft Survival
1999
Cutting Edge: Identification of GL50, a Novel B7-Like Protein That Functionally Binds to ICOS Receptor
2000
CTLA4Ig: Bridging the Basic Immunology with Clinical Application
2006
The role of CD28 and cytotoxic T‐lymphocyte antigen‐4 (CTLA‐4) in regulatory T‐cell biology
2006
Delayed graft function in kidney transplantation
2004 Standout
CD27 is required for generation and long-term maintenance of T cell immunity
2000
Structural basis for co-stimulation by the human CTLA-4/B7-2 complex
2001 Nature
ICOS co-stimulatory receptor is essential for T-cell activation and function
2001 StandoutNatureNobel
Completion of the entire hepatitis C virus life cycle in genetically humanized mice
2013 StandoutNatureNobel
ICOS is critical for CD40-mediated antibody class switching
2001 Nature
The Cluster of BTN Genes in the Extended Major Histocompatibility Complex
2001
Differential recognition by CD28 of its cognate counter receptors CD80 (B7.1) and B70 (B7.2): Analysis by site directed mutagenesis
1996
A reappraisal of CTLA-4 checkpoint blockade in cancer immunotherapy
2018
LICOS, a primordial costimulatory ligand?
2000
An Autoimmune Disease-Associated CTLA-4 Splice Variant Lacking the B7 Binding Domain Signals Negatively in T Cells
2004
Secondary but not primary T cell responses are enhanced in CTLA-4-deficient CD8+ T cells
1998 StandoutNobel
Preferential dependence of autoantibody production in murine lupus on CD86 costimulatory molecule
1995
Regulatory T Cells
2000 StandoutNobel
Coinhibitory Pathways in the B7-CD28 Ligand-Receptor Family
2016
Treatment of Rheumatoid Arthritis by Selective Inhibition of T-Cell Activation with Fusion Protein CTLA4Ig
2003
Augmentation of CTLA-4 expression by wortmannin: involvement of lysosomal sorting properties of CTLA-4
1999
Co-stimulation in T cell responses
1997 StandoutNobel
CTLA-4: new insights into its biological function and use in tumor immunotherapy
2002 StandoutNobel
Regulatory T Cells and Immune Tolerance
2008 StandoutNobel
CTLA-4 Regulates Induction of Anergy In Vivo
2001
Cyclophilin A Regulates TCR Signal Strength in CD4+ T Cells via a Proline-Directed Conformational Switch in Itk
2004
Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-γ but not TH2 cytokines
2001
Structure and evolution of the extended B7 family
1999
The Interaction Properties of Costimulatory Molecules Revisited
2002
B7-H3: A costimulatory molecule for T cell activation and IFN-γ production
2001
Enhanced expression of B7-1, B7-2, and intercellular adhesion molecule 1 in sinusoidal endothelial cells by warm ischemia/reperfusion injury in rat liver
2001 StandoutNobel
Structural mechanisms of costimulation
2002
ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28
1999 Nature
The Emerging Role of CTLA-4 as an Immune Attenuator
1997 StandoutNobel
Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential
2015 StandoutNobel
Structure and Dimerization of a Soluble Form of B7-1
2000
The immunological synapse for B-cell memory: the role of the ICOS and its ligand for the longevity of humoral immunity
2003
T Cell–Mediated Elimination of B7.2 Transgenic B Cells
1997 StandoutNobel
The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses
2011
B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion
1999 Standout
Compartmental specificity of cellular membrane fusion encoded in SNARE proteins
2000 StandoutNatureNobel
Structure/function relationships of axon-associated adhesion receptors of the immunoglobulin superfamily
1996
CTLA‐4, a Negative Regulator of T‐Lymphocyte Activation
1996
Restoring function in exhausted CD8 T cells during chronic viral infection
2005 StandoutNatureNobel
Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
1995 Standout
Negative regulators of T‐cell activation: potential targets for therapeutic intervention in cancer, autoimmune disease, and persistent infections
2009 StandoutNobel
The blockade of immune checkpoints in cancer immunotherapy
2012 Standout
Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion
2002 Standout
CD28 and CTLA‐4 coreceptor expression and signal transduction
2009
Alport's Syndrome, Goodpasture's Syndrome, and Type IV Collagen
2003
Costimulation Blockade with Belatacept in Renal Transplantation
2005 Standout
The Role of CTLA‐4 in the Regulation and Initiation of T‐Cell Responses
1996 StandoutNobel
CTLA-4–Ig regulates tryptophan catabolism in vivo
2002
Instruction of Distinct CD4 T Helper Cell Fates by Different Notch Ligands on Antigen-Presenting Cells
2004 StandoutNobel
B7-1 and B7-2 Selectively Recruit CTLA-4 and CD28 to the Immunological Synapse
2004 StandoutNobel
What's the difference between CD80 and CD86?
2003
Distinct Cellular Mechanisms Underlie Anti-CTLA-4 and Anti-PD-1 Checkpoint Blockade
2017 StandoutNobel
Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses
2001 Nature
Costimulatory regulation of T cell function
1999 StandoutNobel
The Role of T-Cell Costimulatory Activation Pathways in Transplant Rejection
1998
Tyrosine Phosphorylation Controls Internalization of CTLA-4 by Regulating Its Interaction with Clathrin-Associated Adaptor Complex AP-2
1997
The acute respiratory distress syndrome
2012 Standout
The Complexities of T‐Cell Co‐stimulation: CD28 and Beyond
1996
Cytotoxic T Lymphocyte Antigen-4 Accumulation in the Immunological Synapse Is Regulated by TCR Signal Strength
2002 StandoutNobel
B7-H4, a Molecule of the B7 Family, Negatively Regulates T Cell Immunity
2003
Effect of inducible costimulator blockade on the pathological and protective immune responses induced by the gastrointestinal helminth Trichinella spiralis
2004
Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy
2016 StandoutNobel
B7-1 and B7-2 Have Overlapping, Critical Roles in Immunoglobulin Class Switching and Germinal Center Formation
1997
Immune Checkpoint Blockade: A Common Denominator Approach to Cancer Therapy
2015 Standout
B7‐1‐dependent co‐stimulation results in qualitatively and quantitatively different responses by CD4+ and CD8+ T cells
1997
B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy
1995
Cytotoxic T Lymphocyte-associated Molecule-4, a High Avidity Receptor for CD80 and CD86, Contains an Intracellular Localization Motif in Its Cytoplasmic Tail
1995
The B7–CD28 superfamily
2002
Lymphoproliferation in CTLA-4–Deficient Mice Is Mediated by Costimulation-Dependent Activation of CD4 + T Cells
1997 StandoutNobel
New perspectives of C1328-137-mediated T cell costimulation
1995
Intraorganellar calcium and pH control proinsulin cleavage in the pancreatic β cell via two distinct site-specific endopeptidases
1988 Nature
The CD28-Related Molecule ICOS Is Required for Effective T Cell–Dependent Immune Responses
2000
Superantigen responses and co-stimulation: CD28 and CTLA-4 have opposing effects on T cell expansion in vitro and in vivo
1996 StandoutNobel
Differential Role of CTLA-4 in Regulation of Resting Memory Versus Naive CD4 T Cell Activation
1998
Normal Responsiveness of CTLA-4-Deficient Anti-Viral Cytotoxic T Cells
1998
Thymocyte development is normal in CTLA-4-deficient mice
1997 StandoutNobel
Manipulation of T cell costimulatory and inhibitory signals for immunotherapy of prostate cancer
1997 StandoutNobel
Recruitment of Foxp3+ T regulatory cells mediating allograft tolerance depends on the CCR4 chemokine receptor
2005
Phenotypic analysis of CTLA-4 and CD28 expression during transient peptide-induced T cell activation in vivo
1999
Cytolytic T lymphocyte-associated antigen-4 and the TCR zeta/CD3 complex, but not CD28, interact with clathrin adaptor complexes AP-1 and AP-2.
1999
Detection of self-reactive CD8 + T cells with an anergic phenotype in healthy individuals
2014 StandoutScienceNobel
Cd4+Cd25+ Immune Regulatory Cells Are Required for Induction of Tolerance to Alloantigen via Costimulatory Blockade
2001
Interaction of the Cytoplasmic Tail of CTLA-4 (CD152) with a Clathrin-Associated Protein Is Negatively Regulated by Tyrosine Phosphorylation
1997
CD80 (B7-1) Binds Both CD28 and CTLA-4 with a Low Affinity and Very Fast Kinetics
1997
B7x: A widely expressed B7 family member that inhibits T cell activation
2003 StandoutNobel
Manipulation of costimulatory signals to enhance antitumor T-cell responses
1995 StandoutNobel
B7–CTLA4 interaction enhances both production of antitumor cytotoxic T lymphocytes and resistance to tumor challenge
1998
CTLA-4–B7 Interaction Is Sufficient to Costimulate T Cell Clonal Expansion
1997
Absence of CTLA-4 Lowers the Activation Threshold of Primed CD8+ TCR-Transgenic T Cells: Lack of Correlation with Src Homology Domain 2-Containing Protein Tyrosine Phosphatase
2001
Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein
1997 StandoutNobel
Expression and regulation of the PD-L1 immunoinhibitory molecule on microvascular endothelial cells.
2002
Regulated Secretion from Hemopoietic Cells
1999
CTLA-4 (CD152) Can Inhibit T Cell Activation by Two Different Mechanisms Depending on Its Level of Cell Surface Expression
2000
CD28/B7 SYSTEM OF T CELL COSTIMULATION
1996 Standout
Rescue of thymocytes from glucocorticoid-induced cell death mediated by CD28/CTLA-4 costimulatory interactions with B7-1/B7-2.
1996
Regulation of Cell Surface Expression of CTLA-4 by Secretion of CTLA-4-Containing Lysosomes Upon Activation of CD4+ T Cells
2000
Expression and Regulation of the PD-L1 Immunoinhibitory Molecule on Microvascular Endothelial Cells
2002
Cytotoxic T Lymphocyte Antigen 4 (CTLA-4) Interferes with Extracellular Signal-regulated Kinase (ERK) and Jun NH2-terminal Kinase (JNK) Activation, but Does Not Affect Phosphorylation of T Cell Receptor ζ and ZAP70
1997
Molecular Basis of T Cell Inactivation by CTLA-4
1998 Science
THE B7 FAMILY REVISITED
2005 Standout
The Inhibitory Function of CTLA-4 Does Not Require Its Tyrosine Phosphorylation
2000
Fundamental Mechanisms of Immune Checkpoint Blockade Therapy
2018 StandoutNobel
Structural Analysis of CTLA-4 Function In Vivo
2000
Inducible Costimulator Protein Controls the Protective T Cell Response Against Listeria monocytogenes
2002
Neural Science
2000 StandoutNobel
Defective CTLA-4 cycling pathway in Chediak–Higashi syndrome: A possible mechanism for deregulation of T lymphocyte activation
1999
Induction of Cytotoxic T Lymphocyte Antigen 4 (Ctla-4) Restricts Clonal Expansion of Helper T Cells
2001
Cytotoxic T Lymphocyte–Associated Antigen 4 Plays an Essential Role in the Function of Cd25+Cd4+ Regulatory Cells That Control Intestinal Inflammation
2000 Standout
CTLA-4 Overexpression Inhibits T Cell Responses through a CD28-B7-Dependent Mechanism
2006 StandoutNobel
The Yin and Yang of T Cell Costimulation
1995 StandoutScienceNobel
Transport of Peptide-MHC Class II Complexes in Developing Dendritic Cells
2000 StandoutScienceNobel
The future of immune checkpoint therapy
2015 StandoutScienceNobel
Costimulation of T cells by B7-H2, a B7-like molecule that binds ICOS
2000
Crystal structure of the receptor-binding domain of human B7-2: Insights into organization and signaling
2003
Identification of residues in the V domain of CD80 (B7-1) implicated in functional interactions with CD28 and CTLA4.
1995
CTLA-4 ligation blocks CD28-dependent T cell activation.
1996
Complexities of CD28/B7: CTLA-4 Costimulatory Pathways in Autoimmunity and Transplantation
2001
The Role of CTLA-4 in Regulating Th2 Differentiation
1999
Clathrin: A Role in the Intracellular Retention of a Golgi Membrane Protein
1989 StandoutScienceNobel
B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4
1995
Cytotoxic T lymphocyte antigen-4 (CTLA-4) regulates the size, reactivity, and function of a primed pool of CD4+T cells
2000 StandoutNobel
Blockade of CTLA-4 Enhances Host Resistance to the Intracellular Pathogen,Leishmania donovani
1998
CTLA-4-Mediated Inhibition in Regulation of T Cell Responses: Mechanisms and Manipulation in Tumor Immunotherapy
2001 StandoutNobel
The B7 Family of Ligands and Its Receptors: New Pathways for Costimulation and Inhibition of Immune Responses
2002
B7-Dc, a New Dendritic Cell Molecule with Potent Costimulatory Properties for T Cells
2001
Fas-independent death of activated CD4+T lymphocytes induced by CTLA-4 crosslinking
1998
Expression and Function of CTLA-4 in Th1 and Th2 Cells
1998
Structure of Murine CTLA-4 and Its Role in Modulating T Cell Responsiveness
2000 Science
Friends Not Foes: CTLA-4 Blockade and mTOR Inhibition Cooperate during CD8+ T Cell Priming To Promote Memory Formation and Metabolic Readiness
2015 StandoutNobel
B7-Independent Inhibition of T Cells by CTLA-4
2005
Enhancement of Antitumor Immunity by CTLA-4 Blockade
1996 StandoutScienceNobel
Treatment with anti-CD86 costimulatory molecule prevents the autoimmune lesions in murine Sjögren’s syndrome (SS) through up-regulated Th2 response
2000
Cytotoxic T Lymphocyte Antigen 4 (Ctla-4) Engagement Delivers an Inhibitory Signal through the Membrane-Proximal Region in the Absence of the Tyrosine Motif in the Cytoplasmic Tail
1999
Analysis of the Underlying Cellular Mechanisms of Anti-CD154-Induced Graft Tolerance: The Interplay of Clonal Anergy and Immune Regulation
2005 StandoutNobel
Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade
2002 StandoutNobel
B7-1 Engagement of Cytotoxic T Lymphocyte Antigen 4 Inhibits T Cell Activation in the Absence of CD28
1998
Differential control of human Treg and effector T cells in tumor immunity by Fc-engineered anti–CTLA-4 antibody
2018 StandoutNobel
Works of Robert Peach being referenced
Differential effects of B7-1 blockade in the rat experimental autoimmune encephalomyelitis model.
1997
Intracellular Trafficking of CTLA-4 and Focal Localization Towards Sites of TCR Engagement
1996
Endothelial Cells Are Central Orchestrators of Cytokine Amplification during Influenza Virus Infection
2011
CTLA4-Ig inhibits optimal T helper 2 cell development but not protective immunity or memory response toNippostrongylus brasiliensis
1999
Calcium‐dependent KEX2‐like protease found in hepatic secretory vesicles converts proalbumin to albumin
1988
Binding Stoichiometry of the Cytotoxic T Lymphocyte-associated Molecule-4 (CTLA-4)
1995
CD28-B7 blockade in organ dysfunction secondary to cold ischemia/reperfusion injury: Rapid Communication
1997
Immunoglobulin fold characteristics of B7–1 (CD80) and B7–2 (CD86)
1994
CD28-B7-Mediated T Cell Costimulation in Chronic Cardiac Allograft Rejection
2001
Both Extracellular Immunoglobin-like Domains of CD80 Contain Residues Critical for Binding T Cell Surface Receptors CTLA-4 and CD28
1995
CD28-B7 blockade prevents the development of experimental autoimmune glomerulonephritis
2000
Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors
1994
Rational Development of LEA29Y (belatacept), a High-Affinity Variant of CTLA4-Ig with Potent Immunosuppressive Properties
2005
Covalent Dimerization of CD28/CTLA-4 and Oligomerization of CD80/CD86 Regulate T Cell Costimulatory Interactions
1996
Effects of blocking B7-1 and B7-2 interactions during a type 2 in vivo immune response.
1997
Extending the B7 (CD80) gene family
1994
Complementarity determining region 1 (CDR1)- and CDR3-analogous regions in CTLA-4 and CD28 determine the binding to B7-1.
1994
Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection
1996
A Role for Inducible Costimulator Protein in the CD28- Independent Mechanism of Resistance to Toxoplasma gondii
2002
Role of CD28 in the Generation of Effector and Memory Responses Required for Resistance toToxoplasma gondii
1999
CD28-B7 T cell costimulatory blockade by CTLA4Ig in sensitized rat recipients: induction of transplantation tolerance in association with depressed cell-mediated and humoral immune responses.
1997
CD80 Costimulation Is Essential for the Induction of Airway Eosinophilia
1997
The role of donor and recipient B7-1 (CD80) in allograft rejection.
1997
Ex vivo treatment of antigen-presenting cells with CTLA4Ig and encephalitogenic peptide prevents experimental autoimmune encephalomyelitis in the Lewis rat.
1996
IL-13-Mediated Worm Expulsion Is B7 Independent and IFN-γ Sensitive
2000
Differential Requirement for CD80 and CD80/CD86-Dependent Costimulation in the Lung Immune Response to an Influenza Virus Infection
2000