Citation Impact
Citing Papers
Thrombin Receptor (Protease Activated Receptor-1) Antagonists as Potent Antithrombotic Agents with Strong Antiplatelet Effects
2006
Structure/function relationships of Fcγ receptors in phagocytosis
1995
Thrombin Responses in Human Endothelial Cells
2000
Engineered receptors for soluble cellular communication and disease sensing
2024 StandoutNatureNobel
Structural Aspects of the Association of FcεRI with Detergent-resistant Membranes
1999
Inflammation and cancer
2002 StandoutNature
Regulation of antigen receptor signal transduction by protein tyrosine kinases
1996
Protein tyrosine kinases in the initiation of antigen receptor signaling
1995
Molecular regulation of mast cell activation
2006
The Role of Short-Chain Fatty Acids in Health and Disease
2014 Standout
The Proinflammatory Cytokines Interleukin-l and Tumor Necrosis Factor and Treatment of the Septic Shock Syndrome
1991
Extracellular Mutations of Protease-Activated Receptor-1 Result in Differential Activation by Thrombin and Thrombin Receptor Agonist Peptide
2000
Randomized phase II trial of high-dose interleukin-2 either alone or in combination with interferon alfa-2b in advanced renal cell carcinoma.
1993
Sensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory pain
2007
Cell Signaling by Receptor Tyrosine Kinases
2010 Standout
The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme
1993 Standout
Protease‐activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice
2006
Dual Detection of Fungal Infections in Drosophila via Recognition of Glucans and Sensing of Virulence Factors
2006 StandoutNobel
High-resolution crystal structure of human protease-activated receptor 1
2012 StandoutNatureNobel
Nociceptive Signals Induce Trafficking of TRPA1 to the Plasma Membrane
2009 StandoutNobel
Irritant-evoked activation and calcium modulation of the TRPA1 receptor
2020 StandoutNatureNobel
Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria
2009 Standout
Roles of Adaptor Molecules in Mast Cell Activation
2005
Influence of tumour micro-environment heterogeneity on therapeutic response
2013 StandoutNature
The FcϵRIβ Immunoreceptor Tyrosine-based Activation Motif Exerts Inhibitory Control on MAPK and IκB Kinase Phosphorylation and Mast Cell Cytokine Production
2004
Angiogenesis in cancer and other diseases
2000 StandoutNature
The Hallmarks of Cancer
2000 Standout
Structure-guided mutagenesis of a mucin-selective metalloprotease from Akkermansia muciniphila alters substrate preferences
2022 StandoutNobel
The Pathogenesis of Rheumatoid Arthritis
2011 Standout
Protease‐activated receptors in hemostasis, thrombosis and vascular biology
2005
Temporal Activation of Nontransmembrane Protein-tyrosine Kinases following Mast Cell Fc∊RI Engagement
1995
Temsirolimus, Interferon Alfa, or Both for Advanced Renal-Cell Carcinoma
2007 Standout
Visualizing the mechanical activation of Src
2005 StandoutNatureNobel
Thrombin signalling and protease-activated receptors
2000 StandoutNature
Hypoxia and the extracellular matrix: drivers of tumour metastasis
2014 StandoutNobel
Serum amyloid A, the major vertebrate acute‐phase reactant
1999
Platelet Activation and Atherothrombosis
2007 Standout
Constitutive Protease-activated Receptor-2-mediated Migration of MDA MB-231 Breast Cancer Cells Requires Both β-Arrestin-1 and -2
2004 StandoutNobel
Comparison of FcϵRI‐ and FcγRI‐mediated degranulation and TNF‐α synthesis in human mast cells: selective utilization of phosphatidylinositol‐3‐kinase for FcγRI‐induced degranulation
2003
Allergy-Associated FcRβ Is a Molecular Amplifier of IgE- and IgG-Mediated In Vivo Responses
1998
A CAT reporter construct allows ultrasensitive estimation of TNF synthesis, and suggests that the TNF gene has been silenced in non-macrophage cell lines.
1991 StandoutNobel
Tyrosine Phosphorylation of the vav Proto-oncogene Product Links FcεRI to the Rac1-JNK Pathway
1997
The development of allergic inflammation
2008 StandoutNature
Cell Adhesion: The Molecular Basis of Tissue Architecture and Morphogenesis
1996 Standout
Mast Cell Proteases
2007
Signaling—2000 and Beyond
2000 Standout
Signal transduction by cell adhesion receptors
1995
Fc receptors: Rubor redux
1994
Impaired Kit- but Not FcεRI-initiated Mast Cell Activation in the Absence of Phosphoinositide 3-Kinase p85α Gene Products
2000
Cytokines as Endogenous Pyrogens
1999
Programmable synthetic receptors: the next-generation of cell and gene therapies
2024
Cellular Localization of Membrane-type Serine Protease 1 and Identification of Protease-activated Receptor-2 and Single-chain Urokinase-type Plasminogen Activator as Substrates
2000
Interaction of Phosphorylated FcϵRIγ Immunoglobulin Receptor Tyrosine Activation Motif-based Peptides with Dual and Single SH2 Domains of p72
1996
Enhanced Phagocytosis through Inhibition of de Novo Ceramide Synthesis
2003 StandoutNobel
Cellular and Molecular Mechanisms of Pain
2009 StandoutNobel
Bruton's Tyrosine Kinase-mediated Interleukin-2 Gene Activation in Mast Cells
1998
Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis
1999
Mast cells in atopic dermatitis
2009
Interleukin 1: the first interleukin
1990
Adhesive signaling in platelets
1994
Phosphoinositides in cell regulation and membrane dynamics
2006 StandoutNature
Immunomodulatory effects of deacetylase inhibitors: therapeutic targeting of FOXP3+ regulatory T cells
2009
Disseminated Intravascular Coagulation
1999 Standout
β-Arrestins Regulate Protease-activated Receptor-1 Desensitization but Not Internalization or Down-regulation
2002 StandoutNobel
Synovial mast cells: role in acute and chronic arthritis
2007
Points of control in inflammation
2002 StandoutNature
A prospective crossover randomized trial of novobiocin and rifampin prophylaxis for the prevention of intravascular catheter infections in cancer patients treated with interleukin-2
1998
Regulation of mast-cell and basophil function and survival by IgE
2002
Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation
2013 StandoutNature
Acute-Phase Proteins and Other Systemic Responses to Inflammation
1999 Standout
Cancer-related inflammation
2008 StandoutNature
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
2003 StandoutNature
Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling
2009 Standout
Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism
2000
Phosphoinositide Involvement in Phagocytosis and Phagosome Maturation
2004
Nociceptors: the sensors of the pain pathway
2010 StandoutNobel
Heterologous protein expression in the methylotrophic yeastPichia pastoris
2000 Standout
Integrated signalling pathways for mast-cell activation
2006 Standout
Calcium mobilization via sphingosine kinase in signalling by the FcɛRI antigen receptor
1996 Nature
NTAL phosphorylation is a pivotal link between the signaling cascades leading to human mast cell degranulation following Kit activation and Fc RI aggregation
2004
Cell Signaling by Receptor Tyrosine Kinases
2000 Standout
MIF is a pituitary-derived cytokine that potentiates lethal endotoxaemia
1993 StandoutNature
Molecular Basis of Fc Receptor Function
1994
Proteinase-activated receptors: novel mechanisms of signaling by serine proteases
1998 Standout
Sol Sherry Lecture in Thrombosis
1998
Functional rafts in cell membranes
1997 StandoutNature
Preventing Complications of Central Venous Catheterization
2003 Standout
Characterization of Cbl tyrosine phosphorylation and a Cbl-Syk complex in RBL-2H3 cells.
1996
Compartmentalized IgE Receptor–mediated Signal Transduction in Living Cells
1997
Differential Expression of Protease-Activated Receptors-1 and -2 in Stromal Fibroblasts of Normal, Benign, and Malignant Human Tissues
2001
Fc RECEPTOR BIOLOGY
1997
Transmembrane signaling by antigen receptors of B and T lymphocytes
1995
The Four Distal Tyrosines Are Required for LAT-dependent Signaling in FcεRI-mediated Mast Cell Activation
2003
Integrins and Signal Transduction Pathways: the Road Taken
1995 StandoutScience
Immune regulation by histone deacetylases: a focus on the alteration of FOXP3 activity
2011
CELLULAR FUNCTIONS REGULATED BY SRC FAMILY KINASES
1997 Standout
Involvement of Bruton's Tyrosine Kinase in FcεRI-dependent Mast Cell Degranulation and Cytokine Production
1998
SLP-76 deficiency impairs signaling via the high-affinity IgE receptor in mast cells.
1999
Redundant and Opposing Functions of Two Tyrosine Kinases, Btk and Lyn, in Mast Cell Activation
2000
Inhibition of mast cell Fc epsilon R1-mediated signaling and effector function by the Syk-selective inhibitor, piceatannol.
1994
PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine
2001 StandoutNobel
Protease-Activated Receptor Signaling Increases Epithelial Antimicrobial Peptide Expression
2004
Passive immunization against tumor necrosis factor partially abrogates interleukin 2 toxicity.
1989
Induction of phagocytosis by a protein tyrosine kinase
1995
Fc epsilon RI-mediated recruitment of p53/56lyn to detergent-resistant membrane domains accompanies cellular signaling.
1995
Akt-Dependent Cytokine Production in Mast Cells
2000
The molecular dissection of Fc gamma receptor mediated phagocytosis
1995
Tissue-specific contributions of Tmem79 to atopic dermatitis and mast cell-mediated histaminergic itch
2018 StandoutNobel
Transphosphorylation as the mechanism by which the high-affinity receptor for IgE is phosphorylated upon aggregation.
1994
Markedly Different Pathogenicity of Four Immunoglobulin G Isotype-Switch Variants of an Antierythrocyte Autoantibody Is Based on Their Capacity to Interact in Vivo with the Low-Affinity Fcγ Receptor III
2000 StandoutNobel
Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa
2000
Dysregulated FcεRI Signaling and Altered Fyn and SHIP Activities in Lyn-Deficient Mast Cells
2004
Wortmannin blocks lipid and protein kinase activities associated with PI 3-kinase and inhibits a subset of responses induced by Fc epsilon R1 cross-linking.
1995
Interleukin-1 and interleukin-1 antagonism
1991 Standout
JNK1 controls mast cell degranulation and IL-1β production in inflammatory arthritis
2010 StandoutNobel
Works of Robert P. Numerof being referenced
Suppression of IL-2-induced SAA gene expression in mice by the administration of an IL-1 receptor antagonist
1992
Interactions of Mast Cell Tryptase with Thrombin Receptors and PAR-2
1997
Syk-dependent Phosphorylation of Shc
1996
Kinase Activation through the High-Affinity Receptor for Immunoglobulin E
1994
Signal transduction through the conserved motifs of the high affinity IgE receptor FcεRI
1995
Induction of circulating tumor necrosis factor (TNFα) as the mechanism for the febrile response to interleukin-2 (IL-2) in cancer patients
1988
Toxicity of Immunotherapy with Interleukin-2 and Lymphokine-Activated Killer Cells
1988
Pro-interleukin-1β production by a subpopulation of human T cells, but not NK cells, in response to interleukin-2
1990
Expression and Characterization of Recombinant Mast Cell Tryptase
1999
Induction of Foxp3+ regulatory T cells with histone deacetylase inhibitors
2009
Differential control of the tyrosine kinases Lyn and Syk by the two signaling chains of the high affinity immunoglobulin E receptor.
1994
Phosphorylation/dephosphorylation of high-affinity IgE receptors: a mechanism for coupling/uncoupling a large signaling complex.
1992
Regulation by CD45 of the tyrosine phosphorylation of high affinity IgE receptor beta- and gamma-chains.
1995
IL-2 stimulates the production of IL-1 alpha and IL-1 beta by human peripheral blood mononuclear cells.
1988
IgE receptor (Fc epsilon RI) and signal transduction.
1996
Long-Term Safety Profile of the Oral Spleen Tyrosine Kinase Inhibitor Fostamatinib in Immune Thrombocytopenia (ITP) and Other Diseases
2020