Citation Impact
Citing Papers
Multiplex Genome Engineering Using CRISPR/Cas Systems
2013 StandoutScience
Precise and Heritable Genome Editing in Evolutionarily Diverse Nematodes Using TALENs and CRISPR/Cas9 to Engineer Insertions and Deletions
2013 StandoutNobel
Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation
2014 StandoutScienceNobel
Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells
2013 StandoutScience
Generation of knock-in primary human T cells using Cas9 ribonucleoproteins
2015 StandoutNobel
RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection
2014
C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector
2016 StandoutScience
CRISPR/Cas9 in Genome Editing and Beyond
2016
Novel fluorescent genome editing reporters for monitoring DNA repair pathway utilization at endonuclease-induced breaks
2013
Breaking the Code of DNA Binding Specificity of TAL-Type III Effectors
2009 StandoutScience
High-throughput biochemical profiling reveals sequence determinants of dCas9 off-target binding and unbinding
2017 StandoutNobel
Multiplex Genome-Edited T-cell Manufacturing Platform for “Off-the-Shelf” Adoptive T-cell Immunotherapies
2015
RNA-Guided Human Genome Engineering via Cas9
2013 StandoutScience
Rationally engineered Cas9 nucleases with improved specificity
2015 StandoutScience
RNA-seq pinpoints a Xanthomonas TAL-effector activated resistance gene in a large-crop genome
2012
A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity
2012 StandoutScienceNobel
Fungal Small RNAs Suppress Plant Immunity by Hijacking Host RNA Interference Pathways
2013 StandoutScience
Engineering reprogrammable RNA-binding proteins for study and manipulation of the transcriptome
2015
Optimized TAL effector nucleases (TALENs) for use in treatment of sickle cell disease
2012
CRISPR/Cas9 cleavage of viral DNA efficiently suppresses hepatitis B virus
2015 StandoutNatureNobel
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
2014 Standout
Overcoming Transcription Activator-like Effector (TALE) DNA Binding Domain Sensitivity to Cytosine Methylation
2012
Synergistic and tunable human gene activation by combinations of synthetic transcription factors
2013
DNA interrogation by the CRISPR RNA-guided endonuclease Cas9
2014 StandoutNatureNobel
Reading Frame Correction by Targeted Genome Editing Restores Dystrophin Expression in Cells From Duchenne Muscular Dystrophy Patients
2013
The promise and challenge of therapeutic genome editing
2020 StandoutNatureNobel
Efficient gene targeting by TAL effector nucleases coinjected with exonucleases in zygotes
2013
Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
2016 StandoutNature
RNA-guided gene activation by CRISPR-Cas9–based transcription factors
2013
Transcription activator‐like effector nucleases (TALENs): A highly efficient and versatile tool for genome editing
2013
A guide to genome engineering with programmable nucleases
2014 Standout
DNA targeting specificity of RNA-guided Cas9 nucleases
2013 Standout
Addition of transcription activator‐like effector binding sites to a pathogen strain‐specific rice bacterial blight resistance gene makes it effective against additional strains and against bacterial leaf streak
2012
Efficient construction of sequence-specific TAL effectors for modulating mammalian transcription
2011
Long-term dual-color tracking of genomic loci by modified sgRNAs of the CRISPR/Cas9 system
2016
High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects
2016 StandoutNature
Broken TALEs: Transcription Activator-like Effectors Populate Partly Folded States
2016
A transcription activator-like effector toolbox for genome engineering
2012
Classification and evolution of type II CRISPR-Cas systems
2014 StandoutNobel
Genome-wide specificity of DNA binding, gene regulation, and chromatin remodeling by TALE- and CRISPR/Cas9-based transcriptional activators
2015
Broad specificity profiling of TALENs results in engineered nucleases with improved DNA-cleavage specificity
2014
Genome-Editing Technologies: Principles and Applications
2016
Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting
2011 Standout
Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex
2014 StandoutNature
Comprehensive interrogation of natural TALE DNA-binding modules and transcriptional repressor domains
2012
CRISPR/Cas9 systems targeting β-globin and CCR5 genes have substantial off-target activity
2013
ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering
2013 Standout
Enabling functional genomics with genome engineering
2015
Robust, synergistic regulation of human gene expression using TALE activators
2013
An Efficient Antiviral Strategy for Targeting Hepatitis B Virus Genome Using Transcription Activator-Like Effector Nucleases
2013
Modularly assembled designer TAL effector nucleases for targeted gene knockout and gene replacement in eukaryotes
2011
Inactivation of Hepatitis B Virus Replication in Cultured Cells and In Vivo with Engineered Transcription Activator-Like Effector Nucleases
2013
Promoter elements of rice susceptibility genes are bound and activated by specific TAL effectors from the bacterial blight pathogen, Xanthomonas oryzae pv. oryzae
2010
Enhanced proofreading governs CRISPR–Cas9 targeting accuracy
2017 StandoutNatureNobel
Characterization and DNA-Binding Specificities of Ralstonia TAL-Like Effectors
2013
A Broad-Spectrum Inhibitor of CRISPR-Cas9
2017 StandoutNobel
FLASH assembly of TALENs for high-throughput genome editing
2012
CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering
2013
CRISPR/Cas9-Based Engineering of the Epigenome
2017
In vivo genome editing using Staphylococcus aureus Cas9
2015 StandoutNature
Engineered zinc finger nickases induce homology-directed repair with reduced mutagenic effects
2012
TAL Effector Specificity for base 0 of the DNA Target Is Altered in a Complex, Effector- and Assay-Dependent Manner by Substitutions for the Tryptophan in Cryptic Repeat –1
2013
In vivo genome editing using a high-efficiency TALEN system
2012 Nature
De novo design of bioactive protein switches
2019 StandoutNatureNobel
Targeted genome editing in human repopulating haematopoietic stem cells
2014 Nature
Precision genome engineering with programmable DNA-nicking enzymes
2012
Directed evolution of the TALE N-terminal domain for recognition of all 5′ bases
2013
High-throughput screening of a CRISPR/Cas9 library for functional genomics in human cells
2014 Nature
TAL effectors: finding plant genes for disease and defense
2010
Engineering domain fusion chimeras from I-OnuI family LAGLIDADG homing endonucleases
2012 StandoutNobel
CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes
2013 StandoutNobel
Analysis of off-target effects of CRISPR/Cas-derived RNA-guided endonucleases and nickases
2013
A 20-year retrospective review of global aquaculture
2021 StandoutNature
A library of TAL effector nucleases spanning the human genome
2013
TALEN or Cas9 – Rapid, Efficient and Specific Choices for Genome Modifications
2013
A ligation-independent cloning technique for high-throughput assembly of transcription activator–like effector genes
2012
Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease
2013
Refined sgRNA efficacy prediction improves large- and small-scale CRISPR–Cas9 applications
2017 StandoutNobel
The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy
2015 StandoutNature
A TALE nuclease architecture for efficient genome editing
2010 Standout
The Human Condition—A Molecular Approach
2014 StandoutNobel
Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases
2014
Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression
2013 StandoutNobel
Genome-editing Technologies for Gene and Cell Therapy
2016
Differential integrity of TALE nuclease genes following adenoviral and lentiviral vector gene transfer into human cells
2012
Genome Engineering with Targetable Nucleases
2014
Chemical and biological approaches to improve the efficiency of homologous recombination in human cells mediated by artificial restriction DNA cutter
2012
Dynamics of CRISPR-Cas9 genome interrogation in living cells
2015 StandoutScienceNobel
Pivoting the Plant Immune System from Dissection to Deployment
2013 StandoutScience
Extreme stability in de novo-designed repeat arrays is determined by unusually stable short-range interactions
2018 StandoutNobel
Genomes in Focus: Development and Applications of CRISPR‐Cas9 Imaging Technologies
2017 StandoutNobel
The new frontier of genome engineering with CRISPR-Cas9
2014 StandoutScienceNobel
Iterative capped assembly: rapid and scalable synthesis of repeat-module DNA such as TAL effectors from individual monomers
2012
Ancient class of translocated oomycete effectors targets the host nucleus
2010
Imaging Specific Genomic DNA in Living Cells
2016
TALENs: a widely applicable technology for targeted genome editing
2012
TAL Effectors: Customizable Proteins for DNA Targeting
2011 Science
Reprogramming homing endonuclease specificity through computational design and directed evolution
2013 StandoutNobel
Xanthomonas AvrBs3 Family-Type III Effectors: Discovery and Function
2010
Site- and strand-specific nicking of DNA by fusion proteins derived from MutH and I-SceI or TALE repeats
2013
Multicolor CRISPR labeling of chromosomal loci in human cells
2015
Genome Engineering at the Dawn of the Golden Age
2013
Rational design of a split-Cas9 enzyme complex
2015 StandoutNobel
Progressive engineering of a homing endonuclease genome editing reagent for the murine X-linked immunodeficiency locus
2014 StandoutNobel
Demonstration of CRISPR/Cas9/sgRNA-mediated targeted gene modification in Arabidopsis, tobacco, sorghum and rice
2013
Crystal structure of a TALE protein reveals an extended N-terminal DNA binding region
2012
Disease reduction in aquaculture with genetic and genomic technology: current and future approaches
2017
megaTALs: a rare-cleaving nuclease architecture for therapeutic genome engineering
2013 StandoutNobel
Engineering Plant Disease Resistance Based on TAL Effectors
2013
De novo-engineered transcription activator-like effector (TALE) hybrid nuclease with novel DNA binding specificity creates double-strand breaks
2011
Cas9 interrogates DNA in discrete steps modulated by mismatches and supercoiling
2020 StandoutNobel
Dissecting Neural Function Using Targeted Genome Engineering Technologies
2012
Efficient TALEN-mediated gene knockout in livestock
2012
Use and Abuse of RNAi to Study Mammalian Gene Function
2012 StandoutScienceNobel
Targeted gene knock-in by homology-directed genome editing using Cas9 ribonucleoprotein and AAV donor delivery
2017 StandoutNobel
Phylogeny of Cas9 determines functional exchangeability of dual-RNA and Cas9 among orthologous type II CRISPR-Cas systems
2013 StandoutNobel
CRISPR-Cas guides the future of genetic engineering
2018 StandoutScienceNobel
A single plant resistance gene promoter engineered to recognize multiple TAL effectors from disparate pathogens
2009
Rewriting a genome
2013 StandoutNatureNobel
Visualization of repetitive DNA sequences in human chromosomes with transcription activator-like effectors
2013
Works of Robert Morbitzer being referenced
Regulation of selected genome loci using de novo-engineered transcription activator-like effector (TALE)-type transcription factors
2010
Targeting and tracing of specific DNA sequences with dTALEs in living cells
2013
A novel TALE nuclease scaffold enables high genome editing activity in combination with low toxicity
2011
Assembly of custom TALE-type DNA binding domains by modular cloning
2011
Quantitative analysis of TALE–DNA interactions suggests polarity effects
2013
TALENs facilitate targeted genome editing in human cells with high specificity and low cytotoxicity
2014
Targeted transcriptional activation of silent oct4 pluripotency gene by combining designer TALEs and inhibition of epigenetic modifiers
2012
Recognition of AvrBs3-Like Proteins Is Mediated by Specific Binding to Promoters of Matching Pepper Bs3 Alleles
2009