Citation Impact
Citing Papers
Metabolic Signatures of Insulin Resistance in 7,098 Young Adults
2012
Generation of Pluripotent Stem Cells from Adult Mouse Liver and Stomach Cells
2008 StandoutScienceNobel
The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic T reg Cell Homeostasis
2013 StandoutScience
Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice
2005 StandoutScience
Integrated control of hepatic lipogenesis versus glucose production requires FoxO transcription factors
2014
The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism
2013 Standout
Chronic leptin administration promotes lipid utilization until fat mass is greatly reduced and preserves lean mass of normal female rats
2000
Antibiotics in early life alter the murine colonic microbiome and adiposity
2012 Nature
Pathogenesis of type 2 diabetes mellitus
2004
mTOR Signaling in Growth Control and Disease
2012 Standout
Inflammation and metabolic disorders
2006 StandoutNature
GSK3 takes centre stage more than 20 years after its discovery
2001
Inflammatory links between obesity and metabolic disease
2011 Standout
Dual Roles for Glucokinase in Glucose Homeostasis as Determined by Liver and Pancreatic β Cell-specific Gene Knock-outs Using Cre Recombinase
1999
Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase
2002 StandoutNature
Central nervous system control of food intake and body weight
2006 StandoutNature
Congenital leptin deficiency is associated with severe early-onset obesity in humans
1997 StandoutNature
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
2001 StandoutNature
Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1
2001 StandoutNature
The Molecular Physiology of Hepatic Nuclear Factor 3 in the Regulation of Gluconeogenesis
2000
Molecular Physiology of Mammalian Glucokinase
2008
GLUT4 glucose transporter deficiency increases hepatic lipid production and peripheral lipid utilization
2004
Plasma Acylcarnitine Profiles Suggest Incomplete Long-Chain Fatty Acid β-Oxidation and Altered Tricarboxylic Acid Cycle Activity in Type 2 Diabetic African-American Women
2009
Insulin and glucosamine infusions increase O-linked N-acetyl-glucosamine in skeletal muscle proteins in vivo
1998
Autophagy regulates lipid metabolism
2009 StandoutNature
Regulation of hepatic glucose metabolism in health and disease
2017
Recent insights into hepatic lipid metabolism in non-alcoholic fatty liver disease (NAFLD)
2008
Adipocytes as regulators of energy balance and glucose homeostasis
2006 StandoutNature
Hepatic Overexpression of a Constitutively Active Form of Liver Glycogen Synthase Improves Glucose Homeostasis
2010
The adipocyte-secreted protein Acrp30 enhances hepatic insulin action
2001 Standout
Dissociating fatty liver and diabetes
2012
Adiponectin, Leptin, and Fatty Acids in the Maintenance of Metabolic Homeostasis through Adipose Tissue Crosstalk
2016
Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat
2000
Bile Acid Is a Host Factor That Regulates the Composition of the Cecal Microbiota in Rats
2011
The role of protein translocation in the regulation of glycogen metabolism
2007
Magnesium Replacement Improves the Metabolic Profile in Obese and Pre-Diabetic Patients with Mild-to-Moderate Chronic Kidney Disease: A 3-Month, Randomised, Double-Blind, Placebo-Controlled Study
2017 Standout
Perturbation of glucose flux in the liver by decreasing F26P2levels causes hepatic insulin resistance and hyperglycemia
2006
Reductions in circulating anabolic hormones induced by sustained sleep deprivation in rats
2004
Insulin sensitivity: modulation by nutrients and inflammation
2008
Novel Form of Lipolysis Induced by Leptin
1999
Obesity and Nonalcoholic Fatty Liver Disease: Biochemical, Metabolic, and Clinical Implications
2009 Standout
Human nutrition, the gut microbiome and the immune system
2011 StandoutNature
Role of adipose tissue in body-weight regulation: mechanisms regulating leptin production and energy balance
2000
Chronic Adipose Tissue Inflammation Linking Obesity to Insulin Resistance and Type 2 Diabetes
2020
TLR4 links innate immunity and fatty acid–induced insulin resistance
2006 Standout
Skeletal muscle insulin resistance: role of inflammatory cytokines and reactive oxygen species
2007
Metabolic syndrome, diabetes, and hyperuricemia
2013
Epigenetic Regulation of Kupffer Cell Function in Health and Disease
2021
A central role for JNK in obesity and insulin resistance
2002 StandoutNature
Diet–microbiota interactions as moderators of human metabolism
2016 StandoutNature
Ghrelin induces adiposity in rodents
2000 StandoutNature
Central nervous system control of food intake
2000 StandoutNature
Functional interactions between the gut microbiota and host metabolism
2012 StandoutNature
SREBP transcription factors: master regulators of lipid homeostasis
2004
Insulin Receptor Signaling in Normal and Insulin-Resistant States
2014
Insulin action and resistance in obesity and type 2 diabetes
2017
Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes
2005 StandoutNature
Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes
2003 StandoutNatureNobel
The Sweet Path to Metabolic Demise: Fructose and Lipid Synthesis
2016
Insulin Resistance of Glycogen Synthase Mediated byO-Linked N-Acetylglucosamine
2003
Treatment of diet-induced lipodystrophic C57BL/6J mice with long-acting PASylated leptin normalises insulin sensitivity and hepatic steatosis by promoting lipid utilisation
2016
Palmitate Activates the NF-κB Transcription Factor and Induces IL-6 and TNFα Expression in 3T3-L1 Adipocytes
2005
Control of Liver Glycogen Synthase Activity and Intracellular Distribution by Phosphorylation
2009
Diet rapidly and reproducibly alters the human gut microbiome
2013 StandoutNature
Caloric restriction increases gluconeogenic and transaminase enzyme activities in mouse liver
2003
Insulin signalling and the regulation of glucose and lipid metabolism
2001 StandoutNature
Insulin resistance differentially affects the PI 3-kinase– and MAP kinase–mediated signaling in human muscle
2000
Conserved principles of mammalian transcriptional regulation revealed by RNA half-life
2009
Acetate mediates a microbiome–brain–β-cell axis to promote metabolic syndrome
2016 Nature
Chronic tissue inflammation and metabolic disease
2021
The hormone resistin links obesity to diabetes
2001 StandoutNature
Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres
2002 StandoutNature
The biology of leptin: a review.
1998
Increased Glucose Transport–Phosphorylation and Muscle Glycogen Synthesis after Exercise Training in Insulin-Resistant Subjects
1996
Hyperglycemia and Inhibition of Glycogen Synthase in Streptozotocin-treated Mice
2004
Free Fatty Acids and Pathogenesis of Type 2 Diabetes Mellitus
2000
A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction
1998 StandoutNature
Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
2005 StandoutNature
Energy Metabolism in the Liver
2014 Standout
Macrophage biology in development, homeostasis and disease
2013 StandoutNature
Leptin and the regulation of body weight in mammals
1998 StandoutNature
Ras, PI(3)K and mTOR signalling controls tumour cell growth
2006 StandoutNature
Time-dependent effects of Prkce deletion on glucose homeostasis and hepatic lipid metabolism on dietary lipid oversupply in mice
2011
The Role of Adipose Tissue and Lipotoxicity in the Pathogenesis of Type 2 Diabetes
2010
Global quantification of mammalian gene expression control
2011 StandoutNature
Metabolic and molecular basis of insulin resistance
2003
Lipid-Induced Mitochondrial Stress and Insulin Action in Muscle
2012
Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance
2004
Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans
2009
Roles of PPARs in health and disease
2000 StandoutNature
Inflammation in obesity, diabetes, and related disorders
2022 Standout
Palmitic acid mediates hypothalamic insulin resistance by altering PKC-θ subcellular localization in rodents
2009
Pleiotropic Actions of Insulin Resistance and Inflammation in Metabolic Homeostasis
2013 Science
Interacting Appetite-Regulating Pathways in the Hypothalamic Regulation of Body Weight*
1999
Dose-Response Effect of Elevated Plasma Free Fatty Acid on Insulin Signaling
2005
From the Triumvirate to the Ominous Octet: A New Paradigm for the Treatment of Type 2 Diabetes Mellitus
2009 Standout
Regulation of Inflammation by Short Chain Fatty Acids
2011
Liporegulation in Diet-induced Obesity
2001
Mechanisms of Insulin Action and Insulin Resistance
2018 Standout
Divergent Signaling Capacities of the Long and Short Isoforms of the Leptin Receptor
1997
Signals That Regulate Food Intake and Energy Homeostasis
1998 Science
Increasing Dietary Leucine Intake Reduces Diet-Induced Obesity and Improves Glucose and Cholesterol Metabolism in Mice via Multimechanisms
2007
Disruption of the Striated Muscle Glycogen Targeting Subunit PPP1R3A of Protein Phosphatase 1 Leads to Increased Weight Gain, Fat Deposition, and Development of Insulin Resistance
2003
Roles of Chemokines and Chemokine Receptors in Obesity-Associated Insulin Resistance and Nonalcoholic Fatty Liver Disease
2015
Effects of Insulin on Subcellular Localization of Hexokinase II in Human Skeletal Muscle in Vivo
1998
Glucose-6-Phosphate–Mediated Activation of Liver Glycogen Synthase Plays a Key Role in Hepatic Glycogen Synthesis
2013
Immune Regulation in Obesity-Associated Adipose Inflammation
2013
A chemical approach for identifying O -GlcNAc-modified proteins in cells
2003 StandoutNobel
Toll-like receptor 4 modulates skeletal muscle substrate metabolism
2010
Insulin Control of Glycogen Metabolism in Knockout Mice Lacking the Muscle-Specific Protein Phosphatase PP1G/RGL
2001
Effects of Leptin on Insulin Sensitivity in Normal Rats*
1997
The Sleep Apnea cardioVascular Endpoints (SAVE) Trial: Rationale, Ethics, Design, and Progress
2015
Sphingolipids, Insulin Resistance, and Metabolic Disease: New Insights from in Vivo Manipulation of Sphingolipid Metabolism
2008
Skeletal Muscle–Specific Deletion of Lipoprotein Lipase Enhances Insulin Signaling in Skeletal Muscle but Causes Insulin Resistance in Liver and Other Tissues
2008
GLUT4 glucose transporter deficiency increases hepatic lipid production and peripheral lipid utilization
2004
Long-term correction of obesity and diabetes in genetically obese mice by a single intramuscular injection of recombinant adeno-associated virus encoding mouse leptin
1997
Complementary roles of gasotransmitters CO and H2S in sleep apnea
2017 StandoutNobel
Pathophysiology of Sleep Apnea
2010 Standout
Specific features of glycogen metabolism in the liver
1998
Regulation of metabolism by the innate immune system
2015
Role of innate and adaptive immunity in obesity-associated metabolic disease
2017
Cellular Mechanism by Which Estradiol Protects Female Ovariectomized Mice From High-Fat Diet-Induced Hepatic and Muscle Insulin Resistance
2013
The Function of Leptin in Nutrition, Weight, and Physiology
2002
Neuroscience: Breaking Down Scientific Barriers to the Study of Brain and Mind
2000 StandoutScienceNobel
Glucokinase and molecular aspects of liver glycogen metabolism
2008
Characterization of Distinct Subpopulations of Hepatic Macrophages in HFD/Obese Mice
2014
Gut hormone PYY3-36 physiologically inhibits food intake
2002 StandoutNature
Inhibition of the oxygen sensor PHD2 in the liver improves survival in lactic acidosis by activating the Cori cycle
2015 StandoutNobel
Induction by leptin of uncoupling protein-2 and enzymes of fatty acid oxidation
1997
Alternative Macrophage Activation and Metabolism
2011
Glyco-seek: Ultrasensitive Detection of Protein-Specific Glycosylation by Proximity Ligation Polymerase Chain Reaction
2016 StandoutNobel
Works of Robert M. O’Doherty being referenced
Sex-Specific Effect of Estrogen Sulfotransferase on Mouse Models of Type 2 Diabetes
2012
CCAAT/Enhancer-binding Protein β Deletion Reduces Adiposity, Hepatic Steatosis, and Diabetes in Lepr Mice
2007
Diet-induced obesity and acute hyperlipidemia reduce IκBα levels in rat skeletal muscle in a fiber-type dependent manner
2005
Intermittent Hypoxia Causes Insulin Resistance in Lean Mice Independent of Autonomic Activity
2007
Leptin, skeletal muscle lipids, and lipid-induced insulin resistance
2007
Overexpression of Protein Targeting to Glycogen (PTG) in Rat Hepatocytes Causes Profound Activation of Glycogen Synthesis Independent of Normal Hormone- and Substrate-mediated Regulatory Mechanisms
1998
Metabolic Impact of Adenovirus-mediated Overexpression of the Glucose-6-phosphatase Catalytic Subunit in Hepatocytes
1997
Liver Triglyceride Secretion and Lipid Oxidative Metabolism Are Rapidly Altered by Leptin in Vivo
2005
Increased β-Oxidation in Muscle Cells Enhances Insulin-stimulated Glucose Metabolism and Protects against Fatty Acid-induced Insulin Resistance Despite Intramyocellular Lipid Accumulation
2004
Mice Lacking NKT Cells but with a Complete Complement of CD8+ T-Cells Are Not Protected against the Metabolic Abnormalities of Diet-Induced Obesity
2011
Glucose 6-Phosphate Produced by Glucokinase, but Not Hexokinase I, Promotes the Activation of Hepatic Glycogen Synthase
1996
The Repression of Hormone-activated PEPCK Gene Expression by Glucose Is Insulin-independent but Requires Glucose Metabolism
1998
A moderate increase in carnitine palmitoyltransferase 1a activity is sufficient to substantially reduce hepatic triglyceride levels
2008
Whole body overexpression of PGC-1α has opposite effects on hepatic and muscle insulin sensitivity
2009
A modest glucokinase overexpression in the liver promotes fed expression levels of glycolytic and lipogenic enzyme genes in the fasted state without altering SREBP-1c expression
2003
Intermittent hypoxia reverses the diurnal glucose rhythm and causes pancreatic β‐cell replication in mice
2007
Perturbation of Fuel Homeostasis Caused by Overexpression of the Glucose-6-phosphatase Catalytic Subunit in Liver of Normal Rats
1998
Inhibition or deletion of the lipopolysaccharide receptor Toll-like receptor-4 confers partial protection against lipid-induced insulin resistance in rodent skeletal muscle
2007
Fatty Acid-induced Insulin Resistance in L6 Myotubes Is Prevented by Inhibition of Activation and Nuclear Localization of Nuclear Factor κB
2004
Differential Metabolic Effects of Adenovirus-mediated Glucokinase and Hexokinase I Overexpression in Rat Primary Hepatocytes
1996
In vivo regulation of SREBP-1c in skeletal muscle: effects of nutritional status, glucose, insulin, and leptin
2004
Divergent metabolic outcomes arising from targeted manipulation of the gut microbiota in diet-induced obesity
2012
Hexokinase II mRNA and gene structure, regulation by insulin, and evolution.
1993
Regulation of hexokinase II and glycogen synthase mRNA, protein, and activity in human muscle
1995
Correction of diet-induced hyperglycemia, hyperinsulinemia, and skeletal muscle insulin resistance by moderate hyperleptinemia
2000
Regulation of hexokinase II activity and expression in human muscle by moderate exercise
1998
Rat skeletal muscle hexokinase II mRNA and activity are increased by a single bout of acute exercise
1994
Depletion of Liver Kupffer Cells Prevents the Development of Diet-Induced Hepatic Steatosis and Insulin Resistance
2009
Impact of Reduced ATGL-Mediated Adipocyte Lipolysis on Obesity-Associated Insulin Resistance and Inflammation in Male Mice
2015
Disappearance of body fat in normal rats induced by adenovirus-mediated leptin gene therapy
1996
Organizing glucose disposal: emerging roles of the glycogen targeting subunits of protein phosphatase-1.
2000
METABOLIC ENGINEERING WITH RECOMBINANT ADENOVIRUSES
1999
2H enrichment distribution of hepatic glycogen from2H2O reveals the contribution of dietary fructose to glycogen synthesis
2012
Activation of direct and indirect pathways of glycogen synthesis by hepatic overexpression of protein targeting to glycogen
2000
Dendritic Cells Promote Macrophage Infiltration and Comprise a Substantial Proportion of Obesity-Associated Increases in CD11c+ Cells in Adipose Tissue and Liver
2012
Metabolic impact of glucokinase overexpression in liver: lowering of blood glucose in fed rats is accompanied by hyperlipidemia.
1999
Composition and energy harvesting capacity of the gut microbiota: relationship to diet, obesity and time in mouse models
2010