Citation Impact
Citing Papers
Neurotoxic protein expression reveals connections between the circadian clock and mating behavior in Drosophila
2006 StandoutNobel
Role of Ced-3/ICE-family proteases in staurosporine-induced programmed cell death.
1996
Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson's disease
2001
Wild-Type Nonneuronal Cells Extend Survival of SOD1 Mutant Motor Neurons in ALS Mice
2003 Science
Targeted cell killing by reconstituted caspases
2007 StandoutNobel
Onset and Progression in Inherited ALS Determined by Motor Neurons and Microglia
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Suppression of Interleukin-1β-converting Enzyme-mediated Cell Death by Insulin-like Growth Factor
1996
The DNA-damage response in human biology and disease
2009 StandoutNature
Trans-splicing as a possible molecular mechanism for the multiple isotype expression of the immunoglobulin gene.
1991 StandoutNobel
Intrathecal cyclosporin prolongs survival of late-stage ALS mice
2001
Apoptosis in neurodegenerative disorders
2000
Toxicity of Familial ALS-Linked SOD1 Mutants from Selective Recruitment to Spinal Mitochondria
2004
Prevention of cytosolic IAPs degradation: a potential pharmacological target in Huntington's Disease
2005
Caspase Inhibition Selectively Reduces the Apoptotic Component of Oxygen-Glucose Deprivation-Induced Cortical Neuronal Cell Death
1997
Gene-Targeting Technologies for the Study of Neurological Disorders
2004
Death of cortical and striatal neurons induced by mitochondrial defect involves differential molecular mechanisms
2003
Apoptosis in the nervous system
2000 StandoutNature
ICE-related proteases in apoptosis
1996
Synergistic effects of caspase inhibitors and MK‐801 in brain injury after transient focal cerebral ischaemia in mice
1998
The physiology and pathophysiology of nitric oxide in the brain
2005
Blockade of quinolinic acid-induced neurotoxicity by pyruvate is associated with inhibition of glial activation in a model of Huntington's disease
2004
Persistent activation of p38 mitogen-activated protein kinase in a mouse model of familial amyotrophic lateral sclerosis correlates with disease progression
2003
Suppression of oxidative neuronal damage after transient middle cerebral artery occlusion in mice lacking interleukin-1
2003
Calpain I Induces Cleavage and Release of Apoptosis-inducing Factor from Isolated Mitochondria
2004
The permeability transition pore triggers Bax translocation to mitochondria during neuronal apoptosis
2005
Cyclosporin A prevents calpain activation despite increased intracellular calcium concentrations, as well as translocation of apoptosis‐inducing factor, cytochrome c and caspase‐3 activation in neurons exposed to transient hypoglycemia
2003
Regulation of cell death: the calcium–apoptosis link
2003 Standout
Mitochondrial permeability transitions: how many doors to the house?
2004
Increased apoptosis of Huntington disease lymphoblasts associated with repeat length-dependent mitochondrial depolarization
1999
Murine Caspase-11, an ICE-Interacting Protease, Is Essential for the Activation of ICE
1998
Minocycline delays disease onset and mortality in a transgenic model of ALS
2002
Excitotoxic Neuronal Death and the Pathogenesis of Huntington's Disease
2008
Minocycline inhibits apoptosis and inflammation in a rat model of ischemic renal injury
2004
Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β
2000 StandoutNature
Neural mitochondrial Ca2+ capacity impairment precedes the onset of motor symptoms in G93A Cu/Zn‐superoxide dismutase mutant mice
2006
Pathobiology of ischaemic stroke: an integrated view
1999 Standout
A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia
2003
Caspase inhibitor affords neuroprotection with delayed administration in a rat model of neonatal hypoxic-ischemic brain injury.
1998
Superoxide dismutase and the death of motoneurons in ALS
2001
Rescue of polyglutamine-mediated cytotoxicity by double-stranded RNA-mediated RNA interference
2002
Mitochondria and neuronal glutamate excitotoxicity
1998
Dramatic tissue-specific mutation length increases are an early molecular event in Huntington disease pathogenesis
2003
Attenuation of Delayed Neuronal Death after Mild Focal Ischemia in Mice by Inhibition of the Caspase Family
1998
Oxidative Stress in Neurodegenerative Diseases
1996
Mitochondrial creatine kinase in human health and disease
2005
Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release
2001
Age-dependent changes in nitric oxide synthase activity and protein expression in striata of mice transgenic for the Huntington’s disease mutation
2002
Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
1998 StandoutNatureNobel
Mitochondrial contributions to tissue damage in stroke
2002
Mismatch repair gene Msh2 modifies the timing of early disease in HdhQ111 striatum
2003
Cell death and proliferation in acute slices and organotypic cultures of mammalian CNS
2009
ICE Family Proteases: Mediators of All Apoptotic Cell Death?
1996
Minocycline attenuates gentamicin induced hair cell loss in neonatal cochlear cultures
2004
Cyclooxygenase 2 inhibition protects motor neurons and prolongs survival in a transgenic mouse model of ALS
2002
Minocycline inhibits caspase activation and reactivation, increases the ratio of XIAP to smac/DIABLO, and reduces the mitochondrial leakage of cytochrome C and smac/DIABLO
2004
Effect of the mitochondrial transition pore inhibitor, S-15176, on rat liver mitochondria: ATP synthase modulation and mitochondrial uncoupling induction
2006
Differential expression of inflammation‐ and apoptosis‐related genes in spinal cords of a mutant SOD1 transgenic mouse
model of familial amyotrophic lateral sclerosis
2001
Nitric Oxide and Peroxynitrite in Health and Disease
2007 Standout
The biochemistry of apoptosis
2000 StandoutNature
Presenilins and APP in Neuritic and Synaptic Plasticity: Implications for the Pathogenesis of Alzheimer's Disease
2002
Mitochondrial Dysfunction, Endoplasmic Reticulum Stress, and Apoptosis in Alzheimer’s Disease
2005
Inhibition of Human Caspases by Peptide-based and Macromolecular Inhibitors
1998
Crosstalk between Nitric Oxide and Zinc Pathways to Neuronal Cell Death Involving Mitochondrial Dysfunction and p38-Activated K+ Channels
2004
Cdk5 deregulation in the pathogenesis of Alzheimer's disease
2004
Trans-splicing in C. elegans generates the negative RNAi regulator ERI-6/7
2008 StandoutNatureNobel
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
2012 Standout
Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell Death
1996 Standout
Mitochondrial Localization of Mutant Superoxide Dismutase 1 Triggers Caspase-dependent Cell Death in a Cellular Model of Familial Amyotrophic Lateral Sclerosis
2002
Glial and neuronal expression of polyglutamine proteins induce behavioral changes and aggregate formation in Drosophila
2004
Death substrates come alive
1997
Apoptosis-based therapies
2002
Caspase Functions in Cell Death and Disease
2013 Standout
Efficacy of minocycline in patients with amyotrophic lateral sclerosis: a phase III randomised trial
2007
Neuronal Morphogenesis Is Regulated by the Interplay between Cyclin-Dependent Kinase 5 and the Ubiquitin Ligase Mind Bomb 1
2007
Fas (CD95/APO-1) plays a role in the pathophysiology of focal cerebral ischemia
2000
Minocycline Slows Disease Progression in a Mouse Model of Amyotrophic Lateral Sclerosis
2002
Caspase structure, proteolytic substrates, and function during apoptotic cell death
1999
Ischemic Brain Injury is Mediated by the Activation of Poly(ADP-Ribose)Polymerase
1997
A caspase inhibitor blocks ischaemia‐induced delayed neuronal death in the gerbil
1998
The immunology of stroke: from mechanisms to translation
2011 Standout
Sealing one's fate: control of cell death in neurons
1998
Amyotrophic Lateral Sclerosis-Associated SOD1 Mutant Proteins Bind and Aggregate with Bcl-2 in Spinal Cord Mitochondria
2004
Proteases to die for
1998
Caenorhabditis elegans CED-9 protein is a bifunctional cell-death inhibitor
1997 StandoutNatureNobel
Caspase-independent cell death
2005
Mitochondrial Membrane Permeabilization in Cell Death
2007 Standout
Neuroprotection by the Inhibition of Apoptosis
2000
Inflammatory Neurodegeneration Mediated by Nitric Oxide, Glutamate, and Mitochondria
2003
Redundant cell death mechanisms as relics and backups
2005
Neuroinflammation in the pathogenesis of amyotrophic lateral sclerosis
2005
ICE/CED3-like Proteases as Therapeutic Targets for the Control of Inappropriate Apoptosis
1996
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
2006 StandoutNature
Pyroptosis: host cell death and inflammation
2009 Standout
Prolonged Therapeutic Window for Ischemic Brain Damage Caused by Delayed Caspase Activation
1998
JNK activation contributes to DP5 induction and apoptosis following traumatic spinal cord injury
2005
Origin and physiological roles of inflammation
2008 StandoutNature
The structures of caspases-1, -3, -7 and -8 reveal the basis for substrate and inhibitor selectivity
2000
Mammalian MAP kinase signalling cascades
2001 StandoutNature
Neuroprotection by IL-10-producing MOG CD4+ T cells following ischemic stroke
2005
Mutant SOD1 causes motor neuron disease independent of copper chaperone–mediated copper loading
2002
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
The therapeutic role of creatine in Huntington's disease
2005
Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines
2002
Neuronal Cell Death
1998
The repertoire of human germline vH sequences reveals about fifty groups of VH segments with different hypervariable loops
1992 StandoutNobel
Specific Cleavage of α-Fodrin during Fas- and Tumor Necrosis Factor-induced Apoptosis Is Mediated by an Interleukin-1β-converting Enzyme/Ced-3 Protease Distinct from the Poly(ADP-ribose) Polymerase Protease
1996
Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation
2011 StandoutNatureNobel
Reduced activity and protein expression of NOS in R6/2 HD transgenic mice: effects of l-NAME on symptom progression
2001
D4-GDI, a Substrate of CPP32, Is Proteolyzed during Fas-induced Apoptosis
1996
Minocycline Up-regulates Bcl-2 and Protects against Cell Death in Mitochondria
2004
The Hallmarks of Aging
2013 Standout
Huntington's Disease and Related Disorders
2005
Oxidative stress in ALS: A mechanism of neurodegeneration and a therapeutic target
2006
Oxidative stress and nitration in neurodegeneration: Cause, effect, or association?
2003
Mitochondria and Neuronal Death/Survival Signaling Pathways in Cerebral Ischemia
2004
Mitochondrial DNA damage and repair in neurodegenerative disorders
2008
The role of the bcl-2/ced-9 gene family in cancer and general implications of defects in cell death control for tumourigenesis and resistance to chemotherapy
1997
Neurodegenerative diseases and oxidative stress
2003
Presence of dendritic cells, MCP‐1, and activated microglia/macrophages in amyotrophic lateral sclerosis spinal cord tissue
2003
Toll-like receptor signaling in endogenous neuroprotection and stroke
2008
Increased mitochondrial antioxidative activity or decreased oxygen free radical propagation prevent mutant SOD1‐mediated motor neuron cell death and increase amyotrophic lateral sclerosis‐like transgenic mouse survival
2002
Motoneuron Death Triggered by a Specific Pathway Downstream of Fas
2002
The TRA-1A Sex Determination Protein of C. elegans Regulates Sexually Dimorphic Cell Deaths by Repressing the egl-1 Cell Death Activator Gene
1999 StandoutNobel
Apoptosis, Excitotoxicity, and Neuropathology
1998
Treatment with arimoclomol, a coinducer of heat shock proteins, delays disease progression in ALS mice
2004
Evidence That Inhibition of Cathepsin-B Contributes to the Neuroprotective Properties of Caspase Inhibitor Tyr-Val-Ala-Asp-Chloromethyl Ketone
2001
Selective Neuronal Degeneration in Huntington's Disease
2006
Amyotrophic Lateral Sclerosis
2001 Standout
Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection
2016 StandoutNatureNobel
A decade of caspases
2003
Pathways towards and away from Alzheimer's disease
2004 StandoutNature
Minocycline enhances MPTP toxicity to dopaminergic neurons
2003
Evidence for Activation of Caspase‐3‐Like Protease in Excitotoxin‐ and Hypoxia/Hypoglycemia‐Injured Neurons
1998
Pivotal role of cerebral interleukin-17–producing γδT cells in the delayed phase of ischemic brain injury
2009
Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia
1998
Huntington?s disease: pathomechanism and therapeutic perspectives
2004
The Bcl-2 Protein Family: Arbiters of Cell Survival
1998 StandoutScience
Blockade of Microglial Activation Is Neuroprotective in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Mouse Model of Parkinson Disease
2002
Mechanisms of transcriptional dysregulation in Huntington's disease
2003
Neurodegenerative Tauopathies
2001 Standout
Calcineurin-Mediated BAD Dephosphorylation Activates the Caspase-3 Apoptotic Cascade in Traumatic Spinal Cord Injury
2000
Inhibition of Caspase-1-Like Activity by Ac-Tyr-Val-Ala-Asp-Chloromethyl Ketone Induces Long-Lasting Neuroprotection in Cerebral Ischemia through Apoptosis Reduction and Decrease of Proinflammatory Cytokines
2000
CrmA expression in T lymphocytes of transgenic mice inhibits CD95 (Fas/APO-1)-transduced apoptosis, but does not cause lymphadenopathy or autoimmune disease.
1996
Caspase Inhibitors Attenuate 1-Methyl-4-Phenylpyridinium Toxicity in Primary Cultures of Mesencephalic Dopaminergic Neurons
2002
Tauroursodeoxycholic acid, a bile acid, is neuroprotective in a transgenic animal model of Huntington's disease
2002
Gene Expression Induced by Cerebral Ischemia: An Apoptotic Perspective
1997
Calcineurin/NFAT-induced up-regulation of the Fas ligand/Fas death pathway is involved in methamphetamine-induced neuronal apoptosis
2005
DNA Mismatch Repair: Functions and Mechanisms
2005 StandoutNobel
The Calpain System
2003 Standout
Activation and Cleavage of Caspase-3 in Apoptosis Induced by Experimental Cerebral Ischemia
1998
Death Receptors: Signaling and Modulation
1998 StandoutScience
(Peri)vascular production and action of pro-inflammatory cytokines in brain pathology
2006
Minocycline to Improve Neurologic Outcome in Stroke (MINOS)
2010
Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death
2002
Regulation of Caenorhabditis elegans neuronal polarity by heterochronic genes
2019 StandoutNobel
Oxidative stress and nitration in neurodegeneration: Cause, effect, or association?
2003
Reduced Ischemic Brain Injury in Interleukin-1β Converting Enzyme—Deficient Mice
1998
Neural Science
2000 StandoutNobel
Schwann cell chemokine receptors mediate HIV‐1 gp120 toxicity to sensory neurons
2003
Alzheimer's Disease: Genes, Proteins, and Therapy
2001 Standout
Superoxide dismutase and the death of motoneurons in ALS
2001
Kallikrein Gene Transfer Protects Against Ischemic Stroke by Promoting Glial Cell Migration and Inhibiting Apoptosis
2003
The role of proteases during apoptosis
1996
Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase
1998
Caspase and calpain substrates: Roles in synaptic plasticity and cell death
1999
The Role of Caspases in Development, Immunity, and Apoptotic Signal Transduction
1999
Brain ischemia and reperfusion: molecular mechanisms of neuronal injury
2000
Apoptosis, Pyroptosis, and Necrosis: Mechanistic Description of Dead and Dying Eukaryotic Cells
2005 Standout
Caspases: the executioners of apoptosis
1997 Standout
Six-Hour Window of Opportunity for Calpain Inhibition in Focal Cerebral Ischemia in Rats
1998
Ischemic Cell Death in Brain Neurons
1999 Standout
Manganese Superoxide Dismutase Mediates the Early Release of Mitochondrial Cytochrome C and Subsequent DNA Fragmentation after Permanent Focal Cerebral Ischemia in Mice
1999
Caspases as Targets for Anti-Inflammatory and Anti-Apoptotic Drug Discovery
2000
Oxidative stress and neuroinflammation in Alzheimer's disease and amyotrophic lateral sclerosis: Common links and potential therapeutic targets
2004
Bradykinin B1 and B2 receptors both have protective roles in renal ischemia/reperfusion injury
2007 StandoutNobel
Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response
2009 StandoutNobel
Extrahelical (CAG)/(CTG) triplet repeat elements support proliferating cell nuclear antigen loading and MutLα endonuclease activation
2013 StandoutNobel
UNRAVELING THE MECHANISMS INVOLVED IN MOTOR NEURON DEGENERATION IN ALS
2004
Nitric oxide prevents axonal degeneration by inducing HIF-1–dependent expression of erythropoietin
2011 StandoutNobel
Calpain Is a Major Cell Death Effector in Selective Striatal Degeneration InducedIn Vivoby 3-Nitropropionate: Implications for Huntington's Disease
2003
BBF2H7, a Novel Transmembrane bZIP Transcription Factor, Is a New Type of Endoplasmic Reticulum Stress Transducer
2006
Disruption of Axonal Transport by Loss of Huntingtin or Expression of Pathogenic PolyQ Proteins in Drosophila
2003
Specific cleavage of the retinoblastoma protein by an ICE-like protease in apoptosis.
1996
Activation of CPP32-Like Caspases Contributes to Neuronal Apoptosis and Neurological Dysfunction after Traumatic Brain Injury
1997
Cross-Talk between Two Cysteine Protease Families
2000 Standout
Scanning the human proteome for calmodulin-binding proteins
2005 StandoutNobel
Caspases: Enemies Within
1998 StandoutScience
Intracellular Bax Translocation after Transient Cerebral Ischemia: Implications for a Role of the Mitochondrial Apoptotic Signaling Pathway in Ischemic Neuronal Death
2001
Irreversible Inhibitors of Serine, Cysteine, and Threonine Proteases
2002 Standout
E3 ubiquitin ligase Mindbomb 1 facilitates nuclear delivery of adenovirus genomes
2020 StandoutNobel
Withdrawal of Survival Factors Results in Activation of the JNK Pathway in Neuronal Cells Leading to Fas Ligand Induction and Cell Death
1999
Transient Global Forebrain Ischemia Induces a Prolonged Expression of the Caspase-3 mRNA in Rat Hippocampal CA1 Pyramidal Neurons
1998
Induction of Caspase-3-Like Protease May Mediate Delayed Neuronal Death in the Hippocampus after Transient Cerebral Ischemia
1998
Ischemic Preconditioning and Brain Tolerance: Temporal Histological and Functional Outcomes, Protein Synthesis Requirement, and Interleukin-1 Receptor Antagonist and Early Gene Expression
1998
Control of Neuronal Size Homeostasis by Trophic Factor–mediated Coupling of Protein Degradation to Protein Synthesis
1998
Disturbed Ca2+signaling and apoptosis of medium spiny neurons in Huntington's disease
2005
JNK1 controls mast cell degranulation and IL-1β production in inflammatory arthritis
2010 StandoutNobel
Mouse neurexin-1α deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments
2009 StandoutNobel
The Transcription Factor Interferon Regulatory Factor 1 Is Expressed after Cerebral Ischemia and Contributes to Ischemic Brain Injury
1999
Oxidative stress in neurodegeneration: cause or consequence?
2004 Standout
Works of Robert M. Friedlander being referenced
Transgenic mice expressing a dominant negative mutant interleukin-1β converting enzyme show resistance to MPTP neurotoxicity
1999
The Mitochondrial Permeability Transition as a Target for Neuroprotection
2004
Combination therapy using minocycline and coenzyme Q10 in R6/2 transgenic Huntington's disease mice
2005
Additive neuroprotective effects of minocycline with creatine in a mouse model of ALS
2003
Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease
1999 Nature
Complete nucleotide sequence of the membrane form of the human IgM heavy chain
1990
Cytochrome C and Caspase-9 Expression in Huntington 's Disease
2002
Complement in neuroprotection and neurodegeneration
2010
Functional role and therapeutic implications of neuronal caspase-1 and -3 in a mouse model of traumatic spinal cord injury
2000
Prophylactic Creatine Administration Mediates Neuroprotection in Cerebral Ischemia in Mice
2004
Reduction of post-traumatic brain injury and free radical production by inhibition of the caspase-1 cascade
1999
Depletion of wild‐type huntingtin in mouse models of neurologic diseases
2003
Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease
2000
ICE, neuronal apoptosis and neurodegeneration
1998
Apoptosis and Caspases in Neurodegenerative Diseases
2003
Melatonin inhibits the caspase-1/cytochrome c/caspase-3 cell death pathway, inhibits MT1 receptor loss and delays disease progression in a mouse model of amyotrophic lateral sclerosis
2013
Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice
2002 Nature
Functional role of interleukin 1 beta (IL-1 beta) in IL-1 beta-converting enzyme-mediated apoptosis.
1996
Expression of a Dominant Negative Mutant of Interleukin-1β Converting Enzyme in Transgenic Mice Prevents Neuronal Cell Death Induced by Trophic Factor Withdrawal and Ischemic Brain Injury
1997
Functional Role of Caspase-1 and Caspase-3 in an ALS Transgenic Mouse Model
2000 Science
Tumor necrosis factor-induced apoptosis is mediated by a CrmA-sensitive cell death pathway.
1995
Minocycline inhibits contusion-triggered mitochondrial cytochrome c release and mitigates functional deficits after spinal cord injury
2004
Caspase Cascades in Human Immunodeficiency Virus-Associated Neurodegeneration
2002
Inhibition of interleukin 1β converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage
1997
Loss of Huntingtin-Mediated BDNF Gene Transcription in Huntington's Disease
2001 Science
Minocycline Reduces Traumatic Brain Injury-mediated Caspase-1 Activation, Tissue Damage, and Neurological Dysfunction
2001
Fundamental role of the Rip2/caspase-1 pathway in hypoxia and ischemia-induced neuronal cell death
2003
Minocycline Reduces Traumatic Brain Injury-mediated Caspase-1 Activation, Tissue Damage, and Neurological Dysfunction
2001
Neurotoxicity induces cleavage of p35 to p25 by calpain
2000 Nature
Clinically Approved Heterocyclics Act on a Mitochondrial Target and Reduce Stroke-induced Pathology
2004
Attenuation of Transient Focal Cerebral Ischemic Injury in Transgenic Mice Expressing a Mutant ICE Inhibitory Protein
1997
Minocycline inhibits caspase-independent and -dependent mitochondrial cell death pathways in models of Huntington's disease
2003