Standout Papers
- Membrane phospholipid synthesis in Escherichia coli. Cloning of a structural gene (plsB) of the sn-glycerol-3-phosphate acyl/transferase. (1980)
- Membrane phospholipid synthesis in Escherichia coli. Identification of the sn-glycerol-3-phosphate acyltransferase polypeptide as the plsB gene product. (1980)
- Regulation of phospholipid biosynthesis in Escherichia coli. Cloning of the structural gene for the biosynthetic sn-glycerol-3-phosphate dehydrogenase. (1980)
- The DNA sequences encoding plsB and dgk loci of Escherichia coli. (1983)
- Partial NH2- and COOH-terminal sequence and cyanogen bromide peptide analysis of Escherichia coli sn-glycerol-3-phosphate acyltransferase. (1983)
Citation Impact
Citing Papers
Alternative Splicing Increases the Diversity of the Human Protein Kinase C Family
1987
Formation of free sphingosine and ceramide from exogenous ganglioside GM1 by cerebellar granule cells in culture
1992
A Mediator Role of Ceramide in the Regulation of Neuroblastoma Neuro2a Cell Differentiation
1995
Ceramide: an intracellular mediator of apopotosis and growth supression
1996
Tumor necrosis factor-α-mediated signal transduction in human neutrophils: Involvement of sphingomyelin metabolites in the priming effect of tnf-α on the fMLP-stimulated superoxide production
1999
Signal transduction through the sphingomyelin pathway
1994
G Protein-coupled Receptor Kinase and β-Arrestin-mediated Desensitization of the Angiotensin II Type 1A Receptor Elucidated by Diacylglycerol Dynamics
2006 StandoutNobel
Long Chain Ceramides Activate Protein Phosphatase-1 and Protein Phosphatase-2A
1999
The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains
1988 StandoutScience
Regulation of Cytochrome P450 2C11 (CYP2C11) Gene Expression by Interleukin-1, Sphingomyelin Hydrolysis, and Ceramides in Rat Hepatocytes
1995
The C2 domain calcium‐binding motif: Structural and functional diversity
1996
Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling
1994
Phospholipid signaling
1995
Immunochemical identification of protein kinase C isozymes as products of discrete genes
1987
A novel arachidonic acid-selective cytosolic PLA2 contains a Ca2+-dependent translocation domain with homology to PKC and GAP
1991 Standout
Functions of Sphingolipids and Sphingolipid Breakdown Products in Cellular Regulation
1989 Science
Atrial natriuretic peptide administered just prior to reperfusion limits infarction in rabbit hearts
2006
Inhibition of phosphatidic acid phosphohydrolase activity by sphingosine
1990
Protein kinase C and T cell activation
1990
The molecular heterogeneity of protein kinase C and its implications for cellular regulation
1988 StandoutNature
Release of ceramide after membrane sphingomyelin hydrolysis decreases the basolateral secretion of triacylglycerol and apolipoprotein B in cultured human intestinal cells.
1993
Ceramide: a novel second messenger
1992
Metabolic effects of short‐chain ceramide and glucosylceramide on sphingolipids and protein kinase C
1992
Sphingoid bases as endogenous cationic amphiphilic “drugs”
1991
Phospholipase D and immune receptor signalling
2002
Interleukin-1 stimulates diacylglycerol production in T lymphocytes by a novel mechanism
1988
Sequence similarity of phospholipase C with the non-catalytic region of src
1988 Nature
Overproduction of protein kinase C causesdisordered growth control in rat fibroblasts
1988
Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat
2000
Ceramide Triggers Meiotic Cell Cycle Progression in Xenopus Oocytes.
1995
MUSCLE: multiple sequence alignment with high accuracy and high throughput
2004 Standout
Structural requirements for long-chain (sphingoid) base inhibition of protein kinase C in vitro and for the cellular effects of these compounds
1989
Differential Roles of de Novo Sphingolipid Biosynthesis and Turnover in the “Burst” of Free Sphingosine and Sphinganine, and Their 1-Phosphates and N-Acyl-Derivatives, That Occurs upon Changing the Medium of Cells in Culture
1995
Requirement of AP-1 for Ceramide-induced Apoptosis in Human Leukemia HL-60 Cells
1995
Identification of three additional members of rat protein kinase C family: gd‐, ϵ‐ and ξ‐subspecies
1987
An update of the enzymology and regulation of sphingomyelin metabolism
1990
A fourth type of rabbit protein kinase C
1988
The Formation of Ceramide-1-phosphate during Neutrophil Phagocytosis and Its Role in Liposome Fusion
1998 StandoutNobel
The Cost Effectiveness of Preoperative Autologous Blood Donations
1995 Standout
Similarity between phospholipase C and the regulatory domain of protein kinase C
1989
Insulin protects cardiomyocytes against reoxygenation-induced hypercontracture by a survival pathway targeting SR Ca2+ storage☆
2006
Calcium-Independent Activation of Hypothalamic Type I Protein Kinase C by Unsaturated Fatty Acids
1988
Cell regulation by sphingosine and more complex sphingolipids
1991
Role of Ceramide in Cellular Senescence
1995
Modulation of cell growth and differentiation by ceramide
1992
SNAP receptors implicated in vesicle targeting and fusion
1993 StandoutNatureNobel
A monoclonal antibody recognising the site of limited proteolysis of protein kinase C
1988
Modified hippocampal long-term potentiation in PKCγ-mutant mice
1993 Nobel
Differential expression of multiple protein kinase C subspecies in rat central nervous tissue
1987
New directions for protecting the heart against ischaemia–reperfusion injury: targeting the Reperfusion Injury Salvage Kinase (RISK)-pathway
2003
C2-domains, Structure and Function of a Universal Ca2+-binding Domain
1998 StandoutNobel
Reperfusion injury salvage kinase signalling: taking a RISK for cardioprotection
2007
Epsilon protein kinase C as a potential therapeutic target for the ischemic heart
2006
Phospholipid binding by a synaptic vesicle protein homologous to the regulatory region of protein kinase C
1990 Nature
Inhibition of acyl-CoA: cholesterol acyltransferase in chinese hamster ovary (CHO) cells by short-chain ceramide and dihydroceramide
1995
Munc13-1 Is a Presynaptic Phorbol Ester Receptor that Enhances Neurotransmitter Release
1998 StandoutNobel
Enhanced Phagocytosis through Inhibition of de Novo Ceramide Synthesis
2003 StandoutNobel
Erythropoietin protects the myocardium against reperfusion injury in vitro and in vivo
2005
Stepwise assembly of functionally active transport vesicles
1993
Myocardial Reperfusion Injury
2007 Standout
Protein kinase C interaction with calcium: a phospholipid-dependent process
1990
Structure of the first C2 domain of synaptotagmin I: A novel Ca2+/phospholipid-binding fold
1995 StandoutNobel
Inhibition of the Neutral Magnesium-dependent Sphingomyelinase by Glutathione
1997
Ceramide: A New Lipid “Second Messenger”?
2009
Evidence That Ceramide Selectively Inhibits Protein Kinase C-α Translocation and Modulates Bradykinin Activation of Phospholipase D
1995
Isolation and characterization of two new Drosophila protein kinase C genes, including one specifically expressed in photoreceptor cells
1989
Interaction of Ceramides, Sphingosine, and Sphingosine 1-Phosphate in Regulating DNA Synthesis and Phospholipase D Activity
1995
N-Acetylsphingosine (C2--ceramide) Inhibited Neutrophil Superoxide Formation and Calcium Influx
1995
Lipid second messengers
1994
Interaction of protein kinase C with phosphatidylserine. 2. Specificity and regulation
1992
Sphingolipid breakdown products: anti-proliferative and tumor-suppressor lipids
1993
Cell-permeable Ceramides Prevent the Activation of Phospholipase D by ADP-ribosylation Factor and RhoA
1997
Regulation of protein kinase C
1997
Formation of diacylglycerol by a phospholipase D-phosphatidate phosphatase pathway specific for phosphatidylcholine in endothelial cells
1988
Nucleotide sequences of cDNAs for α and γ subspecies of rat brain protein kinase C
1988
Fatty acyl-coenzyme a is required for budding of transport vesicles from Golgi cisternae
1989
Physiological levels of diacylglycerols in phospholipid membranes induce membrane fusion and stabilize inverted phases
1989
Comparative Study of the Metabolic Pools of Sphingomyelin and Phosphatidylcholine Sensitive to Tumor Necrosis Factor
1996
Ceramide: A stress signal and mediator of growth suppression and apoptosis
1995
Primary structures of human protein kinase C βI and βII differ only in their C‐terminal sequences
1987
Realizing the clinical potential of ischemic preconditioning and postconditioning
2005
Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals
1995
Unique substrate specificity and regulatory properties of PKC‐ε: a rationale for diversity
1989
Synaptic targeting of rabphilin-3A, a synaptic vesicle Ca2+/phospholipid-binding protein, depends on rab3A/3C
1994 StandoutNobel
Source and role of diacylglycerol formed during phagocytosis of opsonized yeast particles and associated respiratory burst in human neutrophils
1991
The synaptic vesicle cycle: a cascade of protein–protein interactions
1995 StandoutNatureNobel
The heterogeneity of protein kinase C in various rat tissues
1988
Mechanisms of intracellular protein transport
1994 StandoutNatureNobel
Phosphatidic Acid-mediated Phosphorylation of the NADPH Oxidase Component p47-phox
1997
The common structure and activities of four subspecies of rat brain protein kinase C family
1987
Ceramide Inhibits Phospholipase D in a Cell-free System
1996
Protein kinase C isotypes and signal-transduction in human neutrophils: Selective substrate specificity of calcium-dependent β-PKC and novel calcium-independent nPKC
1993
Universal control mechanism regulating onset of M-phase
1990 StandoutNatureNobel
Regulation of sn-1,2-diacylglycerol second-messenger formation in thrombin-stimulated human platelets. Potentiation by protein kinase C inhibitors
1990
Further studies on the specificity of diacylglycerol for protein kinase C activation
1987
Phosphorylation of synaptotagmin I by casein kinase II.
1993 StandoutNobel
Bcl-2 interrupts the ceramide-mediated pathway of cell death.
1996
Diacylglycerol-Stimulated Formation of Actin Nucleation Sites at Plasma Membranes
1992 Science
Molecular species analysis of a product of phospholipase D activation. Phosphatidylethanol is formed from phosphatidylcholine in phorbol ester- and bradykinin-stimulated PC12 cells.
1992
A ceramide-activated protein phosphatase mediates ceramide-induced G1 arrest of Saccharomyces cerevisiae.
1996
Fatty Acid Binding: A New Kind of Posttranslational Modification of Membrane Proteins
1983
Activation of a Plasma Membrane–Associated Neutral Sphingomyelinase and Concomitant Ceramide Accumulation During IgG-Dependent Phagocytosis in Human Polymorphonuclear Leukocytes
1998 StandoutNobel
A neutral phospholipase D activity from rat brain synaptic plasma membranes. Identification and partial characterization.
1990
Choline-linked Phosphoglycerides
1989
Phospholipase D catalyzes phospholipid metabolism in chemotactic peptide-stimulated HL-60 granulocytes.
1988
Distinct cellular and regional localization of immunoreactive protein kinase C in rat brain.
1987
Modulation of renal epithelial cell growth by glucosylceramide. Association with protein kinase C, sphingosine, and diacylglycerol.
1991
Effect of melittin and melittin fragments on the thermotropic phase transition of dipalmitoyllecithin and on the amount of lipid‐bound water
1976
Sphingosine inhibits phosphatidate phosphohydrolase in human neutrophils by a protein kinase C-independent mechanism
1991
Modulation of the free sphingosine levels in human neutrophils by phorbol esters and other factors.
1988
Purification and characterization of three types of protein kinase C from rabbit brain cytosol.
1987
Dissociation of endogenous cellular ceramide from NF-kappa B activation.
1994
Active site and complete sequence of the suicidal methyltransferase that counters alkylation mutagenesis.
1985 StandoutNobel
Immunochemical evidence that three protein kinase C isozymes increase in abundance during HL-60 differentiation induced by dimethyl sulfoxide and retinoic acid.
1988
Recognition sequence of the dam methylase of Escherichia coli K12 and mode of cleavage of Dpn I endonuclease.
1979 StandoutNobel
Tumor necrosis factor-alpha (TNF-alpha) signal transduction through ceramide. Dissociation of growth inhibitory effects of TNF-alpha from activation of nuclear factor-kappa B.
1993
Ceramide regulates oxidant release in adherent human neutrophils
1994
Three distinct forms of rat brain protein kinase C: Differential response to unsaturated fatty acids
1987
Phorbol ester binding to protein kinase C requires a cysteine-rich zinc-finger-like sequence.
1989
Phosphatidate accumulation in hormone-treated hepatocytes via a phospholipase D mechanism.
1987
Evidence against involvement of the acid lysosomal sphingomyelinase in the tumor-necrosis-factor- and interleukin-1-induced sphingomyelin cycle and cell proliferation in human fibroblasts
1994
Identification of arachidonic acid as a mediator of sphingomyelin hydrolysis in response to tumor necrosis factor alpha.
1994
Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
1997 Standout
Expression and properties of two distinct classes of the phorbol ester receptor family, four conventional protein kinase C types, and a novel protein kinase C.
1990
Daunorubicin-induced apoptosis: triggering of ceramide generation through sphingomyelin hydrolysis.
1996
Interferon-alpha selectively activates the beta isoform of protein kinase C through phosphatidylcholine hydrolysis.
1990
Cell Cycle Arrest Induced by an Inhibitor of Glucosylceramide Synthase
1995
Bombesin stimulates distinct time-dependent changes in the sn-1,2-diradylglycerol molecular species profile from Swiss 3T3 fibroblasts as analysed by 3,5-dinitrobenzoyl derivatization and h.p.l.c. separation
1993
Molecular Genetic Analysis of the Regulatory and Catalytic Domains of Protein Kinase C
1989
Role for ceramide as an endogenous mediator of Fas-induced cytotoxicity.
1995
Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase.
1994
A novel phorbol ester receptor/protein kinase, nPKC, distantly related to the protein kinase C family
1988
Atorvastatin Pretreatment Improves Outcomes in Patients With Acute Coronary Syndromes Undergoing Early Percutaneous Coronary Intervention
2007
Kinetic analysis of 1,2-diacylglycerol mass levels in cultured fibroblasts. Comparison of stimulation by alpha-thrombin and epidermal growth factor.
1988
Homology probing: identification of cDNA clones encoding members of the protein-serine kinase family.
1987
Phosphatidylserine biosynthesis in cultured Chinese hamster ovary cells. I. Inhibition of de novo phosphatidylserine biosynthesis by exogenous phosphatidylserine and its efficient incorporation.
1986
Ceramide-mediated biology. Determination of structural and stereospecific requirements through the use of N-acyl-phenylaminoalcohol analogs.
1992
Diacylglycerol kinase from pig brain. Purification and phospholipid dependencies.
1983
Characterization of a ceramide kinase activity from human leukemia (HL-60) cells. Separation from diacylglycerol kinase activity.
1990
Dissociation of protein kinase C activation and sn-1,2-diacylglycerol formation. Comparison of phosphatidylinositol- and phosphatidylcholine-derived diglycerides in alpha-thrombin-stimulated fibroblasts.
1991
Ceramide-mediated growth inhibition and CAPP are conserved in Saccharomyces cerevisiae
1993
The Regulation of Platelet-activating Factor Production in Endothelial Cells
1989
Synaptic Vesicle Ceramide Kinase
1989
A candidate protein kinase C gene, PKC1, is required for the S. cerevisiae cell cycle
1990 Nobel
Characterization of protein kinase C from normal and transformed cultured murine fibroblasts
1987
Down-regulation of protein kinase C is due to an increased rate of degradation
1987
Cloned mammalian neutral sphingomyelinase: Functions in sphingolipid signaling?
1998
Phospholipase D-mediated diradylglycerol formation coincides with H2O2 and lactoferrin release in adherent human neutrophils.
1994
Fatty Acid Activation and Temperature Perturbation of Rat Brain Microsomal Phospholipase D
1982
Diacylglycerol metabolism in mast cells. Analysis of lipid metabolic pathways using molecular species analysis of intermediates.
1987
Role for Ceramide in Cell Cycle Arrest
1995
A phorbol ester receptor/protein kinase, nPKC eta, a new member of the protein kinase C family predominantly expressed in lung and skin.
1990
Multiple doses of diacylglycerol and calcium ionophore are necessary to activate AP-1 enhancer activity and induce markers of macrophage differentiation.
1990
Ceramide 1-phosphate, a novel phospholipid in human leukemia (HL-60) cells. Synthesis via ceramide from sphingomyelin.
1990
Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C
1992 StandoutScience
Inducibility of κ immunoglobulin enhancer-binding protein NF-κB by a posttranslational mechanism
1986 StandoutNobel
Phosphatidylcholine Hydrolysis by Phospholipase D Determines Phosphatidate and Diglyceride Levels in Chemotactic Peptide-stimulated Human Neutrophils
1989
Phorbol ester treatment of intact rabbit platelets greatly enhances both the basal and guanosine 5′-[γ-thio]triphosphate-stimulated phospholipase D activities of isolated platelet membranes. Physiological activation of phospholipase D may be secondary to activation of phospholipase C
1990
Ceramide stimulates epidermal growth factor receptor phosphorylation in A431 human epidermoid carcinoma cells. Evidence that ceramide may mediate sphingosine action
1991
Sphingosine-1-phosphate, a metabolite of sphingosine, increases phosphatidic acid levels by phospholipase D activation
1992
Regulation of protein kinase C by lysophospholipids. Potential role in signal transduction.
1988
Possible role for fatty acyl-coenzyme A in intracellular protein transport
1987 StandoutNatureNobel
Activation of protein kinase C by oleic acid. Determination and analysis of inhibition by detergent micelles and physiologic membranes: requirement for free oleate.
1992
Postnatal development of a brain-specific subspecies of protein kinase C in rat
1988
Syk Activation Initiates Downstream Signaling Events During Human Polymorphonuclear Leukocyte Phagocytosis
1999 StandoutNobel
Phosphorylation of the EGF receptor from A431 epidermoid carcinoma cells by three distinct types of protein kinase C
1987
Intracellular phospholipases A
1980
Ras GTPase-activating protein physically associates with mitogenically active phospholipids.
1991
Transmembrane signaling pathways involved in phagocytosis and associated activation of NADPH oxidase mediated by FcγRs in human neutrophils
1993
Protein kinase C group B members PKC-δ, -ɛ, -ζ and PKC-L(η). Comparison of properties of recombinant proteins in vitro and in vivo
1992
Monoclonal antibodies against rat brain protein kinase C and their application to immunocytochemistry in nervous tissues
1987
Cell type-specific expression of protein kinase C isozymes in the rabbit cerebellum.
1988
Regulation of Phospholipase D in HL-60 Granulocytes
1989
Raf-1 N-Terminal Sequences Necessary for Ras-Raf Interaction and Signal Transduction
1995
Molecular species analysis of mitogen-stimulated 1,2-diglycerides in fibroblasts. Comparison of alpha-thrombin, epidermal growth factor, and platelet-derived growth factor.
1990
Programmed Cell Death Induced by Ceramide
1993 StandoutScience
Regulation of polymorphonuclear leukocyte degranulation and oxidant production by ceramide through inhibition of phospholipase D
2002 StandoutNobel
Neutral sphingomyelinase action stimulates signal transduction of tumor necrosis factor-alpha in the synthesis of cholesteryl esters in human fibroblasts.
1994
Transmembrane signaling by interferon alpha involves diacylglycerol production and activation of the epsilon isoform of protein kinase C in Daudi cells.
1991
Expression, purification, and characterization of protein kinase C-epsilon.
1990
The regulation and cellular functions of phosphatidylcholine hydrolysis
1990
Activation of a Plasma Membrane–Associated Neutral Sphingomyelinase and Concomitant Ceramide Accumulation During IgG-Dependent Phagocytosis in Human Polymorphonuclear Leukocytes
1998 StandoutNobel
Ceramide induces interleukin 6 gene expression in human fibroblasts.
1995
Functionally active targeting domain of the beta-adrenergic receptor kinase: an inhibitor of G beta gamma-mediated stimulation of type II adenylyl cyclase.
1994 StandoutNobel
Sphingosine Blocks Human Polymorphonuclear Leukocyte Phagocytosis Through Inhibition of Mitogen-Activated Protein Kinase Activation
1999 StandoutNobel
Mutations in a Protein Kinase C Homolog Confer Phorbol Ester Resistance on Caenorhabditis elegans
1989 Science
Isolation of cDNA clones encoding protein kinase C: evidence for a protein kinase C-related gene family.
1987
Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme
1991 Standout
Quantitative Changes in Polyphosphoinositides 1,2-Diacylglycerol and Inositol 1,4,5-Trisphosphate by Platelet-derived Growth Factor and Prostaglandin F2α
1989
Functions of Ceramide in Coordinating Cellular Responses to Stress
1996 StandoutScience
A phorbol ester/diacylglycerol-binding protein encoded by the unc-13 gene of Caenorhabditis elegans.
1991 StandoutNobel
Stimulation of Phosphatidylcholine Hydrolysis, Diacylglycerol Release, and Arachidonic Acid Production by Oncogenic Ras Is a Consequence of Protein Kinase C Activation
1989
Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor alpha and gamma-interferon. Specific role in cell differentiation.
1991
Mass measurement of inositol 1,4,5-trisphosphate and sn-1,2-diacylglycerol in bombesin-stimulated Swiss 3T3 mouse fibroblasts
1990
Association of protein kinase C with phospholipid vesicles
1987
Requirement of an ICE-Like Protease for Induction of Apoptosis and Ceramide Generation by REAPER
1996 Science
Bombesin and phorbol ester stimulate phosphatidylcholine hydrolysis by phospholipase C: Evidence for a role of protein kinase C
1987
Fatty acid-induced β cell apoptosis: A link between obesity and diabetes
1998
Tumor necrosis factor activation of the sphingomyelin pathway signals nuclear factor kappa B translocation in intact HL-60 cells.
1993
Cell-permeable ceramides inhibit the stimulation of DNA synthesis and phospholipase D activity by phosphatidate and lysophosphatidate in rat fibroblasts.
1994
Ceramide formation during heat shock: a potential mediator of alpha B-crystallin transcription.
1995
Isolation and characterization of PKC-L, a new member of the protein kinase C-related gene family specifically expressed in lung, skin, and heart.
1991
Protein kinase C zeta subspecies from rat brain: its structure, expression, and properties.
1989
Retinoblastoma gene product as a downstream target for a ceramide-dependent pathway of growth arrest.
1995
Structural and functional conservation of synaptotagmin (p65) in Drosophila and humans.
1991 StandoutNobel
Activation of Protein Kinase C by Naturally Occurring Ether-linked Diglycerides
1989
The structure, expression, and properties of additional members of the protein kinase C family.
1988
Ceramide activates heterotrimeric protein phosphatase 2A
1993
1,2-Diacylglycerol and phorbol ester inhibit agonist-induced formation of inositol phosphates in human platelets: possible implications for negative feedback regulation of inositol phospholipid hydrolysis.
1985
A novel mechanism of diglyceride formation. 12-O-tetradecanoylphorbol-13-acetate stimulates the cyclic breakdown and resynthesis of phosphatidylcholine.
1986
Sphingosine stimulates cellular proliferation via a protein kinase C-independent pathway.
1990
Purification and characterization of the zeta isoform of protein kinase C from bovine kidney.
1992
Ceramide inhibition of phospholipase D and its relationship to RhoA and ARF1 translocation in GTPγS-stimulated polymorphonuclear leukocytes
2003 StandoutNobel
Intracellular Ca2+ and protein kinase C interact to regulate alpha 1-adrenergic- and bradykinin receptor-stimulated phospholipase A2 activation in Madin-Darby canine kidney cells
1991
Activation of the Sphingomyelin Signaling Pathway in Intact EL4 Cells and in a Cell-Free System By IL-1β
1993 Science
Cell division arrest induced by phorbol ester in CHO cells overexpressing protein kinase C-delta subspecies.
1992
Characteristics and partial purification of a novel cytosolic, magnesium-independent, neutral sphingomyelinase activated in the early signal transduction of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation.
1994
Protein kinase C activity appears to be required for the synthesis of platelet-activating factor and leukotriene B4 by human neutrophils.
1987
Studies and Perspectives of Protein Kinase C
1986 StandoutScience
Identification of the structures of multiple subspecies of protein kinase C expressed in rat brain
1987
Differential distribution of protein kinase C isozymes in the various regions of brain.
1987
Bifunctional role of glycosphingolipids. Modulators for transmembrane signaling and mediators for cellular interactions.
1990
Ceramide Inhibits IgG-Dependent Phagocytosis in Human Polymorphonuclear Leukocytes
1997 StandoutNobel
In vitro maturation of circular bacteriophage P2 DNA. Purification of ter components and characterization of the reaction.
1985 StandoutNobel
A single C2 domain from synaptotagmin I is sufficient for high affinity Ca2+/phospholipid binding.
1993 StandoutNobel
Rab3 reversibly recruits rabphilin to synaptic vesicles by a mechanism analogous to raf recruitment by ras.
1996 StandoutNobel
Molecular cloning of a brain-specific calcium/calmodulin-dependent protein kinase.
1987
Activation and targeting of extracellular signal-regulated kinases by β-arrestin scaffolds
2001 StandoutNobel
Phosphatidylinositol-3-Kinase Signaling Is Required for Erythropoietin-Mediated Acute Protection Against Myocardial Ischemia/Reperfusion Injury
2004 StandoutNobel
Accumulation of neutral lipids by human skin fibroblasts: Differential effects of saturated and unsaturated fatty acids
1981
[51] Enzymes of ceramide biosynthesis
1992
Identification of a distinct pool of sphingomyelin involved in the sphingomyelin cycle.
1994
Multiphasic generation of diacylglycerol in thrombin-activated human platelets
1992
Complete nucleotide sequence of a gene conferring polymyxin B resistance on yeast: similarity of the predicted polypeptide to protein kinases.
1987
Interleukin-1-mediated PGE2 production and sphingomyelin metabolism. Evidence for the regulation of cyclooxygenase gene expression by sphingosine and ceramide.
1992
Sphingolipids are essential for the growth of Chinese hamster ovary cells. Restoration of the growth of a mutant defective in sphingoid base biosynthesis by exogenous sphingolipids.
1992
Distribution of protein kinase C-like immunoreactive neurons in rat brain
1988
Specificity and mechanism of protein kinase C activation by sn-1,2-diacylglycerols.
1986
Complement receptor-mediated phagocytosis is associated with accumulation of phosphatidylcholine-derived diglyceride in human neutrophils. Involvement of phospholipase D and direct evidence for a positive feedback signal of protein kinase.
1992
Synergistic activation of type III protein kinase C by cis-fatty acid and diacylglycerol
1992
Metabolic rate of membrane-permeant diacylglycerol and its relation to human resting T-lymphocyte activation.
1991
The complete coding sequence of the human A-raf-1 oncogene and transforming activity of a human A-rafcarrying retrovirus
1987
Myocardial expression of a constitutively active alpha 1B-adrenergic receptor in transgenic mice induces cardiac hypertrophy.
1994 StandoutNobel
Calcium Dependence of Toxic Cell Death: A Final Common Pathway
1979 StandoutScience
A thousand and one protein kinases
1987
Brefeldin A promotes hydrolysis of sphingomyelin.
1992
Involvement of Protein Kinase C in Platelet-activating Factor-stimulated Diacylglycerol Accumulation in Murine Peritoneal Macrophages
1989
Dynamics of the Diradylglycerol Responses of Stimulated Phagocytes
1989
Evidence that neutral spingomyelinase of cultured murine neuroblastoma cells is oriented externally on the plasma membrane
1984
The action of melittin on phosphatide multibilayers as studied by infrared dichroism and spin labeling. A model approach to lipid-protein interactions
1974
Role of ceramide-activated protein phosphatase in ceramide-mediated signal transduction.
1994
Expression of a constitutively activated mutant of the beta-isozyme of protein kinase C in cardiac myocytes stimulates the promoter of the beta-myosin heavy chain isogene
1991
Tumor Necrosis Factor-α Activates the Sphingomyelin Signal Transduction Pathway in a Cell-Free System
1992 Science
An arachidonoyl (polyenoic)-specific phospholipase A2 activity regulates the synthesis of platelet-activating factor in granulocytic HL-60 cells.
1990
Structure and nucleotide sequence of a Drosophila melanogaster protein kinase C gene.
1987
Isolation and sequencing of cDNA clones encoding alpha and beta subunits of Drosophila melanogaster casein kinase II.
1987
Inhibition of glycoprotein traffic through the secretory pathway by ceramide.
1993
PKC zeta is a molecular switch in signal transduction of TNF-alpha, bifunctionally regulated by ceramide and arachidonic acid.
1995
Developmental regulation and neuronal expression of the mRNA of rat n-chimaerin, a p21rac GAP:cDNA sequence
1992
On the Biological Occurrence and Regulation of 1-Acyl and 1-O-Alkyl-diradylglycerols in Human Neutrophils
1989
The Reperfusion Injury Salvage Kinase Pathway: A Common Target for Both Ischemic Preconditioning and Postconditioning
2005
Sphingomyelinase and cell-permeable ceramide analogs stimulate cellular proliferation in quiescent Swiss 3T3 fibroblasts.
1992
The sphingomyelin cycle and the second messenger function of ceramide.
1994
A new member of the protein kinase C family, nPKC theta, predominantly expressed in skeletal muscle.
1992
Hypoxia-inducible factor 1 is required for remote ischemic preconditioning of the heart
2013 StandoutNobel
The Role of Acidic Phospholipids in Glucagon Action on Rat Liver Adenylate Cyclase
1973 StandoutNobel
Glucagon-like Peptide 1 Can Directly Protect the Heart Against Ischemia/Reperfusion Injury
2005
Free Radicals in the Physiological Control of Cell Function
2002 Standout
Expression and Properties of Two Types of Protein Kinase C: Alternative Splicing from a Single Gene
1987 Science
Regulation of the epidermal growth factor receptor phosphorylation state by sphingosine in A431 human epidermoid carcinoma cells.
1988
Ceramide stimulates a cytosolic protein phosphatase.
1992
Studies on the molecular mechanisms of human neutrophil Fc receptor-mediated phagocytosis. Evidence that a distinct pathway for activation of the respiratory burst results in reactive oxygen metabolite-dependent amplification of ingestion.
1990
Activation of the sphingomyelin cycle by brefeldin A: effects of brefeldin A on differentiation and implications for a role for ceramide in regulation of protein trafficking.
1996
Deduced primary structure of the beta subunit of brain type II Ca2+/calmodulin-dependent protein kinase determined by molecular cloning.
1987
Sphingomyelinase and ceramide activate mitogen-activated protein kinase in myeloid HL-60 cells
1993
Activation of the Sphingomyelin Cycle Through the Low-Affinity Neurotrophin Receptor
1994 Science
The physical map of the whole E. coli chromosome: Application of a new strategy for rapid analysis and sorting of a large genomic library
1987 Standout
Interpretations of enzyme reaction stereospecificity
1975 StandoutNobel
Characterization of a ceramide-activated protein kinase: stimulation by tumor necrosis factor alpha.
1991
Selectivity of ceramide-mediated biology. Lack of activity of erythro-dihydroceramide.
1993
SMART, a simple modular architecture research tool: Identification of signaling domains
1998 Standout
Triglyceride accumulation protects against fatty acid-induced lipotoxicity
2003 Standout
Insulin-like effects of epidermal growth factor and insulin-like growth factor-I on [3H]2-deoxyglucose uptake, diacylglycerol generation and protein kinase C activation in BC3H-1 myocytes
1989
A single form of protein kinase C is expressed in bovine adrenocortical tissue, as compared to four chromatographically resolved isozymes in rat brain
1987
Sphingolipid metabolites: Members of a new class of lipid second messengers
1995
Delineation of two functionally distinct domains of cytosolic phospholipase A2, a regulatory Ca(2+)-dependent lipid-binding domain and a Ca(2+)-independent catalytic domain.
1994
Works of Robert M. Bell being referenced
Lipid topogenesis
1981
Enzymatic quantification of sphingosine in the picomole range in cultured cells
1989
Growth-dependent regulation of cellular ceramides in human T-cells
1994
Two Distinct Raf Domains Mediate Interaction with Ras
1995
Raf-1 Kinase Possesses Distinct Binding Domains for Phosphatidylserine and Phosphatidic Acid
1996
Regulation of protein kinase C by sphingosine and lysosphingolipids
1989
Atorvastatin, administered at the onset of reperfusion, and independent oflipid lowering, protects the myocardiumby up-regulating a pro-survival pathway
2003
PI3 Kinase and not p42/p44 Appears to be Implicated in the Protection Conferred by Ischemic Preconditioning
2002
New DEALEs
1992
Bradykinin limits infarction when administered as an adjunct to reperfusion in mouse heart: the role of PI3K, Akt and eNOS
2003
Effect of harvesting methods, growth conditions and growth phase on diacylglycerol levels in cultured human adherent cells
1988
Elevated ceramide levels in GH4C1 cells treated with retinoic acid
1992
Altered growth regulation and enhanced tumorigenicity of NIH 3T3 fibroblasts transfected with protein kinase C-I cDNA
1988
Protein Kinase C Regulation by Sphingosine/Lysosphingolipids
1988
Changes in bioactive lipids, alkylacylglycerol and ceramide, occur in HIV-infected cells
1992
Inhibition of sphingosine kinase in vitro and in platelets. Implications for signal transduction pathways.
1992
Covalent Enzyme-Substrate Intermediates
1971 Science
Triacylglycerol synthesis in isolated fat cells. Studies on the microsomal diacylglycerol acyltransferase activity using ethanol-dispersed diacylglycerols.
1976
Expression of the alpha, beta II, and gamma protein kinase C isozymes in the baculovirus-insect cell expression system. Purification and characterization of the individual isoforms.
1990
Quantitative measurement of sn-1,2-diacylglycerols present in platelets, hepatocytes, and ras- and sis-transformed normal rat kidney cells.
1986
Activation of protein kinase C by Triton X-100 mixed micelles containing diacylglycerol and phosphatidylserine.
1985
Role of ceramide in mitogenesis induced by exogenous sphingoid bases.
1994
Membrane matrix disruption by melittin
1972
Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets.
1986
Protein kinase C activation in mixed micelles. Mechanistic implications of phospholipid, diacylglycerol, and calcium interdependencies.
1986
The DNA sequences encoding plsB and dgk loci of Escherichia coli.
1983 StandoutNobel
Inhibition of phorbol ester-dependent differentiation of human promyelocytic leukemic (HL-60) cells by sphinganine and other long-chain bases.
1986
sn-1,2-Dioctanoylglycerol. A cell-permeable diacylglycerol that mimics phorbol diester action on the epidermal growth factor receptor and mitogenesis.
1985
Exogenous sn-1,2-diacylglycerols containing saturated fatty acids function as bioregulators of protein kinase C in human platelets.
1985
A phorbol ester binding domain of protein kinase C gamma. High affinity binding to a glutathione-S-transferase/Cys2 fusion protein.
1994
[26] Use of sphingosine as inhibitor of protein kinase C
1991
Protein kinase C activation by diacylglycerol second messengers
1986
The lipid binding, regulatory domain of protein kinase C. A 32-kDa fragment contains the calcium- and phosphatidylserine-dependent phorbol diester binding activity.
1986
Pivotal role of NOX‐2‐containing NADPH oxidase in early ischemic preconditioning
2005
Diacylglycerols release LH: Structure-activity relations reveal a role for protein kinase C
1985
Effect of Phospholipase C Hydrolysis of Membrane Phospholipids on Membranous Enzymes
1972
Inhibition of the oxidative burst in human neutrophils by sphingoid long-chain bases. Role of protein kinase C in activation of the burst.
1986
Sphingomyelin turnover induced by vitamin D3 in HL-60 cells
1989
Limited palmitoyl-CoA penetration into microsomal vesicles as evidenced by a highly latent ethanol acyltransferase activity.
1978
Diacylglycerols mimic phorbol diester induction of leukemic cell differentiation.
1985
Biosynthesis in Escherichia coli of sn-glycerol 3-phosphate, a precursor of phospholipid. Palmitoyl-CoA inhibition of the biosynthetic sn-glycerol-3-phosphate dehydrogenase.
1979
1,2-Diacylglycerols do not potentiate the action of phospholipases A2 and C in human platelets
1984
[25] Mixed micelle assay of protein kinase C
1986
A phorbol ester binding domain of protein kinase C gamma. Deletion analysis of the Cys2 domain defines a minimal 43-amino acid peptide.
1994
Role of ceramide as a lipid mediator of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation.
1990
Identification of discrete segments of human Raf-1 kinase critical for high affinity binding to Ha-Ras.
1994
A facile enzymatic synthesis of sphingosine-1-phosphate and dihydrosphingosine-1-phosphate.
1989
The cysteine-rich region of raf-1 kinase contains zinc, translocates to liposomes, and is adjacent to a segment that binds GTP-ras
1994
Solubilization, partial purification and characterization of rat liver microsomal diacylglycerol acyltransferase
1980
Rat brain protein kinase C. Kinetic analysis of substrate dependence, allosteric regulation, and autophosphorylation.
1990
Cloning and expression of multiple protein kinase C cDNAs
1986
The regulatory region of protein kinase C gamma. Studies of phorbol ester binding to individual and combined functional segments expressed as glutathione S-transferase fusion proteins indicate a complex mechanism of regulation by phospholipids, phorbol esters, and divalent cations.
1994
Sangivamycin, a nucleoside analogue, is a potent inhibitor of protein kinase C.
1988
Attenuation of sn-1,2-diacylglycerol second messengers by diacylglycerol kinase. Inhibition by diacylglycerol analogs in vitro and in human platelets.
1986
Sphingosine inhibition of agonist-dependent secretion and activation of human platelets implies that protein kinase C is a necessary and common event of the signal transduction pathways.
1987
Topography of glycerolepid synthetic enzymes Synthesis of phosphatidylserine, phosphatidylinositol and glycerolipid intermediates occurs on the cytoplasmic surface of rat liver microsomal vesicles
1981
sn-1,2-Diacylglycerol kinase of Escherichia coli. Mixed micellar analysis of the phospholipid cofactor requirement and divalent cation dependence.
1986
Distinct patterns of expression of different protein kinase C mRNAs in rat tissues
1987
Transmembrane movement of phosphatidylglycerol and diacylglycerol sulfhydryl analogs
1984
Quantitative measurement of sn-1,2-diacylglycerols
1987
The solution structure of the Raf-1 cysteine-rich domain: a novel ras and phospholipid binding site.
1996
Lipid activation of protein kinase C.
1991
Attenuation of sn-1,2-diacylglycerol second messengers. Metabolism of exogenous diacylglycerols by human platelets.
1986
Biosynthesis in Escherichia coli fo sn-glycerol 3-phosphate, a precursor of phospholipid.
1978
sn-1,2-Diacylglycerol kinase of Escherichia coli. Purification, reconstitution, and partial amino- and carboxyl-terminal analysis.
1985
Phospholipid Functional Groups Involved in Protein Kinase C Activation, Phorbol Ester Binding, and Binding to Mixed Micelles
1989
Structural requirements for diacylglycerols to mimic tumor-promoting phobol diester action on the epidermal growth factor receptor.
1985
Enzymes of Glycerolipid Synthesis in Eukaryotes
1980
Protein kinase C contains two phorbol ester binding domains.
1991
Phorbol ester binding and activation of protein kinase C on triton X-100 mixed micelles containing phosphatidylserine.
1986
Role of protein kinase C in diacylglycerol-mediated induction of ornithine decarboxylase and reduction of epidermal growth factor binding.
1985
Partial NH2- and COOH-terminal sequence and cyanogen bromide peptide analysis of Escherichia coli sn-glycerol-3-phosphate acyltransferase.
1983 StandoutNobel
Diacylglycerol mass measurements in stimulated HL-60 phagocytes.
1987
Enzymes of phospholipid metabolism: Localization in the cytoplasmic and outer membrane of the cell envelope of Escherichia coli and Salmonella typhimurium
1971