Citation Impact
Citing Papers
Tumor Necrosis Factor-α Promotes Malignant Pleural Effusion
2007
The Serine Protease TMPRSS6 Is Required to Sense Iron Deficiency
2008 StandoutScienceNobel
Molecular Cloning of the Gene Encoding Rabbit Tumor Necrosis Factor
1986
Molecular Cloning and Expression in Escherichia coli of the cDNA Coding for Rabbit Tumor Necrosis Factor
1986
Target-conditioned diffusion generates potent TNFR superfamily antagonists and agonists
2024 StandoutScienceNobel
Inflammation and cancer
2002 StandoutNature
Cell Death Mechanisms and the Immune System
1991
Involvement of Reactive Oxygen Species in Cytokine and Growth Factor Induction of c-fos Expression in Chondrocytes
1995 Standout
The Effect of Dietary Supplementation with n—3 Polyunsaturated Fatty Acids on the Synthesis of Interleukin-1 and Tumor Necrosis Factor by Mononuclear Cells
1989 Standout
The history, properties, and biological effects of cachectin
1988 StandoutNobel
Death by TNF: a road to inflammation
2022
Tumor necrosis factor, cancer and anticancer therapy
2004
Physiological Responses to Cachectin
2007
Multiple Organ Damage Caused by Tumor Necrosis Factor and Prevented by Prior Neutrophil Depletion
1989
Antibody to tumor necrosis factor (TNF) reduces endotoxin fever
1988
TNF? and the TNF receptor superfamily: Structure-function relationship(s)
2000
Enhanced in vivo growth and resistance to rejection of tumor cells expressing dominant negative IFNγ receptors
1994
Neutrophils Express Tumor Necrosis Factor-α During Mouse Skin Wound Healing
1995
Tumor necrosis factor expression in human epithelial tumor cell lines.
1988
University of California/Davis Interdepartmental Conference on Gram-Negative Septicemia
1991 StandoutNobel
Crystal structure of the soluble human 55 kd TNF receptor-human TNFβ complex: Implications for TNF receptor activation
1993
The molecular action of tumor necrosis factor‐α
1991
A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins
1994 StandoutNobel
Macrophage-induced angiogenesis is mediated by tumour necrosis factor-α
1987 StandoutNature
The inducing role of tumor necrosis factor in the development of bactericidal granulomas during BCG infection
1989
Molecular cloning and expression of a receptor for human tumor necrosis factor
1990
Virus-induced autoantibody response to a transgenic viral antigen
1990 StandoutNatureNobel
Interleukin‐12 is required for interferon‐γ production and lethality in lipopolysaccharide‐induced shock in mice
1995
Neural apoptosis
1995
Structure of tumour necrosis factor
1989 Nature
MHC class II-associated variation in the production of tumor necrosis factor in mice and humans: Relevance to the pathogenesis of autoimmune diseases
1991
Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting
2012 StandoutNatureNobel
Tumor necrosis factor or tumor promoting factor?
2002
The TNF and TNF Receptor Superfamilies
2001 Standout
Cancer-related inflammation
2008 StandoutNature
Crystal structure of a soluble form of the human T cell coreceptor CD8 at 2.6 Å resolution
1992 StandoutNobel
Development of partial tolerance to the gastrointestinal effects of high doses of recombinant tumor necrosis factor-alpha in rodents.
1987
Rapid phosphorylation of a 27 kDa protein induced by tumor necrosis factor
1988
The pathogenesis of atherosclerosis: a perspective for the 1990s
1993 StandoutNature
A Novel Protein That Interacts with the Death Domain of Fas/APO1 Contains a Sequence Motif Related to the Death Domain
1995
Inferences, questions and possibilities in Toll-like receptor signalling
2004 StandoutNatureNobel
Tumour necrosis factor α: a potential target for the therapy of solid tumours
2003
The Tumor Necrosis Factor Ligand and Receptor Families
1996 StandoutNobel
Comparative Study of Lipopolysaccharide-, Lipid IVa-, and Lipid X-Induced Tumor Necrosis Factor Production in Murine Macrophage-Like Cell Lines
1990
Local and Systemic Effects of Intradermal Recombinant Interferon-γ in Patients with Lepromatous Leprosy
1986 StandoutNobel
The Structure of Tumor Necrosis Factor-α at 2.6 Å Resolution
1989
Identification of a common nucleotide sequence in the 3'-untranslated region of mRNA molecules specifying inflammatory mediators.
1986 StandoutNobel
Control of Cachectin (Tumor Necrosis Factor) Synthesis: Mechanisms of Endotoxin Resistance
1986 StandoutScienceNobel
Physical contact between lipopolysaccharide and Toll-like receptor 4 revealed by genetic complementation
2000 StandoutNobel
Transient involvement of signal recognition particle and its receptor in the microsomal membrane prior to protein translocation
1983 StandoutNobel
Sequestration From Immune CD4 + T Cells of Mycobacteria Growing in Human Macrophages
1993 StandoutScienceNobel
Ribonuclease inhibitor from human placenta. Purification and properties.
1977
Production of an anti-tumour cytotoxin by human monocytes.
1981
Tumor Necrosis Factor (TNF)
1985 StandoutScience
Recombinant human TNF induces production of granulocyte–monocyte colony-stimulating factor
1986 Nature
Expression of murine interleukin 7 in a murine glioma cell line results in reduced tumorigenicity in vivo.
1992 StandoutNobel
Characterization of receptors for human tumour necrosis factor and their regulation by γ-interferon
1985 Nature
Identity of differentiation inducing factor and tumour necrosis factor
1986 Nature
Human tumor necrosis factor. Production, purification, and characterization.
1985
Cachectin and tumour necrosis factor as two sides of the same biological coin
1986 StandoutNatureNobel
Cachectin/tumor necrosis factor regulates hepatic acute-phase gene expression.
1986
Recombinant human tumor necrosis factor increases mRNA levels and surface expression of HLA-A,B antigens in vascular endothelial cells and dermal fibroblasts in vitro.
1986
Effect of tumor necrosis factor on GTP binding and GTPase activity in HL-60 and L929 cells.
1988
Cachectin/tumor necrosis factor induces cachexia, anemia, and inflammation.
1988 StandoutNobel
Generation and characterization of a lipopolysaccharide-induced and serum-derived cytotoxic factor for tumor cells
1980
Tumor necrosis factor induction by Sendai virus.
1986
Induction of Necrotic-Like Cell Death by Tumor Necrosis Factor Alpha and Caspase Inhibitors: Novel Mechanism for Killing Virus-Infected Cells
2000
Species specificity of human and murine tumor necrosis factor. A comparative study of tumor necrosis factor receptors.
1986
Shock and Tissue Injury Induced by Recombinant Human Cachectin
1986 StandoutScienceNobel
Macrophages as a source of tumoricidal activity (tumor-necrotizing factor)
1980
The active form of tumor necrosis factor is a trimer.
1987
In vitro production of rabbit macrophage tumor cell cytotoxin
1983
PURIFICATION AND PARTIAL AMINO ACID SEQUENCE OF RABBIT TUMOR NECROSIS FACTOR
1985
Purification and characterization of a human tumor necrosis factor from the LuKII cell line.
1985
Macrophage-mediated cytotoxicity: role of a soluble macrophage cytotoxic factor similar to lymphotoxin and tumor necrosis factor.
1983
Tumour-necrosis factor from the rabbit. V. Synthesis in vitro by mononuclear phagocytes from various tissues of normal and BCG-injected rabbits
1981
Antitumor activity of murine tumor necrosis factor (TNF) against transplanted murine tumors and heterotransplanted human tumors in nude mice
1984
Molecular cloning and expression of the type 1 and type 2 murine receptors for tumor necrosis factor.
1991
Tumor necrosis factor: a potent effector molecule for tumor cell killing by activated macrophages.
1986
Tumour-necrosis factor from the rabbit. I. Mode of action, specificity and physicochemical properties
1978
Antiviral effects of recombinant tumour necrosis factor in vitro
1986 Nature
Synthetic lipid A with endotoxic and related biological activities comparable to those of a natural lipid A from an Escherichia coli re-mutant
1985
Human fibroblasts release reactive oxygen species in response to interleukin-1 or tumour necrosis factor-α
1989
Passive Immunization Against Cachectin/Tumor Necrosis Factor Protects Mice from Lethal Effect of Endotoxin
1985 StandoutScienceNobel
Tumor necrosis factor and lymphotoxin induce differentiation of human myeloid cell lines in synergy with immune interferon.
1986
Cloning and expression in Escherichia coli of the gene for human tumour necrosis factor
1985 Nature
Nonhematopoietic cells selected for resistance to tumor necrosis factor produce tumor necrosis factor.
1986
Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2
1997 StandoutNobel
Heritable major histocompatibility complex class II-associated differences in production of tumor necrosis factor alpha: relevance to genetic predisposition to systemic lupus erythematosus.
1990
ASSOCIATION BETWEEN TUMOUR NECROSIS FACTOR IN SERUM AND FATAL OUTCOME IN PATIENTS WITH MENINGOCOCCAL DISEASE
1987
Independent regulation of tumor necrosis factor and lymphotoxin production by human peripheral blood lymphocytes.
1987
Induction of Manganous Superoxide Dismutase by Tumor Necrosis Factor: Possible Protective Mechanism
1988 Science
High affinity binding of 125I-labeled human tumor necrosis factor (LuKII) to specific cell surface receptors.
1985
Cachectin: More Than a Tumor Necrosis Factor
1987 StandoutNobel
Cloning and expression of cDNAs for two distinct murine tumor necrosis factor receptors demonstrate one receptor is species specific.
1991
TNF induces c-fos via a novel pathway requiring conversion of arachidonic acid to a lipoxygenase metabolite.
1991
Prolonged and effective blockade of tumor necrosis factor activity through adenovirus-mediated gene transfer.
1994 StandoutNobel
Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients
2003 StandoutNobel
Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1.
1986 StandoutNobel
Phase I study of recombinant tumor necrosis factor in cancer patients.
1987
Tumor necrosis factor: specific binding and internalization in sensitive and resistant cells.
1985
Fas Preassociation Required for Apoptosis Signaling and Dominant Inhibition by Pathogenic Mutations
2000 StandoutScienceNobel
Molecular Cloning, Characterization, and Expression of TNF cDNA and Gene from Japanese FlounderParalychthys olivaceus
2000
Human Lymphotoxin and tumor necrosis factor genes: structure, homology and chromosomal localization
1985
Cloning and expression in Escherichia coli of the cDNA for murine tumor necrosis factor.
1985
Fibroblast growth enhancing activity of tumor necrosis factor and its relationship to other polypeptide growth factors.
1986
Human tumor necrosis factor produced by human B-cell lines: synergistic cytotoxic interaction with human interferon.
1983
An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death
1996 StandoutScienceNobel
Murine tumor cells transduced with the gene for tumor necrosis factor-alpha. Evidence for paracrine immune effects of tumor necrosis factor against tumors
1991
Secretion requires a cytoplasmically disposed sulphydryl of the RER membrane
1980 StandoutNatureNobel
Seppuku and Autoimmunity
1992 StandoutScienceNobel
Viruses in Human Cancers
1991 StandoutScienceNobel
Recombinant tumor necrosis factor induces procoagulant activity in cultured human vascular endothelium: characterization and comparison with the actions of interleukin 1.
1986
Recombinant Human Tumor Necrosis Factor-α: Effects on Proliferation of Normal and Transformed Cells in Vitro
1985 StandoutScience
Possible roles of tumor necrosis factor in the pathology of malaria.
1987
Mitogenic and cytotoxic actions of tumor necrosis factor in BALB/c 3T3 cells
1989
Cloning and expression of cDNA for human lymphotoxin, a lymphokine with tumour necrosis activity
1984 Nature
Mitochondria and Apoptosis
1998 StandoutScience
Tumour necrosis factor (cachectin) induces phospholipase A2 activity and synthesis of a phospholipase A2-activating protein in endothelial cells
1988
Tumour necrosis factors α and β inhibit virus replication and synergize with interferons
1986 Nature
Stimulation of the adherence of neutrophils to umbilical vein endothelium by human recombinant tumor necrosis factor.
1985
Effect of tumour necrosis factor on cultured human melanoma cells
1975 Nature
Molecular cloning of mouse tumour necrosis factor cDNA and its eukaryotic expression
1985
The antitumor function of tumor necrosis factor (TNF), I. Therapeutic action of TNF against an established murine sarcoma is indirect, immunologically dependent, and limited by severe toxicity.
1988
Antibodies to a soluble form of a tumor necrosis factor (TNF) receptor have TNF-like activity.
1990
Binding of human tumor necrosis factor to high affinity receptors on HeLa and lymphoblastoid cells sensitive to growth inhibition.
1985
Tumor necrosis factor enhances eosinophil toxicity to Schistosoma mansoni larvae.
1986
Biological activities of analogues of lipid A based chemically on the revised structural model
1984
Induction of tumor necrosis factor expression and resistance in a human breast tumor cell line.
1987
Manganous superoxide dismutase is essential for cellular resistance to cytotoxicity of tumor necrosis factor
1989
Molecular cloning and expression of human tumor necrosis factor and comparison with mouse tumor necrosis factor
1985
The Biology and Detection of Immune Complexes
1980
TUMOR NECROSIS FACTOR RECEPTOR AND Fas SIGNALING MECHANISMS
1999
Cytoplasmic Structure and Contractility in Amoeboid Cells
1979
A Macrophage Factor Inhibits Adipocyte Gene Expression: An in Vitro Model of Cachexia
1985 StandoutScienceNobel
Effects of recombinant tumor necrosis factor on proliferation and differentiation of leukemic and normal hemopoietic cells in vitro. Relationship to cell surface receptor.
1986
Purification of rabbit tumor necrosis factor
1985
Recombinant 55-kDa tumor necrosis factor (TNF) receptor. Stoichiometry of binding to TNF alpha and TNF beta and inhibition of TNF activity.
1991
Characterization of macrophage function in Mycobacterium lepraemurium‐infected mice: sensitivity of mice to endotoxin and release of mediators and lysosomal enzymes after endotoxin treatment
1983
Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin
1984 Nature
Identity of tumour necrosis factor and the macrophage-secreted factor cachectin
1985 StandoutNatureNobel
Internal cell manipulation using infrared laser traps.
1989 StandoutNobel
Molecular Cloning of the Complementary DNA for Human Tumor Necrosis Factor
1985 Science
Role of first stimulating agents in the production of tumor necrosis factor
1984
Low endotoxic activities of synthetic Salmonella-type lipid A with an additional acyloxyacyl group on the 2-amino group of beta (1-6) glucosamine disaccharide 1,4'-bisphosphate
1986
Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts.
1985 StandoutNobel
A Receptor for Tumor Necrosis Factor Defines an Unusual Family of Cellular and Viral Proteins
1990 Science
Changes in thermogenesis and brown fat activity in response to tumour necrosis factor in the rat
1987
Tumor necrosis factor-induced degranulation in adherent human neutrophils is dependent on CD11b/CD18-integrin-triggered oscillations of cytosolic free Ca2+.
1990
Unraveling Function in the TNF Ligand and Receptor Families
1994 StandoutScienceNobel
Tumour-necrosis factor from the rabbit. II. Production by monocytes
1978
Works of Robert Kassel being referenced
Comparison of antitumor activities of pancreatic ribonuclease and its cross-linked dimer.
1976
Experimental approaches to the evaluation of fractionation media. I. The action of ions on the protoplasm of Amoeba proteus and Pelomyxa carolinensis
1953
An endotoxin-induced serum factor that causes necrosis of tumors.
1975 Standout
Glomerulonephritis associated with immune complex deposits and viral particles in spontaneous murine leukemia. An electron microscopic study with immunofluorescence.
1973
Partial purification of a serum factor that causes necrosis of tumors.
1976
Endotoxin-Induced Tumor Necrosis Factor
1980