Standout Papers
Citation Impact
Citing Papers
Trans-acting protein factors and the regulation of eukaryotic transcription: lessons from studies on DNA tumor viruses.
1988
Inflammasome-Dependent Release of the Alarmin HMGB1 in Endotoxemia
2010
Identification and Characterization of Ich-3, a Member of the Interleukin-1β Converting Enzyme (ICE)/Ced-3 Family and an Upstream Regulator of ICE
1996
Hallmarks of Cancer: The Next Generation
2011 Standout
Cleavage of ζPKC but Not λ/ιPKC by Caspase-3 during UV-induced Apoptosis
1999
NALPs: a novel protein family involved in inflammation
2003
ICEBERG
2000
ASC is essential for LPS‐induced activation of procaspase‐1 independently of TLR‐associated signal adaptor molecules
2004
Function of c-mos proto-oncogene product in meiotic maturation in Xenopus oocytes
1988 StandoutNature
Activation of Atypical Protein Kinase C ζ by Caspase Processing and Degradation by the Ubiquitin-Proteasome System
2000 StandoutNobel
A Combinatorial Approach Defines Specificities of Members of the Caspase Family and Granzyme B
1997 Standout
Murine Caspase-11, an ICE-Interacting Protease, Is Essential for the Activation of ICE
1998
TECK: A Novel CC Chemokine Specifically Expressed by Thymic Dendritic Cells and Potentially Involved in T Cell Development
1997
Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase
1993
A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F
1992
Autoregulated instability of β-tubulin mRNAs by recognition of the nascent amino terminus of βtubulin
1988 Nature
Protein Kinase C δ Is Essential for Etoposide-induced Apoptosis in Salivary Gland Acinar Cells
1999
Cryopyrin activates the inflammasome in response to toxins and ATP
2006 StandoutNature
ICE-LAP3, a Novel Mammalian Homologue of the Caenorhabditis elegans Cell Death Protein Ced-3 Is Activated during Fas- and Tumor Necrosis Factor-induced Apoptosis
1996
Apoptosis by Death Factor
1997 Standout
Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor
1990 StandoutNature
Critical Role for NALP3/CIAS1/Cryopyrin in Innate and Adaptive Immunity through Its Regulation of Caspase-1
2006
The Inflammasome
2002 Standout
Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties
1992 StandoutNobel
Substrate Specificities of Caspase Family Proteases
1997
Removal of poly(A) and consequent degradation of c-fos mRNA facilitated by 3′ AU-rich sequences
1988 Nature
The molecular control of cell division, differentiation commitment and maturation in haemopoietic cells
1989 StandoutNature
Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6
1991 StandoutNature
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
1993 StandoutNobel
NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice
2012 StandoutNature
Necrotic death as a cell fate
2006
An interleukin‐1β‐converting enzyme‐like protease is a common mediator of apoptosis in thymocytes
1995
Contenders in FasL/TNF death signaling
1995
Interleukin‐1β, Interleukin‐18, and the Interleukin‐1β Converting Enzymea
1998
Protease activation during apoptosis: Death by a thousand cuts?
1995 Standout
Molecular Ordering of the Cell Death Pathway
1996
Differential antisense transcription from the Dictyostelium EB4 gene locus: Implications on antisense-mediated regulation of mRNA stability
1992
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis
1995 StandoutNature
Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase
1995 Standout
Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf
2004 StandoutNature
FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex
1996 Standout
Germline variable region gene segment derivation of human monoclonal anti-Rh(D) antibodies. Evidence for affinity maturation by somatic hypermutation and repertoire shift.
1992 StandoutNobel
Non-canonical inflammasome activation targets caspase-11
2011 StandoutNature
Transcriptional and posttranscriptional regulation of tumor necrosis factor gene expression in human monocytes.
1988
Analysis of tumor necrosis factor promoter responses to ultraviolet light.
1994 StandoutNobel
ICE/CED3-like Proteases as Therapeutic Targets for the Control of Inappropriate Apoptosis
1996
The 5′ flanking region of the gene for the Epstein-Barr virus-encoded nuclear antigen 2 contains a cell type specificcis-acting regulatory element that activates transcription in transfected B-cells
1988
Caspase-dependent Cleavage of Signaling Proteins during Apoptosis
1998
Function of Nod‐like receptors in microbial recognition and host defense
2008
The cell-death machine
1996
A stem-loop in the 3′ untranslated region mediates iron-dependent regulation of transferrin receptor mRNA stability in the cytoplasm
1988
Caspase-3-mediated Cleavage of Protein Kinase C θ in Induction of Apoptosis
1997
Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis
1996 Nature
Dendritic cells and the control of immunity
1998 StandoutNatureNobel
Do the poly(A) tail and 3′ untranslated region control mRNA translation?
1990
Molecular control of tissue‐specific expression at the mouse TNF locus
1989
Caspases: Intracellular Signaling by Proteolysis
1997 Standout
Identification and Characterization of ICH-2, a Novel Member of the Interleukin-1β-converting Enzyme Family of Cysteine Proteases
1995
Identification of Ipaf, a Human Caspase-1-activating Protein Related to Apaf-1
2001
Molecular Cloning and Pro-apoptotic Activity of ICErelII and ICErelIII, Members of the ICE/CED-3 Family of Cysteine Proteases
1995
Identification of a translation inhibitory element (TIE) in the 3′ untranslated region of the human interferon-β mRNA
1988
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
2001 Standout
Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B
1995 Nature
Primary structure and genomic organization of the histidine-rich protein of the malaria parasite Plasmodium lophurae
1984 StandoutNatureNobel
Regulation of c-fosgene expression in hamster fibroblasts: initiation and elongation of transcription and mRNA degradation
1987
Tyrosine phosphorylation within the amino-terminal domain of pp60c-src molecules associated with polyoma virus middle-sized tumor antigen.
1985
Behavior of myc and ras Oncogenes in Transformation of Rat Embryo Fibroblasts
1986
Identification of a common nucleotide sequence in the 3'-untranslated region of mRNA molecules specifying inflammatory mediators.
1986 StandoutNobel
A small segment of polyoma virus DNA enhances the expression of a cloned β-globin gene over a distance of 1400 base pairs
1981
Physical contact between lipopolysaccharide and Toll-like receptor 4 revealed by genetic complementation
2000 StandoutNobel
Sustained expression of the human protooncogene MYCN rescues rat embryo cells from senescence.
1988 StandoutNobel
Isolation and characterization of human DNA fragments with nucleotide sequence homologies with the simian virus 40 regulatory region.
1982
The product of the protooncogene c-src is modified during the cellular response to platelet-derived growth factor.
1985 StandoutNobel
Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes
1983 StandoutNature
Multiple regulatory steps control histone mRNA concentrations
1988
The structure of the human synapsin I gene and protein.
1990 StandoutNobel
The 3' untranslated region of the human interferon-beta mRNA has an inhibitory effect on translation.
1987
In vivo sequence requirements of the SV40 early promoter region
1981 Nature
Poly(A) shortening and degradation of the 3' A+U-rich sequences of human c-myc mRNA in a cell-free system.
1988
Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture
1983 Nature
Studies of in vitro transcription by calf thymus RNA polymerase II using a novel duplex DNA template.
1982
Constitutive activity of the tumor necrosis factor promoter is canceled by the 3' untranslated region in nonmacrophage cell lines; a trans-dominant factor overcomes this suppressive effect.
1992 StandoutNobel
The size of Rous sarcoma virus mRNAs active in cell-free translation
1977 Nature
AUUUA Is Not Sufficient To Promote Poly(A) Shortening and Degradation of an mRNA: the Functional Sequence within AU-Rich Elements May Be UUAUUUA(U/A)(U/A)
1994
Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
1997 Standout
Dual Role of Caspase-11 in Mediating Activation of Caspase-1 and Caspase-3 under Pathological Conditions
2000
Promoters and heterogeneous 5′ termini of the messenger RNAs of adenovirus serotype 2
1981
Expression of c-mos proto-oncogene transcripts in mouse tissues
1985 Nature
THE MOLECULAR GENETICS OF CELLULAR ONCOGENES
1984
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.
1995 StandoutNobel
The T cell antigen receptor complex expressed on normal peripheral blood CD4-, CD8- T lymphocytes. A CD3-associated disulfide-linked gamma chain heterodimer.
1987 StandoutNobel
Location and function of retroviral and SV40 sequences that enhance biochemical transformation after microinjection of DNA
1983 StandoutNobel
Expression and state of phosphorylation of the retinoblastoma susceptibility gene product in cycling and noncycling human hematopoietic cells.
1990
Subunit Structure of Qβ Replicase
1970 Nature
The Human Immunodeficiency Virus: Infectivity and Mechanisms of Pathogenesis
1988 StandoutScience
Activation of Interferon-γ Inducing Factor Mediated by Interleukin-1β Converting Enzyme
1997 Science
Structure and expression of the human metallothionein-IG gene. Differential promoter activity of two linked metallothionein-I genes in response to heavy metals.
1988
Natural Read-through at the UGA Termination Signal of Qβ Coat Protein Cistron
1971
Host-specific activation of transcription by tandem repeats from simian virus 40 and Moloney murine sarcoma virus.
1982
Stability of RNA in developing Xenopus embryos and identification of a destabilizing sequence in TFIIIA messenger RNA
1988
Evolution of the genome and the genetic code: selection at the dinucleotide level by methylation and polyribonucleotide cleavage.
1989 StandoutNobel
The interleukin-1 beta-converting enzyme (ICE) is localized on the external cell surface membranes and in the cytoplasmic ground substance of human monocytes by immuno-electron microscopy.
1995
Identification of DNA sequences required for transcription of the human α1-globin gene in a new SV40 host-vector system
1981
Polyoma virus middle T antigen: relationship to cell membranes and apparent lack of ATP-binding activity.
1982
Cachectin: More Than a Tumor Necrosis Factor
1987 StandoutNobel
Dinucleotide priming of transcription mediated by RNA polymerase II.
1984 StandoutNobel
Enzymatic Amplification of β-Globin Genomic Sequences and Restriction Site Analysis for Diagnosis of Sickle Cell Anemia
1985 StandoutScienceNobel
Controlling mRNA lifespan
1988 StandoutNatureNobel
Phosphorylation of presenilin-2 regulates its cleavage by caspases and retards progression of apoptosis
1999
PROTEOLYTIC ACTIVITIES THAT MEDIATE APOPTOSIS
1998
Molecular thanatopsis: a discourse on the BCL2 family and cell death
1996
Molecular ordering of the Fas-apoptotic pathway: The Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases
1996
Endothelial Leukocyte Adhesion Molecule 1: an Inducible Receptor for Neutrophils Related to Complement Regulatory Proteins and Lectins
1989 StandoutScience
Functional organization of the simian virus 40 origin of DNA replication.
1986
Novel Regulators of Bone Formation: Molecular Clones and Activities
1988 StandoutScience
Sequences that confer β-tubulin autoregulation through modulated mRNA stability reside within exon 1 of a β-tubulin mRNA
1987
Antisense RNA Directed Against the 3′ Noncoding Region Prevents Dormant mRNA Activation in Mouse Oocytes
1988 Science
Activation of the cell death program by inhibition of proteasome function
1997
Molecular cloning of the complete Epstein-Barr virus genome as a set of overlapping restriction endonuclease fragments
1981 StandoutNobel
Expression of N-myc and c-src during the development of fetal human brain.
1987
Salmonella Exploits Caspase-1 to Colonize Peyer's Patches in a Murine Typhoid Model
2000
Translation is required for regulation of histone mRNA degradation
1987
Somatic mutation and the maturation of immune response to 2-phenyl oxazolone
1984 StandoutNatureNobel
Salmonella-Induced Caspase-2 Activation in Macrophages
2000
A putative origin of replication of plasmids derived from Epstein-Barr virus is composed of two cis-acting components.
1985
The potential for isoenzyme‐selective modulation of protein kinase C
1997
The size and genetic composition of virus-specific RNAs in the cytoplasm of cells producing avian sarcoma-leukosis viruses
1977 StandoutNobel
A catalogue of splice junction sequences
1982 Standout
Mammalian Caspases: Structure, Activation, Substrates, and Functions During Apoptosis
1999 Standout
Transient accumulation of c-fos RNA following serum stimulation requires a conserved 5′ element and c-fos 3′ sequences
1985
Enhancement of cellular src gene product associated tyrosyl kinase activity following polyoma virus infection and transformation
1984
A cellular gene encodes scrapie PrP 27-30 protein
1985 StandoutNobel
Biological activities of v-myc and rearranged c-myc oncogenes in rat fibroblast cells in culture.
1984
c-mos proto-oncogene RNA transcripts in mouse tissues: structural features, developmental regulation, and localization in specific cell types.
1987
Multiple Point Mutations Affecting the Simian Virus 40 Enhancer
1983 Science
Isolation of the human gene for bone gla protein utilizing mouse and rat cDNA clones.
1986
Detection of single base substitutions in total genomic DNA
1985 Nature
Association between transplantation antigens and a viral membrane protein synthesized from a mammalian expression vector
1983 StandoutNobel
The silent carrier allele: β thalassemia without a mutation in the β-globin gene or its immediate flanking regions
1984 StandoutNobel
Endotoxin-responsive sequences control cachectin/tumor necrosis factor biosynthesis at the translational level.
1990 StandoutNobel
Translational Blockade Imposed by Cytokine-Derived UA-Rich Sequences
1989 Science
Bovine papilloma virus contains an activator of gene expression at the distal end of the early transcription unit.
1983
Proteolytic activation of the cell death protease Yama/CPP32 by granzyme B.
1996
The novel metallothionein genes of Caenorhabditis elegans. Structural organization and inducible, cell-specific expression.
1993 StandoutNobel
Selective degradation of early-response-gene mRNAs: functional analyses of sequence features of the AU-rich elements.
1994
Multiple mRNA species for the precursor to an adenovirus-encoded glycoprotein: identification and structure of the signal sequence.
1980
Behavior of myc and ras oncogenes in transformation of rat embryo fibroblasts.
1986
Selective Degradation of Early-Response-Gene mRNAs: Functional Analyses of Sequence Features of the AU-Rich Elements
1994
Control of rDNA replication in Tetrahymena involves a cis-acting upstream repeat of a promoter element
1986 StandoutNobel
Works of Robert Kamen being referenced
Caspase-1 processes IFN-γ-inducing factor and regulates LPS-induced IFN- γ production
1997 Nature
Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock
1995
The myeloid blood cell differentiation-inducing protein MGI-2A is interleukin-6
1988
The roles of individual polyoma virus early proteins in oncogenic transformation
1982 Nature
Determination of sequences at the capped 5′ ends of polyoma virus early region transcripts synthesized in vivo and in vitro demonstrates an unusual microheterogeneity
1982
Polyomavirus enhancer contains multiple redundant sequence elements that activate both DNA replication and gene expression.
1985
A region of the polyoma virus genome between the replication origin and late protein coding sequences is required in cis for both early gene expression and viral DNA replication
1981
Proteolytic activation of protein kinase C delta by an ICE-like protease in apoptotic cells.
1995
Localization of Three Major Capped 5′ Ends of Polyoma Virus Late mRNA's Within a Single Tetranucleotide Sequence in the Viral Genome
1980
Location of the sequences coding for capsid proteins VP1 and VP2 on polyoma virus DNA
1976
Comparison of Polyoma Virus Transcription in Productively Infected Mouse Cells and Transformed Rodent Cell Lines
1980
Analysis of polyoma virus nuclear RNA by mini-blot hybridization.
1977
Transformation of rat cells by an altered polyoma virus genome expressing only the middle-T protein
1981 Nature
Expression of the large T protein of polyoma virus promotes the establishment in culture of "normal" rodent fibroblast cell lines.
1983
A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation
1986 Standout
Proteolytic Activation of Protein Kinase C δ by an ICE/CED 3-like Protease Induces Characteristics of Apoptosis
1996
The Human Hematopoietic Colony-Stimulating Factors
1987 Science
Stimulation of haematopoiesis in primates by continuous infusion of recombinant human GM-CSF
1986 Nature
Characterization of the Subunits of Qβ Replicase
1970 Nature
[68] Transcription maps of polyoma virus-specific RNA: Analysis by two-dimensional nuclease S1 gel mapping
1980 Standout
Polyoma virus DNA replication requires an enhancer
1984 Nature
Polyoma virus transcription in vitro
1977
Multiple 5′ terminal cap structures in late polyoma virus RNA
1979
The high affinity binding site on polyoma virus DNA for the viral large-T protein
1981