Standout Papers
Citation Impact
Citing Papers
Recommendations for Cardiac Chamber Quantification by Echocardiography in Adults: An Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging
2015 Standout
Arresting a Transient Receptor Potential (TRP) Channel
2010 StandoutNobel
In situ click chemistry generation of cyclooxygenase-2 inhibitors
2017 Standout
Caffeine-induced expression of c-fos mRNA and NGFI-A mRNA in caudate putamen and in nucleus accumbens are differentially affected by the N-methyl-d-aspartate receptor antagonist MK-801
1996
Discrimination of ascorbate-dependent nonenzymatic and enzymatic, membrane-bound reduction of nitric oxide in denitrifying Pseudomonas perfectomarinus
1982
Epidemiology of acute asthma: IgE antibodies to common inhalant allergens as a risk factor for emergency room visits
1989
Effect of long term caffeine treatment on A1 and A2 adenosine receptor binding and on mRNA levels in rat brain
1993
Leukotrienes and Other Products of the 5-Lipoxygenase Pathway
1990
The development of mechanistic enzymology in the 20th century
2001
Exposure to an Aeroallergen as a Possible Precipitating Factor in Respiratory Arrest in Young Patients with Asthma
1991 Standout
Dust mites: Immunology, allergic disease, and environmental control
1987 Standout
Cushing's Syndrome
1995
Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells Activation in Vivo Increases Blood Leukocyte Counts and Its Blockade Abrogates 13,14-Dihydro-15-keto-prostaglandin D2-Induced Eosinophilia in Rats
2003
Methylxanthines: Toxicity to humans. 2. Caffeine
1988
Eosinophilic Inflammation in Asthma
1990 Standout
Distribution and function of prostanoid receptors: studies from knockout mice
2000
Effects of caffeine with repeated dosing
1991
Paraneoplastic Syndromes Involving the Nervous System
2003 Standout
Pharmacokinetic-pharmacodynamic modeling of caffeine: Tolerance to pressor effects
1993
Loss of Glucocorticoid Fast Feedback in Depression
1991
Neurologic disorders in patients with small cell lung cancer
1987
Suppression of allergic inflammation by the prostaglandin E receptor subtype EP3
2005
Cushing's syndrome
2015 Standout
Molecular basis of human hypertension: Role of angiotensinogen
1992 Standout
The contribution of alveolar macrophages to hyperreactive airway disease
1989
Measurement of immunoreactive angiotensin peptides in rat tissues: Some pitfalls in angiotensin II analysis
1988
The midnight-to-morning urinary cortisol increment method is not reliable for the assessment of hypothalamic-pituitaryadrenal insufficiency in patients with end-stage kidney disease
2003
Clinical Pharmacology of Caffeine
1990
Long-term caffeine treatment leads to a decreased susceptibility to NMDA-induced clonic seizures in mice without changes in adenosine A1 receptor number
1993
Biosynthesis of 15-deoxy-Δ12,14-PGJ2 and the ligation of PPARγ
2003
Coronary heart disease: seven dietary factors
1991 Standout
Peptidomimetics derived from natural products
1993
Caffeine physical dependence: a review of human and laboratory animal studies
1988
Caffeine tolerance and choice in humans
1992
Cardiovascular, behavioral, and subjective effects of caffeine under field conditions
1994
High levels of human chymase expression in the pineal and pituitary glands
1997
Biochemical Mechanism of Caffeine Tolerance
1991
Diabetic autonomic neuropathy—part I
1988
Evolution of novel tricyclic CRTh2 receptor antagonists from a (E)-2-cyano-3-(1H-indol-3-yl)acrylamide scaffold
2012
Dose-dependent surmountability of locomotor activity in caffeine tolerance
1995
Influence of caffeine on information processing stages in well rested and fatigued subjects
1994
The development of allergic inflammation
2008 StandoutNature
A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds
1993 StandoutNature
Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system
2005 StandoutNobel
Glial and neuronal control of brain blood flow
2010 StandoutNature
Hypoxia of the Renal Medulla — Its Implications for Disease
1995 Standout
Angiotensin-converting enzyme 2 protects from severe acute lung failure
2005 StandoutNature
Caffeine as a model drug of abuse
1990
Multiple components of the A1 adenosine receptor-adenylate cyclase system are regulated in rat cerebral cortex by chronic caffeine ingestion.
1988
The effect of dietary caffeine manipulation on blood caffeine, sleep and disturbed behaviour
1994
Effects of caffeine on alertness
1990
Isolation of a cDNA encoding the vascular type-1 angiotensin II receptor
1991 StandoutNature
Local renin–angiotensin system in the pineal gland
1998
Renin immunohistochemistry in the adrenal gland of the mouse fetus and neonate
1990
Physiology of Local Renin-Angiotensin Systems
2006 Standout
Behavioral and physiological effects of xanthines in nonhuman primates
1997
The influence of user status and anxious disposition on the hypertensive effects of caffeine
1990
Exposure to House-Dust Mite Allergen (Der pI) and the Development of Asthma in Childhood
1990 Standout
The influence of chronic caffeine administration on sleep parameters in the cat
1989
The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure
1999 Standout
Allergic lung responses are increased in prostaglandin H synthase–deficient mice
1999
Homeostasis in Mice with Genetically Decreased Angiotensinogen Is Primarily by an Increased Number of Renin-producing Cells
1999 StandoutNobel
Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
2016 StandoutNature
Sympathomimetic effects of paraxanthine and caffeine in humans*
1995
Effects of the acute administration of caffeine in patients with schizophrenia
1990
Tissue renin-angiotensin systems: new insights from experimental animal models in hypertension research
2001
Molecular evidence of tissue renin-angiotensin systems: A focus on the brain
2005
Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects
1992 Standout
Adenosine, Adenosine Receptors and the Actions of Caffeine *
1995
Angiotensin-independent mechanism for aldosterone synthesis during chronic extracellular fluid volume depletion.
1997
Renin expression in the kidney and brain is reciprocally controlled by captopril
1989
The effects of caffeine on graded exercise performance in caffeine naive versus habituated subjects
1991
Mast cells and eicosanoid mediators: a system of reciprocal paracrine and autocrine regulation
2007
Early renal medullary hypoxic injury from radiocontrast and indomethacin
1991
Caffeine abstention in the management of anxiety disorders
1989
Hyponatremia
2000 Standout
Human health implications of environmental contaminants in Arctic Canada: a review
1999 Standout
Caffeine and cigarette smoking: behavioral, cardiovascular, and metabolic interactions
1989
Prorenin and Other Large Molecular Weight Forms of Renin*
1980
Local and Systemic Effects of Intradermal Recombinant Interferon-γ in Patients with Lepromatous Leprosy
1986 StandoutNobel
Three-dimensional structure, specificity and catalytic mechanism of renin
1983 Nature
Rolipram, a type IV-specific phosphodiesterase inhibitor, facilitates the establishment of long-lasting long-term potentiation and improves memory
1998 StandoutNobel
Renin-angiotensin system: biochemistry and mechanisms of action.
1977 Standout
Renin is not synthesized by cardiac and extrarenal vascular tissues. A review of experimental evidence.
1994
Three-dimensional structure of the complex of the Rhizopus chinensis carboxyl proteinase and pepstatin at 2.5 .ANG. resolution
1982
3d Transition Metals for C–H Activation
2018 Standout
The DP receptor, allergic inflammation and asthma
2003
Analysis by immunocytochemistry and in situ hybridization of renin and its mRNA in kidney, testis, adrenal, and pituitary of the rat.
1986
Molecular Recognition of Protein−Ligand Complexes: Applications to Drug Design
1997 Standout
Hippocampal atrophy in recurrent major depression.
1996 Standout
Regular or decaffeinated coffee and subsequent human aggressive behavior
1984
Isorenin, pseudorenin, cathepsin D and renin. A comparative enzymatic study of angiotensin-forming enzymes
1978
Biosynthesis of 15-deoxy-Δ12,14-PGJ2 and the ligation of PPARγ
2003
Pituitary-Dependent Renin-Like Immunoreactivity in the Rat Testis*
1983
Genetic Models of Human Vascular Disease
1995 StandoutNobel
Anxiety and caffeine consumption in people with anxiety disorders
1985
Caffeine intakes of children from a biracial population: The Bogalusa Heart Study
1988
One-step gas-phase catalytic oxidation of benzene to phenol with molecular oxygen over Cu-supported ZSM-5 zeolites
2003
Expression of the DBA/2J Ren-2 gene in the adrenal gland of transgenic mice.
1989
X-ray crystal structure of the complex of human leukocyte elastase (PMN elastase) and the third domain of the turkey ovomucoid inhibitor.
1986 StandoutNobel
The Effects of Caffeine on Psychological Functioning
1985
Prostaglandin D 2 as a Mediator of Allergic Asthma
2000 Science
Diagnostic Evaluation of Cushing’s Syndrome
1988
Endogenous biosynthesis of prostacyclin during cardiac catheterization and angiography in man.
1985
The effects of caffeine on plasma MHPG, subjective anxiety, autonomic symptoms and blood pressure in healthy humans
1984
Biochemical and Radiologic Diagnosis of Cushing’s Syndrome
1994
Localization of renin (EC 3.4.23) and converting enzyme (EC 3.4.15.1) in nerve endings of rat brain
1985
Dietary n-3 polyunsaturated fatty acids and amelioration of cardiovascular disease: possible mechanisms
1990
Accessing Drug Metabolites via Transition‐Metal Catalyzed C−H Oxidation: The Liver as Synthetic Inspiration
2016
Caffeine Use as a Model of Acute and Chronic Insomnia
1992
BIOLOGICAL FUNCTIONS OF ANGIOTENSIN AND ITS RECEPTORS
1997
Chronic caffeine ingestion sensitizes the A1 adenosine receptor-adenylate cyclase system in rat cerebral cortex.
1986
Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas
2016 Standout
Acute Aquaresis by the Nonpeptide Arginine Vasopressin (AVP) Antagonist OPC-31260 Improves Hyponatremia in Patients with Syndrome of Inappropriate Secretion of Antidiuretic Hormone (SIADH)
1997
Angiotensinogen gene is expressed and differentially regulated in multiple tissues of the rat.
1986
Caffeine and Endurance Performance
1985
Immunohistological Evidence for Renin in Human Endocrine Tissues*
1985
Mechanism of CO2 response in cerebral arteries of the newborn pig: role of phospholipase, cyclooxygenase, and lipoxygenase pathways.
1988
Regulation of cell proliferation and differentiation by interferons
1985
An Alternative Transcript of the Rat Renin Gene Can Result in a Truncated Prorenin That Is Transported Into Adrenal Mitochondria
1999
Renin, angiotensins, and angiotensin-converting enzyme in neuroblastoma cells: evidence for intracellular formation of angiotensins.
1981
Prostaglandins and Leukotrienes: Advances in Eicosanoid Biology
2001 StandoutScience
On the mechanism of catalytic hydroxylation of aromatic hydrocarbons by hydrogen peroxide
1991
Activation of the Prostaglandin D2 Receptor DP2/CRTH2 Increases Allergic Inflammation in Mouse
2005
Prevention of Allergic Inflammation by a Novel Prostaglandin Receptor Antagonist, S-5751
2001
The Health Consequences of Caffeine
1983
Actions of Caffeine in the Brain with Special Reference to Factors That Contribute to Its Widespread Use
1999 Standout
The pharmacology of caffeine
1987
Pharmacokinetics, single-dose tolerance, and biological activity of recombinant gamma-interferon in cancer patients.
1985
Caffeine: Clinical and experimental effects in humans
1986
Role of Prostacyclin in the Cardiovascular Response to Thromboxane A 2
2002 StandoutScience
Caffeine down-regulates β adrenoreceptors in rat forebrain
1982
T Cell Trafficking in Allergic Asthma: The Ins and Outs
2008
Aerobic Copper-Catalyzed Organic Reactions
2013 Standout
Chronic caffeine consumption increases the number of brain adenosine receptors
1983
Adrenal and circulating renin-angiotensin system in stroke-prone hypertensive rats.
1992
Evidence for the Low Dose Dexamethasone Suppression Test to Screen for Cushing's Syndrome—Recommendations for a Protocol for Biochemistry Laboratories
1997
Recombinant Human Tumor Necrosis Factor-α: Effects on Proliferation of Normal and Transformed Cells in Vitro
1985 StandoutScience
Activation of C−H Bonds by Metal Complexes
1997 Standout
Chemistry of Biologically Important Synthetic Organoselenium Compounds
2001 Standout
Coffee, Caffeine, and Health
2020
Effects of chronic caffeine on brain adenosine receptors: Regional and ontogenetic studies
1984
Electrostatic Basis for Enzyme Catalysis
2006 StandoutNobel
Behavioral Effects of Caffeine in Children
1984
Light-Directed, Spatially Addressable Parallel Chemical Synthesis
1991 StandoutScience
A micromethod for the measurement of renin in brain nuclei: Its application in spontaneously hypertensive rats
1982
Fluoro ketone inhibitors of hydrolytic enzymes
1985
Caffeine intakes of children from a biracial population: the Bogalusa Heart Study.
1988
The effects of caffeine on caffeine users and non-users
1986
Effects of caffeine on human aggressive behavior
1983
Prostaglandin D2 is a potent chemoattractant for human eosinophils that acts via a novel DP receptor
2001
The Biochemistry of the Renin-Angiotensin System
1980
Effect of decaffeinated versus regular coffee on blood pressure. A 12-week, double-blind trial.
1989
Adenosine receptors: Clinical implications and biochemical mechanisms
1988
Health and ergogenic effects of caffeine.
1989
Caffeine withdrawal: a contrast of withdrawal symptoms in normal subjects who have abstained from caffeine for 24 hours and for 7 days
1991
Chronic caffeine treatment reduces caffeine but not adenosine effects on cortical acetylcholine release
1986
Prostaglandins and Inflammation
2011 Standout
Should caffeine abuse, dependence, or withdrawal be added to DSM-IV and ICD-10?
1992
Failure of ductus arteriosus closure and remodeling in neonatal mice deficient in cyclooxygenase-1 and cyclooxygenase-2
2001 StandoutNobel
Adenosine actions and adenosine receptors after 1 week treatment with caffeine
1982
Increased expression of c-jun, junB, AP-1, and preproenkephalin mRNA in rat striatum following a single injection of caffeine
1995
Increased Anxiogenic Effects of Caffeine in Panic Disorders
1985
Transient up-regulation of P2Y2nucleotide receptor mRNA expression is an immediate early gene response in activated thymocytes
1997 StandoutNobel
In vivo activity of purified mouse brain renin
1981
The Diagnosis of Cushing's Syndrome: An Endocrine Society Clinical Practice Guideline
2008 Standout
The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus
1993 Standout
Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system
2005 StandoutNobel
Novel renin inhibitors containing the amino acid statine
1983 Nature
Studies on the Regulation of Renin Genes Using Transgenic Mice
1988
Immunohistochemical localization of renin in luteinizing hormone-producing cells of rat pituitary.
1981
Works of Robert J. Workman being referenced
Pepsin inhibition by a high specific activity radioiodinated derivative of pepstatin
1979
Association between low plasma levels of dexamethasone and elevated levels of cortisol in psychiatric patients given dexamethasone
1984
Renin. Inhibition by proteins and peptides
1974
A Role for the Adrenal Renin-Angiotensin System in the Regulation of Potassium-Stimulated Aldosterone Production*
1985
Immunohistochemical evidence that angiotensins I and II are formed by intracellular mechanism in juxtaglomerular cells.
1982
Release of Prostaglandin D2into Human Airways during Acute Antigen Challenge
1986
Attenuation of the development of hypertension in spontaneously hypertensive rats by the thromboxane synthetase inhibitor, 4′-(imidazol-1-yl) acetophenone
1982
Management of the syndrome of inappropriate antidiuretic hormone secretion in small cell lung cancer
1983
Oxidation by Molecular Oxygen. I. Reactions of a Possible Model System for Mixed-Function Oxidases
1964
Dexamethasone Suppression Testing in Chronic Renal Failure: Pharmacokinetics of Dexamethasone and Demonstration of a Normal Hypothalamic-Pituitary- Adrenal Axis*
1986
Pepstatin Inhibition of Human Renin
1974
Specific antibody to hog renal renin and its application to the direct radioimmunoassay of renin in various organs.
1979
Relationship of Renal Hemodynamic and Functional Changes Following Intravascular Contrast to the Renin–Angiotensin System and Renal Prostacyclin in the Dog
1983
Renin and prorenin in hog brain: Ubiquitous distribution and high concentration in the pituitary and pineal
1980
Comparison of serum phospholipid fatty acids among fishing and farming Japanese populations and American inlanders.
1985
Renin and Precursors: Purification, Characterization, and Studies on Active Site
1977 StandoutNobel
Caffeine and hypertension
1984
Tolerance to the humoral and hemodynamic effects of caffeine in man.
1981
Pleiotropic activities of human interferons are mediated by multiple response pathways.
1984
Prostaglandin biosynthesis does not participate in hypercapnia-induced cerebral vasodilatation in the dog.
1983
The dexamethasone suppression index: enhancement of DST diagnostic utility for depression by expressing serum cortisol as a function of serum dexamethasone
1988
Immunohistochemical evidence that angiotensins I and II are formed by intracellular mechanism in juxtaglomerular cells.
1982