Citation Impact
Citing Papers
In vivo imaging of hydrogen peroxide production in a murine tumor model with a chemoselective bioluminescent reporter
2010 StandoutNobel
A Sulfilimine Bond Identified in Collagen IV
2009 StandoutScienceNobel
A Conserved Family of Prolyl-4-Hydroxylases That Modify HIF
2001 StandoutScience
A phase I trial of antibody directed enzyme prodrug therapy (ADEPT) in patients with advanced colorectal carcinoma or other CEA producing tumours
2002
The HIF pathway as a therapeutic target
2004
Targeting histone lysine demethylases — Progress, challenges, and the future
2014
Tuning the Transcriptional Response to Hypoxia by Inhibiting Hypoxia-inducible Factor (HIF) Prolyl and Asparaginyl Hydroxylases
2016 StandoutNobel
Proteomics-based Identification of Novel Factor Inhibiting Hypoxia-inducible Factor (FIH) Substrates Indicates Widespread Asparaginyl Hydroxylation of Ankyrin Repeat Domain-containing Proteins
2008 StandoutNobel
Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain
2015 StandoutNobel
Mechanisms of hypoxia signalling: new implications for nephrology
2019 StandoutNobel
The Role of β-Glucuronidase in Drug Disposition and Drug Targeting in Humans
1997
Dual-action inhibitors of HIF prolyl hydroxylases that induce binding of a second iron ion
2012 StandoutNobel
Inhibition of 2-oxoglutarate dependent oxygenases
2011
Wound repair and regeneration
2008 StandoutNature
Nonredox 5-Lipoxygenase Inhibitors Require Glutathione Peroxidase for Efficient Inhibition of 5-Lipoxygenase Activity
1998
Cancer Statistics, 2006
2006 Standout
Selective activation of anticancer prodrugs by monoclonal antibody–enzyme conjugates
2001
Prolyl hydroxylase inhibitor treatment confers whole‐animal hypoxia tolerance
2007
Engineering the perfect (bacterial) cancer therapy
2010 Standout
Pirfenidone in patients with idiopathic pulmonary fibrosis (CAPACITY): two randomised trials
2011 Standout
Cellular oxygen sensing in health and disease
2007 StandoutNobel
Hypoxia and the extracellular matrix: drivers of tumour metastasis
2014 StandoutNobel
Exploiting tumour hypoxia in cancer treatment
2004 Standout
Pharmacological targeting of the HIF hydroxylases – A new field in medicine development
2016 StandoutNobel
Oxygen sensing and hypoxia signalling pathways in animals: the implications of physiology for cancer
2013 StandoutNobel
Structure-function analysis of phytanoyl-CoA 2-hydroxylase mutations causing Refsum's disease
2001
Carboxypeptidase G2-based gene-directed enzyme–prodrug therapy: a new weapon in the GDEPT armoury
2007
Polyphenols: food sources and bioavailability
2004 Standout
Tumor-targeting prodrug-activating bacteria for cancer therapy
2008
Cascade Reactions in Total Synthesis
2006 Standout
Pirfenidone in idiopathic pulmonary fibrosis
2009 Standout
Idiopathic Pulmonary Fibrosis
2001 Standout
Dynamic Combinatorial Chemistry Employing Boronic Acids/Boronate Esters Leads to Potent Oxygenase Inhibitors
2012 StandoutNobel
Selective Stabilization of HIF-1α in Renal Tubular Cells by 2-Oxoglutarate Analogues
2012
Tumor-activated Prodrugs—A New Approach to Cancer Therapy
2004
Liposomal drug delivery systems: From concept to clinical applications
2012 Standout
Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway
2008 StandoutNobel
Hypoxia‐Inducible Factor Prolyl‐Hydroxylase: Purification and Assays of PHD2
2007 StandoutNobel
Carotid body hyperplasia and enhanced ventilatory responses to hypoxia in mice with heterozygous deficiency of PHD2
2013 StandoutNobel
Novel imidazole compounds as a new series of potent, orally active inhibitors of 5-lipoxygenase
2003
Kinetic parameters for small-molecule drug delivery by covalent cell surface targeting
2001 StandoutNobel
The human side of hypoxia‐inducible factor
2008 StandoutNobel
Synthesis of Heterobifunctional Protein Fusions Using Copper‐Free Click Chemistry and the Aldehyde Tag
2012 StandoutNobel
Identification of Chemical Compounds that Induce HIF-1α Activity
2009 StandoutNobel
Collagen Matrix in Spinal Cord Injury
2006
Collagen Hydroxylases and the Protein Disulfide Isomerase Subunit of Prolyl 4‐Hydroxylases
1998
Synthesis of seven-membered oxacycles
1998
Purification and Characterization of the FeII- and α-Ketoglutarate-Dependent Xanthine Hydroxylase from Aspergillus nidulans
2007
An expedient synthesis of ellipticine via Suzuki–Miyaura coupling
2010
Effects of Pirfenidone on Procollagen Gene Expression at the Transcriptional Level in Bleomycin Hamster Model of Lung Fibrosis
1999
Betti reaction enables efficient synthesis of 8-hydroxyquinoline inhibitors of 2-oxoglutarate oxygenases
2015 StandoutNobel
Antibody-directed enzyme prodrug therapy: efficacy and mechanism of action in colorectal carcinoma.
2000
Axially Chiral 1,7-Naphthyridine-6-carboxamide Derivatives as Orally Active Tachykinin NK1 Receptor Antagonists: Synthesis, Antagonistic Activity, and Effects on Bladder Functions
1999
Attenuated Salmonella Targets Prodrug Activating Enzyme Carboxypeptidase G2 to Mouse Melanoma and Human Breast and Colon Carcinomas for Effective Suicide Gene Therapy
2008
Recent synthetic developments in a powerful imino Diels–Alder reaction (Povarov reaction): application to the synthesis of N-polyheterocycles and related alkaloids
2008 Standout
Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas
2016 Standout
Occurrence, Biogenesis, and Synthesis of Biologically Active Carbazole Alkaloids
2012 Standout
Prodrugs of Anthracyclines for Use in Antibody-Directed Enzyme Prodrug Therapy
1998
Routes for the Synthesis of (2S)-2-Methyltetrahydropyran-4-one from Simple Optically Pure Building Blocks
2009
PHD3-mediated prolyl hydroxylation of nonmuscle actin impairs polymerization and cell motility
2014 StandoutNobel
Drug Delivery Systems: Entering the Mainstream
2004 StandoutScience
An Efficient, One-Pot Synthesis of Isomeric Ellipticine Derivatives through Intramolecular Imino-Diels−Alder Reaction
2008
Copper in cross-coupling reactions
2004 Standout
Antibody-directed enzyme prodrug therapy: pharmacokinetics and plasma levels of prodrug and drug in a phase I clinical trial
1997
Synthesis of an organoinsulin molecule that can be activated by antibody catalysis
2001 StandoutNobel
CuI/La(OTf)3 catalyzed, one-pot synthesis of isomeric ellipticine derivatives in ionic liquid
2010
Enzyme-Responsive Snap-Top Covered Silica Nanocontainers
2008 StandoutNobel
Chemistry of Biologically Important Synthetic Organoselenium Compounds
2001 Standout
Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay
2006 StandoutNobel
Large-Scale Applications of Transition Metal-Catalyzed Couplings for the Synthesis of Pharmaceuticals
2011 Standout
Sustained Tumor Regression of Human Colorectal Cancer Xenografts Using a Multifunctional Mannosylated Fusion Protein in Antibody-Directed Enzyme Prodrug Therapy
2005
Efficient Synthesis of Novel NK1 Receptor Antagonists: Selective 1,4-Addition of Grignard Reagents to 6-Chloronicotinic Acid Derivatives
2006
Assessing Atropisomer Axial Chirality in Drug Discovery and Development
2011 Standout
Antibody–Enzyme Fusion Proteins for Cancer Therapy
2011
Aromatic Trifluoromethylation with Metal Complexes
2011 Standout
The Mononuclear Molybdenum Enzymes
2014 Standout
Advances in the Baylis–Hillman reaction-assisted synthesis of cyclic frameworks
2008 Standout
Antioxidant and redox regulation of gene transcription
1996 Standout
Stereoselective synthesis of tri- and tetrasubstituted oxepanes via n-Bu3SnH mediated 7-endo-trig vinyl radical cyclisation
2005
IL-2 gene expression and NF-kappa B activation through CD28 requires reactive oxygen production by 5-lipoxygenase.
1995
Antibody-directed enzyme prodrug therapy (ADEPT): a review
1997
Multiple event activation of a generic prodrug trigger by antibody catalysis
1999 StandoutNobel
Free Radicals in the Physiological Control of Cell Function
2002 Standout
Multiple Binding Modes of Inhibitors to Carbonic Anhydrases: How to Design Specific Drugs Targeting 15 Different Isoforms?
2012 Standout
Works of Robert I. Dowell being referenced
Methoxytetrahydropyrans. A new series of selective and orally potent 5-lipoxygenase inhibitors
1992
DNA interstrand cross-linking and TP53 status as determinants of tumour cell sensitivity in vitro to the antibody-directed enzyme prodrug therapy ZD2767
2002
4-Methoxy-2-methyltetrahydropyrans: chiral leukotriene biosynthesis inhibitors, related to ICI D2138, which display enantioselectivity
1993
Optimization of Alkylating Agent Prodrugs Derived from Phenol and Aniline Mustards: A New Clinical Candidate Prodrug (ZD2767) for Antibody-Directed Enzyme Prodrug Therapy
1995
Novel inhibitors of prolyl 4-hydroxylase
1992
New Mustard Prodrugs for Antibody-Directed Enzyme Prodrug Therapy: Alternatives to the Amide Link
1996
ZD2767, an improved system for antibody-directed enzyme prodrug therapy that results in tumour regressions in colorectal tumour xenografts
1997
A new clinical candidate for antibody-directed enzyme prodrug therapy (ADEPT): ZD2767
1995
Tumour regressions with novel prodrugs in antibody-directed enzyme prodrug therapy (ADEPT)
1994
Structure and activity relationships leading to the discovery of ICI D2138, a selective, potent and orally active inhibitor of 5-lipoxygenase.
1993
ZD2767, an improved system for antibody-directed enzyme prodrug therapy that results in tumor regressions in colorectal tumor xenografts.
1996
Antibody-directed enzyme prodrug therapy (ADEPT) for treatment of major solid tumour disease
1995
ChemInform Abstract: Optimization of Alkylating Agent Prodrugs Derived from Phenol and Aniline Mustards: A New Clinical Candidate Prodrug (ZD2767) for Antibody‐Directed Enzyme Prodrug Therapy (ADEPT).
1996