Standout Papers
Citation Impact
Citing Papers
Potent CRISPR-Cas9 inhibitors from Staphylococcus genomes
2020 StandoutNobel
C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector
2016 StandoutScience
The casposon-encoded Cas1 protein from Aciduliprofundum boonei is a DNA integrase that generates target site duplications
2015
Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage
2016 StandoutScienceNobel
CRISPR–Cas9 Structures and Mechanisms
2017 StandoutNobel
Nucleic acid detection with CRISPR-Cas13a/C2c2
2017 StandoutScience
Recruitment of CRISPR-Cas systems by Tn7-like transposons
2017
Machine learning predicts new anti-CRISPR proteins
2020 StandoutNobel
Structures of the CRISPR genome integration complex
2017 StandoutScienceNobel
Unconstrained genome targeting with near-PAMless engineered CRISPR-Cas9 variants
2020 Science
Interference-driven spacer acquisition is dominant over naive and primed adaptation in a native CRISPR–Cas system
2016
CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity
2018 StandoutScienceNobel
The ϕPA3 phage nucleus is enclosed by a self-assembling 2D crystalline lattice
2023 StandoutNobel
Inhibition of CRISPR-Cas9 ribonucleoprotein complex assembly by anti-CRISPR AcrIIC2
2019 StandoutNobel
CRISPR-Cpf1 mediates efficient homology-directed repair and temperature-controlled genome editing
2017 StandoutNobel
Q/R site interactions with the M3 helix in GluK2 kainate receptor channels revealed by thermodynamic mutant cycles
2013
The promise and challenge of therapeutic genome editing
2020 StandoutNatureNobel
A type III-B CRISPR-Cas effector complex mediating massive target DNA destruction
2016
Multiple nucleic acid cleavage modes in divergent type III CRISPR systems
2016
Broad Targeting Specificity during Bacterial Type III CRISPR-Cas Immunity Constrains Viral Escape
2017
Cutting it close: CRISPR-associated endoribonuclease structure and function
2014 StandoutNobel
Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System
2015 Standout
Asymmetric positioning of Cas1–2 complex and Integration Host Factor induced DNA bending guide the unidirectional homing of protospacer in CRISPR-Cas type I-E system
2016
Degradation of Phage Transcripts by CRISPR-Associated RNases Enables Type III CRISPR-Cas Immunity
2016
Channel opening and gating mechanism in AMPA-subtype glutamate receptors
2017 StandoutNatureNobel
Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA
2014 Standout
Cas3-Derived Target DNA Degradation Fragments Fuel Primed CRISPR Adaptation
2016
Identifying and Visualizing Functional PAM Diversity across CRISPR-Cas Systems
2016
Molecular mechanisms of CRISPR–Cas spacer acquisition
2018
An anti-CRISPR from a virulent streptococcal phage inhibits Streptococcus pyogenes Cas9
2017
Target preference of Type III-A CRISPR-Cas complexes at the transcription bubble
2019 StandoutNobel
New CRISPR–Cas systems from uncultivated microbes
2016 StandoutNatureNobel
CRISPR-Cas Systems Optimize Their Immune Response by Specifying the Site of Spacer Integration
2016
Effects of Argonaute on Gene Expression in Thermus thermophilus
2015
Controlling and enhancing CRISPR systems
2020 StandoutNobel
Anti-CRISPR protein applications: natural brakes for CRISPR-Cas technologies
2020
A decade of discovery: CRISPR functions and applications
2017
Foreign DNA capture during CRISPR–Cas adaptive immunity
2015 StandoutNatureNobel
Enhanced proofreading governs CRISPR–Cas9 targeting accuracy
2017 StandoutNatureNobel
Inhibition of CRISPR-Cas systems by mobile genetic elements
2017
The CRISPR-associated DNA-cleaving enzyme Cpf1 also processes precursor CRISPR RNA
2016 StandoutNatureNobel
CRISPR-Cas immunity in prokaryotes
2015 Nature
The structural biology of CRISPR-Cas systems
2015 StandoutNobel
Transcriptional regulator-mediated activation of adaptation genes triggers CRISPR de novo spacer acquisition
2015
Inhibition of CRISPR-Cas9 with Bacteriophage Proteins
2016
A Broad-Spectrum Inhibitor of CRISPR-Cas9
2017 StandoutNobel
DNA and RNA interference mechanisms by CRISPR-Cas surveillance complexes
2015 StandoutNobel
Different genome stability proteins underpin primed and naïve adaptation inE. coliCRISPR-Cas immunity
2015
The CRISPR-Cas immune system: Biology, mechanisms and applications
2015
Coupling transcriptional activation of CRISPR–Cas system and DNA repair genes by Csa3a in Sulfolobus islandicus
2017
CRISPR–Cas adaptation: insights into the mechanism of action
2016
CRISPR–Cas systems exploit viral DNA injection to establish and maintain adaptive immunity
2017 Nature
The AAV-mediated and RNA-guided CRISPR/Cas9 system for gene therapy of DMD and BMD
2017
Casposon integration shows strong target site preference and recapitulates protospacer integration by CRISPR-Cas systems
2016
Crystal Structure of Streptococcus pyogenes Cas1 and Its Interaction with Csn2 in the Type II CRISPR-Cas System
2015
Biology and Applications of CRISPR Systems: Harnessing Nature’s Toolbox for Genome Engineering
2016 StandoutNobel
Enhancing homology-directed genome editing by catalytically active and inactive CRISPR-Cas9 using asymmetric donor DNA
2016
I can see CRISPR now, even when phage are gone
2015
Integrase-mediated spacer acquisition during CRISPR–Cas adaptive immunity
2015 StandoutNatureNobel
Biogenesis pathways of RNA guides in archaeal and bacterial CRISPR-Cas adaptive immunity
2015 StandoutNobel
Chemistry of Class 1 CRISPR-Cas effectors: Binding, editing, and regulation
2020 StandoutNobel
Protecting genome integrity during CRISPR immune adaptation
2016 StandoutNobel
A natural single-guide RNA repurposes Cas9 to autoregulate CRISPR-Cas expression
2021
The Biology of CRISPR-Cas: Backward and Forward
2018 StandoutNobel
CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes
2016 Standout
Adaptation in CRISPR-Cas Systems
2016 StandoutNobel
CasX enzymes comprise a distinct family of RNA-guided genome editors
2019 StandoutNatureNobel
Type III CRISPR-Cas systems: when DNA cleavage just isn’t enough
2017
Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection
2016 StandoutNatureNobel
How type II CRISPR–Cas establish immunity through Cas1–Cas2-mediated spacer integration
2017 Nature
DNase H Activity of Neisseria meningitidis Cas9
2015
Foreign DNA acquisition by the I-F CRISPR–Cas system requires all components of the interference machinery
2015
Surveillance and Processing of Foreign DNA by the Escherichia coli CRISPR-Cas System
2015 StandoutNobel
Real-time observation of DNA recognition and rejection by the RNA-guided endonuclease Cas9
2016 StandoutNobel
Structural and Mechanistic Basis of PAM-Dependent Spacer Acquisition in CRISPR-Cas Systems
2015
Diverse evolutionary roots and mechanistic variations of the CRISPR-Cas systems
2016 Science
Multiplexed and portable nucleic acid detection platform with Cas13, Cas12a, and Csm6
2018 StandoutScience
CRISPR-Cas: New Tools for Genetic Manipulations from Bacterial Immunity Systems
2015
Systematic discovery of natural CRISPR-Cas12a inhibitors
2018 StandoutScienceNobel
Genomes in Focus: Development and Applications of CRISPR‐Cas9 Imaging Technologies
2017 StandoutNobel
The Discovery, Mechanisms, and Evolutionary Impact of Anti-CRISPRs
2017
The chemistry of Cas9 and its CRISPR colleagues
2017 StandoutNobel
Costs of CRISPR-Cas-mediated resistance inStreptococcus thermophilus
2015
Evolution and Ecology of CRISPR
2016
CRISPR-Cas: biology, mechanisms and relevance
2016 StandoutNobel
CRISPR-CasΦ from huge phages is a hypercompact genome editor
2020 StandoutScienceNobel
Programmed DNA destruction by miniature CRISPR-Cas14 enzymes
2018 StandoutScienceNobel
Mechanism of foreign DNA recognition by a CRISPR RNA-guided surveillance complex from Pseudomonas aeruginosa
2015
Structures and Strategies of Anti-CRISPR-Mediated Immune Suppression
2020
Cas9 function and host genome sampling in Type II-A CRISPR–Cas adaptation
2015
Nuclease Activity of Legionella pneumophila Cas2 Promotes Intracellular Infection of Amoebal Host Cells
2014
Cas9 interrogates DNA in discrete steps modulated by mismatches and supercoiling
2020 StandoutNobel
Intrinsic sequence specificity of the Cas1 integrase directs new spacer acquisition
2015
Simultaneous precise editing of multiple genes in human cells
2019 StandoutNobel
CRISPR-Cas: Adapting to change
2017 Science
Engineering of temperature- and light-switchable Cas9 variants
2013 StandoutNobel
PAM identification by CRISPR-Cas effector complexes: diversified mechanisms and structures
2018
Direct CRISPR spacer acquisition from RNA by a natural reverse transcriptase–Cas1 fusion protein
2016 ScienceNobel
CRISPR-Cas guides the future of genetic engineering
2018 StandoutScienceNobel
Works of Robert Heler being referenced
Cas9 specifies functional viral targets during CRISPR–Cas adaptation
2015 Nature
A High-Throughput Platform to Identify Small-Molecule Inhibitors of CRISPR-Cas9
2019
Homology model and targeted mutagenesis identify critical residues for arachidonic acid inhibition of Kv4 channels
2013
Mutations in Cas9 Enhance the Rate of Acquisition of Viral Spacer Sequences during the CRISPR-Cas Immune Response
2016 StandoutNobel
Adapting to new threats: the generation of memory by CRISPR‐Cas immune systems
2014