Citation Impact
Citing Papers
The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins
2013 StandoutScienceNobel
The Serine Protease TMPRSS6 Is Required to Sense Iron Deficiency
2008 StandoutScienceNobel
Role of vagus nerve signaling in CNI-1493-mediated suppression of acute inflammation
2000
Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide
2012
Hallmarks of Cancer: The Next Generation
2011 Standout
The Acute Metabolic Effects of Tumor Necrosis Factor Administration in Humans
1987
Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin
2000 StandoutNature
Inflammation and cancer
2002 StandoutNature
INTERSEPT
1996
Phylogenetic variation and polymorphism at the Toll-like receptor 4 locus (TLR4)
2000 StandoutNobel
ICOS co-stimulatory receptor is essential for T-cell activation and function
2001 StandoutNatureNobel
Cellular and molecular regulation of tumor necrosis factor-alpha production by pentoxofylline
1988
The history, properties, and biological effects of cachectin
1988 StandoutNobel
Analysis of Tlr4-Mediated LPS Signal Transduction in Macrophages by Mutational Modification of the Receptor
1999 StandoutNobel
Physiological Responses to Cachectin
2007
Nicotinic acetylcholine receptor α7 subunit is an essential regulator of inflammation
2002 StandoutNature
Multiple Organ Damage Caused by Tumor Necrosis Factor and Prevented by Prior Neutrophil Depletion
1989
Detection of Circulating Tumor Necrosis Factor after Endotoxin Administration
1988 Standout
Tumor necrosis factor in the serum of patients with systemic lupus erythematosus
1989
Cachectin: A Hormone that Triggers Acute Shock and Chronic Cachexia
1988
Physiology and immunology of the cholinergic antiinflammatory pathway
2007 Standout
Tumor Necrosis Factor and Disease Severity in Children with Falciparum Malaria
1989
Severe head injury in the United Kingdom and Ireland
1996
Elevated Circulating Levels of Tumor Necrosis Factor in Severe Chronic Heart Failure
1990 Standout
Peptide Regulatory Factors
1989
Tumor Necrosis Factor and Interleuktn-1 in the Serum of Children with Severe Infectious Purpura
1988
Neuroendocrine regulation of in vivo cytokine production and effects: I. In vivo regulatory networks involving the neuroendocrine system, interleukin-1 and tumor necrosis factor-α
1989
Traumatic brain injury
2000 Standout
Circulating tumour necrosis factor‐α (cachectin) in myocardial infarction
1989
Neutrophils Express Tumor Necrosis Factor-α During Mouse Skin Wound Healing
1995
Staphylococcus epidermidis induces complement activation, tumor necrosis factor and interleukin-1, a shock-like state and tissue injury in rabbits without endotoxemia. Comparison to Escherichia coli.
1991
Tumor necrosis factor expression in human epithelial tumor cell lines.
1988
Efficacy of a Monoclonal Antibody Directed against Tumor Necrosis Factor in Protecting Neutropenic Rats from Lethal Infection with Pseudomonas aeruginosa
1990
EBIC-Guidelines for management of severe head injury in adults
1997
University of California/Davis Interdepartmental Conference on Gram-Negative Septicemia
1991 StandoutNobel
Lethal effect of the anti-Fas antibody in mice
1993 StandoutNature
TREM-1 amplifies inflammation and is a crucial mediator of septic shock
2001 StandoutNature
A CAT reporter construct allows ultrasensitive estimation of TNF synthesis, and suggests that the TNF gene has been silenced in non-macrophage cell lines.
1991 StandoutNobel
Plasma Tumor Necrosis Factor in Patients with Septic Shock: Mortality Rate, Incidence of Adult Respiratory Distress Syndrome, and Effects of Methylprednisolone Administration
1990
Continuous infusion of tumor necrosis factor: Mechanisms of toxicity in the rat
1988
Lipopolysaccharide (LPS) recognition in macrophages. Participation of LPS-binding protein and CD14 in LPS-induced adaptation in rabbit peritoneal exudate macrophages.
1993
Absence of evidence for the effectiveness of five interventions routinely used in the intensive care management of severe head injury: a systematic review
1998
The tissue distribution of tumor necrosis factor biosynthesis during endotoxemia.
1992 StandoutNobel
Sepsis: Current Dogma and New Perspectives
2014
Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice
1999 StandoutNobel
Pomalidomide: a novel drug to treat relapsed and refractory multiple myeloma
2013
Cell-mediated cytotoxicity
1993 StandoutNobel
Interleukin‐12 is required for interferon‐γ production and lethality in lipopolysaccharide‐induced shock in mice
1995
MIF as a glucocorticoid-induced modulator of cytokine production
1995 StandoutNature
Participation of tumor necrosis factor in the mediation of gram negative bacterial lipopolysaccharide-induced injury in rabbits.
1988
A novel form of TNF/cachectin is a cell surface cytotoxic transmembrane protein: Ramifications for the complex physiology of TNF
1988
Differences in growth factor response in smooth muscle cells isolated from adult and neonatal rat arteries
1991
Identification of Lps2 as a key transducer of MyD88-independent TIR signalling
2003 StandoutNatureNobel
Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease
1992 StandoutNature
Processing of newly synthesized cachectin/tumor necrosis factor in endotoxin-stimulated macrophages
1990
Pentoxifylline Prevents Tumor Necrosis Factor-induced Lung Injury
1989
The angiogenic switch in carcinogenesis
2009
Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection
1993
Cancer-related inflammation
2008 StandoutNature
The inflammatory reflex
2002 StandoutNature
Development of partial tolerance to the gastrointestinal effects of high doses of recombinant tumor necrosis factor-alpha in rodents.
1987
Role of tumor necrosis factor-alpha in the pathophysiologic alterations after hepatic ischemia/reperfusion injury in the rat.
1990
CDP571, a humanized antibody to human tumor necrosis factor-alpha
1995
The pathogenesis of atherosclerosis: a perspective for the 1990s
1993 StandoutNature
Inferences, questions and possibilities in Toll-like receptor signalling
2004 StandoutNatureNobel
Molecules and mechanisms operating in septic shock: lessons from knockout mice
1997
Prognostic Values of Tumor Necrosis Factor/Cachectin, Interleukin-l, Interferon- , and Interferon- in the Serum of Patients with Septic Shock
1990
Tumor necrosis factor in mediating experimental Haemophilus influenzae type B meningitis.
1989 StandoutNobel
Interleukin-13 Effectively Down-regulates the Monocyte Inflammatory Potential During Traumatic Stress
1995
The Tumor Necrosis Factor Ligand and Receptor Families
1996 StandoutNobel
HMGB1 as a Late Mediator of Lethal Systemic Inflammation
2001
The Structure of Tumor Necrosis Factor-α at 2.6 Å Resolution
1989
Adrenalectomy sensitizes mice to the lethal effects of interleukin 1 and tumor necrosis factor.
1988
Physical contact between lipopolysaccharide and Toll-like receptor 4 revealed by genetic complementation
2000 StandoutNobel
Spermine Inhibition of Monocyte Activation and Inflammation
1999
The Staphylococcal Enterotoxins and Their Relatives
1990 StandoutScience
Telomere length and replicative aging in human vascular tissues.
1995
Endotoxin-induced cytokine gene expression in vivo. II. Regulation of tumor necrosis factor and interleukin-1 alpha/beta expression and suppression.
1990
Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene
1998 StandoutScienceNobel
The structure of tumor necrosis factor-alpha at 2.6 A resolution. Implications for receptor binding.
1989
The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)
2016 Standout
Effect of endotoxin-induced monokines on glucose metabolism in the muscle cell line L6.
1987
Constitutive synthesis of tumor necrosis factor in the thymus.
1992 StandoutNobel
HMG-1 as a Late Mediator of Endotoxin Lethality in Mice
1999 StandoutScience
Endotoxin-induced cytokine gene expression in vivo. I. Expression of tumor necrosis factor mRNA in visceral organs under physiologic conditions and during endotoxemia.
1989
TUMOR NECROSIS FACTOR: A Pleiotropic Cytokine and Therapuetic Target
1994
Association of TNF2, a TNF-α Promoter Polymorphism, With Septic Shock Susceptibility and Mortality
1999 Standout
Dexamethasone and pentoxifylline inhibit endotoxin-induced cachectin/tumor necrosis factor synthesis at separate points in the signaling pathway.
1990 StandoutNobel
Cachectin/tumor necrosis factor induces cachexia, anemia, and inflammation.
1988 StandoutNobel
Tumor Necrosis Factor (Cachectin) as an Essential Mediator in Murine Cerebral Malaria
1987 Science
Tumor necrosis factor/cachectin is an effector of skin and gut lesions of the acute phase of graft-vs.-host disease.
1987
Mind over immunity
2001
The active form of tumor necrosis factor is a trimer.
1987
Antibodies to cachectin/tumor necrosis factor reduce interleukin 1 beta and interleukin 6 appearance during lethal bacteremia.
1989
Crystallization of trimeric recombinant human tumor necrosis factor (cachectin).
1988 StandoutNobel
Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2
1997 StandoutNobel
Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation
2002
Recombinant tumor necrosis factor increases pulmonary vascular permeability independent of neutrophils.
1988
Suppression of proinflammatory cytokines in monocytes by a tetravalent guanylhydrazone.
1996
Lipopolysaccharide Signals Activation of Tumor Necrosis Factor Biosynthesis Through the Ras/Raf-1/MEK/MAPK Pathway
1994 StandoutNobel
Cachectin: More Than a Tumor Necrosis Factor
1987 StandoutNobel
Prolonged and effective blockade of tumor necrosis factor activity through adenovirus-mediated gene transfer.
1994 StandoutNobel
Diphosphoryl lipid A from Rhodopseudomonas sphaeroides ATCC 17023 blocks induction of cachectin in macrophages by lipopolysaccharide
1989 StandoutNobel
High Mobility Group 1 Protein (Hmg-1) Stimulates Proinflammatory Cytokine Synthesis in Human Monocytes
2000
Possible roles of tumor necrosis factor in the pathology of malaria.
1987
Passive immunization against tumor necrosis factor partially abrogates interleukin 2 toxicity.
1989
Tumors secreting human TNF/cachectin induce cachexia in mice
1987
Alternative Cleavage of the Cachectin/Tumor Necrosis Factor Propeptide Results in a Larger, Inactive Form of Secreted Protein
1989 StandoutNobel
An Inhibitor of Macrophage Arginine Transport and Nitric Oxide Production (CNI-1493) Prevents Acute Inflammation and Endotoxin Lethality
1995
A reporter transgene indicates renal-specific induction of tumor necrosis factor (TNF) by shiga-like toxin. Possible involvement of TNF in hemolytic uremic syndrome.
1993 StandoutNobel
Pharmacological Stimulation of the Cholinergic Antiinflammatory Pathway
2002
Effect of gamma interferon on cachectin expression by mononuclear phagocytes. Reversal of the lpsd (endotoxin resistance) phenotype.
1986 StandoutNobel
Secretory products of macrophages.
1987 Standout
Raised serum levels of cachectin/tumor necrosis factor alpha in renal allograft rejection.
1987
Role of tumor necrosis factor-alpha in lipopolysaccharide-induced pathologic alterations.
1990
Pretreatment with recombinant murine tumor necrosis factor alpha/cachectin and murine interleukin 1 alpha protects mice from lethal bacterial infection.
1989
Tumor necrosis factor induces glomerular damage in the rabbit.
1989
Dendritic Cells Exposed to Human Immunodeficiency Virus Type-1 Transmit a Vigorous Cytopathic Infection to CD4 + T Cells
1992 StandoutScienceNobel
Phylogenetic Perspectives in Innate Immunity
1999 StandoutScienceNobel
Endotoxin and tumor necrosis factor challenges in dogs simulate the cardiovascular profile of human septic shock.
1989
Plant and Animal Sensors of Conserved Microbial Signatures
2010 StandoutScienceNobel
Dual Roles for Immunity in Gastrointestinal Cancers
2010
Tumor necrosis factor inhibits the proliferation of cultured capillary endothelial cells
1987
Unraveling Function in the TNF Ligand and Receptor Families
1994 StandoutScienceNobel
Cachectin/tumor necrosis factor mediates changes of skeletal muscle plasma membrane potential.
1986 StandoutNobel
Works of Robert Hariri being referenced
Survey of critical care management of comatose, head-injured patients in the United States
1995
The anti-cancer drug lenalidomide inhibits angiogenesis and metastasis via multiple inhibitory effects on endothelial cell function in normoxic and hypoxic conditions
2008
Aging and arteriosclerosis. Cell cycle kinetics of young and old arterial smooth muscle cells.
1988
Shock and Tissue Injury Induced by Recombinant Human Cachectin
1986 StandoutScienceNobel
Aging and arteriosclerosis. I. Development of myointimal hyperplasia after endothelial injury.
1986