Standout Papers
Citation Impact
Citing Papers
Partitioning of Lipid-Modified Monomeric GFPs into Membrane Microdomains of Live Cells
2002 StandoutScienceNobel
Inositol Hexakisphosphate Is Bound in the ADAR2 Core and Required for RNA Editing
2005 Science
Atg18 Regulates Organelle Morphology and Fab1 Kinase Activity Independent of Its Membrane Recruitment by Phosphatidylinositol 3,5-Bisphosphate
2007
In vivo reconstitution of autophagy in Saccharomyces cerevisiae
2008
Muscarinic stimulation of phospholipid turnover in dissociated avian salt gland cells
1983
Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate
1983 StandoutNature
The localization of calcium release by inositol trisphosphate in Limulus photoreceptors and its control by negative feedback
1988
Inositol phosphates: proliferation, metabolism and function
1988
Agonist-stimulated synthesis of phosphatidylinositol(3,4,5)-trisphosphate
1993
Structure of the TRPA1 ion channel suggests regulatory mechanisms
2015 StandoutNatureNobel
Inositol phosphates and cell signaling: new views of InsP5 and InsP6
1993
Apoptosis and the regulation of cell numbers in normal and neoplastic tissues: an overview
1992
Switching of the coupling of the β2-adrenergic receptor to different G proteins by protein kinase A
1997 StandoutNatureNobel
Dissecting the localization and function of Atg18, Atg21 and Ygr223c
2008
Long-term uncoupling of chloride secretion from intracellular calcium levels by lns(3,4,5,6)P4
1994 StandoutNatureNobel
Phosphoinositide metabolism and the control of cell proliferation
1989
Regulation of Drosophila transient receptor potential‐like (TrpL) channels by phospholipase C‐dependent mechanisms
2001
Molecular mechanisms of nociception
2001 StandoutNatureNobel
Inositol 1,3,4,5-tetrakisphosphate is essential for sustained activation of the Ca2+-dependent K+ current in single internally perfused mouse lacrimal acinar cells
1989
Dynamic control of neuroexocytosis by phosphoinositides in health and disease
2010
Phosphatidylinositol 4-kinases
1998
Inositol phosphates and cell signalling
1989 StandoutNature
The Cvt pathway as a model for selective autophagy
2010
Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor gene in mice
1995 StandoutNatureNobel
‘Quanta’ Ca2+ release and the control of Ca2+ entry by inositol phosphates ‐ a possible mechanism
1990
PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells
1989
The relevance of the phosphatidylinositolphosphat‐binding motif FRRGT of Atg18 and Atg21 for the Cvt pathway and autophagy
2006
The function of inositol high polyphosphate binding proteins
1997
β-Cell CaVchannel regulation in physiology and pathophysiology
2004
Cytosolic Multiple Inositol Polyphosphate Phosphatase in the Regulation of Cytoplasmic Free Ca2+ Concentration
2003
WIPI-1α (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy
2004
Transport of phosphatidylinositol 3‐phosphate into the vacuole via autophagic membranes in Saccharomyces cerevisiae
2008 StandoutNobel
Autophagosome formation can be achieved in the absence of Atg18 by expressing engineered PAS‐targeted Atg2
2012 StandoutNobel
Increase in inositol tris-, pentakis- and hexakisphosphates by high K+ stimulation in cultured rat cerebellar granule cells
1993
Roles of inositol phosphates and inositol pyrophosphates in development, cell signaling and nuclear processes
2009
Inositol Pentakis- and Hexakisphosphate Metabolism Adds Versatility to the Actions of Inositol Polyphosphates Novel Effects on Ion Channels and Protein Traffic
1996
Network organization of the human autophagy system
2010 StandoutNature
Autophagosome formation: core machinery and adaptations
2007 Standout
Calcium-dependent immediate feedback control of inositol 1,4,5-trisphosphate-induced Ca2+ release
1992 Nature
Membrane protein sequestering by ionic protein–lipid interactions
2011 StandoutNatureNobel
Structural and Functional Roles of Glycosyl-Phosphatidylinositol in Membranes
1988 Science
Allergy‐associated Iϵ and Fcϵ receptor II (CD23b) genes activated via binding of an interleukin‐4‐induced transcription factor to a novel responsive element
1993
Bovine brain contains two types of phosphatidylinositol kinase
1987
Structure-based Analyses Reveal Distinct Binding Sites for Atg2 and Phosphoinositides in Atg18
2012 StandoutNobel
The Atg18-Atg2 Complex Is Recruited to Autophagic Membranes via Phosphatidylinositol 3-Phosphate and Exerts an Essential Function
2008 StandoutNobel
Cholesterol Depletion Delocalizes Phosphatidylinositol Bisphosphate and Inhibits Hormone-stimulated Phosphatidylinositol Turnover
1998
Phosphatidylinositol 4-Kinases and the Role of Polyphosphoinositides in Cellular Regulation
1992
Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition
2001 StandoutNatureNobel
VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P2 in yeast and mouse
2008
Phosphoinositide regulation of TRPV1 revisited
2015
A Novel Family of Phosphatidylinositol 4-Kinases Conserved from Yeast to Humans
2001 StandoutNobel
Fab1p PtdIns(3)P 5-Kinase Function Essential for Protein Sorting in the Multivesicular Body
1998
Ca2+ release induced by inositol 1,4,5-trisphosphate is a steady-state phenomenon controlled by luminal Ca2+ in permeabilized cells
1992 Nature
TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action
2016 StandoutNatureNobel
Cell-permeant caged InsP3 ester shows that Ca2+ spike frequency can optimize gene expression
1998 StandoutNatureNobel
Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors
1991 StandoutNatureNobel
Dual activation by thyrotropin of the phospholipase C and cyclic AMP cascades in human thyroid
1987
An inositol tetrakisphosphate-containing phospholipid in activated neutrophils
1988 Nature
Inositol trisphosphate and calcium signalling
1993 StandoutNature
Nuclear localization and signalling activity of phosphoinositidase Cβ in Swiss 3T3 cells
1992 Nature
Involvement of Protein Kinase C-ϵ in Inositol Hexakisphosphate-induced Exocytosis in Mouse Pancreatic β-Cells
2003
Substitution of three amino acids switches receptor specificity of Gqα to that of Giα
1993 StandoutNatureNobel
Phosphoinositides in cell regulation and membrane dynamics
2006 StandoutNature
Effects of Angiotensin II on [3H]Noradrenaline Release and Phosphatidylinositol Hydrolysis in the Parietal Cortex and Locus Coeruleus of the Rat
1987
Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene
1996 StandoutNatureNobel
Myo-inositol(1,4,5)trisphosphorothioate binds to specific [3H]inositol(1,4,5)trisphosphate sites in rat cerebellum and is resistant to 5-phosphatase
1988
Current knowledge of the pre‐autophagosomal structure (PAS)
2010 StandoutNobel
Pathways for phosphoinositide synthesis
1999
Activation of Ca2+ entry into acinar cells by a non-phosphorylatable inositol trisphosphate
1991 Nature
Dynamics and diversity in autophagy mechanisms: lessons from yeast
2009 StandoutNobel
Emptying of intracellular Ca2+ stores releases a novel small messenger that stimulates Ca2+ influx
1993 StandoutNatureNobel
Two-Site Recognition of Phosphatidylinositol 3-Phosphate by PROPPINs in Autophagy
2012
Evidence that the phosphatidylinositol cycle is linked to cell motility
1988
Phospholipid turnover and ultrastructural correlates during spontaneous germinal vesicle breakdown of the bovine oocyte: Effects of a cyclic AMP phosphodiesterase inhibitor
1991
Capacitative calcium entry revisited
1990
Structure and function of inositol triphosphate receptors
1991
The stimulation of inositol lipid metabolism that accompanies calcium mobilization in stimulated cells: defined characteristics and unanswered questions
1981
Calcium, phospholipid turnover and transmembrane signalling
1983
Synergistic effect of A23187 and a phorbol ester on amylase secretion from rabbit pancreatic acini
1984
Guanine nucleotides decrease the free [Ca2+] required for secretion of serotonin from permeabilized blood platelets
1984
Repetitive spikes in cytoplasmic calcium evoked by histamine in human endothelial cells
1988 Nature
Potentiation by thrombin of the secretion of serotonin from permeabilized platelets equilibrated with Ca2+ buffers. Relationship to protein phosphorylation and diacylglycerol formation
1984
Stereospecific recognition of inositol 1,4,5-trisphosphate analogs by the phosphatase, kinase, and binding proteins.
1990
Mechanism of desensitization of neutrophil response to N-formylmethionylleucylphenylalanine by slow rate of receptor occupancy. Studies on changes in Ca2+ concentration and phosphatidylinositol turnover
1985
Coated pits, coated vesicles, and receptor-mediated endocytosis
1979 StandoutNatureNobel
Coupling of polyphosphoinositide breakdown with calcium efflux in formyl‐methionyl‐leucyl‐phenylalanine‐stimulated rabbit neutrophils
1983
Comparison of muscarinic and α-adrenergic receptors in rat atria based on phosphoinositide turnover
1984
Heterologous desensitization of the cyclic AMP-independent glycogenolytic response in rat liver cells
1981
Phytohemagglutinin induces rapid degradation of phosphatidylinositol 4,5-bisphosphate and transient accumulation of phosphatidic acid and diacylglycerol in a human T lymphoblastoid cell line, CCRF-CEM.
1983
Purification and characterization of two types of soluble inositol phosphate 5-phosphomonoesterases from rat brain.
1987
Metabolism of inositol phosphates in parotid cells: Implications for the pathway of the phosphoinositide effect and for the possible messenger role of inositol trisphosphate
1984
PHOSPHOINOSITIDE LIPIDS AS SIGNALING MOLECULES: Common Themes for Signal Transduction, Cytoskeletal Regulation, and Membrane Trafficking
1998
Secretagogue-induced phosphoinositide metabolism in human leucocytes
1984
Purification and characterization of epidermal growth factor receptor/protein kinase from normal mouse liver.
1982 StandoutNobel
Phospholipid degradation and signal translation for protein phosphorylation
1983
Mass changes in inositol tetrakis- and pentakisphosphate isomers induced by chemotactic peptide stimulation in HL-60 cells
1989
The total synthesis of myo-inositol polyphosphates
1989
Degradation of phosphatidylinositol-4,5-bisphosphate is insensitive to Ca2+ mobilization in stimulated platelets
1982
COMPOSITION OF CELLULAR MEMBRANES IN THE PANCREAS OF THE GUINEA PIG
1971 StandoutNobel
Polyphosphoinositide hydrolysis in endothelial cells and carotid artery segments. Bradykinin-2 receptor stimulation is calcium-independent.
1986
Inositol trisphosphates in carbachol-stimulated rat parotid glands
1984
Perspectives on the Role of Protein Kinase C in Stimulus-Response Coupling<xref ref-type="fn" rid="FN4">4</xref>
1986
Synergistic functions of protein phosphorylation and calcium mobilization in platelet activation.
1983
Role of phosphatidylinositol turnover in alpha1 and of adenylate cyclase inhibition in alpha2 effects of catecholamines
1980
Variable Ca sensitivity of a K-selective channel in intact red-cell membranes
1976 Nature
Structural and functional characterization of the two phosphoinositide binding sites of PROPPINs, a β-propeller protein family
2012
The Role of Voltage-Gated Calcium Channels in Pancreatic β-Cell Physiology and Pathophysiology
2006
Effect of inositol-1,4,5-trisphosphate on isolated subcellular fractions of rat pancreas
1984
Regulation of adrenergic receptor function by phosphorylation. II. Effects of agonist occupancy on phosphorylation of alpha 1- and beta 2-adrenergic receptors by protein kinase C and the cyclic AMP-dependent protein kinase.
1987 StandoutNobel
Lithium inhibits muscarinic-receptor-stimulated inositol tetrakisphosphate accumulation in rat cerebral cortex
1987
Renewed interest in the polyphosphoinositides
1984
Inositol trisphosphate mediates thyrotropin-releasing hormone mobilization of nonmitochondrial calcium in rat mammotropic pituitary cells.
1984
The stereospecific activation of protein kinase C
1984
Intracellular Distribution of Radioactive Vitamin B12 in Rat Liver
1971
Potassium-channel blockers inhibit inositol trisphosphate-induced calcium release in the microsomal fractions isolated from the rat brain
1988
Bradykinin-induced rapid breakdown of phosphatidylinositol 4,5-bisphosphate in neuroblastoma X glioma hybrid NG108-15 cells.
1984
Characterization of a novel inositol 1,4,5-trisphosphate receptor in isolated olfactory cilia
1992
A role of calcium-activated, phospholipid-dependent protein kinase in platelet-activating factor-induced serotonin release from rabbit platelets
1982
Second messengers involved in the mechanism of action of bradykinin in sensory neurons in culture
1989
Characteristics of inositol trisphosphate-mediated Ca2+ release from permeabilized hepatocytes.
1986
Highly Cooperative Opening of Calcium Channels by Inositol 1,4,5-Trisphosphate
1988 Science
Activation of protein kinase C by Triton X-100 mixed micelles containing diacylglycerol and phosphatidylserine.
1985
Subcellular site and mechanism of vasopressin-stimulated hydrolysis of phosphoinositides in rat hepatocytes.
1984
Triphosphoinositide increases glycoprotein lateral mobility in erythrocyte membranes
1982 Nature
Inositol 1,4,5-trisphosphate and inositol 1,3,4-trisphosphate formation in Ca2+-mobilizing-hormone-activated cells
1985
A model for receptor-regulated calcium entry
1986 Standout
Membrane Phospholipid Turnover, Receptor Function and Protein Phosphorylation
1982
Quantitation and early kinetics of inositol lipid changes induced by vasopressin in isolated and cultured hepatocytes.
1983
Reduction of epidermal growth factor receptor affinity by heterologous ligands: Evidence for a mechanism involving the breakdown of phosphoinositides and the activation of protein kinase C
1984
Transforming protein of avian sarcoma virus UR2 is associated with phosphatidylinositol kinase activity: possible role in tumorigenesis.
1984
Pituitary hormones influence polyphosphoinositide metabolism in rat brain
1979
Early changes in phosphatidylinositol and arachidonic acid metabolism in quiescent swiss 3T3 cells stimulated to divide by platelet-derived growth factor.
1981
Early steps of lymphocyte activation bypassed by synergy between calcium ionophores and phorbol ester
1985 Nature
G-protein-coupled receptor genes as protooncogenes: constitutively activating mutation of the alpha 1B-adrenergic receptor enhances mitogenesis and tumorigenicity.
1991
Interleukin-2 stimulates association of protein kinase C with plasma membrane
1985 Nature
myo-inositol polyphosphate may be a messenger for visual excitation in Limulus photoreceptors
1984 Nature
Production of diglyceride from phosphatidylinositol in activated human platelets.
1979
Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.
1982 Standout
A rapid stimulation of phosphatidylinositol metabolism in rabbit leukocytes by pseudomonal leukocidin
1983
Phorbol esters inhibit alpha1 adrenergic stimulation of glycogenolysis in isolated rat hepatocytes
1984
The calcium signal and phosphatidylinositol breakdown in 2H3 cells.
1984
Phospholipase A2 activity specific for phosphatidic acid. A possible mechanism for the production of arachidonic acid in platelets.
1981
Phosphoinositide interconversion in thrombin-stimulated human platelets.
1985
Inositol(1,4,5)trisphosphate-promoted Ca2+ release from microsomal fractions of rat liver
1984
Light-regulated biochemical events in invertebrate photoreceptors. 2. Light-regulated phosphorylation of rhodopsin and phosphoinositides in squid photoreceptor membranes
1984
Ca2+ regulates the inositol tris/tetrakisphosphate pathway in intact and broken preparations of insulin-secreting RINm5F cells.
1986
The enzymology of stimulated inositol lipid turnover
1982
Inositol trisphosphate, a novel second messenger in cellular signal transduction
1984 StandoutNature
Desensitization and antagonism of vasopressin-induced phosphoinositide metabolism and elevation of cytosolic free calcium concentration in human platelets
1986
Rapid decrease of phosphatidylinositol 4,5-bisphosphate in thrombin-stimulated platelets.
1982
Inositol 1,3,4,5-Tetrakisphosphate Induces Ca 2+ Sequestration in Rat Liver Cells
1988 Science
Inositol cyclic phosphates are produced by cleavage of phosphatidylphosphoinositols (polyphosphoinositides) with purified sheep seminal vesicle phospholipase C enzymes.
1985
Phosphatidyldmositol hydrolysis: A multifunctional transducing mechanism
1981
Cell Signalling Through Phospholipid Metabolism
1986
Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides
1983 Standout
Phorbol esters promote alpha 1-adrenergic receptor phosphorylation and receptor uncoupling from inositol phospholipid metabolism.
1985 StandoutNobel
Biphasic Ca2+ dependence of inositol 1,4,5-trisphosphate-induced Ca release in smooth muscle cells of the guinea pig taenia caeci.
1990
Phorbol ester effects on α1-adrenoceptor binding and phosphatidylinositol metabolism in cultured vascular smooth muscle cells
1985 StandoutNobel
Modified kinetics of platelet-derived growth factor-induced Ca2+ increases in NIH-3T3 cells overexpressing phospholipase Cγ1
1992
Protein kinase C: Rapid enzyme purification and substrate-dependence of the diacylglycerol effect
1984
Activation of frog (Xenopus laevis) eggs by inositol trisphosphate. I. Characterization of Ca2+ release from intracellular stores.
1985
Regulation of adrenergic receptor function by phosphorylation. I. Agonist-promoted desensitization and phosphorylation of alpha 1-adrenergic receptors coupled to inositol phospholipid metabolism in DDT1 MF-2 smooth muscle cells.
1987 StandoutNobel
Phosphatidylinositol-4,5-bisphosphate phosphodiesterase and phosphomonoesterase activities of rat brain. Some properties and possible control mechanisms
1984
Mechanism of Ca2+ wave propagation in pancreatic acinar cells.
1992
Inositol hexakisphosphate promotes dynamin I- mediated endocytosis
2002
Inositol-lipid-specific phospholipase C isoenzymes and their differential regulation by receptors
1992
Role of alpha1 adrenoceptors in the turnover of phosphatidylinositol and of alpha2 adrenoceptors in the regulation of cyclic AMP accumulation in hamster adipocytes
1980 StandoutNobel
ACYLATION OF LYSOPHOSPHATIDES BY PLASMA MEMBRANE FRACTIONS OF RAT LIVER
1968
Cell Cycle Control and Cancer
1994 StandoutScienceNobel
ADP-Induced changes in [32P]phosphate labeling of phosphatidylinositol-4,5-bisphosphate in washed rabbit platelets made refractory by prior ADP stimulation
1983
Ion channels activated by inositol 1,4,5-trisphosphate in plasma membrane of human T-lymphocytes
1987 Nature
Inositol hexakisphosphate increases L‐type Ca 2+ channel activity by stimulation of adenylyl cyclase
2001
Intercellular communication between follicular angiotensin receptors and Xenopus laevis oocytes: medication by an inositol 1,4,5-trisphosphate-dependent mechanism
1992
Metabolism of inositol 1,4,5-trisphosphate and inositol 1,3,4-trisphosphate in rat parotid glands
1985
Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomes
2006
IgG receptors on foetal chick yolk sac
1978
Growth factors immediately raise cytoplasmic free Ca2+ in human fibroblasts.
1984
Synthesis of myo-inositol 1,3,4,5,6-pentakisphosphate from inositol phosphates generated by receptor activation
1988
Inhibitory action of adenosine 3′,5′-monophosphate on phosphatidylinositol turnover: Difference in tissue response
1982
Purification of polyphosphoinositides by chromatography on immobilized neomycin.
1978
Phorbol esters inhibit alpha 1-adrenergic effects and decrease the affinity of liver cell alpha 1-adrenergic receptors for (-)-epinephrine.
1986
Atg21 Is a Phosphoinositide Binding Protein Required for Efficient Lipidation and Localization of Atg8 during Uptake of Aminopeptidase I by Selective Autophagy
2004
Intracellular Ca2+ activates phospholipase C
1988
Molecular Biology of Learning: Modulation of Transmitter Release
1982 StandoutScienceNobel
Phosphorylation of the ribosomal protein S6 during agonist‐induced exocytosis in exocrine glands is catalyzed by calcium‐phospholipid‐dependent protein kinase (protein kinase C)
1985
Phytohemagglutinin induces rapid degradation of phosphatidylinositol 4, 5-bisphosphate and transient accumulation of phosphatidic acid and diacylglycerol in a human T lymphoblastoid cell line, CCRF-CEM
1983
The role of protein kinase C in cell surface signal transduction and tumour promotion
1984 StandoutNature
Relationship between inositol polyphosphate production and the increase of cytosolic free Ca2+ induced by vasopressin in isolated hepatocytes.
1984
Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: Selective externalization of the receptor
1983 Standout
Changes in phosphatidylinositol and phosphatidic acid in stimulated human neutrophils
1983
Coordination of membrane events during autophagy by multiple class III PI3-kinase complexes
2009
Rapid accumulation of inositol trisphosphate reveals that agonists hydrolyse polyphosphoinositides instead of phosphatidylinositol
1983 Standout
Does phosphatidylinositol breakdown control the Ca2+-gating mechanism?
1981
Effects of lithium on angiotensin‐stimulated phosphatidylinositol turnover and aldosterone production in adrenal glomerulosa cells: a possible causal relationship
1984
Thrombin-induced phosphodiesteratic cleavage of phosphatidylinositol bisphosphate in human platelets.
1983
An early decrease in phosphatidylinositol turnover occurs on induction of friend cell differentiation and precedes the decrease in c-myc expression
1985
1,2-Didecanoylglycerol and Phorbol 12,13-Dibutyrate Enhance Anterior Pituitary Hormone Secretionin Vitro
1985
Phorbol esters inhibit agonist-induced [3H] inositol-1-phosphate accumulation in rat hippocampal slices
1984
Three Multifunctional Protein Kinase Systems in Transmembrane Control
1980
Inositol 1,4,5-trisphosphate mobilizes intracellular Ca2+ from permeabilized insulin-secreting cells
1984
Phosphoinositide turnover provides a link in stimulus—response coupling
1985
Effect of insulin, catecholamines and calcium ions on phospholipid metabolism in isolated white fat-cells
1980
Activation of calcium and phospholipid-dependent protein kinase by diacylglycerol, its possible relation to phosphatidylinositol turnover.
1980
Mechanisms of slow postsynaptic potentials
1981 Nature
Differential effects of phorbol ester on phenylephrine and vasopressin-induced Ca2+ mobilization in isolated hepatocytes.
1985
The inositol phospholipids: a stereochemical view of biological activity
1986
Phosphatidylinositol phosphodiesterase in higher plants
1980
An improved, reproducible method of preparing rat liver plasma cell membranes in buffered isotonic sucrose
1969
Inositol trisphosphate and diacylglycerol as intracellular second messengers in liver
1985
Acetylcholine Action: Biochemical Aspects
1969 Science
Inositol 1:2-cyclic,4,5-trisphosphate is only a weak agonist at inositol 1,4,5-trisphosphate receptors
1989
Calcium and cell cycle control
1990
Internal calcium release and activation of sea urchin eggs by cGMP are independent of the phosphoinositide signaling pathway.
1992
Activation of protein kinase C induces rapid internalization and subsequent degradation of muscarinic acetylcholine receptors in neuroblastoma cells.
1986
Diacylglycerol and phorbol ester stimulate secretion without raising cytoplasmic free calcium in human platelets
1983 Nature
Pharmacological Characterizations of Adrenergic Receptors in Human Adipocytes
1981 StandoutNobel
Identification and metabolism of polyphosphoinositides in isolated islets of Langerhans
1983
Synergistic action of protein kinase C and calcium for histamine release from rat peritoneal mast cells
1984
Reconstitution of steps in the constitutive secretory pathway in permeabilized cells. Secretion of glycosylated tripeptide and truncated sphingomyelin.
1990 StandoutNobel
Corticotropin-(1–24)-tetracosapeptide affects protein phosphorylation and polyphosphoinositide metabolism in rat brain
1981
Beclin 1 Forms Two Distinct Phosphatidylinositol 3-Kinase Complexes with Mammalian Atg14 and UVRAG
2008
An early transient decrease in phosphatidylinositol 4,5-bisphosphate upon stimulation of rabbit platelets with acetylglycerylether phosphorylcholine (platelet activating factor)
1983
Involvement of guanine nucleotide-binding protein in the gating of Ca2+ by receptors
1983 Nature
Inositol hexakisphosphate suppresses excitatory neurotransmission via synaptotagmin-1 C2B domain in the hippocampal neuron
2012 StandoutNobel
Quantitative changes in inositol 1,4,5-trisphosphate in chemoattractant-stimulated neutrophils.
1986
Phorbol myristate acetate inhibits thrombin-stimulated Ca2+ mobilization and phosphatidylinositol 4,5-bisphosphate hydrolysis in human platelets.
1985
Inositol 1,4,5-trisphosphate releases Ca2+ from intracellular store sites in skinned single cells of porcine coronary artery
1984
Bradykinin and angiotensin II activation of arachidonic acid deacylation and prostaglandin E2 formation in rabbit kidney. Hormone-sensitive versus hormone-insensitive lipid pools of arachidonic acid.
1981
Rapid mobilization of Ca2+ from rat insulinoma microsomes by inositol-1,4,5-trisphosphate
1984 Nature
Bidirectional control of cytosolic free calcium by thyrotropin-releasing hormone in pituitary cells
1985 Nature
Role of guanine nucleotide binding protein in the activation of polyphosphoinositide phosphodiesterase
1985 StandoutNature
How is the level of free arachidonic acid controlled in mammalian cells?
1982
Studies and Perspectives of Protein Kinase C
1986 StandoutScience
Inositol trisphosphate and diacylglycerol as second messengers
1984 Standout
Diacylglycerol downregulates junctional membrane permeability. TMB-8 blocks this effect
1985
Evidence for the role of phosphorylase kinase, protein kinase C, and other Ca2+-sensitive protein kinases in the response of hepatocytes to angiotensin II and vasopressin.
1984
Protein kinases in signal transduction
1984
1988
Evidence that the Rous sarcoma virus transforming gene product phosphorylates phosphatidylinositol and diacylglycerol.
1984
Plasma-membrane location of phosphatidylinositol hydrolysis in rabbit neutrophils stimulated with formylmethionyl-leucylphenylalanine
1982
Two growth factor signalling pathways in fibroblasts distinguished by pertussis toxin
1987 Nature
An experimental examination of the scrapie agent in cell membrane mixtures
1971
Turnover of inositol polyphosphate pyrophosphates in pancreatoma cells.
1993
A non-disruptive technique for loading calcium buffers and indicators into cells
1981 StandoutNatureNobel
f‐MetLeuPhe‐induced phosphatidylinositol turnover in rabbit neutrophils is dependent on extracellular calcium
1980
Polyphosphoinositide metabolism in excitable membranes
1983
alpha-Adrenergic activation of phosphorylase in liver cells involves mobilization of intracellular calcium without influx of extracellular calcium.
1982
Inositol phosphates: synthesis and degradation.
1988
Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands
1982 Standout
Synaptotagmin: a Calcium Sensor on the Synaptic Vesicle Surface
1992 StandoutScienceNobel
Specificity of inositol trisphosphate-induced calcium release from permeabilized Swiss-mouse 3T3 cells
1984
Hepatocyte gap junctions are permeable to the second messenger, inositol 1,4,5-trisphosphate, and to calcium ions.
1989
Secretagogue-induced formation of inositol phosphates in rat exocrine pancreas. Implications for a messenger role for inositol trisphosphate
1984
Effects of secretagogues on [32P]phosphatidylinositol 4,5-bisphosphate metabolism in the exocrine pancreas
1983
Phorbol ester effects on neurotransmission: interaction with neurotransmitters and calcium in smooth muscle.
1985
Does Receptor-Linked Phosphoinositide Metabolism Provide Messengers Mobilizing Calcium in Nervous Tissue?
1986
A possible role of protein kinase C in signal-induced lysosomal enzyme release
1983
Micro-injection of inositol 1,3,4,5-tetrakisphosphate activates sea urchin eggs by a mechanism dependent on external Ca2+
1986
Requirement for calcium ions in acetylcholine-stimulated phosphodiesteratic cleavage of phosphatidyl-myo-inositol 4,5-bisphosphate in rabbit iris smooth muscle
1980
G 1 Events and Regulation of Cell Proliferation
1989 StandoutScience
A MOLECULAR DESCRIPTION OF NERVE TERMINAL FUNCTION
1983
Unsaturated diacylglycerol as a possible messenger for the activation of calcium-activated, phospholipid-dependent protein kinase system
1979
Norepinephrine causes alpha 1-adrenergic receptor-mediated decrease of phosphatidylinositol in isolated rat liver plasma membranes supplemented with cytosol.
1983
Evidence for the Role of Calcium and Diacylglycerol as Dual Second Messengers in Thyrotropin-Releasing Hormone Action: Involvement of Diacylglycerol*
1984
Evidence for multiple metabolic pools of phosphatidylinositol in stimulated platelets.
1982
II. Biochemical mechanisms in the phosphatidylinositol effect
1983
Breakdown of polyphosphoinositides and not phosphatidylinositol accounts for muscarinic agonist-stimulated inositol phospholipid metabolism in rat parotid glands
1983
Mitogenesis in Response to PDGF and Bombesin Abolished by Microinjection of Antibody to PIP 2
1988 Science
Agonist-induced oscillations in cytoplasmic free calcium concentration in single rat hepatocytes
1987
Phosphoinositide breakdown in blowfly salivary glands
1984
Ca2+-dependent conversion of phosphatidylinositol to phosphatidate in neutrophils stimulated with fMet-Leu-Phe or ionophore A23187
1984
Specific interaction between phosphatidylinositol 4,5-bisphosphate and profilactin
1985 StandoutNature
Affinity chromatography of protein kinase C-phorbol ester receptor on polyacrylamide-immobilized phosphatidylserine.
1984
Chemistry of Inositol Lipid Mediated Cellular Signaling
1995
Association between human erythrocyte calmodulin and the cytoplasmic surface of human erythrocyte membranes.
1983 StandoutNobel
Acetylcholine increases the breakdown of triphosphoinositide of rabbit iris muscle prelabelled with [32P] phosphate
1977
Thyroliberin stimulates rapid hydrolysis of phosphatidylinositol 4,5-bisphosphate by a phosphodiesterase in rat mammotropic pituitary cells. Evidence for an early Ca2+-independent action
1983
Release of Ca2+ from a non-mitochondrial store site in peritoneal macrophages treated with saponin by inositol 1,4,5-trisphosphate
1984
Inositol phosphates: Profusion and confusion
1986 Nature
Inhibitory action of chlorpromazine, dibucaine, and other phospholipid-interacting drugs on calcium-activated, phospholipid-dependent protein kinase.
1980
Possible involvement of protein kinase C and calcium ion in growth factor-induced expression of c-myc oncogene in Swiss 3T3 fibroblasts.
1986
Thrombin-induced hydrolysis of phosphatidylinositol in human platelets.
1980
Phosphorylation of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase and modulation of its enzymic activity by calcium-activated and phospholipid-dependent protein kinase.
1985
Roles for hydroxyl groups of D-myo-inositol 1,4,5-trisphosphate in the recognition by its receptor and metabolic enzymes.
1993
The second messenger linking receptor activation to internal Ca release in liver
1984 Nature
Calcium-activated, phospholipid-dependent protein kinase from rat brain. Subcellular distribution, purification, and properties.
1982
Binding of inositol trisphosphate by a liver microsomal fraction
1986
Phorbol ester and 1-oleoyl-2-acetylglycerol inhibit angiotensin activation of phospholipase C in cultured vascular smooth muscle cells.
1985
Enhancement of calcium uptake and phosphatidylinositol turnover by epidermal growth factor in A-431 cells
1981 StandoutNobel
The hydrolysis of phosphatidylinositol by lysosomal enzymes of rat liver and brain
1978
Fatty acid stimulation of membrane phosphatidylinositol hydrolysis by brain phosphatidylinositol phosphodiesterase
1979
Receptor-mediated net breakdown of phosphatidylinositol 4,5-bisphosphate in parotid acinar cells
1982
Inositol trisphosphate formation and calcium mobilization in Swiss 3T3 cells in response to platelet-derived growth factor
1984
Thyrotropin-releasing hormone rapidly activates the phosphodiester hydrolysis of polyphosphoinositides in GH3 pituitary cells. Evidence for the role of a polyphosphoinositide-specific phospholipase C in hormone action.
1983
Phorbol ester inhibits phosphoinositide hydrolysis and calcium mobilization in cultured astrocytoma cells.
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Repetitive transient rises in cytoplasmic free calcium in hormone-stimulated hepatocytes
1986 Nature
Phosphatidylinositol turnover in platelet activation; Calcium mobilization and protein phosphorylation
1982
Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration
2000 StandoutScienceNobel
Phosphorylation of cardiac sarcoplasmic reticulum by a calcium-activated, phospholipid-dependent protein kinase
1980
Atg21 Is Required for Effective Recruitment of Atg8 to the Preautophagosomal Structure during the Cvt Pathway
2004
Inositol 1,4,5-trisphosphorothioate, a stable analogue of inositol trisphosphate which mobilizes intracellular calcium
1989
Molecular Biology of Prion Diseases
1991 StandoutScienceNobel
Rapid formation of inositol 1,3,4,5-tetrakisphosphate following muscarinic receptor stimulation of rat cerebral cortical slices
1985
A phorbol ester and A23187 act synergistically to release acetylcholine from the guinea pig ileum
1984
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1994
Turnover of Inositol Phospholipids and Signal Transduction
1984 Science
The WD40 and FYVE domain containing protein 2 defines a class of early endosomes necessary for endocytosis
2006 StandoutNobel
Acetylglyceryl ether phosphorylcholine. A potent activator of hepatic phosphoinositide metabolism and glycogenolysis.
1983
Oncogenes, Inositol Lipids and Cellular Proliferation
1984
Metabolism of the inositol phosphates produced upon receptor activation
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Isolation and characterization of the inositol cyclic phosphate products of polyphosphoinositide cleavage by phospholipase C. Physiological effects in permeabilized platelets and Limulus photoreceptor cells.
1985
COMPOSITION OF CELLULAR MEMBRANES IN THE PANCREAS OF THE GUINEA PIG
1971 StandoutNobel
The formation of inositol 1,2-cyclic 4,5-trisphosphate and inositol 1,2-cyclic 4-bisphosphate on stimulation of mouse pancreatic minilobules with carbamylcholine.
1987
Serotonin and cyclic AMP close single K+ channels in Aplysia sensory neurones
1982 StandoutNatureNobel
Solubilization, purification, and characterization of an inositol trisphosphate receptor.
1988
The mechanism for synergism between phospholipase C- and adenylylcyclase-linked hormones in liver. Cyclic AMP-dependent kinase augments inositol trisphosphate-mediated Ca2+ mobilization without increasing the cellular levels of inositol polyphosphates.
1991
Structure of molecular aggregates of 1-(3-sn-phosphatidyl)-l-myo-inositol 3,4-bis(phosphate) in water
1981
Purification and characterization of inositol-1,3,4-trisphosphate 5/6-kinase from rat liver using an inositol hexakisphosphate affinity column.
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Cooperative roles of various membrane phospholipids in the activation of calcium-activated, phospholipid-dependent protein kinase.
1981
Prostaglandin F2α stimulates phosphatidylinositol turnover and increases the cellular content of 1,2‐diacylglycerol in confluent resting swiss 3T3 cells
1984
Phospholipid Turnover in Hormone Action
1984
Mass changes in myoinositol trisphosphate in human platelets stimulated by thrombin. Inhibitory effects of phorbol ester.
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Calcium oscillations in electrically non-excitable cells
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The Ca2+-activated polyphosphoinositide phosphodiesterase of human and rabbit neutrophil membranes
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Fertilization increases the polyphosphoinositide content of sea urchin eggs
1984 Nature
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myo-Inositol 1,4,5-trisphosphate. A second messenger for the hormonal mobilization of intracellular Ca2+ in liver.
1984
Assortment of Phosphatidylinositol 3-Kinase Complexes—Atg14p Directs Association of Complex I to the Pre-autophagosomal Structure inSaccharomyces cerevisiae
2006 StandoutNobel
Stimulus-response coupling in human platelets. Changes evoked by platelet-activating factor in cytoplasmic free calcium monitored with the fluorescent calcium indicator quin2
1984
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The Role of Atg Proteins in Autophagosome Formation
2011 StandoutNobel
The mechanism of modification by propranolol of the metabolism of phosphatidyl-CMP (CDP-diacylglycerol) and other lipids in the rat pineal gland
1979
Diglyceride lipase: a pathway for arachidonate release from human platelets.
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Inositol lipids and phosphates in the regulation of the growth and differentiation of haemopoietic and other cells
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Vac14 Controls PtdIns(3,5) P 2 Synthesis and Fab1-Dependent Protein Trafficking to the Multivesicular Body
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Novel inositol containing phospholipids and phosphates: their synthesis and possible new roles in cellular signalling
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Phosphatidylinositol 3,5-bisphosphate: metabolism and cellular functions
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Interleukin 4 activates human B lymphocytes via transient inositol lipid hydrolysis and delayed cyclic adenosine monophosphate generation
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The stress-activated phosphatidylinositol 3-phosphate 5-kinase Fab1p is essential for vacuole function in S. cerevisiae
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Svp1p defines a family of phosphatidylinositol 3,5‐bisphosphate effectors
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Changes in the levels of inositol lipids and phosphates during the differentiation of HL60 promyelocytic cells towards neutrophils or monocytes
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The site of diphosphoinositide synthesis in rat liver
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A membrane-bound activity catalysing phosphatidylinositol breakdown to 1,2-diacylglycerol, d -myoinositol 1:2-cyclic phosphate and d -myoinositol 1-phosphate. Properties and subcellular distribution in rat cerebral cortex
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Phosphatidylinositol metabolism in cells receiving extracellular stimulation
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Selective release of plasma-membrane enzymes from rat hepatocytes by a phosphatidylinositol-specific phospholipase C
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Muscarinic cholinergic stimulation of phosphatidylinositol turnover in the longitudinal smooth muscle of guinea-pig ileum
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The polyphosphoinositide phosphodiesterase of erythrocyte membranes
1981
Enhanced Phosphatidylinositol Breakdown as a Calcium-Independent Response of Rat Parotid Fragments to Substance P
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Phosphatidylinositol metabolism in rat hepatocytes stimulated by vasopressin
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The role of inositol lipid hydrolysis in the selection of immature thymocytes
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Phosphatidylinositol cleavage in lymphocytes. Requirement for calcium ions at a low concentration and effects of other cations
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Ca2+-DEPENDENT POLYPHOSPHOINOSITIDE (PPI) BREAKDOWN IN STIMULATED RAT HEPATOCYTES
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Inositol trisphosphate and tetrakisphosphate phosphomonoesterases of rat liver
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Inositol phospholipids and cell surface receptor function
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PtdIns-specific MPR Pathway Association of a Novel WD40 Repeat Protein, WIPI49
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Calcium ion-dependent diacylglycerol accumulation in erythrocytes is associated with microvesiculation but not with efflux of potassium ions
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Similar Effects of Substance P and Related Peptides on Salivation and on Phosphatidylinositol Turnover in Rat Salivary Glands
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A calcium-activated polyphosphoinositide phosphodiesterase in the plasma membrane of human and rabbit erythrocytes
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The inositol trisphosphate phosphomonoesterase of the human erythrocyte membrane
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Inositol lipids and phosphates in erythrocytes and HL60 cells.
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Analysis of the metabolic turnover of the individual phosphate groups of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate. Validation of novel analytical techniques by using 32P-labelled lipids from erythrocytes
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Receptors and recognition
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The labelling of polyphosphoinositides with [32P]Pi and the accumulation of inositol phosphates in vasopressin-stimulated hepatocytes
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Production of Cyclic Inositol Phosphate in Stimulated Tissues
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Inhibition of Phosphatases and Increased Ca 2+ Channel Activity by Inositol Hexakisphosphate
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Phosphatidylinositol metabolism in rat hepatocytes stimulated by glycogenolytic hormones. Effects of angiotensin, vasopressin, adrenaline, ionophore A23187 and calcium-ion deprivation
1979
Inositol lipid metabolism in dividing and differentiating cells
1982
Dephosphorylation of myo-inositol 1,4,5-trisphosphate and myo-inositol 1,3,4-triphosphate
1987
Stimulation of the Breakdown and Resynthesis of Phosphatidylinositol in Rat Hepatocytes by Angiotensin, Vasopressin and Adrenaline
1978
Effects of calcium-antagonistic drugs on the stimulation by carbamoylcholine and histamine of phosphatidylinositol turnover in longitudinal smooth muscle of guinea-pig ileum
1976
Incorporation of phosphate into diphosphoinositide by subcellular fractions from liver
1965
1d -myo-inositol 1,4,5-trisphosphate dephosphorylation by rat enterocytes involves an intracellular 5-phosphatase and non-specific phosphatase activity at the cell surface
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Release of diacylglycerol-enriched vesicles from erythrocytes with increased intracellular [Ca2+]
1976 Nature
Characteristics of rat liver phosphatidylinositol kinase and its presence in the plasma membrane
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Stepwise enzymatic dephosphorylation of inositol 1,4,5-trisphosphate to inositol in liver
1984 Nature
The opening of the inositol 1,4,5-trisphosphate-sensitive Ca2+ channel in rat cerebellum is inhibited by caffeine
1992
Phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate: Lipids in search of a function
1982
Transfer of very low density lipoprotein from hen plasma into egg yolk
1974
Rapid breakdown of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate in rat hepatocytes stimulated by vasopressin and other Ca2+-mobilizing hormones
1983
Metabolism of d -myo-inositol 1,3,4,5-tetrakisphosphate by rat liver, including the synthesis of a novel isomer of myo-inositol tetrakisphosphate
1987
The control by Ca2+ of the polyphosphoinositide phosphodiesterase and the Ca2+-pump ATPase in human erythrocytes
1982
Inositol 1:2(cyclic),4,5-trisphosphate is not a major product of inositol phospholipid metabolism in vasopressin-stimulated WRK1 cells
1988
A comparison of the effects of phytohaemagglutinin and of calcium ionophore A23187 on the metabolism of glycerolipids in small lymphocytes
1977
Inositol hexakisphosphate in Schizosaccharomyces pombe: synthesis from Ins(1,4,5)P3 and osmotic regulation
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Comparison of the levels of inositol metabolites in transformed haemopoietic cells and their normal counterparts
1993
The interrelationships of the inositol phosphates formed in vasopressin-stimulated WRK-1 rat mammary tumour cells
1992
V. Polyphosphoinositide breakdown as the initiating reaction in receptor-stimulated inositol phospholipid metabolism
1983
Preferential localization of rat liver d -myo-inositol 1,4,5-trisphosphate/1,3,4,5-tetrakisphosphate 5-phosphatase in bile-canalicular plasma membrane and ‘late’ endosomal vesicles
1988
Is phosphatidylinositol really out of the calcium gate?
1982 Nature
Accumulation of 1,2-diacylglycerol in the plasma membrane may lead to echinocyte transformation of erythrocytes
1975 Nature
The intracellular distribution of inositol polyphosphates in HL60 promyeloid cells
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Partial purification and some properties of rat brain inositol 1,4,5-trisphosphate 3-kinase
1988
A purified plasma membrane fraction isolated from rat liver under isotonic conditions
1967
Multiple metabolic pools of phosphoinositides and phosphatidate in human erythrocytes incubated in a medium that permits rapid transmembrane exchange of phosphate
1987
The pathway of myo-inositol 1,3,4-trisphosphate dephosphorylation in liver
1987
The relationship of calcium to receptor-controlled stimulation of phosphatidylinositol turnover. Effects of acetylcholine, adrenaline, calcium ions, cinchocaine and a bivalent cation ionophore on rat parotid-gland fragments
1975
Human erythrocyte membranes exhibit a cooperative calmodulin-dependent Ca2+-ATPase of high calcium sensitivity
1981 Nature
Extraction of polyphosphoinositides with neutral and acidified solvents A comparison of guinea-pig brain and liver, and measurements of rat liver inositol compounds which are resistant to extraction
1970
Cell regulation: editorial overview
1989
Breakdown of phosphatidylinositol provoked by muscarinic cholinergic stimulation of rat parotid-gland fragments
1974
Rapid accumulation of inositol phosphates in isolated rat superior cervical sympathetic ganglia exposed to V1-vasopressin and muscarinic cholinergic stimuli
1984
Inositol tetrakisphosphates in WRK-1 cells
1988
Cholinergically stimulated phosphatidylinositol breakdown in parotid-gland fragments is independent of the ionic environment
1976
Are polyphosphoinositides associated with glycophorin in human erythrocyte membranes?
1979
A vasopressin-like peptide in the mammalian sympathetic nervous system
1984 Nature
The inositol phosphates in WRK1 rat mammary tumour cells
1992
Stimulation by acetylcholine of phosphatidylinositol labelling. Subcellular distribution in rat cerebral-cortex slices
1972
Receptor occupancy dose—response curve suggests that phosphatidyl‐inositol breakdown may be intrinsic to the mechanism of the muscarinic cholinergic receptor
1976
Accumulation of inositol phosphates in sympathetic ganglia. Effects of depolarization and of amine and peptide neurotransmitters
1985
Inositol 1,2,3-trisphosphate and inositol 1,2- and/or 2,3-bisphosphate are normal constituents of mammalian cells
1995
Stimulated inositol lipid metabolism: An introduction
1982
Hormonal Stimulation of Phosphatidylinositol Breakdown, with Particular Reference to the Hepatic Effects of Vasopressin
1979
Phosphatidylinositol cleavage catalysed by the soluble fraction from lymphocytes. Activity at pH5.5 and pH7.0
1974
Enhanced synthesis de novo of phosphatidylinositol in lymphocytes treated with cationic amphiphilic drugs
1975
The Possible Involvement of Phosphatidylinositol Breakdown in the Mechanism of Stimulus-Response Coupling at Receptors which Control Cell-Surface Calcium Gates
1977
Investigation of the relationship between cell-surface calcium-ion gating and phosphatidylinositol turnover by comparison of the effects of elevated extracellular potassium ion concentration on ileium smooth muscle and pancreas
1976
Hormone-stimulated metabolism of inositol lipids and its relationship to hepatic receptor function
1981
Stimulation of phosphatidylinositol turnover in various tissues by cholinergic and adrenergic agonists, by histamine and by caerulein
1979
Synergism between diacylglycerols and calcium ionophore in the induction of human B cell proliferation mimics the inositol lipid polyphosphate breakdown signals induced by crosslinking surface immunoglobulin
1985
Metabolism of Phosphatidate at the Plasma Membrane
1977
The biosynthesis of triphosphoinositide by rat brain in vitro
1966
Inositol phospholipids in membrane function
1979
Stimulus-Response Coupling at α-Adrenergic Receptors
1978
Why is phosphatidylinositol degraded in response to stimulation of certain receptors?
1981
Dephosphorylation of 1d -myo-inositol 1,4-bisphosphate in rat liver
1988
Inositol phosphates in growing and differentiating HL60 cells
1988
Turkey erythrocytes possess a membrane-associated inositol 1,4,5-trisphosphate 3-kinase that is activated by Ca2+ in the presence of calmodulin
1987
A simple assay method for determination of the specific radioactivity of the γ-phosphate group of 32P-labelled ATP.
1983
Membranes and their cellular functions
1974