Citation Impact
Citing Papers
Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain in vivo
2003
[44] Insulysin and pitrilysin: Insulin-degrading enzymes of mammals and bacteria
1995
Management of Hyperglycemia in Type 2 Diabetes: A Patient-Centered Approach
2012 Standout
Ligand-tethered lipid nanoparticles for targeted RNA delivery to treat liver fibrosis
2023 StandoutNobel
Relaxin gene delivery mitigates liver metastasis and synergizes with check point therapy
2019
Clinical Applications of Positron Emission Tomography in Cardiology: A Review
2004
The role of hepatic insulin receptors in the regulation of glucose production
2005
Amyloid beta: structure, biology and structure-based therapeutic development
2017
International Union of Basic and Clinical Pharmacology. XCV. Recent Advances in the Understanding of the Pharmacology and Biological Roles of Relaxin Family Peptide Receptors 1–4, the Receptors for Relaxin Family Peptides
2015
Regulation of Insulin Degradation: Expression of an Evolutionarily Conserved Insulin-Degrading Enzyme Increases Degradation via an Intracellular Pathway
1991
Insulin degradation by Madin-Darby canine kidney cells expressing the insulin receptor
1997 StandoutNobel
The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders
2008 Standout
Effects of PEG conjugation on insulin properties
2002
Is nonalcoholic fatty liver disease an endogenous alcoholic fatty liver disease? – A mechanistic hypothesis
2015
Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1
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The Failing Heart — An Engine Out of Fuel
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Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide
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Gestational diabetes mellitus
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Cellular senescence in aging and age-related disease: from mechanisms to therapy
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FAST‐TRACK: Integrating QTL mapping and genome scans towards the characterization of candidate loci under parallel selection in the lake whitefish (Coregonus clupeaformis)
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Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure
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Effect of pegylation on pharmaceuticals
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Pramlintide acetate injection for the treatment of type 1 and type 2 diabetes mellitus
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New Perspectives into the Molecular Pathogenesis and Treatment of Type 2 Diabetes
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The Science of Stroke: Mechanisms in Search of Treatments
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Effects of stress throughout the lifespan on the brain, behaviour and cognition
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Reduced Hippocampal Insulin-Degrading Enzyme in Late-Onset Alzheimer's Disease Is Associated with the Apolipoprotein E-ε4 Allele
2003
Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo
2002 StandoutNature
Metabolism of amyloid-β peptide and Alzheimer's disease
2005
Clearance of Alzheimer's Aβ Peptide
2004
Type 2 diabetes as an inflammatory disease
2011 Standout
Amyloid β-degrading cryptidases: insulin degrading enzyme, presequence peptidase, and neprilysin
2008
Human neprilysin is capable of degrading amyloid β peptide not only in the monomeric form but also the pathological oligomeric form
2003
NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice
2012 StandoutNature
Protein degradation and aging
2005
Substrate Activation of Insulin-degrading Enzyme (Insulysin)
2003
Prevention of Steatosis by Hepatic JNK1
2009
Functional Human Insulin-Degrading Enzyme Can Be Expressed in Bacteria
2000
FGF-21 as a novel metabolic regulator
2005 Standout
The antifibrotic effects of relaxin in human renal fibroblasts are mediated in part by inhibition of the Smad2 pathway
2005 Standout
Myocardial Substrate Metabolism in the Normal and Failing Heart
2005 Standout
Matrix Metalloproteinases Expressed by Astrocytes Mediate Extracellular Amyloid-β Peptide Catabolism
2006
Insulin, insulin-degrading enzyme and amyloid-β peptide in Alzheimer's disease: review and hypothesis
2005
Energy metabolism of the heart: From basic concepts to clinical applications applications
1994
Regulation of insulin action by CEACAM1
2002
The Effects of Relaxin on Extracellular Matrix Remodeling in Health and Fibrotic Disease
2008
Insulin signalling and the regulation of glucose and lipid metabolism
2001 StandoutNature
Effects of Prolonged Exposure to Hypobaric Hypoxia on Oxidative Stress, Inflammation and Gluco-Insular Regulation: The Not-So-Sweet Price for Good Regulation
2014
CEACAM1 regulates insulin clearance in liver
2002
Relaxin is up-regulated in the rat ovary by orthodontic tooth movement
2011
Anti-Aβ Drug Screening Platform Using Human iPS Cell-Derived Neurons for the Treatment of Alzheimer's Disease
2011 StandoutNobel
Clearing the Brain's Amyloid Cobwebs
2001
Alzheimer's Disease
2010 Standout
Ageing and diabetes: implications for brain function
2002
Reactive oxygen species have a causal role in multiple forms of insulin resistance
2006 StandoutNature
Effects of Chronic Glucocorticoid Administration on Insulin-Degrading Enzyme and Amyloid-Beta Peptide in the Aged Macaque
2005
Design of amyloidogenic peptide traps
2024 StandoutNobel
Mechanisms for Insulin Resistance: Common Threads and Missing Links
2012 Standout
Insulin Secretion during and after Pregnancy in Patients with Gestational Diabetes Mellitus1
2001
Environmental Enrichment Reduces Aβ Levels and Amyloid Deposition in Transgenic Mice
2005 Standout
Hyperinsulinemia: the missing link among oxidative stress and age-related diseases?
2000
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
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Energy Metabolism in the Liver
2014 Standout
Fibroblasts in cancer
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Enhanced Proteolysis of β-Amyloid in APP Transgenic Mice Prevents Plaque Formation, Secondary Pathology, and Premature Death
2003
Chronic Kidney Disease
2016 Standout
Islet Amyloid: A Critical Entity in the Pathogenesis of Type 2 Diabetes
2004
Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders
2011 Standout
Gut microbiota in human metabolic health and disease
2020 Standout
Brain Insulin: Regulation, Mechanisms of Action and Functions
2003
Hepatic macrophages act as a central hub for relaxin-mediated alleviation of liver fibrosis
2021
Reaction of Carnosine with Aged Proteins
2002
The TSC1-2 tumor suppressor controls insulin–PI3K signaling via regulation of IRS proteins
2004 Standout
Physiology and Pathophysiology of Carnosine
2013 Standout
Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
2007 Standout
From the Triumvirate to the Ominous Octet: A New Paradigm for the Treatment of Type 2 Diabetes Mellitus
2009 Standout
Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
2006 Standout
Coordinating Radiometals of Copper, Gallium, Indium, Yttrium, and Zirconium for PET and SPECT Imaging of Disease
2010 Standout
Hibernating Myocardium Retains Metabolic and Contractile Reserve Despite Regional Reductions in Flow, Function, and Oxygen Consumption at Rest
2003
Mechanisms of Insulin Action and Insulin Resistance
2018 Standout
Type 2 diabetes: principles of pathogenesis and therapy
2005 Standout
Myocardial Fatty Acid Metabolism in Health and Disease
2010 Standout
Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1
2008
Systematics and Evolution of Spiders (Araneae)
1991 Standout
Loss of Insulin Signaling in Hepatocytes Leads to Severe Insulin Resistance and Progressive Hepatic Dysfunction
2000
Molecular Mechanism of Insulin-Induced Degradation of Insulin Receptor Substrate 1
2002
Cardiac carbon 13 magnetic resonance spectroscopy: On the horizon or over the rainbow?
2002
Relaxin Augments BMP-2–Induced Osteoblast Differentiation and Bone Formation
2014 Standout
Muscle acylcarnitines during short-term fasting in lean healthy men
2008
β-Cell Failure in Type 2 Diabetes: A Case of Asking Too Much of Too Few?
2013
Estimating Glomerular Filtration Rate in Older People
2014
Inflammatory Mechanisms in Obesity
2011 Standout
β-Arrestin-1 Competitively Inhibits Insulin-Induced Ubiquitination and Degradation of Insulin Receptor Substrate 1
2004 StandoutNobel
Essential Role of Pten in Body Size Determination and Pancreatic β-Cell Homeostasis In Vivo
2006 StandoutNobel
Islet Amyloid in Type 2 Diabetes, and the Toxic Oligomer Hypothesis
2008
Wortmannin-Sensitive Pathway Is Required for Insulin-Stimulated Phosphorylation of Inhibitor κBα
2002
On the pivotal role of PPARa in adaptation of the heart to hypoxia and why fat in the diet increases hypoxic injury
2016 StandoutNobel
Mutant mice lacking acetyl-CoA carboxylase 1 are embryonically lethal
2005
Inducible expression and cellular localization of insulin-degrading enzyme in a stably transfected cell line.
1994
Relaxin’s Physiological Roles and Other Diverse Actions
2004
Extreme Diversity, Conservation, and Convergence of Spider Silk Fibroin Sequences
2001 StandoutScience
Hepatic Insulin Clearance Is Closely Related to Metabolic Syndrome Components
2013
Inhibition of the oxygen sensor PHD2 in the liver improves survival in lactic acidosis by activating the Cori cycle
2015 StandoutNobel
Quantitative Trait Loci for Life Span in Drosophila melanogaster: Interactions With Genetic Background and Larval Density
2000
Works of Robert G. Bennett being referenced
Relaxin Activates Peroxisome Proliferator-activated Receptor γ (PPARγ) through a Pathway Involving PPARγ Coactivator 1α (PGC1α)
2014
Control of proteolysis: hormones, nutrients, and the changing role of the proteasome
2004
Insulin Inhibition of Proteasome Activity in Intact Cells
1997
Insulin Inhibits Peroxisomal Fatty Acid Oxidation in Isolated Rat Hepatocytes1
2001
Insulin Acts Intracellularly on Proteasomes through Insulin-Degrading Enzyme
1998
Identification and Isolation of a Cytosolic Proteolytic Complex Containing Insulin Degrading Enzyme and the Multicatalytic Proteinase
1994
Degradation of Amylin by Insulin-degrading Enzyme
2000
Identification of the metal associated with the insulin degrading enzyme
1991
Relaxin and its role in the development and treatment of fibrosis
2009
Inhibition of markers of hepatic stellate cell activation by the hormone relaxin
2003
Relaxin signaling activates peroxisome proliferator-activated receptor gamma
2009
Anti‐fibrotic actions of relaxin
2016
Novel Anti-fibrotic Therapies
2017
A direct inhibitory effect of insulin on a cytosolic proteolytic complex containing insulin-degrading enzyme and multicatalytic proteinase.
1994
Insulin Inhibits the Ubiquitin-Dependent Degrading Activity of the 26S Proteasome
2000
Characterization of the Insulin Inhibition of the Peptidolytic Activities of the Insulin-Degrading Enzyme–Proteasome Complex
1997
Regulation of Multicatalytic Enzyme Activity by Insulin and the Insulin-Degrading Enzyme**This work was supported by the Department of Veterans Affairs Research Service and the Bly Memorial Research Fund.
1998
Relaxin Stimulates Bronchial Epithelial Cell PKA Activation, Migration, and Ciliary Beating1
2002
Insulin Degradation: Progress and Potential*
1998
An Insulin-Degrading Enzyme Inhibitor Decreases Amylin Degradation, Increases Amylin-Induced Cytotoxicity, and Increases Amyloid Formation in Insulinoma Cell Cultures
2003
Exposure of precision-cut rat liver slices to ethanol accelerates fibrogenesis
2010
Human red blood cell insulin-degrading enzyme and rat skeletal muscle insulin protease share antigenic sites and generate identical products from insulin.
1990
Regional blood flow, oxidative metabolism, and glucose utilization in patients with recent myocardial infarction.
1993
The Spider Genus Cybaeota (Araneae, Agelenidae)
1988
Insulin Inhibits the Ubiquitin-Dependent Degrading Activity of the 26S Proteasome*
2000