Standout Papers
- The relationship of cellular permeability to the degree of inhibition by amethopterin and pyrimethamine in several species of bacteria (1961)
- Folate Cofactor Biosynthesis by Plasmodium berghei. Comparison of Folate and Dihydrofolate as Substrates* (1966)
- Condensed pyrimidine systems. XXV. 2,4-Diaminopyrido[2,3-d]pyrimidines. Biological data (1968)
- Plasmodium berghei Dihydrofolate Reductase Isolation, Properties, and Inhibition by Antifolates (1969)
Citation Impact
Citing Papers
Comparative genomics of bacterial and plant folate synthesis and salvage: predictions and validations
2007
Structure and Function of Photolyase and in Vivo Enzymology: 50th Anniversary
2008 StandoutNobel
Creating new fluorescent probes for cell biology
2002 StandoutNobel
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
The large diverse gene family var encodes proteins involved in cytoadherence and antigenic variation of plasmodium falciparum-infected erythrocytes
1995 Standout
Hydrophobic interactions via mutants of Escherichia coli dihydrofolate reductase: separation of binding and catalysis
1989
Structure of and kinetic channelling in bifunctional dihydrofolate reductase–thymidylate synthase
1994
Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS
2000 StandoutNature
The Sec13p complex and reconstitution of vesicle budding from the ER with purified cytosolic proteins.
1993 StandoutNobel
Indigenous Bacteria from the Gut Microbiota Regulate Host Serotonin Biosynthesis
2015 Standout
In vitro activities of ferrochloroquine against 55 Senegalese isolates of Plasmodium falciparum in comparison with those of standard antimalarial drugs
2002
UCSF Chimera—A visualization system for exploratory research and analysis
2004 Standout
An orthogonal dexamethasone–trimethoprim yeast three-hybrid system
2006
Approaching a stable, green twisted heteroacene through “clean reaction” strategy
2012
[14] Detection of protein-protein interactions by protein fragment complementation strategies
2000
Purification and Characterization of Three Members of the Photolyase/Cryptochrome Family Blue-light Photoreceptors from Vibrio cholerae
2003 StandoutNobel
Cloning, sequencing, expression and characterization of DNA photolyase fromSalmonella typhimurium
1991 StandoutNobel
10-formyl-5,8,10-trideazafolic acid (10-formyl-TDAF): A potent inhibitor of glycinamide ribonucleotide transformylase
1997
Reaction Mechanism of (6-4) Photolyase
1997 StandoutNobel
In Situ Click Chemistry: Enzyme‐Generated Inhibitors of Carbonic Anhydrase II
2004 StandoutNobel
Membrane transport of natural folates and antifolate compounds in murine L1210 leukemia cells: role of carrier- and receptor-mediated transport systems.
1991
3d Transition Metals for C–H Activation
2018 Standout
Roles of FAD and 8-hydroxy-5-deazaflavin chromophores in photoreactivation by Anacystis nidulans DNA photolyase.
1992 StandoutNobel
Molecular Recognition of Protein−Ligand Complexes: Applications to Drug Design
1997 Standout
Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)
2013 Standout
Bioorganometallic Chemistry of Ferrocene
2004 Standout
Active site and complete sequence of the suicidal methyltransferase that counters alkylation mutagenesis.
1985 StandoutNobel
Interaction of chlamydiae and host cells in vitro
1991
Mycobacterium avium Complex Infection Presenting as Endobronchial Lesions in Immunosuppressed Patients
1988
Cryptochrome: The Second Photoactive Pigment in the Eye and Its Role in Circadian Photoreception
2000 StandoutNobel
Cloning and expression of the gene encoding Lactobacillus casei folylpoly-gamma-glutamate synthetase in Escherichia coli and determination of its primary structure.
1990
De Novo-Designed Enzymes as Small-Molecule-Regulated Fluorescence Imaging Tags and Fluorescent Reporters
2014 StandoutNobel
Functions of the gene products of Escherichia coli
1993
Synthesis of Phosphaisoquinolin‐1‐one by Annulation of Aryl Phosphinamides with Allenes through a Cobalt‐Promoted C−H Functionalization
2017
Multiple membrane transport systems for the uptake of folate-based thymidylate synthase inhibitors.
1990
Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations
1994 StandoutScience
FOLATE ANTAGONISTS AS ANTIBACTERIAL and ANTIPROTOZOAL AGENTS
1971 StandoutNobel
Purification and Properties of Methanobacterium thermoautotrophicum DNA Photolyase
1989 StandoutNobel
Conditional Glycosylation in Eukaryotic Cells Using a Biocompatible Chemical Inducer of Dimerization
2008 StandoutNobel
Luminescent Chemodosimeters for Bioimaging
2012 Standout
Identification of chromophore binding domains of yeast DNA photolyase.
1992 StandoutNobel
Dihydropteridine reductase from Escherichia coli.
1988
Coupling of Tetrahymena Ribosomal RNA Splicing to β-Galactosidase Expression in Escherichia coli
1985 StandoutScienceNobel
Classical Electrostatics in Biology and Chemistry
1995 StandoutScience
Life with 6000 Genes
1996 StandoutScience
Intervening sequence in the thymidylate synthase gene of bacteriophage T4.
1984
Role of enzyme-bound 5,10-methenyltetrahydropteroylpolyglutamate in catalysis by Escherichia coli DNA photolyase
1989 StandoutNobel
Identification of the second chromophore of Escherichia coli and yeast DNA photolyases as 5,10-methenyltetrahydrofolate.
1988 StandoutNobel
Advances in the Chemistry of Tetrahydroquinolines
2011 Standout
Folate-Synthesizing Enzyme System as Target for Development of Inhibitors and Inhibitor Combinations against Candida albicansSynthesis and Biological Activity of New 2,4-Diaminopyrimidines and 4‘-Substituted 4-Aminodiphenyl Sulfones
2003
A Fluorogenic TMP-Tag for High Signal-to-Background Intracellular Live Cell Imaging
2013
Synthesis and Biological Activity of a Novel Series of Nonsteroidal, Peripherally Selective Androgen Receptor Antagonists Derived from 1,2-Dihydropyridono[5,6-g]quinolines
1998
Selective inhibition of human immunodeficiency viruses by racemates and enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine
1992
Insertion of an intracisternal A particle within the 5'-regulatory region of a gene encoding folate-binding protein in L1210 leukemia cells in response to low folate selection. Association with increased protein expression.
1992 StandoutNobel
Transition-Metal-Catalyzed C−S, C−Se, and C−Te Bond Formation via Cross-Coupling and Atom-Economic Addition Reactions
2011 Standout
The folate cofactor of Escherichia coli DNA photolyase acts catalytically.
1990 StandoutNobel
Structure-Based Strategies for Drug Design and Discovery
1992 Science
Crystal Structure of DNA Photolyase from Escherichia coli
1995 StandoutScienceNobel
Molecular cloning and sequence analysis of the Plasmodium falciparum dihydrofolate reductase-thymidylate synthase gene.
1987
The presence and distribution of reduced folates in Escherichia coli dihydrofolate reductase mutants.
1990 StandoutNobel
Boron in Drug Discovery: Carboranes as Unique Pharmacophores in Biologically Active Compounds
2011
Evidence that a point mutation in dihydrofolate reductase-thymidylate synthase confers resistance to pyrimethamine in falciparum malaria.
1988
Construction of an SfiI macrorestriction map of the Candida albicans genome
1993
Electrostatic Basis for Enzyme Catalysis
2006 StandoutNobel
Transition Metal-Free Cascade Reactions of Alkynols to Afford Isoquinolin-1(2H)-one and Dihydroisobenzofuran Derivatives
2014
In Situ Selection of Lead Compounds by Click Chemistry: Target-Guided Optimization of Acetylcholinesterase Inhibitors
2005 StandoutNobel
The Complete Genome Sequence of Escherichia coli K-12
1997 StandoutScience
Site-directed mutagenesis of mouse dihydrofolate reductase. Mutants with increased resistance to methotrexate and trimethoprim.
1988
De Novo Carborane-Containing Macrocyclic Peptides Targeting Human Epidermal Growth Factor Receptor
2019 StandoutNobel
Construction of a dihydrofolate reductase-deficient mutant of Escherichia coli by gene replacement
1988
An electrostatic highway
1994
Force display in molecular docking
1988
A Genomic Perspective on Protein Families
1997 StandoutScience
FOLATE ANTAGONISTS AS ANTIBACTERIAL and ANTIPROTOZOAL AGENTS
1971 StandoutNobel
Heterocyclic Nanographenes and Other Polycyclic Heteroaromatic Compounds: Synthetic Routes, Properties, and Applications
2016 Standout
Irreversible Inhibitors of Serine, Cysteine, and Threonine Proteases
2002 Standout
Mycobacterium aviumComplex Infection in the Acquired Immunodeficiency Syndrome
1991 Standout
Probing the infra-structure of thymidylate synthase and deoxycytidylate deaminase
1984
An In Vivo Covalent TMP-Tag Based on Proximity-Induced Reactivity
2009
Targeted killing of a mammalian cell based upon its specialized metabolic state
2011
Computational design of a red fluorophore ligase for site-specific protein labeling in living cells
2014 StandoutNobel
Gold(I)-Catalyzed Activation of Alkynes for the Construction of Molecular Complexity
2015 Standout
Genome Sequence of an Obligate Intracellular Pathogen of Humans: Chlamydia trachomatis
1998 StandoutScience
Construction of a fol mutant strain of Escherichia coli for use in dihydrofolate reductase mutagenesis experiments
1988
Structure and Function of DNA Photolyase and Cryptochrome Blue-Light Photoreceptors
2003 StandoutNobel
Works of Robert Ferone being referenced
Synthesis and biological activity of an acyclic analog of 5,6,7,8-tetrahydrofolic acid, N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl]amino]benzoyl]-L-glutamic acid
1990
Folate analogs. 32. Synthesis and biological evaluation of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid and related compounds
1989
Folate analogs. 31. Synthesis of the reduced derivatives of 11-deazahomofolic acid, 10-methyl-11-deazahomofolic acid, and their evaluation as inhibitors of glycinamide ribonucleotide formyltransferase
1989
Synthesis and biological activity of open-chain analogs of 5,6,7,8-tetrahydrofolic acid-potential antitumor agents
1992
Folate analogs. 35. Synthesis and biological evaluation of 1-deaza, 3-deaza, and bridge-elongated analogs of N10-propargyl-5,8-dideazafolic acid
1991
2,4-Diamino-5-benzylpyrimidines as antibacterial agents. 13. Some alkenyl derivatives with high in vitro activity against anaerobic organisms
1989
In vivo antitumor activity and metabolism of a series of 5-deazaacyclotetrahydrofolate (5-DACTHF) analogues
1992
Receptor-based design of dihydrofolate reductase inhibitors: comparison of crystallographically determined enzyme binding with enzyme affinity in a series of carboxy-substituted trimethoprim analogs
1985
Dihydrofolate reductase: thymidylate synthase, a bifunctional polypeptide from Crithidia fasciculata.
1980
Purification and partial characterization of 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase and 7,8-dihydropteroate synthase from Escherichia coli MC4100
1991
Folate metabolism in malaria.
1977
Multisubstrate Analogue Inhibitors of Glycinamide Ribonucleotide Transformylase Based on 5-Deazaacyclo Tetrahudrofolate (5-DACTHF)
1993
Cloning, purification, and properties of Candida albicans thymidylate synthase
1989
Isolation of a dihydrofolate reductase-deficient mutant of Escherichia coli
1985
Antibacterial activity and mechanism of action of 3'-azido-3'-deoxythymidine (BW A509U)
1987
The characteristics and significance of sulfonamides as substrates for Escherichia coli dihydropteroate synthase.
1979
Plasmodium berghei Dihydrofolate Reductase Isolation, Properties, and Inhibition by Antifolates
1969 StandoutNobel
Receptor-based design of dihydrofolate reductase inhibitors: comparison of crystallographically determined enzyme binding with enzyme affinity in a series of carboxy-substituted trimethoprim analogs
1982
Dihydrofolate Reductase from Pyrimethamine-resistant Plasmodium berghei
1970
alpha-Carboxyl-linked glutamates in the folylpolyglutamates of Escherichia coli.
1986
In vitro synthesis of alpha-carboxyl-linked folylpolyglutamates by an enzyme preparation from Escherichia coli.
1986
2,4-Diamino-5-benzylpyrimidines and analogs as antibacterial agents. 5. 3',5'-Dimethoxy-4'-substituted-benzyl analogs of trimethoprim
1981
Folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase. Cloning and high expression of the Escherichia coli folC gene and purification and properties of the gene product.
1985
The relationship of cellular permeability to the degree of inhibition by amethopterin and pyrimethamine in several species of bacteria
1961 StandoutNobel