Citation Impact
Citing Papers
Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation
2001 StandoutScienceNobel
HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing
2001 StandoutScienceNobel
α-Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro
2010 StandoutScienceNobel
Hypoxia Inducible Factor-α Binding and Ubiquitylation by the von Hippel-Lindau Tumor Suppressor Protein
2000 StandoutNobel
S. cerevisiae 26S protease mutants arrest cell division in G2/metaphase
1993 Nature
Ordering S phase and M phase in the cell cycle
1994 StandoutNobel
C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation
2001 StandoutNobel
p25rum1 orders S phase and mitosis by acting as an inhibitor of the p34cdc2 mitotic kinase
1995 StandoutNobel
Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL
2002 StandoutNatureNobel
Ubiquitination of full‐length cyclin
1995
Noninvasive Imaging beyond the Diffraction Limit of 3D Dynamics in Thickly Fluorescent Specimens
2012 StandoutNobel
The Ubiquitin-activating Enzyme E1 Is Phosphorylated and Localized to the Nucleus in a Cell Cycle-dependent Manner
1996 StandoutNobel
The ubiquitin-proteasome proteolytic pathway
1994 StandoutNobel
Roles of ubiquitin-mediated proteolysis in cell cycle control
1997 StandoutNobel
Ubiquitin-mediated Processing of NF-κB Transcriptional Activator Precursor p105
1995 StandoutNobel
The spindle assembly checkpoint
1996
Binding of Activated Cyclosome to p13
1997 StandoutNobel
A MAP kinase-dependent spindle assembly checkpoint in Xenopus egg extracts
1994
Anaphase is initiated by proteolysis rather than by the inactivation of maturation-promoting factor
1993
Degradation of 3-Hydroxy-3-methylglutaryl-CoA Reductase in Endoplasmic Reticulum Membranes Is Accelerated as a Result of Increased Susceptibility to Proteolysis
1996 StandoutNobel
Lessons from the discovery ofthe ubiquitin system
1996 StandoutNobel
Triggering of cyclin degradation in interphase extracts of amphibian eggs by cdc2 kinase
1990 StandoutNatureNobel
α-Synuclein Cooperates with CSPα in Preventing Neurodegeneration
2005 StandoutNobel
Identification of a novel ubiquitin-conjugating enzyme involved in mitotic cyclin degradation
1996
α-Synuclein: Normal Function and Role in Neurodegenerative Diseases
2004
Cyclin Ubiquitination: The destructive end of mitosis
1995
Ubiquitin C-Terminal Hydrolase Is an Immediate-Early Gene Essential for Long-Term Facilitation in Aplysia
1997 StandoutNobel
Regulating S Phase: CDKs, Licensing and Proteolysis
1996 StandoutNobel
Production of a Specific Major Histocompatibility Complex Class I-restricted Epitope by Ubiquitin-dependent Degradation of Modified Ovalbumin in Lymphocyte Lysate
1997
The Anaphase-Promoting Complex
2002
Developmental Changes of the 26 S Proteasome in Abdominal Intersegmental Muscles of Manduca sexta during Programmed Cell Death
1995
Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex
2004 StandoutNatureNobel
tsBN75 and tsBN423, temperature-sensitive X-linked mutants of the BHK21 cell line, can be complemented by the ubiquitin-activating enzyme E1 cDNA
1992
Ca2+ is involved through type II calmodulin-dependent protein kinase in cyclin degradation and exit from metaphase
1994
Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules
1994 Standout
Cyclin A‐Cys41 does not undergo cell cycle‐dependent degradation in Xenopus extracts
1992
CDC5 and CKII Control Adaptation to the Yeast DNA Damage Checkpoint
1997 StandoutNobel
A 20s complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B
1995
A ubiquitin-like system mediates protein lipidation
2000 StandoutNatureNobel
Cut2 proteolysis required for sister-chromatid separation in fission yeast
1996 StandoutNatureNobel
The ubiquitin system
2000 StandoutNobel
Mitosis in transition
1994
Imaging the division process in living tissue culture cells
2005
Inhibition of Proteasome Activities and Subunit-Specific Amino-Terminal Threonine Modification by Lactacystin
1995 ScienceNobel
Universal control mechanism regulating onset of M-phase
1990 StandoutNatureNobel
Cyclin-like accumulation and loss of the putative kinetochore motor CENP-E results from coupling continuous synthesis with specific degradation at the end of mitosis.
1994
Dephosphorylation of cdc2 on threonine 161 is required for cdc2 kinase inactivation and normal anaphase.
1992
Degradation of Proteins with Acetylated Amino Termini by the Ubiquitin System
1989 StandoutScienceNobel
A Ubiquitin-Conjugating Enzyme in Fission Yeast That Is Essential for the Onset of Anaphase in Mitosis
1997
Requirement for PP1 phosphatase and 20S cyclosome/APC for the onset of anaphase is lessened by the dosage increase of a novel gene sds23+.
1996
γ‐Synuclein and the progression of cancer
2007
The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis.
1995 StandoutNobel
Regulation of Receptor Fate by Ubiquitination of Activated β 2 -Adrenergic Receptor and β-Arrestin
2001 StandoutScienceNobel
Both cyclin A delta 60 and B delta 97 are stable and arrest cells in M-phase, but only cyclin B delta 97 turns on cyclin destruction.
1991
APC-Mediated Proteolysis of Ase1 and the Morphogenesis of the Mitotic Spindle
1997 Science
Destruction of Xenopus cyclins A and B2, but not B1, requires binding to p34cdc2.
1994 StandoutNobel
In vivo inhibition of cyclin B degradation and induction of cell-cycle arrest in mammalian cells by the neutral cysteine protease inhibitor N-acetylleucylleucylnorleucinal.
1993
Ubiquitin and the Enigma of Intracellular Protein Degradation
1995
TPR proteins required for anaphase progression mediate ubiquitination of mitotic B-type cyclins in yeast.
1996
Memory Suppressor Genes: Inhibitory Constraints on the Storage of Long-Term Memory
1998 StandoutScienceNobel
The ‘destruction box’ of cyclin A allows B-type cyclins to be ubiquitinated, but not efficiently destroyed.
1996 StandoutNobel
Human ubiquitin-activating enzyme, E1. Indication of potential nuclear and cytoplasmic subpopulations using epitope-tagged cDNA constructs
1994 StandoutNobel
Ubiquitin metabolism in cycling Xenopus egg extracts.
1993
Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway.
1995
The proteolysis of mitotic cyclins in mammalian cells persists from the end of mitosis until the onset of S phase.
1996 StandoutNobel
Microtubule minus-end anchorage at centrosomal and non-centrosomal sites: the role of ninein
2000
Complementation by a Cloned Human Ubiquitin-Activating Enzyme E1 of the S-Phase-Arrested Mouse FM3A Cell Mutant with Thermolabile E1.
1992
E2-C, a cyclin-selective ubiquitin carrier protein required for the destruction of mitotic cyclins.
1996 StandoutNobel
Fission Yeast Slp1: An Effector of the Mad2-Dependent Spindle Checkpoint
1998 Science
Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway.
1995 StandoutNobel
Mutagenic analysis of the destruction signal of mitotic cyclins and structural characterization of ubiquitinated intermediates.
1996
Identification, purification, and characterization of a protein activator (PA28) of the 20 S proteasome (macropain).
1992
Nuclear localization of the ubiquitin-activating enzyme, E1, is cell-cycle-dependent
1994 StandoutNobel
Control of programmed cyclin destruction in a cell-free system.
1989
The ubiquitin‐mediated proteolytic pathway: mechanisms of recognition of the proteolytic substrate and involvement in the degradation of native cellular proteins
1994 StandoutNobel
Ubiquitination of the G1 cyclin Cln2p by a Cdc34p-dependent pathway.
1995
Mechanisms and regulation of the degradation of cyclin B
1999 StandoutNobel
Aberrantly segregating centromeres activate the spindle assembly checkpoint in budding yeast.
1996
The bacterially expressed yeast CDC34 gene product can undergo autoubiquitination to form a multiubiquitin chain-linked protein.
1993
A Localized Wnt Signal Orients Asymmetric Stem Cell Division in Vitro
2013 StandoutScienceNobel
The role of proteolysis in cell cycle progression in Schizosaccharomyces pombe.
1996 StandoutNobel
A 26 S protease subunit that binds ubiquitin conjugates.
1994
Components of a system that ligates cyclin to ubiquitin and their regulation by the protein kinase cdc2.
1994 StandoutNobel
Degradation of the Proto-Oncogene Product c-Fos by the Ubiquitin Proteolytic System In Vivo and In Vitro: Identification and Characterization of the Conjugating Enzymes
1995 StandoutNobel
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
1997 StandoutScienceNobel
Mitosis
1989 Science
Block in Anaphase Chromosome Separation Caused by a Telomerase Template Mutation
1997 StandoutScienceNobel
THE UBIQUITIN SYSTEM
1998 StandoutNobel
Cell cycle-regulated degradation of Xenopus cyclin B2 requires binding to p34cdc2.
1994
Whose end is destruction: cell division and the anaphase-promoting complex
1999
Rescue of the complex temperature-sensitive phenotype of Chinese hamster ovary E36ts20 cells by expression of the human ubiquitin-activating enzyme cDNA
1994 StandoutNobel
Reversible phosphorylation controls the activity of cyclosome-associated cyclin-ubiquitin ligase.
1995 StandoutNobel
Works of Robert E. Palazzo being referenced
Gamma synuclein: Subcellular localization in neuronal and non‐neuronal cells and effect on signal transduction
2001
Disassembly of the nuclear envelope of spisula oocytes in a cell-free system
1989
Effect of γ-synuclein overexpression on matrix metalloproteinases in retinoblastoma Y79 cells
2003
In vitro reactivation of anaphase B in isolated spindles of the sea urchin egg
1988
Methylated ubiquitin inhibits cyclin degradation in clam embryo extracts.
1991 StandoutNobel
Colcemid and the mitotic cycle
1992
Centrosomes Isolated from Spisula solidissima Oocytes Contain Rings and an Unusual Stoichiometric Ratio of α/β Tubulin
1997