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osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification
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Myofibrillar Proteolysis in Chick Myotubes during Oxidative Stress
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Conditioned medium of Estrogen-treated osteoblasts inhibits osteoclast maturation and function in vitro
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Cytokine production in the bone marrow microenvironment: failure to demonstrate estrogen regulation in early postmenopausal women.
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Bone-Resorbing Cytokines from Peripheral Blood Mononuclear Cells after Hormone Replacement Therapy: A Longitudinal Study
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Transgenic mice expressing soluble tumor necrosis factor-receptor are protected against bone loss caused by estrogen deficiency.
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Regulatory effects of estrogen on acute lung inflammation in mice
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Regulation of osteoclast activity
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Degradation of oxidatively denatured proteins in Escherichia coli
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A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
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1998
RNA hyperediting and alternative splicing of hematopoietic cell phosphatase (PTPN6) gene in acute myeloid leukemia
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2000
Degradation of Oxidized Proteins in K562 Human Hematopoietic Cells by Proteasome
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Protein degradation and protection against misfolded or damaged proteins
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The 26S proteasome of the yeast Saccharomyces cerevisiae
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Targeting the function of the HER2 oncogene in human cancer therapeutics
2007
Estrogen deficiency induces bone loss by enhancing T-cell production of TNF-α
2000
Hypothesis: A damaging role in aging for reactive protein oxidation products?
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Oxidative and other DNA damages as the basis of aging: a review
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An investigation of antioxidant status, DNA repair capacity and mutation as a function of age in humans
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Estradiol Down‐Regulates LPS‐Induced Cytokine Production and NFkB Activation in Murine Macrophages
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[24] Multicatalytic endopeptidase complex: Proteasome
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HORMONAL MODULATION OF INTERLEUKIN-6, TUMOR NECROSIS FACTOR AND ASSOCIATED RECEPTOR SECRETION IN POSTMENOPAUSAL WOMEN
2002
Osteoclast differentiation and activation
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1998
Effect of oestrogen replacement on bone metabolism and cytokines in surgical menopause
1995
Oxidants, oxidative stress and the biology of ageing
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1993
Estrogen decreases TNF gene expression by blocking JNK activity and the resulting production of c-Jun and JunD
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Noninvasive measures of oxidative stress status in humans
1991
Relationship between Antioxidants, Prooxidants, and the Aging Processa
1992
Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone
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Requirement for NF-κB in osteoclast and B-cell development
1997
Metal ion-catalyzed oxidation of proteins: Biochemical mechanism and biological consequences
1990
Reactive oxygen species and Alzheimer's disease
1997
Reactive oxygen species have a causal role in multiple forms of insulin resistance
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1989
Glypican-1 identifies cancer exosomes and detects early pancreatic cancer
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Estrogen Modulates the Hypothalamic-Pituitary-Adrenal and Inflammatory Cytokine Responses to Endotoxin in Women1
2001
Estriol: A potent regulator of TNF and IL-6 expression in a murine model of endotoxemia
1996
17ß-Oestradiol and 1a, 25-dihydroxy;-cholecalciferol modulate constitutive and bone matrix-induced interleukin-1ß (IL-1ß) production by peripheral blood mononuclear cells isolated from postmenopausal women
1998
The effect of 17β-estradiol on production of cytokines in cultures of peripheral blood
2001
Lipopolysaccharide-stimulated osteoclastogenesis is mediated by tumor necrosis factor via its P55 receptor.
1997
Kainic acid-induced lipid peroxidation: protection with butylated hydroxytoluene and U78517F in primary cultures of cerebellar granule cells
1993
Heme Protein Radicals
1998
Estrogen’s bone-protective effects may involve differential IL-1 receptor regulation in human osteoclast-like cells
1999
Increased Osteoclast Development After Estrogen Loss: Mediation by Interleukin-6
1992 Science
Regulation of interleukin-6, osteoclastogenesis, and bone mass by androgens. The role of the androgen receptor.
1995
Bicyclic Imidazoles as a Novel Class of Cytokine Biosynthesis Inhibitors
1993
Regulation of estrogen synthesis in postmenopausal women
2002
Immune responses and bone loss: the estrogen connection
2005
The Role of IL‐6 Type Cytokines and Their Receptors in Boneaa
1998
Reactive species and their accumulation on radical-damaged proteins
1993
Matrix Elasticity Directs Stem Cell Lineage Specification
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Hormonal Regulation of Osteoclast Function
1998
Inflammasomes in health and disease
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Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage
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2004
Estrogen, cytokines, and pathogenesis of postmenopausal osteoporosis
1996
Proteasome regulation of activation-induced T cell death
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The Free Radical Theory of Aging Matures
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Interleukin-1 Receptor Signaling Mediates Atherosclerosis Associated With Bacterial Exposure and/or a High-Fat Diet in a Murine Apolipoprotein E Heterozygote Model
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Interleukin-18 (Interferon-γ–inducing Factor) Is Produced by Osteoblasts and Acts Via Granulocyte/Macrophage Colony-stimulating Factor and Not Via Interferon-γ to Inhibit Osteoclast Formation
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Carbonylated Proteins Are Detectable Only in a Degradation-Resistant Aggregate State in Escherichia coli
2008
In Vitro Secretion of Cytokines by Human Bone Marrow: Effects of Age and Estrogen Status1
1998
Estrogen inhibits release of tumor necrosis factor from peripheral blood mononuclear cells in postmenopausal women
1990
Inhibition of Caspases Increases the Sensitivity of L929 Cells to Necrosis Mediated by Tumor Necrosis Factor
1998
Free Radicals as Mediators of Tissue Injury
1991
Modification of glucose-6-phosphate dehydrogenase by 4-hydroxy-2-nonenal. Formation of cross-linked protein that inhibits the multicatalytic protease.
1994
Bone Resorption by Osteoclasts
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Protein damage and degradation by oxygen radicals. III. Modification of secondary and tertiary structure.
1987
Dialogue between E. coli free radical pathways and the mitochondria of C. elegans
2015 StandoutNobel
Osteoporosis induced in mice by overproduction of interleukin 4.
1993
Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion.
1994
Tumor Necrosis Factor α Regulatesα vβ5 Integrin Expression by Osteoclast Precursors in Vitro and in Vivo1
2000
A randomised controlled trial of the effect of hormone replacement therapy on disease activity in postmenopausal rheumatoid arthritis.
1994
TNFα Potently Activates Osteoclasts, through a Direct Action Independent of and Strongly Synergistic with RANKL
2002
Protein damage and degradation by oxygen radicals. II. Modification of amino acids.
1987
Cellular and molecular mechanisms of osteoporosis
1998
Lack of telomere shortening during senescence inParamecium.
1994 StandoutNobel
Estrogen and Angiogenesis
2001
Purification of an 11 S regulator of the multicatalytic protease.
1992
Oxidative stress and recovery from oxidative stress are associated with altered ubiquitin conjugating and proteolytic activities in bovine lens epithelial cells
1995
Tumor necrosis factor α induces a caspase-independent death pathway in human neutrophils
2003
Oxidative Stress, Caloric Restriction, and Aging
1996 StandoutScience
Regulation of Osteoclast Function
1997
Leukotrienes promote plasma leakage and leukocyte adhesion in postcapillary venules: in vivo effects with relevance to the acute inflammatory response.
1981 StandoutNobel
The Age-Related Accumulation of Protein Carbonyl in Rat Liver Correlates With the Age-Related Decline in Liver Proteolytic Activities
1999
Proteasomes in the archaea: from structure to function
2000
Mitochondrial Diseases in Man and Mouse
1999 StandoutScience
Birth and Death of Bone Cells: Basic Regulatory Mechanisms and Implications for the Pathogenesis and Treatment of Osteoporosis*
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Requirement for Generation of H 2 O 2 for Platelet-Derived Growth Factor Signal Transduction
1995 StandoutScience
Changes in Proinflammatory Cytokine Activity after Menopause
2002
Steroid Sex Hormones and Macrophage Function: Regulation of Chemiluminescence and Phagocytosis
1996
The impact of chronic estrogen deprivation on immunologic parameters in the ovariectomized rhesus monkey (Macaca mulatta) model of menopause
2001
A Chimeric Form of Osteoprotegerin Inhibits Hypercalcemia and Bone Resorption Induced by IL-1β, TNF-α, PTH, PTHrP, and 1,25(OH)2D3
1999
The process and theories of aging.
1995
Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.
1991 Standout
The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis
1997 StandoutScience
Estrogen inhibits interleukin-6 production and gene expression in a human osteoblastic cell line with high levels of estrogen receptors
1996
The GO system protects organisms from the mutagenic effect of the spontaneous lesion 8-hydroxyguanine (7,8-dihydro-8-oxoguanine)
1992
The Role of Estrogen in the Control of Rat Osteocyte Apoptosis
1998
ATP-dependent incorporation of 20S protease into the 26S complex that degrades proteins conjugated to ubiquitin.
1989 StandoutNobel
Estradiol repression of tumor necrosis factor-α transcription requires estrogen receptor activation function-2 and is enhanced by coactivators
1999
Response of a primary human fibroblast cell line to H2O2: senescence-like growth arrest or apoptosis?
1997
Age-associated, oxidatively modified proteins: A critical evaluation
1997
Estrogen and progesterone induction of survival of monoblastoid cells undergoing TNF‐α‐induced apoptosis
1999
Protein damage and degradation by oxygen radicals. I. general aspects.
1987 Standout
Neutrophil Extracellular Traps Kill Bacteria
2004 StandoutScience
Increased B-lymphopoiesis by interleukin 7 induces bone loss in mice with intact ovarian function: Similarity to estrogen deficiency
1997
Mitochondria contain a proteolytic system which can recognize and degrade oxidatively-denatured proteins
1988
Degradation of oxidized proteins in mammalian cells
1997
Protein oxidation and degradation during cellular senescence of human BJ fibroblasts: part II—aging of nondividing cells
2000
Molecular cloning and functional expression of a human cDNA encoding the antimutator enzyme 8-hydroxyguanine-DNA glycosylase
1997 StandoutNobel
Oxidative Stress, Glutamate, and Neurodegenerative Disorders
1993 StandoutScience
Endogenous bone-resorbing factors in estrogen deficiency: Cooperative effects of IL-1 and IL-6
1995
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction
2002 StandoutNobel
Involvement of the proteasome in various degradative processes in mammalian cells.
1989
Compact Biocompatible Quantum Dots Functionalized for Cellular Imaging
2008 StandoutNobel
THE UBIQUITIN SYSTEM
1998 StandoutNobel
Autophagy as a Regulated Pathway of Cellular Degradation
2000 StandoutScience
Inhibitors of the proteasome pathway interfere with induction of nitric oxide synthase in macrophages by blocking activation of transcription factor NF-kappa B.
1996 StandoutNobel
Metal-catalyzed oxidation of proteins. Physiological consequences
1991
Free Radicals in the Physiological Control of Cell Function
2002 Standout
Protein hydroperoxides can give rise to reactive free radicals
1995
Suppression of TNF-α-Induced Apoptosis by NF-κB
1996 StandoutScience
Androgen and estrogen receptors are present in primary cultures of human synovial macrophages.
1996
Proteostasis Failure in Neurodegenerative Diseases: Focus on Oxidative Stress
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17β-Estradiol Antagonizes Effects of 1α,25-Dihydroxyvitamin D3 on Interleukin-6 Production and Osteoclast-Like Cell Formation in Mouse Bone Marrow Primary Cultures*
1997
Involvement of the proteasome in the programmed cell death of NGF-deprived sympathetic neurons.
1996
Protein oxidation and degradation during cellular senescence of human BJ fibroblasts: part I— effects of proliferative senescence
2000
Age-Associated Increased Interleukin-6 Gene Expression, Late-Life Diseases, and Frailty
2000
Journal of Bone and Mineral Research
1993
Works of Robert E. Pacifici being referenced
ErbB Receptor Activation, Cell Morphology Changes, and Apoptosis Induced by Anti-Her2 Monoclonal Antibodies
1996
Macroxyproteinase (M.O.P.): A 670 kDa Proteinase complex that degrades oxidatively denatured proteins in red blood cells
1989
Interleukin-1 receptor antagonist and tumor necrosis factor binding protein decrease osteoclast formation and bone resorption in ovariectomized mice.
1994
Protein, Lipid and DNA Repair Systems in Oxidative Stress: The Free-Radical Theory of Aging Revisited
1991
The Measurement of Protein Degradation in Response to Oxidative Stress
1988
Bone matrix constituents stimulate interleukin-1 release from human blood mononuclear cells.
1991
Transient Adaptation to Oxidative Stress in Mammalian Cells
1995
Altered Cell Surface Expression and Signaling of Leptin Receptors Containing the fattyMutation
1998
Exposure of Hydrophobic Moieties Promotes the Selective Degradation of Hydrogen Peroxide-Modified Hemoglobin by the Multicatalytic Proteinase Complex, Proteasome
1994
Superoxide dismutase is preferentially degraded by a proteolytic system from red blood cells following oxidative modification by hydrogen peroxide
1988
Protein damage and degradation by oxygen radicals. IV. Degradation of denatured protein.
1987
Monocytic secretion of interleukin-1 receptor antagonist in normal and osteoporotic women: effects of menopause and estrogen/progesterone therapy.
1993
Superoxide dismutase undergoes proteolysis and fragmentation following oxidative modification and inactivation.
1990
Hematopoietic Cell Phosphatase Negatively Regulates Erythropoietin-Induced Hemoglobinization in Erythroleukemic SKT6 Cells
1997
Hydrophobicity as the signal for selective degradation of hydroxyl radical-modified hemoglobin by the multicatalytic proteinase complex, proteasome
1993
[51] Protein degradation as an index of oxidative stress
1990
Simultaneous block of interleukin-1 and tumor necrosis factor is required to completely prevent bone loss in the early postovariectomy period.
1995
Effect of surgical menopause and estrogen replacement on cytokine release from human blood mononuclear cells.
1991
Ligand binding to monocyte alpha 5 beta 1 integrin activates the alpha 2 beta 1 receptor via the alpha 5 subunit cytoplasmic domain and protein kinase C.
1994
Ovarian steroid treatment blocks a postmenopausal increase in blood monocyte interleukin 1 release.
1989