Standout Papers
Citation Impact
Citing Papers
SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase
2019 StandoutNobel
Combinatorial computational method gives new picomolar ligands for a known enzyme
2002
Expansive discovery of chemically diverse structured macrocyclic oligoamides
2024 StandoutScienceNobel
Iridium‐Catalyzed Asymmetric Intramolecular Allylic Amidation: Enantioselective Synthesis of Chiral Tetrahydroisoquinolines and Saturated Nitrogen Heterocycles
2011 StandoutNobel
Further development and validation of empirical scoring functions for structure-based binding affinity prediction
2002
Reaching for high-hanging fruit in drug discovery at protein–protein interfaces
2007 StandoutNature
Formation of the ∼350-kDa Apg12-Apg5·Apg16 Multimeric Complex, Mediated by Apg16 Oligomerization, Is Essential for Autophagy in Yeast
2002 StandoutNobel
Rapid Diversity‐Oriented Synthesis in Microtiter Plates for In Situ Screening of HIV Protease Inhibitors
2003
Netropsin and spermine conjugates of a water-soluble quinocarcin analog: analysis of sequence-specific DNA interactions
1995
Small‐Molecule Affinity Ligands for Protein Purification: Combined Computational Enrichment and Automated In‐line Screening of an Optically Encoded Library
2010 StandoutNobel
Targeting mammalian target of rapamycin (mTOR) for health and diseases
2006
Utilization of the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold in the design of potent inhibitors of serine proteases: SAR studies using carboxylates
2000
Inhibition of α-helix-mediated protein–protein interactions using designed molecules
2013
Molybdenum and Tungsten Imido Alkylidene Complexes as Efficient Olefin‐Metathesis Catalysts
2003 StandoutNobel
Recent progress in the total synthesis of naphthyridinomycin and lemonomycin tetrahydroisoquinoline antitumor antibiotics (TAAs)
2008
Targeting protein–protein interactions: Lessons from p53/MDM2
2007
Catalytic C–H functionalization by metal carbenoid and nitrenoid insertion
2008 StandoutNature
A Computationally Designed Inhibitor of an Epstein-Barr Viral Bcl-2 Protein Induces Apoptosis in Infected Cells
2014 StandoutNobel
Design, synthesis, and biological evaluation of HIV/FIV protease inhibitors incorporating a conformationally constrained macrocycle with a small P3′ residue
2001
Receptor‐Assisted Combinatorial Chemistry: Thermodynamics and Kinetics in Drug Discovery
2004
Inhibition of serine proteases by functionalized sulfonamides coupled to the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold
2001
Peptidomimetic design
1998
Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease
2010 Standout
Matrix Metalloproteinases: Regulators of the Tumor Microenvironment
2010 Standout
Natural products and Pharma 2011: Strategic changes spur new opportunities
2011
Palladium‐Catalyzed anti‐Markovnikov Oxidation of Terminal Alkenes
2014 StandoutNobel
Exploration of Backbone Space in Foldamers Containing α‐ and β‐Amino Acid Residues: Developing Protease‐Resistant Oligomers that Bind Tightly to the BH3‐Recognition Cleft of Bcl‐xL
2007
A Rh-Catalyzed C−H Insertion Reaction for the Oxidative Conversion of Carbamates to Oxazolidinones
2001
Synthesis and preliminary biological evaluation of MMP inhibitor radiotracers [11C]methyl-halo-CGS 27023A analogs, new potential PET breast cancer imaging agents
2002
Isosteric replacement of sulfur with other chalcogens in peptides and proteins
2005
1,2,5-Thiadiazolidin-3-one 1,1 Dioxide: A Powerful Scaffold for Probing the S′ Subsites of (Chymo)trypsin-Like Serine Proteases
2001
A Bioorthogonal Reaction of N‐Oxide and Boron Reagents
2015 StandoutNobel
Inhibitors of HIV‐1 Protease by Using In Situ Click Chemistry
2006 StandoutNobel
AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading
2009 Standout
In Situ Click Chemistry: Enzyme‐Generated Inhibitors of Carbonic Anhydrase II
2004 StandoutNobel
Future challenges facing the development of specific active-site-directed synthetic inhibitors of MMPs
2004
Asymmetric 1,3-Dipolar Cycloaddition Reactions
1998 Standout
Iron-Catalyzed Reactions in Organic Synthesis
2004 Standout
Click Chemistry for Drug Development and Diverse Chemical–Biology Applications
2013 Standout
Peptidotriazoles on Solid Phase: [1,2,3]-Triazoles by Regiospecific Copper(I)-Catalyzed 1,3-Dipolar Cycloadditions of Terminal Alkynes to Azides
2002 StandoutNobel
Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)
2013 Standout
Bioorganometallic Chemistry of Ferrocene
2004 Standout
Stanna-Brook Rearrangement of Carboxylic Acid Derivatives. Synthetic Utility and Mechanistic Studies
2004
Peptidomimetics—Tailored Enzyme Inhibitors
1994
Water as an Active Constituent in Cell Biology
2007 Standout
Solid Phase Combinatorial Library of Phosphinic Peptides for Discovery of Matrix Metalloproteinase Inhibitors
2000 StandoutNobel
Efficient synthesis of unsymmetrically disubstituted ferrocenes: towards electrochemical dipeptide-Fc-biosensors
2001
Nitrile-Containing Pharmaceuticals: Efficacious Roles of the Nitrile Pharmacophore
2010 Standout
Glide: A New Approach for Rapid, Accurate Docking and Scoring. 1. Method and Assessment of Docking Accuracy
2004 Standout
Protein‐Templated Fragment Ligations—From Molecular Recognition to Drug Discovery
2017
Implicit Solvation Models: Equilibria, Structure, Spectra, and Dynamics
1999 Standout
Peptido- and Glycocalixarenes: Playing with Hydrogen Bonds around Hydrophobic Cavities
2003
(α/β+α)-Peptide Antagonists of BH3 Domain/Bcl-xL Recognition: Toward General Strategies for Foldamer-Based Inhibition of Protein−Protein Interactions
2006
A de novo synthesis of ethyl 2-deoxy-l-ribosides
1998
Dynamic Combinatorial Chemistry
2006 Standout
Maintaining Biological Activity by Using Triazoles as Disufide Bond Mimetics
2011 StandoutNobel
Saccharide Recognition-Induced Transformation of Pyridine−Pyridone Alternate Oligomers from Self-Dimer to Helical Complex
2008
Chemistry and Biology of the Tetrahydroisoquinoline Antitumor Antibiotics
2002 Standout
Copper-Catalyzed Synthesis of Mixed Alkyl Aryl Phosphonates
2014 StandoutNobel
Aryl−Aryl Bond Formation by Transition-Metal-Catalyzed Direct Arylation
2007 Standout
Formal Total Synthesis of (−)-Balanol: Concise Approach to the Hexahydroazepine Segment Based on RCM
2000
Update 1 of: Proteases Universally Recognize Beta Strands In Their Active Sites
2010
Functional π-Gelators and Their Applications
2014 Standout
Cis−Trans Isomerization of Organic Molecules and Biomolecules: Implications and Applications
2003
Synthesis of piperazinones and benzopiperazinones from 1,2-diamines and organoboronic acids
2000
Reversible Photocontrol of Biological Systems by the Incorporation of Molecular Photoswitches
2013 StandoutNobel
Rational Tuning of Fluorobenzene Probes for Cysteine‐Selective Protein Modification
2018 StandoutNobel
A Field Guide to Foldamers
2001 Standout
Analysis of the S3 and S3′ subsite specificities of feline immunodeficiency virus (FIV) protease: Development of a broad-based protease inhibitor efficacious against FIV, SIV, and HIV in vitro and ex vivo
1998
Boronic acids in medicinal chemistry: anticancer, antibacterial and antiviral applications
2010
Supramolecular Helical Systems: Helical Assemblies of Small Molecules, Foldamers, and Polymers with Chiral Amplification and Their Functions
2016 Standout
An approach to the 3,8-diazabicyclo[3.2.1]octane moiety of naphthyridinomycin and quinocarcin via 1,3-dipolar cycloaddition of photochemically generated azomethine ylides.
1988
Artificial Molecular Machines
2015 Standout
Catalytic Carbene Insertion into C−H Bonds
2009 Standout
Protease Inhibitors: Current Status and Future Prospects
2000
Frontiers, Opportunities, and Challenges in Biochemical and Chemical Catalysis of CO2 Fixation
2013 Standout
The Combinatorial Synthesis of Bicyclic Privileged Structures or Privileged Substructures
2003 Standout
From Peptides to Non-Peptide Peptidomimetics: Design and Synthesis of New Piperidine Inhibitors of Aspartic Peptidases
2001
Rational Design of Potent, Bioavailable, Nonpeptide Cyclic Ureas as HIV Protease Inhibitors
1994 Science
Matrix Metalloproteinase Inhibitors and Cancer—Trials and Tribulations
2002 StandoutScience
Structure-Based Generation of a New Class of Potent Cdk4 Inhibitors: Newde NovoDesign Strategy and Library Design
2001
Specific Electrostatic Molecular Recognition in Water
2016 StandoutNobel
Imaging and Photodynamic Therapy: Mechanisms, Monitoring, and Optimization
2010 Standout
Synthesis and Properties of Cyclopropane-Derived Peptidomimetics
2006
Structure-Based Design of Potent Inhibitors of Scytalone Dehydratase: Displacement of a Water Molecule from the Active Site
1998
Redesigning an FKBP–ligand interface to generate chemical dimerizers with novel specificity
1998
Calculation of Relative Binding Free Energies of Peptidic Inhibitors to HIV-1 Protease and Its I84V Mutant
1998
Transition Metal-Catalyzed C–H Amination: Scope, Mechanism, and Applications
2017 Standout
Dendrimers Designed for Functions: From Physical, Photophysical, and Supramolecular Properties to Applications in Sensing, Catalysis, Molecular Electronics, Photonics, and Nanomedicine
2010 Standout
Design and Therapeutic Application of Matrix Metalloproteinase Inhibitors
1999
Chemistry and Biology Of Multicomponent Reactions
2012 Standout
Cu-Catalyzed Azide−Alkyne Cycloaddition
2008 StandoutNobel
Catalytic Asymmetric Protonation of Silyl Ketene Imines
2013 StandoutNobel
Glide: A New Approach for Rapid, Accurate Docking and Scoring. 2. Enrichment Factors in Database Screening
2004 Standout
Sequence-Specific DNA Minor Groove Binders. Design and Synthesis of Netropsin and Distamycin Analogues
1998
Irreversible Inhibitors of Serine, Cysteine, and Threonine Proteases
2002 Standout
Saframycin synthetic studies
1991
Synthetic Analogues Relevant to the Structure and Function of Zinc Enzymes
2004
Works of Robert E. Babine being referenced
Synthesis and in vitro biological evaluation of aryl boronic acids as potential inhibitors of factor XIa
2006
Structural and Mutational Analyses of the Molecular Interactions between the Catalytic Domain of Factor XIa and the Kunitz Protease Inhibitor Domain of Protease Nexin 2
2005
Synthesis, SAR exploration, and X-ray crystal structures of factor XIa inhibitors containing an α-ketothiazole arginine
2006
Molecular Recognition of Protein−Ligand Complexes: Applications to Drug Design
1997 Standout
The Effect on DNA Cleavage Potency of Tethering a Simple Cyclic Enediyne to a Netropsin Analog
1994
Towards an Experimental de Novo Design Protocol. The use of Protein Crystallography to Deconvolute Dynamic Combinatorial Processes
2004
Design, structure activity and x-ray crystallographic studies of pseudosymmetrical nonpeptidyl HIV-1 protease inhibitors
1994
FKBP immunophilin patents for neurological disorders
2005
Design, synthesis and X-ray crystallographic studies of novel FKBP-12 ligands
1995
Asymmetric epoxidation of divinyl carbinol: A new approach to the synthesis of 2,6-dideoxyhexoses
1986
The use of HIV-1 protease structure in inhibitor design
1992
Approaches to the isoquinoline quinone antibiotics. Additions of an amino acid derivative to a quinone monoacetal.
1984