Citation Impact
Citing Papers
Comprehensive single-cell transcriptional profiling of a multicellular organism
2017 Science
Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2
2020 StandoutScience
Bi-cycling the furin pathway: from TGN localization to pathogen activation and embryogenesis
1999
Dense Core Vesicle Dynamics in Caenorhabditis elegans Neurons and the Role of Kinesin UNC‐104
2004
The bHLH protein Dimmed controls neuroendocrine cell differentiation inDrosophila
2003
Analysis of the genome sequence of the flowering plant Arabidopsis thaliana
2000 StandoutNature
Coronavirus biology and replication: implications for SARS-CoV-2
2020 Standout
Discoveries in structure and physiology of mechanically activated ion channels
2020 StandoutNatureNobel
Angiopoietin-like protein 4: health effects, modulating agents and structure–function relationships
2012
Coronaviruses and the human airway: a universal system for virus-host interaction studies
2016
SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
2020 Standout
Prorenin processing by cathepsin B in vitro and in transfected cells
1999
Novel insights into proteolytic cleavage of influenza virus hemagglutinin
2010
The somatostatin receptor family
1995
Virological assessment of hospitalized patients with COVID-2019
2020 StandoutNature
Carboxypeptidase E Is a Regulated Secretory Pathway Sorting Receptor: Genetic Obliteration Leads to Endocrine Disorders in Cpefat Mice
1997
Melanin Pigmentation in Mammalian Skin and Its Hormonal Regulation
2004 Standout
mRNA-based therapeutics — developing a new class of drugs
2014 StandoutNobel
Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy volunteers: a randomised, single-blind, placebo-controlled, phase 1 trial
2013
Role of host cellular proteases in the pathogenesis of influenza and influenza-induced multiple organ failure
2011
Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity
2019 Nature
X-ray structure of a voltage-dependent K+ channel
2003 StandoutNatureNobel
An Extended Tyrosine‐Targeting Motif for Endocytosis and Recycling of the Dense‐Core Vesicle Membrane Protein Phogrin
2005
Somatostatin receptor subtype gene expression in pituitary adenomas.
1995
Crystal structure and mechanism of a calcium-gated potassium channel
2002 StandoutNatureNobel
Inactivation of Conserved C. elegans Genes Engages Pathogen- and Xenobiotic-Associated Defenses
2012 StandoutNobel
Translational regulation of proinsulin biosynthesis and proinsulin conversion in the pancreaticβ-cell
2000
Identification of a Second Human Subtilisin-Like Protease Gene in the fes/fps Region of Chromosome 15
1991
Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides1Published on the World Wide Web on 17 August 1999.1
1999
O-Glycosylation Modulates Proprotein Convertase Activation of Angiopoietin-like Protein 3
2010
Inhibition of Chikungunya Virus Infection in Cultured Human Muscle Cells by Furin Inhibitors
2008
Genes regulating hypothalamic and pituitary development
1997
Angiotensin-Converting Enzyme in Murine Testis: Step-Specific Expression of the Germinal Isoform during Spermiogenesis
1994
The single-cell transcriptional landscape of mammalian organogenesis
2019 StandoutNature
Expression of mRNA for all five human somatostatin receptors (hSSTR1-5) in pituitary tumors
1994
Molecular biology of somatostatin receptor subtypes
1996
Distinct Gene Expression Profiles Characterize Cellular Phenotypes of Follicle-Associated Epithelium and M Cells
2005
A role of PIEZO1 in iron metabolism in mice and humans
2021 StandoutNobel
A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila
2007 StandoutNature
A Serpin Shapes the Extracellular Environment to Prevent Influenza A Virus Maturation
2015 StandoutNobel
Molecular Biology of Somatostatin Receptors*
1995
Diverse Viruses Require the Calcium Transporter SPCA1 for Maturation and Spread
2017 StandoutNobel
In vivo genome editing using Staphylococcus aureus Cas9
2015 StandoutNature
Kex2p: a model for cellular endoprotease processing human immunodeficiency virus type 1 envelope glycoprotein precursor
1994 StandoutNobel
A Furin-like Convertase Mediates Propeptide Cleavage of BACE, the Alzheimer's β-Secretase
2000
Identification of Genes Needed for Regeneration, Stem Cell Function, and Tissue Homeostasis by Systematic Gene Perturbation in Planaria
2005
Bioactive peptides in anterior pituitary cells
1994
The function and differential sorting of a family of aplysia prohormone processing enzymes
1994 StandoutNobel
Molecular imaging by mass spectrometry — looking beyond classical histology
2010
Click Chemistry in Complex Mixtures: Bioorthogonal Bioconjugation
2014
Somatostatin receptor subtype specificity in human fetal pituitary cultures. Differential role of SSTR2 and SSTR5 for growth hormone, thyroid-stimulating hormone, and prolactin regulation.
1997
Mucin Granule Intraluminal Organization in Living Mucous/Goblet Cells
2005 StandoutNobel
Somatostatin: the neuroendocrine story
1997
Systematic analysis of genes required for synapse structure and function
2005 StandoutNatureNobel
Leptin and the regulation of body weight in mammals
1998 StandoutNature
Complexin Activates Exocytosis of Distinct Secretory Vesicles Controlled by Different Synaptotagmins
2013 StandoutNobel
Bifidobacteria can protect from enteropathogenic infection through production of acetate
2011 StandoutNature
TMEM41B Is a Pan-flavivirus Host Factor
2020 StandoutNobel
Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin protective antigen.
1992
SYSTEMIN: A Polypeptide Signal for Plant Defensive Genes
1998
Host cell entry of Middle East respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein
2014
Molecular Recognition of Protein−Ligand Complexes: Applications to Drug Design
1997 Standout
Hydrolysis by Cathepsin B of Fluorescent Peptides Derived From Human Prorenin
2000 StandoutNobel
Plasminogen activator inhibitor 1 is an intracellular inhibitor of furin proprotein convertase
2011
Molecular pharmacology of somatostatin receptor subtypes
1997
Severe Acute Respiratory Syndrome Coronavirus Infection Causes Neuronal Death in the Absence of Encephalitis in Mice Transgenic for Human ACE2
2008
Surprising gene expression patterns within and between PDF-containing circadian neurons in Drosophila
2010 StandoutNobel
A look at the Caenorhabditis elegans Kex2/Subtilisin-like proprotein convertase family
2000
Activation of the SARS coronavirus spike protein via sequential proteolytic cleavage at two distinct sites
2009
Impaired processing of brain proneurotensin and promelanin-concentrating hormone in obese fat/fat mice.
1996
Inhibition of Influenza Virus Infection in Human Airway Cell Cultures by an Antisense Peptide-Conjugated Morpholino Oligomer Targeting the Hemagglutinin-Activating Protease TMPRSS2
2010
Functional mapping of disease susceptibility loci using cell biology
2006 StandoutNobel
A model of anthrax toxin lethal factor bound to protective antigen
2005 StandoutNobel
Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members
2001 StandoutNobel
Kininase I-type carboxypeptidases enhance nitric oxide production in endothelial cells by generating bradykinin B1receptor agonists
2003
Angiopoietin-like 4: a decade of research
2011
Calcium depletion blocks proteolytic cleavages of plasma protein precursors which occur at the Golgi and/or trans-Golgi network. Possible involvement of Ca(2+)-dependent Golgi endoproteases.
1992
Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation
2020 StandoutScience
Site-directed mutagenesis and expression of PC2 in microinjected Xenopus oocytes.
1991
Sequence requirements for precursor cleavage within the constitutive secretory pathway.
1992
Ionic milieu controls the compartment-specific activation of pro-opiomelanocortin processing in AtT-20 cells.
1995
Engineering Orthogonal Polypeptide GalNAc-Transferase and UDP-Sugar Pairs
2019 StandoutNobel
The EGL-3 Proprotein Convertase Regulates Mechanosensory Responses ofCaenorhabditis elegans
2001
Prolactin: Structure, Function, and Regulation of Secretion
2000 Standout
Processing of the Ebola virus glycoprotein by the proprotein convertase furin
1998
Activation of human furin precursor processing endoprotease occurs by an intramolecular autoproteolytic cleavage.
1992
Repeated pulses of serotonin required for long-term facilitation activate mitogen-activated protein kinase in sensory neurons of Aplysia
1998 StandoutNobel
Angiotensin-converting enzyme and male fertility
1998 StandoutNobel
Proteolytic processing of Middle East respiratory syndrome coronavirus spikes expands virus tropism
2016
Measurement of cytosolic, mitochondrial, and Golgi pH in single living cells with green fluorescent proteins
1998 StandoutNobel
Expression of mutant ELH prohormones in AtT-20 cells: the relationship between prohormone processing and sorting.
1993
A Novel Coronavirus from Patients with Pneumonia in China, 2019
2020 Standout
Bradykinin B1 and B2 receptors both have protective roles in renal ischemia/reperfusion injury
2007 StandoutNobel
Hypoxic retinal Müller cells promote vascular permeability by HIF-1–dependent up-regulation of angiopoietin-like 4
2013 StandoutNobel
Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response
2009 StandoutNobel
The prohormone convertases PC1 and PC2 mediate distinct endoproteolytic cleavages in a strict temporal order during proopiomelanocortin biosynthetic processing.
1993
Notch Signaling: Cell Fate Control and Signal Integration in Development
1999 StandoutScience
The Notch1 receptor is cleaved constitutively by a furin-like convertase
1998
Mammalian subtilisin/kexin isozyme SKI-1: A widely expressed proprotein convertase with a unique cleavage specificity and cellular localization
1999
Prohormone processing in Xenopus oocytes: characterization of cleavage signals and cleavage enzymes.
1991 StandoutNobel
Proprotein-processing endoproteases PC6 and furin both activate hemagglutinin of virulent avian influenza viruses
1994
Rational Design of Bisphosphonate Lipid-like Materials for mRNA Delivery to the Bone Microenvironment
2022 StandoutNobel
Ghrelin is a growth-hormone-releasing acylated peptide from stomach
1999 StandoutNature
The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade
2020
CalFluors: A Universal Motif for Fluorogenic Azide Probes across the Visible Spectrum
2015 StandoutNobel
E3 ubiquitin ligase Mindbomb 1 facilitates nuclear delivery of adenovirus genomes
2020 StandoutNobel
Deconstructing complexin function in activating and clamping Ca 2+ -triggered exocytosis by comparing knockout and knockdown phenotypes
2013 StandoutNobel
Furin: a mammalian subtilisin/Kex2p-like endoprotease involved in processing of a wide variety of precursor proteins
1997
Chemical Glycoproteomics
2016 StandoutNobel
Neuroendocrine Control of Growth Hormone Secretion
1999
Structure of the catalytic domain of the hepatitis C virus NS2-3 protease
2006 StandoutNatureNobel
Works of Robert Day being referenced
Highly Potent Inhibitors of Proprotein Convertase Furin as Potential Drugs for Treatment of Infectious Diseases
2012
Targeting Host Cell Furin Proprotein Convertases as a Therapeutic Strategy against Bacterial Toxins and Viral Pathogens
2007
Substrate Cleavage Analysis of Furin and Related Proprotein Convertases
2008
Subtilase-like pro-protein convertases: from molecular specificity to therapeutic applications
2000
The family of subtilisin/kexin like pro-protein and pro-hormone convertases: Divergent or shared functions
1994
Mammalian Paired Basic Amino Acid Convertases of Prohormones and Proproteinsa
1993
Autocatalytic Activation of the Furin Zymogen Requires Removal of the Emerging Enzyme's N-Terminus from the Active Site
2009
The Mouse Homeoprotein mLIM-3 Is Expressed Early in Cells Derived from the Neuroepithelium and Persists in Adult Pituitary
1994
Dissection of the Endogenous Cellular Pathways of PCSK9-induced Low Density Lipoprotein Receptor Degradation
2009
Proparathyroid Hormone Is Preferentially Cleaved to Parathyroid Hormone by the Prohormone Convertase Furin
1995
Cutting back on pro-protein convertases: the latest approaches to pharmacological inhibition
2005
Cleavage of a Neuroinvasive Human Respiratory Virus Spike Glycoprotein by Proprotein Convertases Modulates Neurovirulence and Virus Spread within the Central Nervous System
2015
The Posttranslational Processing of Prodynorphin in the Rat Anterior Pituitary*
1989
TACE/ADAM‐17 maturation and activation of sheddase activity require proprotein convertase activity
2003
Cloning and Sequence Analysis of cDNA Encoding Rat Carboxypeptidase D
1997
Neuroendocrine Protein 7B2 Is Essential for Proteolytic Conversion and Activation of Proprotein Convertase 2 in Vivo
1998
Processing Specificity and Biosynthesis of the Drosophila melanogaster Convertases dfurin1, dfurin1-CRR, dfurin1-X, and dfurin2
1995
IDA-1, aCaenorhabditis elegans homolog of the diabetic autoantigens IA-2 and phogrin, is expressed in peptidergic neurons in the worm
2000
Prorenin activation and prohormone convertases in the mouse As4.1 cell line
1997
Region specific expression of furin mRNA in the rat brain
1993
Precursor Convertases: An Evolutionary Ancient, Cell‐Specific, Combinatorial Mechanism Yielding Diverse Bioactive Peptides and Proteins
1998
Proteolytic Processing of Angiopoietin-like Protein 4 by Proprotein Convertases Modulates Its Inhibitory Effects on Lipoprotein Lipase Activity
2011
The distinct gene expression of the pro-hormone convertases in the rat heart suggests potential substrates
1995
Secretory granule biogenesis and chromogranin A: master gene, on/off switch or assembly factor?
2003
Processing of proendothelin‐1 by members of the subtilisin‐like pro‐protein convertase family
2002
Expression of mRNA for somatostatin receptor (sstr) types 2 and 5 in individual rat pituitary cells. A double labeling in situ hybridization analysis.
1995
cDNA structure, tissue distribution, and chromosomal localization of rat PC7, a novel mammalian proprotein convertase closest to yeast kexin-like proteinases.
1996
Distinct mRNA expression of the highly homologous convertases PC5 and PACE4 in the rat brain and pituitary
1995
cDNA structure of the mouse and rat subtilisin/kexin-like PC5: a candidate proprotein convertase expressed in endocrine and nonendocrine cells.
1993
Furin Processing and Proteolytic Activation of Semliki Forest Virus
2003
The family of pro-hormone and pro-protein convertases
1993
Testicular expression of PC4 in the rat: molecular diversity of a novel germ cell-specific Kex2/subtilisin-like proprotein convertase.
1992
Expression of mRNA for somatostatin receptor (sstr) types 2 and 5 in individual rat pituitary cells. A double labeling in situ hybridization analysis
1995
Molecular cloning, functional characterization, and chromosomal localization of a human somatostatin receptor (somatostatin receptor type 5) with preferential affinity for somatostatin-28.
1994
Prohormone Convertase PC5 Is a Candidate Processing Enzyme for Prorenin in the Human Adrenal Cortex
1996
Neuroinvasion by Human Respiratory Coronaviruses
2000
Specific MALDI Imaging and Profiling for Biomarker Hunting and Validation: Fragment of the 11S Proteasome Activator Complex, Reg Alpha Fragment, Is a New Potential Ovary Cancer Biomarker
2007
Modification of Peptide and Protein Cysteine Thiol Groups by Conjugation with a Degradation Product of Ascorbate
2013
Potent Inhibitors of Furin and Furin-like Proprotein Convertases Containing Decarboxylated P1 Arginine Mimetics
2009
Distribution and regulation of the prohormone convertases PC1 and PC2 in the rat pituitary
1992
Gene expression of prohormone and proprotein convertases in the rat CNS: a comparative in situ hybridization analysis
1993
PC1 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues.
1991