Citation Impact
Citing Papers
Activity-Dependent Internalization of Smoothened Mediated by ß-Arrestin 2 and GRK2
2004 StandoutScienceNobel
Identification of a Primary Target of Thalidomide Teratogenicity
2010 StandoutScience
The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins
2013 StandoutScienceNobel
Sonic hedgehogin feather morphogenesis: Induction of mesenchymal condensation and association with cell death
1996
1 Developmental roles and clinical significance of Hedgehog signaling
2003
Cholesterol Modification of Sonic Hedgehog Is Required for Long-Range Signaling Activity and Effective Modulation of Signaling by Ptc1
2001
Direct and continuous assessment by cells of their position in a morphogen gradient
1995 StandoutNatureNobel
Evidence for genetic control of Sonic hedgehog by Gli3 in mouse limb development
1997
The initiation of the limb bud: Growth factors, Hox genes, and retinoids
1995
Fate map of mouse ventral limb ectoderm and the apical ectodermal ridge
2003
The Whereabouts of a Morphogen: Direct Evidence for Short- and Graded Long-Range Activity of Hedgehog Signaling Peptides
2001
Vertebrate limb development
1995
Sonic hedgehog induces the differentiation of ventral forebrain neurons: A common signal for ventral patterning within the neural tube
1995
Dorsal differentiation of neural plate cells induced by BMP-mediated signals from epidermal ectoderm
1995 Standout
Mesodermal patterning by an inducer gradient depends on secondary cell–cell communication
1994
Some distal limb structures develop in mice lacking Sonic hedgehog signaling
2001
Maintenance of functional equivalence during paralogous Hox gene evolution
2000 StandoutNatureNobel
Multiple calvarial defects inlmx1b mutant mice
1998
Hedgehog-Regulated Processing of Gli3 Produces an Anterior/Posterior Repressor Gradient in the Developing Vertebrate Limb
2000 Standout
Induction of motor neurons by Sonic hedgehog is independent of floor plate differentiation
1995
Fgf8 is required for outgrowth and patterning of the limbs
2000 StandoutNobel
Hedgehog Elicits Signal Transduction by Means of a Large Complex Containing the Kinesin-Related Protein Costal2
1997 Nobel
Inhibition of Sonic hedgehog signaling in vivo results in craniofacial neural crest cell death
1999
Somite Differentiation: Sonic signals somites
1995
Sonic Hedgehog (SHH) specifies muscle pattern at tissue and cellular chick level, in the chick limb bud
1999
Hedgehog and Patched in Neural Development and Disease
1998
A molecular approach to the evolution of vertebrate paired appendages
1996
Hedgehog Signalling Is Required for Maintenance of myf5 and myoD Expression and Timely Terminal Differentiation in Zebrafish Adaxial Myogenesis
2001
Developmental basis of limblessness and axial patterning in snakes
1999 Nature
Fin development in a cartilaginous fish and the origin of vertebrate limbs
2002 Nature
Early stages of chick somite development
1995
Control of Muscle Cell-Type Specification in the Zebrafish Embryo by Hedgehog Signalling
1999
Cells’ Perception of Position in a Concentration Gradient
1998 StandoutNobel
A Mammalian patched Homolog Is Expressed in Target Tissues of sonic hedgehog and Maps to a Region Associated with Developmental Abnormalities
1996
Wing development and specification of dorsal cell fates in the absence of apterous in Drosophila
1998
The role of Hox genes during vertebrate limb development
2007
Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless
1998
Fibroblast growth factor receptors (FGFRs) and their roles in limb development
1999
Colocalization of BMP 7 and BMP 2 RNAs suggests that these factors cooperatively mediate tissue interactions during murine development
1995
Limb-patterning activity and restricted posterior localization of the amino-terminal product of Sonic hedgehog cleavage
1995
Temporal and Spatial Effects of Sonic Hedgehog Signaling in Chick Eye Morphogenesis
2001
Indian hedgehog couples chondrogenesis to osteogenesis in endochondral bone development
2001
An Acylatable Residue of Hedgehog Is Differentially Required in Drosophila and Mouse Limb Development
2001
The roles of FGFs in the early development of vertebrate limbs
1998
The long and short of hedgehog signaling
1995
Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function
1996 StandoutNature
Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis
1995
Induction of a specific muscle cell type by a hedgehog-like protein in zebrafish
1996 Nature
The Interpretation of Position in a Morphogen Gradient as Revealed by Occupancy of Activin Receptors
1998 StandoutNobel
The loss of ventral ectoderm identity correlates with the inability to form an AER in the legless hindlimb bud
1998
Sonic hedgehog signaling by the Patched–Smoothened receptor complex
1999
EVOLUTION OF HOX GENES
1994
A role for FGF-8 in the initiation and maintenance of vertebrate limb bud outgrowth
1995
Induction of oligodendrocyte progenitors in the trunk neural tube by ventralizing signals: effects of notochord and floor plate grafts, and of sonic hedgehog
1996
Long-range sclerotome induction by sonic hedgehog: Direct role of the amino-terminal cleavage product and modulation by the cyclic AMP signaling pathway
1995
Biochemical evidence that Patched is the Hedgehog receptor
1996 StandoutNature
The SH2 tyrosine phosphatase Shp2 is required for mammalian limb development
2000
Kinesin-2 controls development and patterning of the vertebrate skeleton by Hedgehog- and Gli3-dependent mechanisms
2007
A freely diffusible form of Sonic hedgehog mediates long-range signalling
2001 Nature
Vertebrate Proteins Related to Drosophila Naked Cuticle Bind Dishevelled and Antagonize Wnt Signaling
2001
Patterning of mammalian somites by surface ectoderm and notochord: Evidence for sclerotome induction by a hedgehog homolog
1994
Dorsoventral patterning of the vertebrate limb: a process governed by multiple events
1999
Vertebrate Homologs of Drosophila Suppressor of Fused Interact with the Gli Family of Transcriptional Regulators
1999
Analysis of Epithelial–Mesenchymal Interactions in the Initial Morphogenesis of the Mammalian Tooth
1998
Hedgehog, the floor plate, and the zone of polarizing activity
1994
Activin signalling and response to a morphogen gradient
1994 StandoutNatureNobel
The role of the notochord and floor plate in inductive interactions
1995
The seven-transmembrane receptor Smoothened cell-autonomously induces multiple ventral cell types
2000
Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord
1994 Standout
Odorant Receptors Govern the Formation of a Precise Topographic Map
1998 StandoutNobel
Ptc1 and Ptc2 Transcripts Provide Distinct Readouts of Hedgehog Signaling Activity during Chick Embryogenesis
2001
Toward a molecular understanding of skeletal development
1995
Expression of genes encoding bone morphogenetic proteins and sonic hedgehog in talpid (ta3) limb buds: Their relationships in the signalling cascade involved in limb patterning
1995
A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos
1993
An autopodial-like pattern of Hox expression in the fins of a basal actinopterygian fish
2007 Nature
Notochord induction of zebrafish slow muscle mediated by Sonic hedgehog
1997
The murine Hoxc cluster contains five neighboring AbdB-related Hox genes that show unique spatially coordinated expression in posterior embryonic subregions
1994
Hedgehog-Mediated Patterning of the Mammalian Embryo Requires Transporter-like Function of Dispatched
2002
BMP4 Plays a Key Role in Left–Right Patterning in Chick Embryos by Maintaining Sonic Hedgehog Asymmetry
2001
Expression pattern of the Tbr2 (Eomesodermin) gene during mouse and chick brain development
1999
Nonredundant Roles of the mPer1 and mPer2 Genes in the Mammalian Circadian Clock
2001
Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation
2001
Constitutive Activation of Sonic Hedgehog Signaling in the Chicken Mutant talpid2: Shh-Independent Outgrowth and Polarizing Activity
1999
Fgf10 is essential for limb and lung formation
1999
Comparative biological responses to human Sonic, Indian, and Desert hedgehog
2001
Control of Neuronal Precursor Proliferation in the Cerebellum by Sonic Hedgehog
1999 Standout
Sonic hedgehogParticipates in Craniofacial Morphogenesis and Is Down-regulated by Teratogenic Doses of Retinoic Acid
1997
Hedgehog signaling in animal development: paradigms and principles
2001 Standout
Sonic hedgehog and Fgf-4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developing limb bud
1994 Standout
Topographically Specific Effects of ELF-1 on Retinal Axon Guidance In Vitro and Retinal Axon Mapping In Vivo
1996
Fibroblast growth factors induce additional limb development from the flank of chick embryos
1995
Segmental expression of Hoxb-1 is controlled by a highly conserved autoregulatory loop dependent upon exd/pbx
1995 StandoutNobel
Limb and kidney defects in Lmx1b mutant mice suggest an involvement of LMX1B in human nail patella syndrome
1998
Identification of Sonic hedgehog as a candidate gene responsible for holoprosencephaly
1996 Standout
Spatial Representation of the Glomerular Map in the Drosophila Protocerebrum
2002 StandoutNobel
A positive feedback loop coordinates growth and patterning in the vertebrate limb
1994 Nature
Control of Cell Pattern in the Neural Tube by the Zinc Finger Transcription Factor and Oncogene Gli-1
1997
Induction of Osteogenic Differentiation by Hedgehog Proteins
1997
A potential catalytic site revealed by the 1.7-Å crystal structure of the amino-terminal signalling domain of Sonic hedgehog
1995 Nature
Induction of the hair growth phase in postnatal mice by localized transient expression of Sonic hedgehog
1999
The evolution of the hedgehog gene family in chordates: insights from amphioxus hedgehog
1999
Dorsalizing signal Wnt-7a required for normal polarity of D–V and A–P axes of mouse limb
1995 StandoutNature
Ectopic expression of Hoxb-8 causes duplication of the ZPA in the forelimb and homeotic transformation of axial structures
1994
Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis
2003 Nature
Wnt3a-/--like phenotype and limb deficiency in Lef1-/-Tcf1-/- mice
1999
Prostate Development Requires Sonic Hedgehog Expressed by the Urogenital Sinus Epithelium
1999
Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog.
1996 Standout
Patterning activities of vertebrate hedgehog proteins in the developing eye and brain
1995
Expression of the Sonic hedgehog (SHH) Gene during Early Human Development and Phenotypic Expression of New Mutations Causing Holoprosencephaly
1999
Limbs: a model for pattern formation within the vertebrate body plan
1996
p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development
1999 StandoutNature
CREB1 Encodes a Nuclear Activator, a Repressor, and a Cytoplasmic Modulator that Form a Regulatory Unit Critical for Long-Term Facilitation
1998 StandoutNobel
Fibroblast Growth Factors as Multifunctional Signaling Factors
1998
An FGF receptor signaling pathway is required for the normal cell migrations of the sex myoblasts in C. elegans hermaphrodites
1995 StandoutNobel
The winged-helix transcription factor HNF-3β is required for notochord development in the mouse embryo
1994
Molecular Models for Vertebrate Limb Development
1997
The mouse Engrailed-1 gene and ventral limb patterning
1996 Nature
The product of hedgehog autoproteolytic cleavage active in local and long-range signalling
1995 Nature
Integration of positional signals and regulation of wing formation and identity by Drosophila vestigial gene
1996 Nature
Problems and paradigms: Morphogens and pattern formation
1997
Are Complex Behaviors Specified by Dedicated Regulatory Genes? Reasoning from Drosophila
2001 StandoutNobel
Induction of dopaminergic neuron phenotype in the midbrain by Sonic hedgehog protein
1995
fringe, a boundary-specific signaling molecule, mediates interactions between dorsal and ventral cells during Drosophila wing development
1994 StandoutNobel
Mutations in the human Sonic Hedgehog gene cause holoprosencephaly
1996 Standout
Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity
1993 Standout
Absence of radius and ulna in mice lacking hoxa-11 andhoxd-11
1995 StandoutNatureNobel
Identification of a Human LMX1 (LMX1.1)-Related Gene, LMX1.2: Tissue-Specific Expression and Linkage Mapping on Chromosome 9
1997
Hox genes in vertebrate development
1994 Standout
A molecular pathway determining left-right asymmetry in chick embryogenesis
1995
Identification of a Palmitic Acid-modified Form of Human Sonic hedgehog
1998 Standout
The TRA-1A Sex Determination Protein of C. elegans Regulates Sexually Dimorphic Cell Deaths by Repressing the egl-1 Cell Death Activator Gene
1999 StandoutNobel
Quantitative effects of hedgehog and decapentaplegic activity on the patterning of the Drosophila wing
1995
Protein Sequence Editing of SKN-1A/Nrf1 by Peptide:N-Glycanase Controls Proteasome Gene Expression
2019 StandoutNobel
The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog
1996 StandoutNature
The T-box transcription factor Tbx15 is required for skeletal development
2004
Drosophila hedgehog acts as a morphogen in cellular patterning
1994
Integration and diversity of the regulatory network composed of Maf and CNC families of transcription factors
2002
Evidence for an Expansion-Based Temporal Shh Gradient in Specifying Vertebrate Digit Identities
2004 Standout
Sonic hedgehog promotes somitic chondrogenesis by altering the cellular response to BMP signaling
1999
Eomesodermin is required for mouse trophoblast development and mesoderm formation
2000 StandoutNatureNobel
Compartment boundaries and the control of Drosopfiffa limb pattern by hedgehog protein
1994 Nature
Gli1 is a target of Sonic hedgehog that induces ventral neural tube development
1997
Roles for FGF8 in the Induction, Initiation, and Maintenance of Chick Limb Development
1996
Fibroblasts expressing Sonic hedgehog induce osteoblast differentiation and ectopic bone formation
1997
Stage-Specific Effects ofSonic HedgehogExpression in the Epidermis
1998
BMP controls proximodistal outgrowth, via induction of the apical ectodermal ridge, and dorsoventral patterning in the vertebrate limb
2001
A class act: conservation of homeodomain protein functions
1994
The Vestigial gene product provides a molecular context for the interpretation of signals during the development of the wing in Drosophila
1999
Sonic hedgehog is an endodermal signal inducing Bmp-4 and Hox genes during induction and regionalization of the chick hindgut
1995
Distinct expression and shared activities of members of the hedgehog gene family of Xenopus laevis
1995
Lhx2, a LIM homeobox gene, is required for eye, forebrain, and definitive erythrocyte development
1997
Combinatorial Gli gene function in floor plate and neuronal inductions by Sonic hedgehog
1998
The hedgehog gene family in Drosophila and vertebrate development
1994
Autoregulation ofShhexpression and Shh induction of cell death suggest a mechanism for modulating polarising activity during chick limb development
2000
Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation
2000 Standout
Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development
1997
β-Arrestin–Mediated Localization of Smoothened to the Primary Cilium
2008 StandoutScienceNobel
Control of somite patterning by Sonic hedgehog and its downstream signal response genes
1998
Normal limb development in conditional mutants of Fgf4
2000 StandoutNobel
Lhx2, a vertebrate homologue of apterous, regulates vertebrate limb outgrowth
1998
Involvement of FGF-8 in initiation, outgrowth and patterning of the vertebrate limb
1996
Expression of Sonic hedgehog and its putative role as a precursor cell mitogen in the developing mouse retina
1997
A duplicated zone of polarizing activity in polydactylous mouse mutants.
1995
How to Make a Limb?
1994 Science
Characterization of two patched receptors for the vertebrate hedgehog protein family
1998
Hox10 and Hox11 Genes Are Required to Globally Pattern the Mammalian Skeleton
2003 StandoutScienceNobel
Protein kinase A is a common negative regulator of Hedgehog signaling in the vertebrate embryo.
1996
Regulation of retinal ganglion cell production by Sonic hedgehog
2001
Hoxa-13 and Hoxd-13 play a crucial role in the patterning of the limb autopod
1995
EctodermalWnt3/β-cateninsignaling is required for the establishment and maintenance of the apical ectodermal ridge
2003 StandoutNobel
Reconstructing the DNA Methylation Maps of the Neandertal and the Denisovan
2014 StandoutScienceNobel
Distribution of Sonic hedgehog peptides in the developing chick and mouse embryo
1995
Proteolytic Processing Yields Two Secreted Forms of Sonic hedgehog
1995
Midline signalling is required for Pax gene regulation and patterning of the eyes
1995
Targeted expression of the signaling molecule decapentaplegic induces pattern duplications and growth alterations in Drosophila wings.
1994
Patterning of the neural ectoderm of Xenopus laevis by the amino-terminal product of hedgehog autoproteolytic cleavage
1995
Distinct WNT Pathways Regulating AER Formation and Dorsoventral Polarity in the Chick Limb Bud
1998 Science
Morphogens, Compartments, and Pattern: Lessons from Drosophila?
1996
Vitronectin regulates Sonic hedgehog activity during cerebellum development through CREB phosphorylation
2001
Relationship between retinoic acid and sonic hedgehog, two polarizing signals in the chick wing bud
1994
Role of dHAND in the anterior-posterior polarization of the limb bud: implications for the Sonic hedgehog pathway
2000
The Caenorhabditis elegans lim-6 LIM homeobox gene regulates neurite outgrowth and function of particular GABAergic neurons
1999 StandoutNobel
The concentric structure of the developing gut is regulated by Sonic hedgehog derived from endodermal epithelium
2000
Control of chick tectum territory along dorsoventral axis by Sonic hedgehog
2000
Analysis of Hoxd-13 and Hoxd-11 misexpression in chick limb buds reveals that Hox genes affect both bone condensation and growth
1997
Autoproteolysis in hedgehog protein biogenesis
1994 Science
Hedgehog Proteins Stimulate Chondrogenic Cell Differentiation and Cartilage Formation
2000
The Taxonomy of Developmental Control in Caenorhabditis elegans
1998 StandoutScienceNobel
A Drosophila CREB/CREM Homolog Encodes Multiple Isoforms, Including a Cyclic AMP-Dependent Protein Kinase-Responsive Transcriptional Activator and Antagonist
1995
Sonic hedgehog is required for survival of both myogenic and chondrogenic somitic lineages
1998
Hox genes and the evolution of vertebrate axial morphology
1995
A Hedgehog activity gradient contributes to AP axial patterning of the Drosophila wing
1997
The limb deformity mutation disrupts the SHH/FGF-4 feedback loop and regulation of 5′ HoxD genes during limb pattern formation
1995
Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways fromDrosophilato vertebrates
2005
Cell fate in the chick limb bud and relationship to gene expression
1997
Expression of ptc and gli genes in talpid 3 suggests bifurcation in Shh pathway*
1999
Sonic Hedgehog Control of Size and Shape in Midbrain Pattern Formation
2001 Science
The cancer connection
2002 StandoutNatureNobel
patched overexpression alters wing disc size and pattern: transcriptional and post-transcriptional effects on hedgehog targets
1995
Sonic Hedgehog induces proliferation of committed skeletal muscle cells in the chick limb
1998
Sonic Hedgehog Promotes Rod Photoreceptor Differentiation in Mammalian Retinal CellsIn Vitro
1997
Regionalization within the mammalian telencephalon is mediated by changes in responsiveness to Sonic Hedgehog
1998
Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction
1998
Relationship between dose, distance and time in Sonic Hedgehog-mediated regulation of anteroposterior polarity in the chick limb
1997
The limb field mesoderm determines initial limb bud anteroposterior asymmetry and budding independent of sonic hedgehog or apical ectodermal gene expressions
1996
hedgehog is required for the proliferation and specification of ovarian somatic cells prior to egg chamber formation in Drosophila
1996
The mesenchymal factor, FGF10, initiates and maintains the outgrowth of the chick limb bud through interaction with FGF8, an apical ectodermal factor
1997
Axial homeosis and appendicular skeleton defects in mice with a targeted disruption of hoxd-11
1994 StandoutNobel
Requirement of 19K form of Sonic hedgehog for induction of distinct ventral cell types in CNS explants
1995 Nature
Formin isoforms are differentially expressed in the mouse embryo and are required for normal expression of gf-4 and shh in the limb bud
1995
Dorsalization of the neural tube by the non-neural ectoderm
1995
A binding site for Gli proteins is essential for HNF-3β floor plate enhancer activity in transgenics and can respond to Shh in vitro
1997
Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins.
1996
Human Homolog of patched , a Candidate Gene for the Basal Cell Nevus Syndrome
1996 StandoutScience
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
1997 StandoutScienceNobel
Conservation in hedgehog signaling: induction of a chicken patched homolog by Sonic hedgehog in the developing limb
1996
Polydactylous limbs in Strong’s Luxoid mice result from ectopic polarizing activity
1995
Regulation of patched by sonic hedgehog in the developing neural tube.
1996 Standout
Synaptic Assembly of the Brain in the Absence of Neurotransmitter Secretion
2000 StandoutScienceNobel
Transient establishment of anteroposterior polarity in the zebrafish pectoral fin bud in the absence of sonic hedgehog activity
1999 Nobel
The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo
1995
Sonic hedgehog signaling is required during the appearance of spinal cord oligodendrocyte precursors
1999
Regulation of Rate of Cartilage Differentiation by Indian Hedgehog and PTH-Related Protein
1996 StandoutScience
Sonic hedgehog controls epaxial muscle determination through Myf5 activation
1999
Diversity and Pattern in the Developing Spinal Cord
1996 Science
BMPR-IA signaling is required for the formation of the apical ectodermal ridge and dorsal-ventral patterning of the limb
2001
Combinatorial signaling by Sonic hedgehog and Wnt family members induces myogenic bHLH gene expression in the somite.
1995
A model for anteroposterior patterning of the vertebrate limb based on sequential long- and short-range Shh signalling and Bmp signalling
2000
A new function of BMP4: dual role for BMP4 in regulation ofSonic hedgehogexpression in the mouse tooth germ
2000
Products, genetic linkage and limb patterning activity of a murine hedgehog gene
1994
Analysis of the genetic pathway leading to formation of ectopic apical ectodermal ridges in mouse Engrailed-1 mutant limbs
1998
Morphogen gradient interpretation
2001 StandoutNatureNobel
Involvement of FGF8 in initiation, outgrowth and patterning of the vertebrate limb
1996
Works of Robert D. Riddle being referenced
Induction of the LIM homeobox gene Lmx1 by WNT6a establishes dorsoventral pattern in the vertebrate limb
1995
Mechanisms of limb patterning
1994
Ectopic expression of Sonic hedgehog alters dorsal-ventral patterning of somites
1994
Structure and regulation of the chicken erythroid δ-aminolevulinate synthase gene
1994
Sonic hedgehog mediates the polarizing activity of the ZPA
1993 Standout
Sonic hedgehog regulates patterning in early embryos.
1996
Expression of delta-aminolevulinate synthase in avian cells: separate genes encode erythroid-specific and nonspecific isozymes.
1989