Standout Papers
Citation Impact
Citing Papers
BdlA, a Chemotaxis Regulator Essential for Biofilm Dispersion in Pseudomonas aeruginosa
2006
Regeneration of misprimed nonribosomal peptide synthetases by type II thioesterases
2002
Iron, manganese, and cobalt transport by Nramp1 (Slc11a1) and Nramp2 (Slc11a2) expressed at the plasma membrane
2003
Interaction of Lipocalin 2, Transferrin, and Siderophores Determines the Replicative Niche of Klebsiella pneumoniae during Pneumonia
2012
Gamma Interferon, Tumor Necrosis Factor Alpha, and Nitric Oxide Synthase 2, Key Elements of Cellular Immunity, Perform Critical Protective Functions during Humoral Defense against Lethal Pulmonary Yersinia pestis Infection
2006
Plague Bacteria Target Immune Cells During Infection
2005 Science
Genome sequence of an industrial microorganism Streptomyces avermitilis : Deducing the ability of producing secondary metabolites
2001 StandoutNobel
Catalytic Mechanism of Cyclic Di-GMP-Specific Phosphodiesterase: a Study of the EAL Domain-Containing RocR from Pseudomonas aeruginosa
2008
Subpolar addition of new cell wall is directed by DivIVA in mycobacteria
2014 StandoutNobel
Salmonella typhimuriumEncodes a Putative Iron Transport System within the Centisome 63 Pathogenicity Island
1999
The role of iron uptake in pathogenicity and symbiosis in Photorhabdus luminescens TT01
2010
PilZ Domain Proteins Bind Cyclic Diguanylate and Regulate Diverse Processes in Vibrio cholerae
2007
Structure of the Cytoplasmic Region of PelD, a Degenerate Diguanylate Cyclase Receptor That Regulates Exopolysaccharide Production in Pseudomonas aeruginosa
2012
Comparative analysis of Klebsiella pneumoniae genomes identifies a phospholipase D family protein as a novel virulence factor
2014
UV Light Potentiates STING (Stimulator of Interferon Genes)-dependent Innate Immune Signaling through Deregulation of ULK1 (Unc51-like Kinase 1)
2015 StandoutNobel
Analysis of Pseudomonas aeruginosa diguanylate cyclases and phosphodiesterases reveals a role for bis-(3′-5′)-cyclic-GMP in virulence
2006
Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality
2009 StandoutNobel
Pathogenicity islands: a molecular toolbox for bacterial virulence
2006
Bacterial zinc uptake and regulators
2005
Role of the GGDEF protein family in Salmonella cellulose biosynthesis and biofilm formation
2004
The structural basis of cyclic diguanylate signal transduction by PilZ domains
2007
Sticky Situations: Key Components That Control Bacterial Surface Attachment
2012
Erwinia carotovora Evf antagonizes the elimination of bacteria in the gut of Drosophila larvae
2006
Plague as a Biological Weapon
2000
The effect of Photorhabdus luminescens (Enterobacteriaceae) on the survival, development, reproduction and behaviour of Caenorhabditis elegans (Nematoda: Rhabditidae)
2006
Cell-Mediated Defense Against Yersinia pestis Infection
2007
Metal-Substituted Protein MRI Contrast Agents Engineered for Enhanced Relaxivity and Ligand Sensitivity
2010 StandoutNobel
Identification of genes involved in the switch between the smooth and rugose phenotypes ofVibrio cholerae
2003
Differential Control of Yersinia pestis Biofilm Formation In Vitro and in the Flea Vector by Two c-di-GMP Diguanylate Cyclases
2011
Genome-wide Transcriptional Profile of Escherichia coli in Response to High Levels of the Second Messenger 3′,5′-Cyclic Diguanylic Acid
2006
Bacterial iron homeostasis
2003 Standout
c-di-GMP is an effective immunomodulator and vaccine adjuvant against pneumococcal infection
2008
Biofilm formation ofKlebsiella pneumoniaeon urethral catheters requires either type 1 or type 3 fimbriae
2012
Plant diversity enhances ecosystem responses to elevated CO2 and nitrogen deposition
2001 Nature
A Polymeric Protein Anchors the Chromosomal Origin/ParB Complex at a Bacterial Cell Pole
2008 StandoutNobel
Identification of a Mycobacterium tuberculosis gene cluster encoding the biosynthetic enzymes for assembly of the virulence-conferring siderophore mycobactin
1998
Pathogenicity islands of virulent bacteria: structure, function and impact on microbial evolution
1997
Current challenges in the development of vaccines for pneumonic plague
2008
Identification of a novel regulatory protein (CsrD) that targets the global regulatory RNAs CsrB and CsrC for degradation by RNase E
2006
Mechanisms of iron import in anthrax
2011
Nutritional immunity: transition metals at the pathogen–host interface
2012 Standout
Lateral gene transfer and the nature of bacterial innovation
2000 StandoutNature
Combinatorial and computational challenges for biocatalyst design
2001 StandoutNatureNobel
The high‐pathogenicity island of Yersinia pseudotuberculosis can be inserted into any of the three chromosomal asn tRNA genes
1998
Yersiniabactin Synthetase
2002
Occurrence of the Yersinia high-pathogenicity island and iron uptake systems in clinical isolates of Klebsiella pneumoniae
2003
Chrysobactin-dependent Iron Acquisition inErwinia chrysanthemi
2002
Dual Detection of Fungal Infections in Drosophila via Recognition of Glucans and Sensing of Virulence Factors
2006 StandoutNobel
Coordinated Cyclic-Di-GMP Repression of Salmonella Motility through YcgR and Cellulose
2012
Exchangeability of N Termini in the Ligand-gated Porins ofEscherichia coli
2001
Allosteric Control of Cyclic di-GMP Signaling
2006
Structure-Guided Reprogramming of Human cGAS Dinucleotide Linkage Specificity
2014 StandoutNobel
Serum‐Induced Iron‐Acquisition Systems and TonB Contribute to Virulence inKlebsiella pneumoniaeCausing Primary Pyogenic Liver Abscess
2008
Recognition of microorganisms and activation of the immune response
2007 StandoutNature
The crystal structure of pneumococcal surface antigen PsaA reveals a metal-binding site and a novel structure for a putative ABC-type binding protein
1998
Protection against experimental bubonic and pneumonic plague by a recombinant capsular F1-V antigen fusion protein vaccine
1998
Cyclic di-guanosine-monophosphate comes of age: a novel secondary messenger involved in modulating cell surface structures in bacteria?
2004
Inactivation of Conserved C. elegans Genes Engages Pathogen- and Xenobiotic-Associated Defenses
2012 StandoutNobel
Genomic Heterogeneity inKlebsiella pneumoniaeStrains Is Associated with Primary Pyogenic Liver Abscess and Metastatic Infection
2005
The structure and inhibition of a GGDEF diguanylate cyclase complexed with (c-di-GMP)2at the active site
2011
Heme acquisition by hemophores
2007
Crystal Structure of the Iron-dependent Regulator (IdeR) from Mycobacteriumtuberculosis Shows Both Metal Binding Sites Fully Occupied
1999
Salicylate Biosynthesis in Pseudomonas aeruginosa
2002
c-di-GMP Turn-Over in Clostridium difficile Is Controlled by a Plethora of Diguanylate Cyclases and Phosphodiesterases
2011
TheyddV-dosoperon controls biofilm formation through the regulation of genes encoding curli fibers' subunits in aerobically growingEscherichia coli
2010
MICROBIAL IRON TRANSPORT
1994
The Human/Animal Interface: Emergence and Resurgence of Zoonotic Infectious Diseases
2007
Biofilm formation at the air–liquid interface by the Pseudomonas fluorescens SBW25 wrinkly spreader requires an acetylated form of cellulose
2003
Genetic analysis of two phosphodiesterases reveals cyclic diguanylate regulation of virulence factors in Dickeya dadantii
2010
Molecular Insights into the Biosynthesis of Guadinomine: A Type III Secretion System Inhibitor
2012 StandoutNobel
Identification and Characterization of a Cyclic di-GMP-specific Phosphodiesterase and Its Allosteric Control by GTP
2005
Assembly of aryl‐capped siderophores by modular peptide synthetases and polyketide synthases
2000
The dhb Operon of Bacillus subtilisEncodes the Biosynthetic Template for the Catecholic Siderophore 2,3-Dihydroxybenzoate-Glycine-Threonine Trimeric Ester Bacillibactin
2001
C‐di‐GMP: the dawning of a novel bacterial signalling system
2005
Ferri‐bacillibactin uptake and hydrolysis in Bacillus subtilis
2006
The RNA binding protein CsrA controls cyclic di‐GMP metabolism by directly regulating the expression of GGDEF proteins
2008
Environmental factors influence the production of enterobactin, salmochelin, aerobactin, and yersiniabactin in Escherichia coli strain Nissle 1917
2006
A cyclic‐di‐GMP receptor required for bacterial exopolysaccharide production
2007
Bacterial ATP-driven transporters of transition metals: physiological roles, mechanisms of action, and roles in bacterial virulence
2011
The biosynthesis, molecular genetics and enzymology of the polyketide-derived metabolites
2005
The specificity-conferring code of adenylation domains in nonribosomal peptide synthetases
1999
The Pks13/FadD32 Crosstalk for the Biosynthesis of Mycolic Acids in Mycobacterium tuberculosis
2009
Mechanisms of major histocompatibility complex class II‐restricted processing and presentation of the V antigen of Yersinia pestis
2006
3′,5′-Cyclic diguanylic acid (c-di-GMP) inhibits basal and growth factor-stimulated human colon cancer cell proliferation
2005
Novel domains of the prokaryotic two-component signal transduction systems
2001
Organocatalytic Enantioselective Decarboxylative Aldol Reaction of Malonic Acid Half Thioesters with Aldehydes
2013 StandoutNobel
Emerging themes in manganese transport, biochemistry and pathogenesis in bacteria
2003
Evaluation of the Role of theYersinia pestisPlasminogen Activator and Other Plasmid‐Encoded Factors in Temperature‐Dependent Blockage of the Flea
1998
Functional domains of theEscherichia coli ferric uptake regulator protein (Fur)
1995
YopH of Yersinia pseudotuberculosis interrupts early phosphotyrosine signalling associated with phagocytosis
1996
Stat 4 but not Stat 6 mediated immune mechanisms are essential in protection against plague
2004
PchR‐box recognition by the AraC‐type regulator PchR of Pseudomonas aeruginosa requires the siderophore pyochelin as an effector
2005
Targeting of LcrV virulence protein from Yersinia pestis to dendritic cells protects mice against pneumonic plague
2010 StandoutNobel
Output Targets and Transcriptional Regulation by a Cyclic Dimeric GMP-Responsive Circuit in the Vibrio parahaemolyticus Scr Network
2011
The plasmid‐encoded Yop2b protein of Yersinia pseudotuberculosis is a virulence determinant regulated by calcium and temperature at the level of transcription
1988
Cyclic di-GMP is Essential for the Survival of the Lyme Disease Spirochete in Ticks
2011
Bacterial Birth Scar Proteins Mark Future Flagellum Assembly Site
2006
A global synthesis reveals biodiversity loss as a major driver of ecosystem change
2012 StandoutNature
Cloning and Characterization of an Iron Regulated Locus, IroA, in salmonella enterica Serovar Choleraesuis
2002
Small-molecule inhibition of siderophore biosynthesis in Mycobacterium tuberculosis and Yersinia pestis
2005
Plague bacteria biofilm blocks food intake
2002 Nature
Plant pathogens and integrated defence responses to infection
2001 StandoutNature
Cyclic Di-GMP Phosphodiesterases RmdA and RmdB Are Involved in Regulating Colony Morphology and Development in Streptomyces coelicolor
2012
Iron Storage in Bacteria
1998
Inhibition of aryl acid adenylation domains involved in bacterial siderophore synthesis
2005
Cell cycle-dependent dynamic localization of a bacterial response regulator with a novel di-guanylate cyclase output domain
2004
Aminoglycoside antibiotics induce bacterial biofilm formation
2005 Nature
Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron
2004 StandoutNature
Iron and Oxidative Stress in Bacteria
2000
A census of membrane-bound and intracellular signal transduction proteins in bacteria: Bacterial IQ, extroverts and introverts
2005
The Plasmid-Encoded Outer-Membrane Proteins of Yersinia pestis
1988
Cyclic di‐GMP, an established secondary messenger still speeding up
2011
Immune responses to V antigen of Yersinia pestis co-encapsulated with IFN-$gamma;: effect of dose and formulation
1998
The surface‐located YopN protein is involved in calcium signal transduction in Yersinia pseudotuberculosis
1991
Plague
2007
The challenge of emerging and re-emerging infectious diseases
2004 StandoutNature
Serotypes, Hemagglutinins, Siderophore Synthesis, and Serum Resistance of Klebsiella Isolates Causing Human Urinary Tract Infections
1993
Determination of the virulence of the pigmentation-deficient and pigmentation-/plasminogen activator-deficient strains of Yersinia pestis in non-human primate and mouse models of pneumonic plague
2002
The EAL Domain Protein VieA Is a Cyclic Diguanylate Phosphodiesterase
2005
A Molecular Mechanism for Bacterial Susceptibility to Zinc
2011
Phosphorylation-Independent Regulation of the Diguanylate Cyclase WspR
2008
Iron uptake mechanisms of pathogenic bacteria
1993
Characterization of the rdar morphotype, a multicellular behaviour in Enterobacteriaceae
2005
Heme binding by a bacterial repressor protein, the gene product of the ferric uptake regulation (fur) gene ofEscherichia coli
1996
SREA is involved in regulation of siderophore biosynthesis, utilization and uptake in Aspergillus nidulans
2001
TheYersiniahigh-pathogenicity island is present in different members of the familyEnterobacteriaceae
2000
Yersinia enterocolitica Infection with Multiple Liver Abscesses Uncovering a Primary Hemochromatosis
2001
Molecular mechanism of YbtA-mediated transcriptional regulation of divergent overlapping promotersybtAandirp6ofYersinia enterocolitica
2005
The biosynthetic gene cluster for the antitumor drug bleomycin from Streptomyces verticillus ATCC15003 supporting functional interactions between nonribosomal peptide synthetases and a polyketide synthase
2000
Pseudomonas aeruginosa cupA ‐encoded fimbriae expression is regulated by a GGDEF and EAL domain‐dependent modulation of the intracellular level of cyclic diguanylate
2007
Helicobacter pyloriInfection
2002 Standout
Incidence of plague associated with increased winter-spring precipitation in New Mexico.
1999
Cyclic‐di‐GMP‐mediated signalling within the σS network of Escherichia coli
2006
Inhibition of Biological Activities of the Aerobactin Receptor Protein in Rough Strains of Escherichia coli by Polyclonal Antiserum Raised against Native Protein
1989
Virulence factors of Yersinia pestis are overcome by a strong lipopolysaccharide response
2006
Design and Testing for a Nontagged F1‐V Fusion Protein as Vaccine Antigen against Bubonic and Pneumonic Plague
2005
Post-translational regulation of Lcr plasmid-mediated peptides in pesticinogenic Yersinia pestis
1987
Binding of the Fur (ferric uptake regulator) repressor of Escherichia coli to arrays of the GATAAT sequence
1998
System for the expression of recombinant hemoproteins in Escherichia coli
2004
Phosphate‐dependent modulation of c‐di‐GMP levels regulates Pseudomonas fluorescens Pf0‐1 biofilm formation by controlling secretion of the adhesin LapA
2006
Second messenger signalling governs Escherichia coli biofilm induction upon ribosomal stress
2009
Broad T cell immunity to the LcrV virulence protein is induced by targeted delivery to DEC‐205/CD205‐positive mouse dendritic cells
2007 StandoutNobel
Novel Anion-independent Iron Coordination by Members of a Third Class of Bacterial Periplasmic Ferric Ion-binding Proteins
2004
Regulation by Ca2+ in the Yersinia low‐Ca2+ response
1993
Emerging strategies in microbial haem capture
2001
Nutritional immunity beyond iron: a role for manganese and zinc
2009
Vaccination against bubonic and pneumonic plague
2001
The role of c-di-GMP signaling in anAeromonas veroniibiovarsobriastrain
2007
Discrete Cyclic di-GMP-Dependent Control of Bacterial Predation versus Axenic Growth in Bdellovibrio bacteriovorus
2012
Zinc uptake by Streptococcus pneumoniae depends on both AdcA and AdcAII and is essential for normal bacterial morphology and virulence
2011
Complex c-di-GMP Signaling Networks Mediate Transition between Virulence Properties and Biofilm Formation in Salmonella enterica Serovar Typhimurium
2011
Structural and mechanistic determinants of c-di-GMP signalling
2009
Transmission of Yersinia pestis from an Infectious Biofilm in the Flea Vector
2004
Analysis of FimX, a phosphodiesterase that governs twitching motility in Pseudomonas aeruginosa
2006
Complete genome sequence of the entomopathogenic and metabolically versatile soil bacterium Pseudomonas entomophila
2006
HD‐GYP domain proteins regulate biofilm formation and virulence in Pseudomonas aeruginosa
2008
The Yersinia yop regulon
1989
Virulence of pPst+ and pPst- strains of Yersinia pestis for guinea-pigs
1996
Principles of c-di-GMP signalling in bacteria
2009
Transcriptional regulation of high pathogenicity island iron uptake genes by YbtA
2005
Allosteric activation of exopolysaccharide synthesis through cyclic di‐GMP‐stimulated protein–protein interaction
2012
Subtraction hybridisation and shot-gun sequencing: a new approach to identify symbiotic loci
1994 StandoutNobel
Design and Synthesis ofbis-carbamate Analogs of Cyclicbis-(3′-5′)-Diguanylic Acid (c-di-GMP) and the Acyclic Dimer PGPG
2008
Cyclic di-GMP as a second messenger
2006
Co‐regulation of Xanthomonas campestris virulence by quorum sensing and a novel two‐component regulatory system RavS/RavR
2009
Pathogenicity Islands: Bacterial Evolution in Quantum Leaps
1996
Pathogen Recognition and Innate Immunity
2006 Standout
Crystal Structures of YkuI and Its Complex with Second Messenger Cyclic Di-GMP Suggest Catalytic Mechanism of Phosphodiester Bond Cleavage by EAL Domains
2009
The high-pathogenicity island: an iron-uptake island
2001
Metal ion acquisition in Staphylococcus aureus: overcoming nutritional immunity
2011
The virulence protein Yop5 of Yersinia pseudotuberculosis is regulated at transcriptional level by plasmid‐plB1 ‐encoded trans‐acting elements controlled by temperature and calcium
1988
Structural Insight into the Mechanism of c-di-GMP Hydrolysis by EAL Domain Phosphodiesterases
2010
Cyclic diguanylate turnover mediated by the sole GGDEF/EAL response regulator in Pseudomonas putida : its role in the rhizosphere and an analysis of its target processes
2011
PILZ Protein Structure and Interactions with PILB and the FIMX EAL Domain: Implications for Control of Type IV Pilus Biogenesis
2009
Yersinia pestis , the cause of plague, is a recently emerged clone of Yersinia pseudotuberculosis
1999 Standout
Yersinia pestisV Protein Epitopes Recognized by CD4 T Cells
2005
Cell-Mediated Protection against PulmonaryYersinia pestisInfection
2005
Structural organization of microcystin biosynthesis in Microcystis aeruginosa PCC7806: an integrated peptide–polyketide synthetase system
2000
Practice Guidelines for the Diagnosis and Management of Skin and Soft Tissue Infections: 2014 Update by the Infectious Diseases Society of America
2014 Standout
Translocation of Helicobacter pylori CagA into Gastric Epithelial Cells by Type IV Secretion
2000 StandoutScience
Harnessing the Biosynthetic Code: Combinations, Permutations, and Mutations
1998 Science
Cyclic Diguanylate Inversely Regulates Motility and Aggregation in Clostridium difficile
2012
The Bacterial Second Messenger cdiGMP Exhibits Promising Activity as a Mucosal Adjuvant
2007
BifA, a Cyclic-Di-GMP Phosphodiesterase, Inversely Regulates Biofilm Formation and Swarming Motility byPseudomonas aeruginosaPA14
2007
Passive immunity to yersiniae mediated by anti-recombinant V antigen and protein A-V antigen fusion peptide
1994
Bacterial c-di-GMP Is an Immunostimulatory Molecule
2007
Structure and regulation of the Yersinia pestis yscBCDEF operon
1992
Ribosomal Synthesis of N-Methyl Peptides
2008 StandoutNobel
DgrA is a member of a new family of cyclic diguanosine monophosphate receptors and controls flagellar motor function in Caulobacter crescentus
2007
Control of Formation and Cellular Detachment from Shewanella oneidensis MR-1 Biofilms by Cyclic di-GMP
2006
BordetellaAlcS Transporter Functions in Alcaligin Siderophore Export and Is Central to Inducer Sensing in Positive Regulation of Alcaligin System Gene Expression
2005
Role of Cyclic Di-GMP during El Tor Biotype Vibrio cholerae Infection: Characterization of the In Vivo-Induced Cyclic Di-GMP Phosphodiesterase CdpA
2008
c-di-GMP (3′-5′-Cyclic Diguanylic Acid) Inhibits Staphylococcus aureus Cell-Cell Interactions and Biofilm Formation
2005
In Vitro Reconstitution of the Pseudomonas aeruginosa Nonribosomal Peptide Synthesis of Pyochelin: Characterization of Backbone Tailoring Thiazoline Reductase and N-Methyltransferase Activities
2001
YopB and YopD constitute a novel class of Yersinia Yop proteins
1993
Assembly-Line Enzymology for Polyketide and Nonribosomal Peptide Antibiotics: Logic, Machinery, and Mechanisms
2006
The structure–function relationship of WspR, a Pseudomonas fluorescens response regulator with a GGDEF output domain
2007
The diguanylate cyclase YddV controls production of the exopolysaccharide poly-N-acetylglucosamine (PNAG) through regulation of the PNAG biosynthetic pgaABCD operon
2010
Yops of Yersinia spp. pathogenic for humans
1993
Role of MrkJ, a Phosphodiesterase, in Type 3 Fimbrial Expression and Biofilm Formation in Klebsiella pneumoniae
2010
Bacterial scaffold directs pole-specific centromere segregation
2014 StandoutNobel
Export of the siderophore enterobactin in Escherichia coli: involvement of a 43 kDa membrane exporter
2002
Impact of regional climate change on human health
2005 StandoutNature
Cyclic Di-GMP Stimulates Protective Innate Immunity in Bacterial Pneumonia
2007
Vaccination with Live Yersinia pestis Primes CD4 and CD8 T Cells That Synergistically Protect against Lethal Pulmonary Y. pestis Infection
2006
SirR, a Novel Iron-Dependent Repressor in Staphylococcus epidermidis
1998
Differential effects of deletions in lcrV on secretion of V antigen, regulation of the low-Ca2+ response, and virulence of Yersinia pestis
1995
Identification of an ABC Transporter Required for Iron Acquisition and Virulence inMycobacterium tuberculosis
2005
Development of rRNA-Targeted PCR and In Situ Hybridization with Fluorescently Labelled Oligonucleotides for Detection of Yersinia Species
1998
Depolymerization of β-1,6-N-Acetyl-d -Glucosamine Disrupts the Integrity of Diverse Bacterial Biofilms
2004
SitABCD Is the Alkaline Mn2+Transporter ofSalmonella entericaSerovar Typhimurium
2002
Multiple effects of lcrD mutations in Yersinia pestis
1993
Role of EAL-Containing Proteins in Multicellular Behavior ofSalmonella entericaSerovar Typhimurium
2007
Hierarchical involvement of various GGDEF domain proteins in rdar morphotype development of Salmonella enterica serovar Typhimurium
2006
Allosteric Control of Cyclic di-GMP Signaling
2006
Biosynthesis of Nonribosomal Peptides
2004
The 102-KilobasepgmLocus ofYersinia pestis: Sequence Analysis and Comparison of Selected Regions among DifferentYersinia pestisandYersinia pseudotuberculosisStrains
1999
Identification of a pathogenicity island required for Salmonella survival in host cells.
1996
cag , a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors
1996 Standout
GGDEF and EAL domains inversely regulate cyclic di‐GMP levels and transition from sessility to motility
2004
Differential clearance and host-pathogen interactions of YopE- and YopK- YopL- Yersinia pestis in BALB/c mice
1989
lbtAandlbtBAre Required for Production of theLegionella pneumophilaSiderophore Legiobactin
2006
The Cyclic-di-GMP Phosphodiesterase BinA Negatively Regulates Cellulose-Containing Biofilms inVibrio fischeri
2010
The Hidden World within Plants: Ecological and Evolutionary Considerations for Defining Functioning of Microbial Endophytes
2015 Standout
Quantification of high-specificity cyclic diguanylate signaling
2012
Suppression of cytokines in mice by protein A-V antigen fusion peptide and restoration of synthesis by active immunization
1995
Cyclic di-GMP Signaling Regulates Invasion by Ehrlichia chaffeensis of Human Monocytes
2010
The Phosphodiesterase DipA (PA5017) Is Essential for Pseudomonas aeruginosa Biofilm Dispersion
2012
Active immunization with recombinant V antigen from Yersinia pestis protects mice against plague
1995
Cyclic‐diGMP signal transduction systems in Vibrio cholerae: modulation of rugosity and biofilm formation
2006
Yersinia pestis YopM: thrombin binding and overexpression
1992
VirG, a Yersinia enterocolitica lipoprotein involved in Ca2+ dependency, is related to exsB of Pseudomonas aeruginosa
1995
Plague pandemics investigated by ribotyping of Yersinia pestis strains
1994
Aerobactin, but Not Yersiniabactin, Salmochelin, or Enterobactin, Enables the Growth/Survival of Hypervirulent (Hypermucoviscous) Klebsiella pneumoniae Ex Vivo and In Vivo
2015
Characterization of the Poly-β-1,6- N -Acetylglucosamine Polysaccharide Component of Burkholderia Biofilms
2011
Analysis of the V antigen lcrGVH-yopBD operon of Yersinia pseudotuberculosis: evidence for a regulatory role of LcrH and LcrV
1991
PchC Thioesterase Optimizes Nonribosomal Biosynthesis of the Peptide Siderophore Pyochelin in Pseudomonas aeruginosa
2004
Genetic analysis of the yopE region of Yersinia spp.: identification of a novel conserved locus, yerA, regulating yopE expression
1990
Genetic reductionist approach for dissecting individual roles of GGDEF proteins within the c-di-GMP signaling network in Salmonella
2009
ROS-based lethality of Caenorhabditis elegans mitochondrial electron transport mutants grown on Escherichia coli siderophore iron release mutants
2019 StandoutNobel
Klebsiella pneumoniae: Going on the Offense with a Strong Defense
2016 Standout
V antigen-polyhistidine fusion peptide: binding to LcrH and active immunity against plague
1996
Comparable T helper 1 (Th1) and CD8 T-cell immunity by targeting HIV gag p24 to CD8 dendritic cells within antibodies to Langerin, DEC205, and Clec9A
2011 StandoutNobel
Klebsiella pneumoniae Yersiniabactin Promotes Respiratory Tract Infection through Evasion of Lipocalin 2
2011
Yersinia pestis LcrV forms a stable complex with LcrG and may have a secretion-related regulatory role in the low-Ca2+ response
1997
Role of Fraction 1 Antigen ofYersinia pestisin Inhibition of Phagocytosis
2002
Antibacterial Effect of the Scandium and Indium Complexes of Enterochelin on Escherichia coli
1982
Biofilm infections, their resilience to therapy and innovative treatment strategies
2012
Mechanisms of Cyclic-di-GMP Signaling in Bacteria
2006
LcrD, a membrane-bound regulator of the Yersinia pestis low-calcium response
1991
lcrR, a low-Ca2(+)-response locus with dual Ca2(+)-dependent functions in Yersinia pestis
1990
Yersinia enterocolitica, a Primary Model for Bacterial Invasiveness
1987
Modulation of Pseudomonas aeruginosa Biofilm Dispersal by a Cyclic-Di-GMP Phosphodiesterase with a Putative Hypoxia-Sensing Domain
2010
Adaptive Divergence in Experimental Populations ofPseudomonas fluorescens. II. Role of the GGDEF Regulator WspR in Evolution and Development of the Wrinkly Spreader Phenotype
2006
Biofilm formation by the small colony variant phenotype of Pseudomonas aeruginosa
2004
ideR , an Essential Gene in Mycobacterium tuberculosis : Role of IdeR in Iron-Dependent Gene Expression, Iron Metabolism, and Oxidative Stress Response
2002
lcrH, a gene necessary for virulence of Yersinia pestis and for the normal response of Y. pestis to ATP and calcium
1989
Effect of Salmonella typhimurium ferric uptake regulator (fur) mutations on iron- and pH-regulated protein synthesis
1992
HrpI of Erwinia amylovora functions in secretion of harpin and is a member of a new protein family
1993
Correlation of the virulence of Klebsiella pneumoniae K1 and K2 with the presence of a plasmid encoding aerobactin
1986
The pgaABCD Locus of Escherichia coli Promotes the Synthesis of a Polysaccharide Adhesin Required for Biofilm Formation
2004
Bacillus anthracis requires siderophore biosynthesis for growth in macrophages and mouse virulence
2004
Identification of additional virulence determinants on the pYV plasmid of Yersinia enterocolitica W227
1989
Antimicrobial resistance of Staphylococcus aureus: genetic basis
1987
Assembly of the Pseudomonas aeruginosa Nonribosomal Peptide Siderophore Pyochelin: In Vitro Reconstitution of Aryl-4,2-bisthiazoline Synthetase Activity from PchD, PchE, and PchF
1999
Role of the FeoB Protein and Siderophore in Promoting Virulence ofXanthomonas oryzaepv. oryzae on Rice
2010
Exposure of Salmonella enterica Serovar Typhimurium to a Protective Monoclonal IgA Triggers Exopolysaccharide Production via a Diguanylate Cyclase-Dependent Pathway
2012
Ribosomal Synthesis of Dehydroalanine-Containing Peptides
2006 StandoutNobel
High-Resolution Crystal Structure of Manganese Peroxidase: Substrate and Inhibitor Complexes,
2005
Determination of genome size, macrorestriction pattern polymorphism, and nonpigmentation-specific deletion in Yersinia pestis by pulsed-field gel electrophoresis
1992
Expression of the temperature-inducible outer membrane proteins of yersiniae
1985
Cyclic di-GMP: the First 25 Years of a Universal Bacterial Second Messenger
2013 Standout
The aerobactin iron transport system genes in Shigella flexneri are present within a pathogenicity island
1999
Two Zinc Uptake Systems Contribute to the Full Virulence of Listeria monocytogenes during Growth In Vitro and In Vivo
2011
Emerging and re-emerging infectious diseases
2002
Association between virulence of Yersinia pestis and suppression of gamma interferon and tumor necrosis factor alpha
1993
Expression of antigens encoded by the virulence plasmid of Yersinia enterocolitica under different growth conditions
1985
The Manganese Transporter MntH Is a Critical Virulence Determinant forBrucella abortus2308 in Experimentally Infected Mice
2009
Identification and mapping of the temperature-inducible, plasmid-encoded proteins of Yersinia spp
1988
CdpA Is a Burkholderia pseudomallei Cyclic di-GMP Phosphodiesterase Involved in Autoaggregation, Flagellum Synthesis, Motility, Biofilm Formation, Cell Invasion, and Cytotoxicity
2010
Transcriptional Activation of Bordetella Alcaligin Siderophore Genes Requires the AlcR Regulator with Alcaligin as Inducer
2001
Siderophore-Based Iron Acquisition and Pathogen Control
2007 Standout
Iron Metabolism in Pathogenic Bacteria
2000
Virulence plasmid-encoded YopK is essential for Yersinia pseudotuberculosis to cause systemic infection in mice
1995
Functional analysis of yersiniabactin transport genes of Yersinia enterocolitica
2001
Status of YopM and YopN in the Yersinia Yop virulon: YopM of Y.enterocolitica is internalized inside the cytosol of PU5-1.8 macrophages by the YopB, D, N delivery apparatus.
1996
The Crisis in Antibiotic Resistance
1992 StandoutScience
Yersinia V–Antigen Exploits Toll-like Receptor 2 and CD14 for Interleukin 10–mediated Immunosuppression
2002
Analysis of the boundaries of Salmonella pathogenicity island 2 and the corresponding chromosomal region of Escherichia coli K-12
1997
Mutations in yscC, yscD, and yscG prevent high-level expression and secretion of V antigen and Yops in Yersinia pestis
1995
Sortases and the Art of Anchoring Proteins to the Envelopes of Gram-Positive Bacteria
2006
Identification of Small Molecules That Antagonize Diguanylate Cyclase Enzymes To Inhibit Biofilm Formation
2012
Cyclic Diguanylate Regulates Vibrio cholerae Virulence Gene Expression
2005
Excision of large DNA regions termed pathogenicity islands from tRNA-specific loci in the chromosome of an Escherichia coli wild-type pathogen
1994
Survival of a bacterioferritin deletion mutant of Brucella melitensis 16M in human monocyte-derived macrophages
1997
A low-Ca2+ response (LCR) secretion (ysc) locus lies within the lcrB region of the LCR plasmid in Yersinia pestis
1994
Antitubercular Nucleosides That Inhibit Siderophore Biosynthesis: SAR of the Glycosyl Domain
2006
Autolysis and Autoaggregation in Pseudomonas aeruginosa Colony Morphology Mutants
2002
3′,5′-Cyclic Diguanylic Acid Reduces the Virulence of Biofilm-Forming Staphylococcus aureus Strains in a Mouse Model of Mastitis Infection
2005
Roles of Cyclic Diguanylate in the Regulation of Bacterial Pathogenesis
2007
Role of iron in regulation of virulence genes
1993
Helicobacter pylori Adhesin Binding Fucosylated Histo-Blood Group Antigens Revealed by Retagging
1998 StandoutScience
The Host Defense of Drosophila melanogaster
2007 StandoutNobel
Type III Protein Secretion Systems in Bacterial Pathogens of Animals and Plants
1998 Standout
Characterization of common virulence plasmids in Yersinia species and their role in the expression of outer membrane proteins
1984
An IgG1 titre to the F1 and V antigens correlates with protection against plague in the mouse model
1999
Naturally occurring deletions in the centisome 63 pathogenicity island of environmental isolates of Salmonella spp
1997
Meat consumption, health, and the environment
2018 StandoutScience
Nitric Oxide Signaling inPseudomonas aeruginosaBiofilms Mediates Phosphodiesterase Activity, Decreased Cyclic Di-GMP Levels, and Enhanced Dispersal
2009
Helicobacter pylori Virulence and Genetic Geography
1999 StandoutScience
A full-length bifunctional protein involved in c-di-GMP turnover is required for long-term survival under nutrient starvation in Mycobacterium smegmatis
2012
The salicylate-derived mycobactin siderophores of Mycobacterium tuberculosis are essential for growth in macrophages
2000
Salicylate Biosynthesis: Overexpression, Purification, and Characterization of Irp9, a Bifunctional Salicylate Synthase fromYersinia enterocolitica
2005
Yersinia pseudotuberculosis inhibits Fc receptor-mediated phagocytosis in J774 cells
1995
Identification of a virulence locus encoding a second type III secretion system in Salmonella typhimurium.
1996
Cyclic di-GMP as a bacterial second messenger
2004
Integration of Cyclic di-GMP and Quorum Sensing in the Control of vpsT and aphA in Vibrio cholerae
2011
Cyclic di-nucleotide signaling enters the eukaryote domain
2013
Vibrio parahaemolyticusScrC Modulates Cyclic Dimeric GMP Regulation of Gene Expression Relevant to Growth on Surfaces
2007
Dendritic cell targeted HIV gag protein vaccine provides help to a DNA vaccine including mobilization of protective CD8 + T cells
2010 StandoutNobel
Transition Metal Homeostasis
2009
Lipidomics reveals control of Mycobacterium tuberculosis virulence lipids via metabolic coupling
2007 StandoutNobel
Bacterial Iron Sources: From Siderophores to Hemophores
2004
Invasin production by Yersinia pestis is abolished by insertion of an IS200-like element within the inv gene
1996
Localized Protein Interaction Surfaces on the EntB Carrier Protein Revealed by Combinatorial Mutagenesis and Selection
2006
The putative iron transport system SitABCD encoded on SPI1 is required for full virulence of Salmonella typhimurium
2000
Prevailing Concepts of c-di-GMP Signaling
2009
In Vitro Characterization of Salmochelin and Enterobactin Trilactone Hydrolases IroD, IroE, and Fes
2005
Signal transduction and transcriptional and posttranscriptional control of iron-regulated genes in bacteria
1997
Yersiniabactin Is a Virulence Factor for Klebsiella pneumoniae during Pulmonary Infection
2007
CsrA post‐transcriptionally represses pgaABCD, responsible for synthesis of a biofilm polysaccharide adhesin of Escherichia coli
2005
Structural Basis for Double-Stranded RNA Processing by Dicer
2006 StandoutScienceNobel
LcrG, a secreted protein involved in negative regulation of the low-calcium response in Yersinia pestis
1993
Mechanistic and inhibition studies of chorismate-utilizing enzymes
2005
PilZ domain is part of the bacterial c-di-GMP binding protein
2005
Molecular analysis of lcrGVH, the V antigen operon of Yersinia pestis
1989
The Functional Role of a Conserved Loop in EAL Domain-Based Cyclic di-GMP-Specific Phosphodiesterase
2009
Genetics and Assembly Line Enzymology of Siderophore Biosynthesis in Bacteria
2002
Factors promoting acute and chronic diseases caused by yersiniae
1991
YopM inhibits platelet aggregation and is necessary for virulence of Yersinia pestis in mice
1990
Aerobactin Mediates Virulence and Accounts for Increased Siderophore Production under Iron-Limiting Conditions by Hypervirulent (Hypermucoviscous) Klebsiella pneumoniae
2014
Structural Classification of Bacterial Response Regulators: Diversity of Output Domains and Domain Combinations
2006
Cadmium resistance from Staphylococcus aureus plasmid pI258 cadA gene results from a cadmium-efflux ATPase.
1989
Characterization of starvation‐induced dispersion in Pseudomonas putida biofilms
2005
A method for direct cloning of Fur-regulated genes: identification of seven new Fur-regulated loci in Escherichia coli
2000
Caenorhabditis elegans responses to bacteria from its natural habitats
2016 StandoutNobel
Genetically manipulated virulence of Yersinia enterocolitica
1984
Get the Message Out: Cyclic-Di-GMP Regulates Multiple Levels of Flagellum-Based Motility
2007
Opening the Iron Box: Transcriptional Metalloregulation by the Fur Protein
1999
N-Acetylglucosamine-dependent biofilm formation in Pectobacterium atrosepticum is cryptic and activated by elevated c-di-GMP levels
2011
The yopM gene of Yersinia pestis encodes a released protein having homology with the human platelet surface protein GPIb alpha
1989
Genome Sequence of an Obligate Intracellular Pathogen of Humans: Chlamydia trachomatis
1998 StandoutScience
A CsgD-Independent Pathway for Cellulose Production and Biofilm Formation inEscherichia coli
2006
ScrG, a GGDEF-EAL Protein, Participates in Regulating Swarming and Sticking inVibrio parahaemolyticus
2007
Genetic Organization of the Region Encoding Regulation, Biosynthesis, and Transport of Rhizobactin 1021, a Siderophore Produced by Sinorhizobium meliloti
2001
Brucella melitensis Cyclic di-GMP Phosphodiesterase BpdA Controls Expression of Flagellar Genes
2011
YERSINIA OUTER PROTEINS: Role in Modulation of Host Cell Signaling Responses and Pathogenesis
2005
Yersinia pseudotuberculosis mntH functions in intracellular manganese accumulation, which is essential for virulence and survival in cells expressing functional Nramp1
2010
Works of Robert D. Perry being referenced
Replication of Yersinia pestis in interferon γ-activated macrophages requires ripA , a gene encoded in the pigmentation locus
2005
The hmu locus of Yersinia pestis is essential for utilization of free haemin and haem‐protein complexes as iron sources
1996
Iron acquisition in plague: modular logic in enzymatic biogenesis of yersiniabactin by Yersinia pestis
1998
HmsP, a putative phosphodiesterase, and HmsT, a putative diguanylate cyclase, control Hms‐dependent biofilm formation in Yersinia pestis
2004
Systematic analysis of cyclic di‐GMP signalling enzymes and their role in biofilm formation and virulence in Yersinia pestis
2010
Acquisition and storage of inorganic iron and hemin by the yersiniae
1993
The Treponema pallidum tro Operon Encodes a Multiple Metal Transporter, a Zinc-dependent Transcriptional Repressor, and a Semi-autonomously Expressed Phosphoglycerate Mutase
2003
Environmental modulation of gene expression and pathogenesis in Yersinia
1995
Insights into Yersinia pestis biofilm development: topology and co‐interaction of Hms inner membrane proteins involved in exopolysaccharide production
2008
Polyamines are required for the expression of key Hms proteins important for Yersinia pestis biofilm formation
2010
Regulation of Biofilm Formation in Yersinia pestis
2007
Proteins essential for expression of the Hms+ phenotype of Yersinia pestis
1993
The tc genes of Photorhabdus: a growing family
2001
Loss of the pigmentation phenotype in Yersinia pestis is due to the spontaneous deletion of 102 kb of chromosomal DNA which is flanked by a repetitive element
1992
Roles of the Yfe and Feo transporters of Yersinia pestis in iron uptake and intracellular growth
2007
YbtA, an AraC‐type regulator of the Yersinia pestis pesticin/yersiniabactin receptor
1996
The phosphodiesterase activity of the HmsP EAL domain is required for negative regulation of biofilm formation inYersinia pestis
2005
Sequence and genetic analysis of the hemin storage (hms) system of Yersinia pestis
1997
Characterization of a hemin-storage locus ofYersinia pestis
1991
Yersinia ironomics: comparison of iron transporters among Yersinia pestis biotypes and its nearest neighbor, Yersinia pseudotuberculosis
2010
The pigmentation locus of Yersinia pestis KIM6+ is flanked by an insertion sequence and includes the structural genes for pesticin sensitivity and HMWP2
1994
Cadmium and manganese transport in Staphylococcus aureus membrane vesicles
1982
The Yfe system of Yersinia pestis transports iron and manganese and is required for full virulence of plague
1999
Manganese transporters Yfe and MntH are Fur-regulated and important for the virulence of Yersinia pestis
2012
Vwa+ phenotype of Yersinia enterocolitica
1983
Iron uptake and iron-repressible polypeptides in Yersinia pestis
1996
Molecular Characterization of the Hemin Uptake Locus ( hmu ) from Yersinia pestis and Analysis of hmu Mutants for Hemin and Hemoprotein Utilization
1999
The Yersiniabactin Transport System Is Critical for the Pathogenesis of Bubonic and Pneumonic Plague
2010
The Nonribosomal Peptide Synthetase HMWP2 Forms a Thiazoline Ring during Biogenesis of Yersiniabactin, an Iron-Chelating Virulence Factor of Yersinia pestis
1998
YbtP and YbtQ: two ABC transporters required for iron uptake in Yersinia pestis
1999
A low-Ca2+ response operon encodes the V antigen of Yersinia pestis
1986
An ABC Transporter System of Yersinia pestis Allows Utilization of Chelated Iron by Escherichia coli SAB11
1998
Identification of critical amino acid residues in the plague biofilm Hms proteins
2006
The Nonribosomal Peptide Synthetase HMWP2 Forms a Thiazoline Ring during Biogenesis of Yersiniabactin, an Iron-Chelating Virulence Factor of Yersinia pestis
1998
Genetic organization of the yersiniabactin biosynthetic region and construction of avirulent mutants in Yersinia pestis
1997
HmsT, a protein essential for expression of the haemin storage (Hms+) phenotype of Yersinia pestis
1999
Yersiniabactin Production Requires the Thioesterase Domain of HMWP2 and YbtD, a Putative Phosphopantetheinylate Transferase
2002
Temperature Regulation of the Hemin Storage (Hms + ) Phenotype of Yersinia pestis Is Posttranscriptional
2004
Hierarchy of Iron Uptake Systems: Yfu and Yiu Are Functional in Yersinia pestis
2006
Identification and Characterization of the Hemophore-Dependent Heme Acquisition System of Yersinia pestis
2001
Yersinia pestis--etiologic agent of plague.
1997
Yersinia pestis YbtU and YbtT Are Involved in Synthesis of the Siderophore Yersiniabactin but Have Different Effects on Regulation
2000
Storage reservoirs of hemin and inorganic iron in Yersinia pestis
1993
Transport of Ca2+ by Yersinia pestis
1987
Characterization of the Yersinia pestis Yfu ABC Inorganic Iron Transport System
2001
Invasion of Epithelial Cells byYersinia pestis: Evidence for aY. pestis-Specific Invasin
2000
Accumulation of iron by yersiniae
1979
Pleiotropic effects of a Yersinia pestis fur mutation
1994
Role of the Yersinia pestis Hemin Storage ( hms ) Locus in the Transmission of Plague by Fleas
1996 Science
Yersinia pestis--etiologic agent of plague
1997 Standout
Phenotypic Convergence Mediated by GGDEF-Domain-Containing Proteins
2005
The Yersinia pestis V antigen is a regulatory protein necessary for Ca2(+)-dependent growth and maximal expression of low-Ca2+ response virulence genes
1991
Znu Is the Predominant Zinc Importer in Yersinia pestis during In Vitro Growth but Is Not Essential for Virulence
2010
Siderophore synthesis in Klebsiella pneumoniae and Shigella sonnei during iron deficiency
1979
Yersinia pestisTonB: Role in Iron, Heme, and Hemoprotein Utilization
2003
Biofilm formation is not required for early-phase transmission of Yersinia pestis
2010
Yersiniabactin from Yersinia pestis: biochemical characterization of the siderophore and its role in iron transport and regulation
1999
The haemin storage (Hms+) phenotype of Yersinia pestis is not essential for the pathogenesis of bubonic plague in mammals
1999
Regulation of expression of V antigen and outer membrane proteins in Yersinia pestis.
1987
Identification and cloning of a fur regulatory gene in Yersinia pestis
1991
Analysis of the pesticin receptor from Yersinia pestis: role in iron-deficient growth and possible regulation by its siderophore
1995
DNA Sequencing and Analysis of the Low-Ca2+-Response Plasmid pCD1 ofYersinia pestisKIM5
1998
Identification and cloning of a hemin storage locus involved in the pigmentation phenotype of Yersinia pestis
1990