Standout Papers
- Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix. (2001)
- Carbonic Anhydrase (CA IX) Expression, a Potential New Intrinsic Marker of Hypoxia: Correlations with Tumor Oxygen Measurements and Prognosis in Locally Advanced Carcinoma of the Cervix 1 (2001)
Citation Impact
Citing Papers
Endogenous Markers of Two Separate Hypoxia Response Pathways (hypoxia inducible factor 2 alpha and carbonic anhydrase 9) Are Associated With Radiotherapy Failure in Head and Neck Cancer Patients Recruited in the CHART Randomized Trial
2006
CA IX is an Independent Prognostic Marker in Premenopausal Breast Cancer Patients with One to Three Positive Lymph Nodes and a Putative Marker of Radiation Resistance
2006
Hypoxia‐inducible factors: coupling glucose metabolism and redox regulation with induction of the breast cancer stem cell phenotype
2016 StandoutNobel
Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis
2014 StandoutNobel
Diagnostic, prognostic and therapeutic implications of carbonic anhydrases in cancer
2003
Hypoxia-inducible factor-1α expression in the gastric carcinogenesis sequence and its prognostic role in gastric and gastro-oesophageal adenocarcinomas
2006
Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m 6 A-demethylation of NANOG mRNA
2016 StandoutNobel
Contrasting Properties of Hypoxia-Inducible Factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-Associated Renal Cell Carcinoma
2005 StandoutNobel
Hypoxia-regulated carbonic anhydrase IX expression is associated with poor survival in patients with invasive breast cancer
2007
Tumor-associated Carbonic Anhydrase 9 Spatially Coordinates Intracellular pH in Three-dimensional Multicellular Growths
2008
Hypoxia-Inducible Factors in Physiology and Medicine
2012 StandoutNobel
Hypoxia — a key regulatory factor in tumour growth
2002 Standout
Stromal Expression of Hypoxia Regulated Proteins Is an Adverse Prognostic Factor in Colorectal Carcinomas
2007
Se-methylselenocysteine sensitizes hypoxic tumor cells to irinotecan by targeting hypoxia-inducible factor 1α
2010
Concurrent Cisplatin-Based Radiotherapy and Chemotherapy for Locally Advanced Cervical Cancer
1999 Standout
Targeting HIF-1 for cancer therapy
2003 StandoutNobel
The Role of Carbonic Anhydrase 9 in Regulating Extracellular and Intracellular pH in Three-dimensional Tumor Cell Growths
2009
Prognostic value of facilitative glucose transporter Glut-1 in oral squamous cell carcinomas treated by surgical resection
2004
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides
2003
Overexpression of Intrinsic Hypoxia Markers HIF1α and CA-IX Predict for Local Recurrence in Stage T1-T2 Glottic Laryngeal Carcinoma Treated With Radiotherapy
2008
Cancer Metastasis: Building a Framework
2006 Standout
Pelvic Radiation with Concurrent Chemotherapy Compared with Pelvic and Para-Aortic Radiation for High-Risk Cervical Cancer
1999 Standout
Lung Cancer
2008 Standout
Regulation of tumor pH and the role of carbonic anhydrase 9
2007
Comparison of Molecular Markers of Hypoxia and Imaging with 60Cu-ATSM in Cancer of the Uterine Cervix
2007
HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations
2013 StandoutNobel
HIF2α cooperates with RAS to promote lung tumorigenesis in mice
2009 StandoutNobel
Invasive oxygen measurements and pimonidazole labeling in human cervix carcinoma
2001
HIF-1α Induces Genetic Instability by Transcriptionally Downregulating MutSα Expression
2005 StandoutNobel
Sunitinib versus Interferon Alfa in Metastatic Renal-Cell Carcinoma
2007 Standout
Targeting tumor-associated carbonic anhydrase IX in cancer therapy
2006
Scleroderma
2009 Standout
Temsirolimus, Interferon Alfa, or Both for Advanced Renal-Cell Carcinoma
2007 Standout
Tumor Hypoxia and Malignant Progression
2004
Hypoxia drives glucose transporter 3 expression through hypoxia-inducible transcription factor (HIF)–mediated induction of the long noncoding RNA NICI
2019 StandoutNobel
Hypoxia and the extracellular matrix: drivers of tumour metastasis
2014 StandoutNobel
Hypoxia-inducible factor–dependent breast cancer–mesenchymal stem cell bidirectional signaling promotes metastasis
2012 StandoutNobel
Differential Sensitivity of Hypoxia Inducible Factor Hydroxylation Sites to Hypoxia and Hydroxylase Inhibitors
2011 StandoutNobel
Expression of carbonic anhydrase 9 at the invasion front of gastric cancers
2005
Endogenous Hypoxia Markers in Locally Advanced Cancers of the Uterine Cervix: Reality or Wishful Thinking?
2006
Assessment of tumour hypoxia for prediction of response to therapy and cancer prognosis
2009
Hypoxia in cancer: significance and impact on clinical outcome
2007 Standout
Hypoxia-induced Expression of Carbonic Anhydrase 9 Is Dependent on the Unfolded Protein Response
2009
Novel approaches in the therapy of metastatic renal cell carcinoma
2005
GLUT1 and CAIX as intrinsic markers of hypoxia in bladder cancer: relationship with vascularity and proliferation as predictors of outcome of ARCON
2003
Carbonic anhydrases: novel therapeutic applications for inhibitors and activators
2008 Standout
Measurements of hypoxia using pimonidazole and polarographic oxygen-sensitive electrodes in human cervix carcinomas
2003
Differential prognostic impact of hypoxia induced and diffuse HIF-1α expression in invasive breast cancer
2005
The Hypoxic Tumour Microenvironment, Patient Selection and Hypoxia-modifying Treatments
2007
Hypoxic gene expression and metastasis
2004
Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer
2010
The hypoxic tumor microenvironment and gene expression
2004
Regulatory Effects of microRNA-92 (miR-92) on VHL Gene Expression and the Hypoxic Activation of miR-210 in Clear Cell Renal Cell Carcinoma
2011
The Genomic Analysis of Lactic Acidosis and Acidosis Response in Human Cancers
2008
Immunohistochemical detection of osteopontin in advanced head-and-neck cancer: Prognostic role and correlation with oxygen electrode measurements, hypoxia-inducible-factor-1α-related markers, and hemoglobin levels
2006
Carbonic anhydrase IX expression is associated with tumor progression and a poor prognosis of lung adenocarcinoma
2006
The prognostic value of endogenous hypoxia-related markers for head and neck squamous cell carcinomas treated with ARCON
2006
Dysregulated pH: a perfect storm for cancer progression
2011 Standout
Negative Regulation of Hypoxic Responses via Induced Reptin Methylation
2010 StandoutNobel
Tumor oxygenation status as a prognostic marker
2004
High levels of carbonic anhydrase IX in tumour tissue and plasma are biomarkers of poor prognostic in patients with non-small cell lung cancer
2010
Porous platinum nanoparticles as a high-Z and oxygen generating nanozyme for enhanced radiotherapy in vivo
2019
Oxygen Sensing, Homeostasis, and Disease
2011 StandoutNobel
Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway
2008 StandoutNobel
The Spatial Organization of Proton and Lactate Transport in a Rat Brain Tumor
2011
Imaging the hypoxia surrogate marker CA IX requires expression and catalytic activity for binding fluorescent sulfonamide inhibitors
2007
Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling
2009 Standout
Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1
2011 StandoutNobel
Prognostic significance of tumor oxygenation in humans
2003
Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
2009 StandoutNobel
The role of hypoxia in recurrence following resection of Dukes’ B colorectal cancer
2008
Hypoxia-activated tumor pathways of angiogenesis and pH regulation independent of anemia in head-and-neck cancer
2004
The Presence of a Fibrotic Focus in Invasive Breast Carcinoma Correlates with the Expression of Carbonic Anhydrase IX and is a Marker of Hypoxia and Poor Prognosis
2003
Pretreatment and treatment factors associated with improved outcome in squamous cell carcinoma of the uterine cervix: A final report of the 1973 and 1978 patterns of care studies
1991
Spermidine/Spermine N1-Acetyltransferase-1 Binds to Hypoxia-inducible Factor-1α (HIF-1α) and RACK1 and Promotes Ubiquitination and Degradation of HIF-1α
2007 StandoutNobel
Detection and Characterization of Tumor Hypoxia Using pO 2 Histography
2007
Sulfatase-activated fluorophores for rapid discrimination of mycobacterial species and strains
2013 StandoutNobel
Life with Oxygen
2007 StandoutScienceNobel
Tumor vascularity: a histological measure of angiogenesis and hypoxia.
2001
Digoxin and other cardiac glycosides inhibit HIF-1α synthesis and block tumor growth
2008 StandoutNobel
Coordinating Radiometals of Copper, Gallium, Indium, Yttrium, and Zirconium for PET and SPECT Imaging of Disease
2010 Standout
Nanozymes: Classification, Catalytic Mechanisms, Activity Regulation, and Applications
2019 Standout
Luminescent Chemodosimeters for Bioimaging
2012 Standout
Expression of HIF-1α, CA IX, VEGF, and MMP-9 in surgically resected non-small cell lung cancer
2005
Physiology meets biophysics: Visualizing the interaction of hypoxia-inducible factor 1α with p300 and CBP
2002 StandoutNobel
Applications of carbonic anhydrase inhibitors and activators in therapy
2002
Inhibition of mitochondrial respiration elevates oxygen concentration but leaves regulation of hypoxia-inducible factor (HIF) intact
2005
Proteasomal Inhibition Attenuates Transcriptional Activity of Hypoxia-Inducible Factor 1 (HIF-1) via Specific Effect on the HIF-1α C-Terminal Activation Domain
2006
Pimonidazole binding and tumor vascularity predict for treatment outcome in head and neck cancer.
2002
Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation
2011 StandoutNobel
Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release
2016 Standout
Metabolic reprogramming by HIF-1 promotes the survival of bone marrow–derived angiogenic cells in ischemic tissue
2011 StandoutNobel
Tumour oxygenation levels correlate with dynamic contrast-enhanced magnetic resonance imaging parameters in carcinoma of the cervix
2000
Pathobiology, prognosis, and targeted therapy for renal cell carcinoma: exploiting the hypoxia-induced pathway.
2003
Adaptive and Maladaptive Cardiorespiratory Responses to Continuous and Intermittent Hypoxia Mediated by Hypoxia-Inducible Factors 1 and 2
2012 StandoutNobel
Nanotechnology for Multimodal Synergistic Cancer Therapy
2017 Standout
Nanoparticles in Photodynamic Therapy
2015 Standout
Crystal structure of human carbonic anhydrase II at 1.95 Å resolution in complex with 667-coumate, a novel anti-cancer agent
2005
Identification of osteopontin as a prognostic plasma marker for head and neck squamous cell carcinomas.
2003
Carbonic anhydrase IX is an independent predictor of survival in advanced renal clear cell carcinoma: implications for prognosis and therapy.
2003
Glucose transporter glut-1 expression correlates with tumor hypoxia and predicts metastasis-free survival in advanced carcinoma of the cervix.
2001
Comparative Measurements of Hypoxia in Human Brain Tumors Using Needle Electrodes and EF5 Binding
2004
Reactive Oxygen Species (ROS)-Based Nanomedicine
2019 Standout
Role of Carbonic Anhydrase IX in Human Tumor Cell Growth, Survival, and Invasion
2004
Hypoxia-inducible factor 1-dependent expression of platelet-derived growth factor B promotes lymphatic metastasis of hypoxic breast cancer cells
2012 StandoutNobel
Tumor‐associated Carbonic Anhydrases and Their Clinical Significance
2006
Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression
2012 StandoutNobel
Hypoxia-inducible factor-1 alpha in non small cell lung cancer: relation to growth factor, protease and apoptosis pathways.
2004
HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells
2015 StandoutNobel
In vivo activation of the hypoxia-targeted cytotoxin AQ4N in human tumor xenografts
2009
Photodynamic Therapy for Treatment of Solid Tumors — Potential and Technical Challenges
2008
Hypoxia-inducible factor-dependent signaling between triple-negative breast cancer cells and mesenchymal stem cells promotes macrophage recruitment
2014 StandoutNobel
Prediction of radiotherapy outcome using dynamic contrast enhanced MRI of carcinoma of the cervix
2002
Steroid Sulfatase: Molecular Biology, Regulation, and Inhibition
2005
The differential expression of VEGF, VEGFR-2, and GLUT-1 proteins in disease subtypes of systemic sclerosis
2005
Carbonic anhydrase IX expression, hypoxia, and prognosis in patients with uterine cervical carcinomas.
2003
Microregional Expression of Glucose Transporter-1 and Oxygenation Status: Lack of Correlation in Locally Advanced Cervical Cancers
2005
Structures of Human Carbonic Anhydrase II/Inhibitor Complexes Reveal a Second Binding Site for Steroidal and Nonsteroidal Inhibitors,
2010
Multiple Binding Modes of Inhibitors to Carbonic Anhydrases: How to Design Specific Drugs Targeting 15 Different Isoforms?
2012 Standout
Works of Robert D. Hunter being referenced
Changes in oxygenation during radiotherapy in carcinoma of the cervix
1999
GLUT‐1 and CAIX as intrinsic markers of hypoxia in carcinoma of the cervix: Relationship to pimonidazole binding
2003
A clinical trial of two conceptually different radical radiotherapy treatments in Stage III carcinoma of the cervix
1986
Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix.
2001 StandoutNobel
Carbonic Anhydrase (CA IX) Expression, a Potential New Intrinsic Marker of Hypoxia: Correlations with Tumor Oxygen Measurements and Prognosis in Locally Advanced Carcinoma of the Cervix 1
2001 StandoutNobel
Hypoxia-Inducible Factor 1α Expression as an Intrinsic Marker of Hypoxia
2004