Standout Papers
Citation Impact
Citing Papers
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
2005 Standout
Notch signalling controls pancreatic cell differentiation
1999 StandoutNatureNobel
Gridlock signalling pathway fashions the first embryonic artery
2001 Nature
Functional Interaction between SEL-10, an F-box Protein, and the Nuclear Form of Activated Notch1 Receptor
2001 StandoutNobel
Epithelial-Mesenchymal Transition in Cancer: Parallels Between Normal Development and Tumor Progression
2010
Hallmarks of Cancer: The Next Generation
2011 Standout
PCI proteins eIF3e and eIF3m define distinct translation initiation factor 3 complexes
2005
Translation Initiation Factor eIF4G-1 Binds to eIF3 through the eIF3e Subunit
2006
Notch signaling is required for arterial-venous differentiation during embryonic vascular development
2001
Mucins in cancer: function, prognosis and therapy
2009
Arteries and veins: making a difference with zebrafish
2002
Notch and neurogenesis
1998
Notch function in the vasculature: insights from zebrafish, mouse and man
2004
At least four different chromosomal regions are involved in loss of heterozygosity in human breast carcinoma
1989
Maintenance of functional equivalence during paralogous Hox gene evolution
2000 StandoutNatureNobel
An Activated Form of Notch Influences the Choice between CD4 and CD8 T Cell Lineages
1996
How Tumors Become Angiogenic
1996
The cancer glycocalyx mechanically primes integrin-mediated growth and survival
2014 StandoutNatureNobel
ALLELE LOSS ON SHORT ARM OF CHROMOSOME 17 IN BREAST CANCERS
1988
A genetic model for colorectal tumorigenesis
1990 Standout
Oncoprotein Networks
1997
The Hallmarks of Cancer
2000 Standout
Notch signaling in T cell development
2000
Loss of distinct arterial and venous boundaries in mice lacking endoglin, a vascular-specific TGFβ coreceptor
2003
COMMENTARY: p53 Tumor suppressor gene: from the basic research laboratory to the clinic—an abridged historical perspective
1996
The Notch target genes Hey1 and Hey2 are required for embryonic vascular development
2004
Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas
1995
The molecular biology of breast cancer
1991
Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN
1998 StandoutNobel
Evidence implicating at least two genes on chromosome 17p in breast carcinogenesis
1990
Cloning and characterization of the common fragile site FRA6F harboring a replicative senescence gene and frequently deleted in human tumors
2002
Notch Signaling in Vertebrate Development and Disease
1997
Structure of mammalian eIF3 in the context of the 43S preinitiation complex
2015 StandoutNatureNobel
Notchic-ER chimeras display hormone-dependent transformation, nuclear accumulation, phosphorylation and CBF1 activation
2000
Development of mammary hyperplasia and neoplasia in MMTV-TGFα transgenic mice
1990
Individual Overexpression of Five Subunits of Human Translation Initiation Factor eIF3 Promotes Malignant Transformation of Immortal Fibroblast Cells
2006
Gene amplification on chromosome band 11q13 and oestrogen receptor status in breast cancer
1990
Signalling downstream of activated mammalian Notch
1995 Nature
Biosynthesis of the reverse transcriptase of hepatitis B viruses involves de novo translational initiation not ribosomal frameshifting
1989 StandoutNatureNobel
Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation
1991 Standout
Mutation in the DNA mismatch repair gene homologue hMLH 1 is associated with hereditary non-polyposis colon cancer
1994 StandoutNature
Single amino-acid changes in HIV envelope affect viral tropism and receptor binding
1989 StandoutNatureNobel
Angiogenic Signalling Pathways
2008
Mismatch Repair Deficiency in Phenotypically Normal Human Cells
1995 StandoutScienceNobel
Mechanisms of Bone Metastasis
2004 Standout
Genetic Alterations during Colorectal-Tumor Development
1988 Standout
TGFα deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice
1993 StandoutNobel
Expression of the Notch 3 intracellular domain in mouse central nervous system progenitor cells is lethal and leads to disturbed neural tube development
1996
The shortest path from the surface to the nucleus: RBP‐Jκ/Su(H) transcription factor
1996 StandoutNobel
Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-Jκ/Su(H)
1995 StandoutNobel
The translation initiation complex eIF3 in trypanosomatids and other pathogenic excavates – identification of conserved and divergent features based on orthologue analysis
2014
A novel cyclin encoded by a bcl1-linked candidate oncogene
1991 StandoutNature
sel-10, a negative regulator of lin-12 activity inCaenorhabditis elegans, encodes a member of the CDC4 family of proteins
1997
Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants
2004 StandoutNobel
Allelic Loss in Colorectal Carcinoma
1989
Response : Amplification c- erb B-2 and Aggressive Human Breast Tumors?
1988 Science
The Drosophila melanogaster Suppressor of deltex Gene, a Regulator of the Notch Receptor Signaling Pathway, Is an E3 Class Ubiquitin Ligase
1999
Alterations in Notch signaling in neoplastic lesions of the human cervix.
1995
glp-1 can substitute for lin-12 in specifying cell fate decisions in Caenorhabditis elegans
1993
Characterizatiion of rat genetic sequences of Kirsten sarcoma virus: distinct class of endogenous rat type C viral sequences
1976
Expression pattern of Motch, a mouse homolog of Drosophila Notch, suggests an important role in early postimplantation mouse development
1992
Nucleotide sequence of the visna lentivirus: relationship to the AIDS virus
1985
Gene losses in human tumours
1988 Nature
Notch1 is essential for postimplantation development in mice.
1994
eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation
2016 StandoutNatureNobel
Dll4, a novel Notch ligand expressed in arterial endothelium
2000
Genome organization and transactivation of the human immunodeficiency virus type 2
1987 StandoutNatureNobel
Isolation of an hMSH2-p160 Heterodimer That Restores DNA Mismatch Repair to Tumor Cells
1995 StandoutScienceNobel
A History of HIV Discovery
2002 StandoutScienceNobel
Transformation by murine and feline sarcoma viruses specifically blocks binding of epidermal growth factor to cells
1976 StandoutNatureNobel
Tumor Suppressor Genes: The Puzzle and the Promise
1989 Science
Ectopic Expression of the Serotonin 1c Receptor and the Triggering of Malignant Transformation
1989 StandoutScienceNobel
Evolution of Type C Viral Genes: I. Nucleic Acid from Baboon Type C Virus as a Measure of Divergence among Primate Species
1974
Japanese wild mouse, Mus musculus molossinus, has duplicated immunoglobulin γ2a genes
1982 StandoutNatureNobel
Isolation of a New Human Retrovirus from West African Patients with AIDS
1986 StandoutScienceNobel
Regulation of Notch1 and Dll4 by Vascular Endothelial Growth Factor in Arterial Endothelial Cells: Implications for Modulating Arteriogenesis and Angiogenesis
2002
Immunology: Approaches to AIDS therapy
1986 StandoutNatureNobel
Cell Cycle Control and Cancer
1994 StandoutScienceNobel
Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei.
1993
A mutant murine leukemia virus with a single missense codon in pol is defective in a function affecting integration.
1984 StandoutNobel
Molecular biology: Reverse transcriptase rides again
1985 StandoutNatureNobel
The chronology of AIDS research
1987 StandoutNatureNobel
Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: Synergistic action of oncogenes in vivo
1987
The gag and pol genes of bovine leukemia virus: Nucleotide sequence and analysis
1985
FREQUENCY DISTRIBUTION OF HISTOCOMPATIBILITY‐2 ANTIGENIC SPECIFICITIES IN THE JAPANESE WILD MOUSE GENETICALLY REMOTE FROM THE EUROPEAN SUBSPECIES
1979
Characterization of a candidate bcl-1 gene.
1991
Allelic losses of chromosomes 9, 11, and 17 in human bladder cancer.
1990
Complete nucleotide sequence of an infectious clone of human T-cell leukemia virus type II: an open reading frame for the protease gene.
1985
Nucleotide sequence evidence for relationship of AIDS retrovirus to lentiviruses
1985 Nature
Identification of Germline and Somatic Mutations Affecting the Retinoblastoma Gene
1988 Science
Nucleotide sequence of the AIDS virus, LAV
1985
Linkage of Early-Onset Familial Breast Cancer to Chromosome 17q21
1990 StandoutScience
Disruption of the mouse RBP-Jк gene results in early embryonic death
1995 StandoutNobel
Vascular patterning defects associated with expression of activated Notch4 in embryonic endothelium
2001
Tumor Rejection After Direct Costimulation of CD8 + T Cells by B7-Transfected Melanoma Cells
1993 StandoutScienceNobel
Evolution of C-type viral genes: inheritance of exogenously acquired viral genes
1974 Nature
Wnt-3, a gene activated by proviral insertion in mouse mammary tumors, is homologous to int-1/Wnt-1 and is normally expressed in mouse embryos and adult brain.
1990
A suppressor mutation in the nematode acting on specific alleles of many genes
1978 StandoutNatureNobel
DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA
1976 StandoutNatureNobel
Complete nucleotide sequence of the genome of bovine leukemia virus: its evolutionary relationship to other retroviruses.
1985
Signaling Pathways in Vascular Development
2002
Expression and functional properties of transforming growth factor alpha and epidermal growth factor during mouse mammary gland ductal morphogenesis.
1991
Low incidence of loss of chromosome 10 in sporadic and hereditary human medullary thyroid carcinoma.
1989
Distal deletion of chromosome Ip in ductal carcinoma of the breast.
1989
Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian Cancer
1989 StandoutScience
Overexpression of TGFα in transgenic mice: Induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast
1990
Expression of the Rous Sarcoma Virus pol Gene by Ribosomal Frameshifting
1985 StandoutScienceNobel
Association of low nm23 RNA levels in human primary infiltrating ductal breast carcinomas with lymph node involvement and other histopathological indicators of high metastatic potential.
1989
An activated Notch suppresses neurogenesis and myogenesis but not gliogenesis in mammalian cells
1994 StandoutNobel
Transforming growth factor alpha dramatically enhances oncogene-induced carcinogenesis in transgenic mouse pancreas and liver.
1993
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
1997 StandoutScienceNobel
Mechanisms of Suppression
1973
Comparison of mouse mammary tumor virus-specific DNA in inbred, wild and Asian mice, and in tumors and normal organs from inbred mice
1977 StandoutNobel
Regulation of the Ets-Related Transcription Factor Elf-1 by Binding to the Retinoblastoma Protein
1993 StandoutScienceNobel
Transforming Growth Factor Alpha Dramatically Enhances Oncogene-Induced Carcinogenesis in Transgenic Mouse Pancreas and Liver
1993
Mismatch Repair, Genetic Stability, and Cancer
1994 StandoutScienceNobel
Molecular cloning and polymorphism of the human immune deficiency virus type 2
1986 StandoutNatureNobel
Allelotype of Colorectal Carcinomas
1989 Science
LAV Revisited: Origins of the Early HIV-1 Isolates from Institut Pasteur
1991 StandoutScienceNobel
Complete nucleotide sequence of the AIDS virus, HTLV-III
1985 StandoutNature
Fragments of the HIV-1 Tat Protein Specifically Biand TAR RNA
1990 StandoutScienceNobel
Oncogenes and human breast cancer.
1989
Recombination signal sequence-binding protein Jκ alters mesodermal cell fate decisions by suppressing cardiomyogenesis
2003 StandoutNobel
Nucleotide Sequence and Expression of an AIDS-Associated Retrovirus (ARV-2)
1985 Science
Works of Robert Callahan being referenced
The Chromosome Location of the Human Homolog of the Mouse Mammary Tumor-Associated GeneINT6and Its Status in Human Breast Carcinomas
1997
Presence of Two Members of c-erbA Receptor Gene Family (c-erbAbeta and c-erbA2) in Smallest Region of Somatic Homozygosity on Chromosome 3p21-p25 in Human Breast Carcinoma
1989
Mutations in Human Breast Cancer: An Overview
1989
The mouse mammary tumor associated gene INT3 is a unique member of the NOTCH gene family (NOTCH4)
1997
Transforming growth factor-α messenger RNA localization in the developing adult rat and human mammary gland by in situ hybridization
1990
Transformation of an established mouse mammary epithelial cell line following transfection with a human transforming growth factor alpha cDNA
1989
Amplification of the proto-oncogenes int-2, c-erbB-2 and c-myc in human breast cancer
1989
Multiple regions of chromosome 6q affected by loss of heterozygosity in primary human breast carcinomas
1996
Evidence for the transforming activity of a truncated Int6 gene, in vitro
2001
Overexpression of Human Cripto-1 in Transgenic Mice Delays Mammary Gland Development and Differentiation and Induces Mammary Tumorigenesis
2005
Mouse mammary tumor gene int-3: a member of the notch gene family transforms mammary epithelial cells
1992
Constitutive expression of a truncated INT3 gene in mouse mammary epithelium impairs differentiation and functional development.
1995
Expression of int-2 mRNA in human tumors amplified at the int-2 locus.
1989
Loss of a c-H-ras-1 allele and aggressive human primary breast carcinomas.
1986
Detection of Baboon Type C Viral Sequences in Various Primate Tissues by Molecular Hybridization
1974
Notch signaling is essential for vascular morphogenesis in mice
2000 Standout
Mammary tumorigenesis in feral mice: identification of a new int locus in mouse mammary tumor virus (Czech II)-induced mammary tumors
1987
Int-6, a highly conserved, widely expressed gene, is mutated by mouse mammary tumor virus in mammary preneoplasia
1995
Frequent alteration of the DF3 tumor-associated antigen gene in primary human breast carcinomas.
1989
Tryptophan Operon: Structural Gene Mutation Creating a "Promoter" and Leading to 5-Methyltryptophan Dependence
1970 Science
Amplification of c-erbB-2 and Aggressive Human Breast Tumors?
1988 Science
Major pol Gene Progenitors in the Evolution of Oncoviruses
1984 Science
Expression of a truncated Int3 gene in developing secretory mammary epithelium specifically retards lobular differentiation resulting in tumorigenesis.
1996
Two distinct endogenous type C viruses isolated from the asian rodent Mus cervicolor: conservation of virogene sequences in related rodent species
1977
Reduced expression of INT-6/eIF3-p48 in human tumors.
2001
Int6 Expression Can Predict Survival in Early-Stage Non–Small Cell Lung Cancer Patients
2005
Reduction to Homozygosity of Genes on Chromosome 11 in Human Breast Neoplasia
1987 Science
Expression of an activated Notch-related int-3 transgene interferes with cell differentiation and induces neoplastic transformation in mammary and salivary glands.
1992
Nucleic acid homology of murine xenotropic type C viruses
1975
A new common integration region (int-3) for mouse mammary tumor virus on mouse chromosome 17
1987
The amplification unit on chromosome 11q13 in aggressive primary human breast tumors entails the bcl-1, int-2 and hst loci.
1989
Amplification of the int-2 gene in primary human breast tumors.
1988
p53 Alterations in non-small cell lung cancers correlate with metastatic involvement of hilar and mediastinal lymph nodes
1994