Citation Impact
Citing Papers
Targeting the Phosphoinositide 3-Kinase Isoform p110δ Impairs Growth and Survival in Neuroblastoma Cells
2008
Genome-wide CRISPR screens reveal a specific ligand for the glycan-binding immune checkpoint receptor Siglec-7
2021 StandoutNobel
Molecular Chaperone Functions in Protein Folding and Proteostasis
2013
Functional specialization of β-arrestin interactions revealed by proteomic analysis
2007 StandoutNobel
Impaired B and T Cell Antigen Receptor Signaling in p110δ PI 3-Kinase Mutant Mice
2002 Science
Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity
2008
Regulation of phosphoinositide 3-kinase expression in health and disease
2009
Facts and Controversies in Systemic Treatment of Metastatic Breast Cancer
2004
HER2-Mutated Breast Cancer Responds to Treatment With Single-Agent Neratinib, a Second-Generation HER2/EGFR Tyrosine Kinase Inhibitor
2015
A Phase II Study of Trastuzumab Emtansine in Patients With Human Epidermal Growth Factor Receptor 2–Positive Metastatic Breast Cancer Who Were Previously Treated With Trastuzumab, Lapatinib, an Anthracycline, a Taxane, and Capecitabine
2012
Pertuzumab, Trastuzumab, and Docetaxel in HER2-Positive Metastatic Breast Cancer
2015
Survival Effect of Maximal Cytoreductive Surgery for Advanced Ovarian Carcinoma During the Platinum Era: A Meta-Analysis
2002 Standout
Phosphoinositide 3-Kinases and the Regulation of Vesicular Trafficking
2000
Structure and function of phosphoinositide 3-kinases
1998
Gβγ Stimulates Phosphoinositide 3-Kinase-γ by Direct Interaction with Two Domains of the Catalytic p110 Subunit
1998
COPII-Coated Vesicle Formation Reconstituted with Purified Coat Proteins and Chemically Defined Liposomes
1998 StandoutNobel
Characterization of p150, an Adaptor Protein for the Human Phosphatidylinositol (PtdIns) 3-Kinase
1997
Breast cancer
2016 Standout
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
2006 Standout
Hsp70 and Hsp90—a relay team for protein folding
2004
Insulin Activates the α Isoform of Class II Phosphoinositide 3-Kinase
1999
A family of phosphoinositide 3-kinases in Drosophila identifies a new mediator of signal transduction
1995
Firefly luciferase mutants as sensors of proteome stress
2011
Dynamic control of neuroexocytosis by phosphoinositides in health and disease
2010
Oncogenic kinase signalling
2001 StandoutNature
Role of ERas in promoting tumour-like properties in mouse embryonic stem cells
2003 StandoutNatureNobel
Coupling of Coat Assembly and Vesicle Budding to Packaging of Putative Cargo Receptors
1999 StandoutNobel
Crystal Structure and Functional Analysis of Ras Binding to Its Effector Phosphoinositide 3-Kinase γ
2000
Mammalian phosphoinositide kinases and phosphatases
2009 StandoutNobel
Class I PI3K in oncogenic cellular transformation
2008
Requirement of Phosphatidylinositol 3-Kinase Activity for Bradykinin Stimulation of NF-κB Activation in Cultured Human Epithelial Cells
1999
Candidate Gene Association Study in Type 2 Diabetes Indicates a Role for Genes Involved in β-Cell Function as Well as Insulin Action
2003
A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans
1996 StandoutNatureNobel
Altered states: selectively drugging the Hsp90 cancer chaperone
2004
Hsp90 and Cdc37 – a chaperone cancer conspiracy
2004
Structural and Biochemical Evaluation of the Interaction of the Phosphatidylinositol 3-Kinase p85α Src Homology 2 Domains with Phosphoinositides and Inositol Polyphosphates
1999
Trastuzumab mediates antibody-dependent cell-mediated cytotoxicity and phagocytosis to the same extent in both adjuvant and metastatic HER2/neu breast cancer patients
2013
A Novel Integrin-activated Pathway Forms PKB/Akt- stimulatory Phosphatidylinositol 3,4-Bisphosphate via Phosphatidylinositol 3-Phosphate in Platelets
1998
Stromal gene expression predicts clinical outcome in breast cancer
2008
Rab proteins as membrane organizers
2001 Standout
Independent ATPase Activity of Hsp90 Subunits Creates a Flexible Assembly Platform
2004
Navigating the Chaperone Network: An Integrative Map of Physical and Genetic Interactions Mediated by the Hsp90 Chaperone
2005
A Functional Phosphatidylinositol 3,4,5-Trisphosphate/Phosphoinositide Binding Domain in the Clathrin Adaptor AP-2 α Subunit. IMPLICATIONS FOR THE ENDOCYTIC PATHWAY
1996
Mouse p170 Is a Novel Phosphatidylinositol 3-Kinase Containing a C2 Domain
1996
Circulating Tumor Cells, Disease Progression, and Survival in Metastatic Breast Cancer
2004 Standout
PI3K: Downstream AKTion Blocks Apoptosis
1997 Standout
HSP90 and the chaperoning of cancer
2005 Standout
The role of lipid signaling in constitutive membrane traffic
1997
Isolation of rare circulating tumour cells in cancer patients by microchip technology
2007 StandoutNature
Visualizing the mechanical activation of Src
2005 StandoutNatureNobel
The Identification of Phosphatidylinositol 3,5-bisphosphate in T-lymphocytes and Its Regulation by Interleukin-2
1999
Insulin/IGF and target of rapamycin signaling: a TOR de force in growth control
2003
Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery
2004
Ovarian function and childbearing issues in breast cancer survivors
2007
Autophosphorylation of p110delta phosphoinositide 3-kinase: a new paradigm for the regulation of lipid kinases invitro and invivo
1999
Phosphoinositide 3‐kinases in cell migration
2008
Angiogenesis selectively requires the p110α isoform of PI3K to control endothelial cell migration
2008 Nature
A Type II Phosphoinositide 3-Kinase Is Stimulated via Activated Integrin in Platelets
1998
PIPkins1We introduce here the abbreviation PIPkin (an abbreviation we have used in our lab for years) for cogent reasons. Previously, PtdIns4P 5-kinase was the favoured abbreviation, but in view of the extensive revision and uncertainty as to substrates and products that we discuss in this review, only PtdInsP kinase would now suffice. Moreover, we have recently recorded evidence that type II PIPkin is subject to multiple phosphorylations by protein kinases [1]. As we progress in our characterisation of these kinases, we feel that ‘PtdInsP kinase kinases’ is a very confusing term for them, and using PIPkins for PtdInsP kinases (and thus PIPkin kinases for the protein kinases that phosphorylate them) is much to be preferred for general use. A fuller abbreviation, where the reaction catalysed is known, e.g. type I PtdIns4P 5-kinase, is of course a suitable alternative in many instances.1, their substrates and their products: new functions for old enzymes
1998
Phosphoinositide 3-kinases: A conserved family of signal transducers
1997
Membrane protein sequestering by ionic protein–lipid interactions
2011 StandoutNatureNobel
Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kγ
2000 StandoutNatureNobel
Vacuolar biogenesis in yeast: Sorting out the sorting proteins
1995
Heterodimeric Phosphoinositide 3-Kinase Consisting of p85 and p110β Is Synergistically Activated by the βγ Subunits of G Proteins and Phosphotyrosyl Peptide
1997
Hsp90 Cochaperone Aha1 Downregulation Rescues Misfolding of CFTR in Cystic Fibrosis
2006
Phosphatidylinositol 3-Kinase Mediates the Inhibitory Effect of Epidermal Growth Factor on Calcium-dependent Chloride Secretion
1996
Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN
1998 StandoutNobel
Natural RNA circles function as efficient microRNA sponges
2013 StandoutNature
Membrane Fusion
2003 StandoutNobel
Essential role for the p110 isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia
2005
The CC Chemokine Monocyte Chemotactic Peptide-1 Activates both the Class I p85/p110 Phosphatidylinositol 3-Kinase and the Class II PI3K-C2α
1998
The Gβγ Sensitivity of a PI3K Is Dependent upon a Tightly Associated Adaptor, p101
1997
Phospholipase D regulation and localisation is dependent upon a phosphatidylinositol 4,5-bisphosphate-specific PH domain
2000
Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery
2004
The Class II Phosphoinositide 3-Kinase C2α Is Activated by Clathrin and Regulates Clathrin-Mediated Membrane Trafficking
2001
Insulin signalling and the regulation of glucose and lipid metabolism
2001 StandoutNature
Proliferative Defect and Embryonic Lethality in Mice Homozygous for a Deletion in the p110α Subunit of Phosphoinositide 3-Kinase
1999
The stress-activated phosphatidylinositol 3-phosphate 5-kinase Fab1p is essential for vacuole function in S. cerevisiae
1998
Distinct PI(3)Ks mediate mitogenic signalling and cell migration in macrophages
1999
The Class II Phosphoinositide 3-Kinase PI3K-C2α Is Concentrated in the Trans-Golgi Network and Present in Clathrin-coated Vesicles
2000
Phospholipid-binding protein domains
1998
Therapeutic and diagnostic implications of Hsp90 activation
2004
TOR signalling and control of cell growth
1997
Identification of Wortmannin-sensitive Targets in 3T3-L1 Adipocytes
1999
Dissociation of Apoptosis from Proliferation, Protein Kinase B Activation, and BAD Phosphorylation in Interleukin-3-mediated Phosphoinositide 3-Kinase Signaling
1999
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
The hormone resistin links obesity to diabetes
2001 StandoutNature
Identification and characterization of a new oncogene derived from the regulatory subunit of phosphoinositide 3-kinase
1998
Clinical use of biomarkers in breast cancer: Updated guidelines from the European Group on Tumor Markers (EGTM)
2017
Direct targets of phosphoinositide 3-kinase products in membrane traffic and signal transduction
1998
The Mechanism of Hsp90 Regulation by the Protein Kinase-Specific Cochaperone p50cdc37
2004
Localization of a Class II Phosphatidylinositol 3-Kinase, PI3KC2α, to Clathrin-Coated Vesicles
1999
Distinct Mechanisms of α5β1 Integrin Activation by Ha-Ras and R-Ras
2000
Early embryonic lethality in mice deficient in the p110β catalytic subunit of PI 3-kinase
2002
Selective Membrane Recruitment of EEA1 Suggests a Role in Directional Transport of Clathrin-coated Vesicles to Early Endosomes
2000
Targeting PI3K signalling in cancer: opportunities, challenges and limitations
2009 Standout
Distinct Classes of Phosphatidylinositol 3′-Kinases Are Involved in Signaling Pathways That Control Macroautophagy in HT-29 Cells
2000
Secreted transcription factor controls Mycobacterium tuberculosis virulence
2008 Nature
A selective inhibitor of the p110δ isoform of PI 3-kinase inhibits AML cell proliferation and survival and increases the cytotoxic effects of VP16
2006
Proteomics to study genes and genomes
2000 StandoutNature
Membrane transport in Caenorhabditis elegans: an essential role for VPS34 at the nuclear membrane
2002
Roles of Non-catalytic Subunits in Gβγ-induced Activation of Class I Phosphoinositide 3-Kinase Isoforms β and γ
1999
Phosphoinositide signaling and the regulation of membrane trafficking in yeast
2000
Structural and Functional Analysis of the Middle Segment of Hsp90: Implications for ATP Hydrolysis and Client Protein and Cochaperone Interactions
2003
Preservation of Fertility in Patients with Cancer
2009 Standout
Phosphoinositide 3-Kinases and Their FYVE Domain-containing Effectors as Regulators of Vacuolar/Lysosomal Membrane Trafficking Pathways
1999
Phosphatidylinositol 3,5-bisphosphate defines a novel PI 3-kinase pathway in resting mouse fibroblasts
1997
Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase
2005
Cytoplasm-to-vacuole targeting and autophagy employ the same machinery to deliver proteins to the yeast vacuole.
1996 StandoutNobel
Signaling and Subcellular Targeting by Membrane-Binding Domains
2000
Synthesis and Function of 3-Phosphorylated Inositol Lipids
2001 Standout
Antiapoptotic Signalling by the Insulin-Like Growth Factor I Receptor, Phosphatidylinositol 3-Kinase, and Akt
1997
Identification of an early endosomal protein regulated by phosphatidylinositol 3-kinase
1997
The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth.
1996
Defective lymphocyte chemotaxis in β-arrestin2- and GRK6-deficient mice
2002 StandoutNobel
Cloning and characterization of a 92 kDa soluble phosphatidylinositol 4-kinase
1996
ATG Systems from the Protein Structural Point of View
2009 StandoutNobel
Membrane proteomics of phagosomes suggests a connection to autophagy
2008 StandoutNobel
Essential, Nonredundant Role for the Phosphoinositide 3-Kinase p110δ in Signaling by the B-Cell Receptor Complex
2002
A Crucial Role for the p110δ Subunit of Phosphatidylinositol 3-Kinase in B Cell Development and Activation
2002
Novel PtdIns(3)P-binding protein Etf1 functions as an effector of the Vps34 PtdIns 3-kinase in autophagy
2002
Inhibition of Class I Phosphoinositide 3-Kinase Activity Impairs Proliferation and Triggers Apoptosis in Acute Promyelocytic Leukemia without Affecting Atra-Induced Differentiation
2009
Coat Proteins and Vesicle Budding
1996 StandoutScienceNobel
Inhibitors of HSP90 and other chaperones for the treatment of cancer
2004
AKT/PKB and Other D3 Phosphoinositide-Regulated Kinases: Kinase Activation by Phosphoinositide-Dependent Phosphorylation
1999
Altered Hsp90 function in cancer: A unique therapeutic opportunity
2004
Breast Cancer Treatment
2019 Standout
Mass spectrometry-based proteomics
2003 StandoutNature
Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling
1998
A Redox-triggered Ras-Effector Interaction
1998
Rabs and their effectors: Achieving specificity in membrane traffic
2006
Osmosensory signaling in Mycobacterium tuberculosis mediated by a eukaryotic-like Ser/Thr protein kinase
2013 StandoutNobel
Small molecule probes to quantify the functional fraction of a specific protein in a cell with minimal folding equilibrium shifts
2014 StandoutNobel
Rotational dynamics and transition mechanisms of surface-adsorbed proteins
2022 StandoutNobel
Cloning and Characterization of a G Protein-Activated Human Phosphoinositide-3 Kinase
1995 Science
A Pictet-Spengler ligation for protein chemical modification
2012 StandoutNobel
Identification of a Proline-Rich Sequence in the CD2 Cytoplasmic Domain Critical for Regulation of Integrin-Mediated Adhesion and Activation of Phosphoinositide 3-Kinase
1998
A Function for Phosphatidylinositol 3-Kinase β (p85α-p110β) in Fibroblasts during Mitogenesis: Requirement for Insulin- and Lysophosphatidic Acid-Mediated Signal Transduction
1998
Membrane Localization of Phosphatidylinositol 3-Kinase Is Sufficient To Activate Multiple Signal-Transducing Kinase Pathways
1996
CELLULAR FUNCTIONS REGULATED BY SRC FAMILY KINASES
1997 Standout
Lipid kinase and protein kinase activities of G-protein-coupled phosphoinositide 3-kinase γ: structure–activity analysis and interactions with wortmannin
1997
1997 StandoutNobel
Regulation of the p85/p110 Phosphatidylinositol 3′-Kinase: Stabilization and Inhibition of the p110α Catalytic Subunit by the p85 Regulatory Subunit
1998
Cellular Function of Phosphoinositide 3-Kinases: Implications for Development, Immunity, Homeostasis, and Cancer
2001
Endosomal sorting of readily releasable synaptic vesicles
2010 StandoutNobel
Class II Phosphoinositide 3-Kinases Are Downstream Targets of Activated Polypeptide Growth Factor Receptors
2000
Analysis of Proteins and Proteomes by Mass Spectrometry
2001
Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression
2012 StandoutNobel
The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway
1998
Phosphoinositides as Regulators in Membrane Traffic
1996 Science
Effects of 2-(4-Morpholinyl)-8-Phenyl-4H-1-Benzopyran-4-One on Synaptic Vesicle Cycling at the Frog Neuromuscular Junction
2002
MicroRNA-7 targets IGF1R (insulin-like growth factor 1 receptor) in tongue squamous cell carcinoma cells
2010
The Caenorhabditis elegans IMPAS gene, imp-2, is essential for development and is functionally distinct from related presenilins
2004 StandoutNobel
Regulation of breast cancer cell chemotaxis by the phosphoinositide 3-kinase p110delta.
2003
A Fluorogenic Dye Activated by the Staudinger Ligation
2003 StandoutNobel
Molecular pharmacology and antitumor activity of PX-866, a novel inhibitor of phosphoinositide-3-kinase signaling
2004
Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration
2000 StandoutScienceNobel
The WD40 and FYVE domain containing protein 2 defines a class of early endosomes necessary for endocytosis
2006 StandoutNobel
Molecular Basis for Interactions of G Protein βγ Subunits with Effectors
1998 StandoutScienceNobel
Two Distinct Vps34 Phosphatidylinositol 3–Kinase Complexes Function in Autophagy and Carboxypeptidase Y Sorting inSaccharomyces cerevisiae
2001 StandoutNobel
Cytokine-Induced Protein Kinase B Activation and Bad Phosphorylation Do Not Correlate with Cell Survival of Hemopoietic Cells
1999
Wortmannin Inactivates Phosphoinositide 3-Kinase by Covalent Modification of Lys-802, a Residue Involved in the Phosphate Transfer Reaction
1996
The Phosphoinositide 3-Kinase Pathway
2002 StandoutScience
Assortment of Phosphatidylinositol 3-Kinase Complexes—Atg14p Directs Association of Complex I to the Pre-autophagosomal Structure inSaccharomyces cerevisiae
2006 StandoutNobel
PHOSPHOINOSITIDE KINASES
1998
Works of Robert C. Stein being referenced
Trastuzumab Beyond Progression in Human Epidermal Growth Factor Receptor 2–Positive Advanced Breast Cancer: A German Breast Group 26/Breast International Group 03-05 Study
2009
PI3-kinase inhibition: a target for drug development?
2000
Trastuzumab beyond progression: Overall survival analysis of the GBG 26/BIG 3-05 phase III study in HER2-positive breast cancer
2011
Structural and functional diversity of phosphoinositide 3-kinases
1996
Tumour-Stromal Interactions in Breast Cancer: The Role of Stroma in Tumourigenesis
2005
Solution structure of the C-terminal SH2 domain of the p85α regulatory subunit of phosphoinositide 3-kinase 1 1Edited by P. E. Wright
1998
A randomised study of carboplatin vs sequential ifosfamide/carboplatin for patients with FIGO stage III epithelial ovarian carcinoma
1993
Aromatization inhibition alone or in combination with GnRH agonists for the treatment of premenopausal breast cancer patients
1992
Prospects for phosphoinositide 3-kinase inhibition as a cancer treatment.
2001
Natural variants of human p85α phosphoinositide 3-kinase in severe insulin resistance: a novel variant with impaired insulin-stimulated lipid kinase activity
2000
Human Phosphoinositide 3-Kinase C2β, the Role of Calcium and the C2 Domain in Enzyme Activity
1998
Predictors of ovarian reserve in young women with breast cancer
2007
Activation of the ATPase Activity of Hsp90 by the Stress-Regulated Cochaperone Aha1
2002
Comparing Breast Cancer Multiparameter Tests in the OPTIMA Prelim Trial: No Test Is More Equal Than the Others
2016
Mutation in the Transcriptional Regulator PhoP Contributes to Avirulence of Mycobacterium tuberculosis H37Ra Strain
2008
Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin
1997
A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system.
1995
Proteomic definition of normal human luminal and myoepithelial breast cells purified from reduction mammoplasties
1999
The study of phosphoinositide 3-kinase function.
1996
p110δ, a novel phosphoinositide 3-kinase in leukocytes
1997