Citation Impact
Citing Papers
Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors
2012 Standout
C-terminal region of activation-induced cytidine deaminase (AID) is required for efficient class switch recombination and gene conversion
2014 StandoutNobel
Mediation of Poly(ADP-Ribose) Polymerase-1-Dependent Cell Death by Apoptosis-Inducing Factor
2002 StandoutScience
PARP inhibitors: Synthetic lethality in the clinic
2017 StandoutScience
Depletion of nuclear poly(ADP-ribose) polymerase by antisense RNA expression: influences on genomic stability, chromatin organization, and carcinogen cytotoxicity.
1994
Differential effects of the poly (ADP-ribose) polymerase (PARP) inhibitor NU1025 on topoisomerase I and II inhibitor cytotoxicity in L1210 cells in vitro
2001
Association of poly(ADP-ribose) polymerase with the nuclear matrix: The role intermolecular disulfide bond formation, RNA retention, and cell type
1991
Base-excision repair of oxidative DNA damage
2007 StandoutNature
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
2005 StandoutNature
Reconstitution of an in vitro poly(ADP-ribose) turnover system
1990
Poly(ADP ribose) polymerase-defective mutant cell clone of mouse L1210 cells
1992
Binding of adenosine diphosphoribosyltransferase to the termini and internal regions of linear DNAs
1989
Mammalian single-strand break repair: Mechanisms and links with chromatin
2006
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
Chromatin Modifications and Their Function
2007 Standout
Lateral gene transfer and the nature of bacterial innovation
2000 StandoutNature
Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE
1994 StandoutNature
Poly(ADP-ribose)polymerase: a perplexing participant in cellular responses to DNA breakage
1991
The DNA Damage Response Kinases DNA-dependent Protein Kinase (DNA-PK) and Ataxia Telangiectasia Mutated (ATM) Are Stimulated by Bulky Adduct-containing DNA
2011 StandoutNobel
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
2005 StandoutNature
When Checkpoints Fail
1997 StandoutNobel
Complete inhibition of poly(ADP-ribose) polymerase activity prevents the recovery of C3H1OT1/2 cells from oxidative stress
1996
Structure and function of poly(ADP-ribose) polymerase
1994
Poly(ADP-Ribose) Polymerase Inhibition in Oxidant-Stressed Endothelial Cells Prevents Oncosis and Permits Caspase Activation and Apoptosis
1999
Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c
1996 Standout
Illegitimate and homologous recombination in mammalian cells: differential sensitivity to an inhibitor of poly(ADP-ribosylation)
1990
Zinc-binding domain of poly(ADP-ribose)polymerase participates in the recognition of single strand breaks on DNA
1989
Equilibrium model in an in vitro poly(ADP-ribose) turnover system
1995
Poly(ADP-ribose)polymerase: a novel finger protein
1989
XRCC1 Polypeptide Interacts with DNA Polymerase and Possibly Poly (ADP-Ribose) Polymerase, and DNA Ligase III Is a Novel Molecular 'Nick-Sensor' In Vitro
1996
Temozolomide: a review of its discovery, chemical properties, pre-clinical development and clinical trials
1997
A Broad-Spectrum Inhibitor of CRISPR-Cas9
2017 StandoutNobel
Inhibitors and activators of ADP-ribosylation reactions
1994
The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage
1999 StandoutNatureNobel
4-Amino-1,8-naphthalimide: a novel inhibitor of poly(ADP-ribose) polymerase and radiation sensitizer
1999
DNA Damage and Oxygen Radical Toxicity
1988 StandoutScience
Stimulation of the catalytic activity of poly(ADP‐ribosyl) transferase by transcription factor Yin Yang 1
1999
TET enzymes, TDG and the dynamics of DNA demethylation
2013 StandoutNature
Role of poly(ADP-ribose) formation in DNA repair
1992 StandoutNatureNobel
Role of Glutamic Acid 988 of Human Poly-ADP-ribose Polymerase in Polymer Formation
1995
Cloning and functional expression of poly(ADP‐ribose) polymerase cDNA from Sarcophaga peregrina
1994
Inhibition of cell proliferation in Saccharomyces cerevisiae by expression of human NAD+ ADP-ribosyltransferase requires the DNA binding domain (“zinc fingers”)
1992
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis
1995 StandoutNature
The challenge of emerging and re-emerging infectious diseases
2004 StandoutNature
Stimulation of intrachromosomal homologous recombination in mammalian cells by ain inhibitor of poly(ADP-ribosylation)
1991
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
2000 StandoutNature
Poly(ADP-ribose) polymerase forms loops with DNA
1987
Poly(ADP-ribose) catabolism in mammalian cells exposed to DNA-damaging agents
1989
Nitric Oxide Acts Directly in the Presynaptic Neuron to Produce Long-Term Potentiationin Cultured Hippocampal Neurons
1996 StandoutNobel
Interactive effects of inhibitors of poly(ADP-ribose) polymerase and DNA-dependent protein kinase on cellular responses to DNA damage
1999
Poly(ADP‐Ribose) Polymerase in Plant Nuclei
1994
Radiotherapy plus Concomitant and Adjuvant Temozolomide for Glioblastoma
2005 Standout
Direct stimulation of poly(ADP ribose) polymerase in permeabilized cells by double-stranded DNA oligomers
1991
The DNA damage response: putting checkpoints in perspective
2000 StandoutNature
Prolongation of the p53 Response to DNA Strand Breaks in Cells Depleted of PARP by Antisense RNA Expression
1998
Histone shuttle driven by the automodification cycle of poly(ADP‐ribose) polymerase
1993
Isolation of Chinese hamster ovary cells with reduced poly(ADP-ribose) polymerase activity
1990
Base Excision Repair
2004
Cellular regulation of ADP-ribosylation of proteins
1991
ADP-ribosylation is involved in the integration of foreign DNA into the mammalian cell genome
1988
Rearrangements of the nucleosome structure in chromatin by poly(ADP-ribose)
1992
Poly(ADP-ribosyl)ation of chromatin in an in-vitro poly(ADP-ribose)-turnover system
1992
Bacteriophage Mu genome sequence: analysis and comparison with Mu-like prophages in Haemophilus, Neisseria and Deinococcus
2002
Identification and characterization of genomic loci unique to the Brazilian purpuric fever clonal group of H. influenzae biogroup aegyptius: functionality explored using meningococcal homology
2003
Expression in Escherichia coli of the 36 kDa domain of poly(ADP-ribose) polymerase and investigation of its DNA binding properties
1993
Review: Modulation of chromatin structure by poly(ADP-ribosyl)ation
1988
Molecular and biochemical features of poly (ADP-ribose) metabolism
1993
NAD depletion after in vitro exposure of murine lung slices to bleomycin
1993
Inhibition of gene-specific repair of alkylation damage in cells deplated of poly(ADP-ribose) polymerase
1994
Potentiation of N-methyl-N′-nitro-N-nitrosoguanidine-induced O6-methylguanine-DNA-methyltransferase activity in a rat hepatoma cell line by poly (ADP-ribose) synthesis inhibitors
1989
Modulation of nicotinamide adenine dinucleotide and poly(adenosine diphosphoribose) metabolism by calicheamicin γ1 in human HL-60 cells
1990
Contribution of incorporated 5-bromodeoxyuridine in DNA to the frequencies of sister-chromatid exchanges induced by inhibitors of poly-(ADP-ribose)-polymerase
1981
Long-Term Potentiation in the Hippocampal CA1 Region of Mice Lacking cGMP-Dependent Kinases Is Normal and Susceptible to Inhibition of Nitric Oxide Synthase
1999
Purification and characterization of human lymphoid poly(adenosine diphosphate ribose) polymerase
1982
Nuclear ADP-Ribosylation Reactions in Mammalian Cells: Where Are We Today and Where Are We Going?
2006
Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease.
1995
DNA Strand Break-Mediated Partitioning of Poly(ADP-Ribose) Polymerase Function
1994
Role of poly(adenosine diphosphate ribose) in deoxyribonucleic acid repair in human fibroblasts
1982
Photoaffinity labelling of human poly(ADP-ribose) polymerase catalytic domain
1997
Purification and characterization of poly(ADP-ribose) glycohydrolase. Different modes of action on large and small poly(ADP-ribose).
1986
Selective isolation of domains of chromatin proximal to both carcinogen-induced DNA damage and poly-adenosine diphosphate-ribosylation.
1985
Poly(ADP‐ribose) polymerase is a zinc metalloenzyme
1984
A new form of cerebellar long-term potentiation is postsynaptic and depends on nitric oxide but not cAMP
2002 StandoutNobel
DNA excision-repair defect of xeroderma pigmentosum prevents removal of a class of oxygen free radical-induced base lesions.
1993 StandoutNobel
Mammalian DNA ligases. Catalytic domain and size of DNA ligase I.
1990 StandoutNobel
Poly(ADP-ribose) biosynthesis and suicidal NAD+ depletion following carcinogen exposure of mammalian cells
1986
Ethidium bromide provides a simple tool for identifying genuine DNA-independent protein associations.
1992
Inhibitors of poly-(adenosine diphosphoribose) synthesis slow the resealing rate of x-ray-induced DNA strand breaks
1982
Reconstitution and poly(ADP-ribosyl)ation of proteolytically fragmented poly(ADP-ribose) synthetase.
1986
Role of DNA breaks and ADP-ribosyl transferase activity in eukaryotic differentiation demonstrated in human lymphocytes
1982 Nature
5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole inhibits transcription elongation by RNA polymerase II in vitro
1989 StandoutNobel
DNA strand breaks, NAD metabolism, and programmed cell death
1986
Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis.
1993 Standout
Frequency and Distribution of DNA Uptake Signal Sequences in the Haemophilus influenzae Rd Genome
1995 ScienceNobel
DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells
2000 StandoutNobel
Different substrate specificities of the two DNA ligases of mammalian cells.
1986 StandoutNobel
Histone shuttling by poly(ADP-ribosylation).
1992
Inhibition of poly(ADP-ribosyl)ation by overexpressing the poly(ADP-ribose) polymerase DNA-binding domain in mammalian cells.
1990
Effects of altered [ADP-ribose]n metabolism on expression of fetal functions by adult hepatocytes
1982 Nature
3-Aminobenzamide synergistically increases sister-chromatid exchanges in cells exposed to methyl methanesulfonate but not to ultraviolet light
1982
Inhibition of (ADP-ribose)n biosynthesis retards DNA repair but does not inhibit DNA repair synthesis
1981
Prooxidant States and Tumor Promotion
1985 StandoutScience
Poly(ADP-ribose) synthetase. The DNA binding domain and the automodification domain.
1982
Identification and arrangement of the DNA sequence recognized in specific transformation of Neisseria gonorrhoeae.
1988
Macromolecular association of ADP-ribosyltransferase and its correlation with enzymic activity
1990
DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways.
1994
Mechanism of the inhibition of Ca2+, Mg2+-dependent endonuclease of bull seminal plasma induced by ADP-ribosylation.
1984
Poly (ADP-Ribose) synthetase. Separation and identification of three proteolytic fragments as the substrate-binding domain, the DNA-binding domain, and the automodification domain.
1984
Preferential degradation of protein-bound (ADP-ribose)n by nuclear poly(ADP-ribose) glycohydrolase from human placenta.
1993
An ADP-ribosyltransferase as a potential target for nitric oxide action in hippocampal long-term potentiation.
1994
Cancer Cell Cycles
1996 StandoutScience
Effect of 3-aminobenzamide on the rate of ligation during repair of alkylated DNA in human fibroblasts.
1983
Human autoantibodies to poly(adenosine diphosphate-ribose) polymerase.
1987
Depletion of poly(ADP-ribose) polymerase by antisense RNA expression results in a delay in DNA strand break rejoining.
1992
Poly(ADP-ribose) polymerase inhibitors preserve oxidized nicotinamide adenine dinucleotide and adenosine 5'-triphosphate pools in DNA-damaged cells: mechanism of stimulation of unscheduled DNA synthesis
1983
NAD turnover during early development of Xenopus laevis
1983
Poly(ADP-ribose) catabolism in mammalian cells
1994
Cell Cycle Control and Cancer
1994 StandoutScienceNobel
Potentiation of cell killing by inhibitors of poly(adenosine diphosphate-ribose) synthesis in bleomycin-treated Chinese hamster ovary cells.
1985
Purification and characterization of NAD+:ADP-ribosyltransferase (polymerizing) from Dictyostelium discoideum
1993
One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products
2000 Standout
Accumulation of 10-kilobase DNA replication intermediates in cells treated with 3-aminobenzamide.
1985
Presence of branched portion in poly(adenosine diphosphate ribose) in vivo.
1982
cDNA sequence, protein structure, and chromosomal location of the human gene for poly(ADP-ribose) polymerase.
1987
The second zinc-finger domain of poly(ADP-ribose) polymerase determines specificity for single-stranded breaks in DNA.
1990
DNA fragmentation and NAD depletion. Their relation to the turnover of endogenous mono(ADP-ribosyl) and poly(ADP-ribosyl) proteins.
1982
Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53
1998 StandoutScience
Dinucleotide priming of transcription mediated by RNA polymerase II.
1984 StandoutNobel
Specific interaction between the self-splicing RNA of Tetrahymena and its guanosine substrate: implications for biological catalysis by RNA
1984 StandoutNatureNobel
Interactions between RNA polymerase II, factors, and template leading to accurate transcription.
1984 StandoutNobel
Three distinct DNA ligases in mammalian cells.
1991 StandoutNobel
Poly(ADP-ribose) synthetase, a main acceptor of poly(ADP-ribose) in isolated nuclei.
1981
3′-Deoxy-NAD+ as a substrate for poly(ADP-ribose)polymerase and the reaction mechanism of poly(ADP-ribose) elongation.
1988
Interaction of DNA-Dependent Protein Kinase and Poly(ADP-Ribose) Polymerase with Radiation-Induced DNA Strand Breaks
1997
Characterization of human poly(ADP-ribose) polymerase with autoantibodies.
1988
Purification and properties of poly(ADPribose)) polymerase from lamb thymus
1981
Expression and site-directed mutagenesis of the catalytic domain of human poly(ADP-ribose)polymerase in Escherichia coli. Lysine 893 is critical for activity.
1990
Participation of poly(ADP-ribosyl)ation in the depression of RNA synthesis caused by treatment of mouse lymphoma cells with methylnitrosourea.
1982
trans-Dominant Inhibition of Poly(ADP-Ribosyl)ation Sensitizes Cells against γ-Irradiation and N-Methyl-N′-Nitro-N-Nitrosoguanidine but Does Not Limit DNA Replication of a Polyomavirus Replicon
1995
Relative affinities of poly(ADP-ribose) polymerase and DNA-dependent protein kinase for DNA strand interruptions
1999
Loss of amplified genes by poly(ADP-ribose) polymerase inhibitors.
1991
A Shuttle Mechanism for DNA‐Protein Interactions
1982
Separation and characterization of factors mediating accurate transcription by RNA polymerase II.
1982 StandoutNobel
Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions
1999 Standout
Poly(ADP-ribose) degradation by glycohydrolase starts with an endonucleolytic incision.
1988
Differential regulation of S-region hypermutation and class-switch recombination by noncanonical functions of uracil DNA glycosylase
2014 StandoutNobel
Poly(ADP-ribose) polymerase auto-modification and interaction with DNA: electron microscopic visualization.
1983
The production of antibodies to DNA in normal mice following immunization with poly(ADP-ribose).
1986
TFIIF, a basal eukaryotic transcription factor, is a substrate for poly(ADP-ribosyl)ation
1997
Characterization of polymers of adenosine diphosphate ribose generated in vitro and in vivo
1987
Functional interactions of p53 with poly(ADP-ribose) polymerase (PARP) during apoptosis following DNA damage: covalent poly(ADP-ribosyl)ation of p53 by exogenous PARP and noncovalent binding of p53 to the M(r) 85,000 proteolytic fragment.
1998
Poly(ADP-Ribose) Polymerase Binds with Transcription Enhancer Factor 1 to MCAT1 Elements To Regulate Muscle-Specific Transcription
1999
Modulation of chromatin superstructure induced by poly(ADP-ribose) synthesis and degradation.
1986
Bacterial gene transfer by natural genetic transformation in the environment
1994
Poly(ADP-ribose) polymerase stimulates DNA polymerase alpha by physical association.
1993
Poly(ADP-ribosylation) in vitro. Reaction parameters and enzyme mechanism.
1982
Cooperative Interactions Between the Caenorhabditis elegans Homeoproteins UNC-86 and MEC-3
1993 StandoutScienceNobel
Tumor promoter phorbol-12-myristate-13-acetate induces poly(ADP)-ribosylation in fibroblasts.
1985
The Effect of Inhibition of (ADP‐ribose)n Biosynthesis on DNA Repair Assayed by the Nucleoid Technique
1981
Worthy of a detour
1982 StandoutNatureNobel
Modification of Nucleolar Protein B23 after Exposure to Ionizing Radiation
1995
Cloning and expression of cDNA for human poly(ADP-ribose) polymerase.
1987
Regulation of DNA ligase activity by poly(ADP-ribose)
1982 Nature
Irreversible binding of poly(ADP)ribose polymerase cleavage product to DNA ends revealed by atomic force microscopy: possible role in apoptosis.
1998
The zinc fingers of human poly(ADP-ribose) polymerase are differentially required for the recognition of DNA breaks and nicks and the consequent enzyme activation. Other structures recognize intact DNA.
1990
Differences in the regulation by poly(ADP-ribose) of repair of DNA damage from alkylating agents and ultraviolet light according to cell type.
1983
Poly ADP-ribosylation: a histone shuttle mechanism in DNA excision repair
1992
Oxidant injury of cells. DNA strand-breaks activate polyadenosine diphosphate-ribose polymerase and lead to depletion of nicotinamide adenine dinucleotide.
1986
ADP-ribosylation of diadenosine 5',5“-P1,P4-tetraphosphate by poly(ADP-ribose) polymerase in vitro.
1981
Inhibitors of poly(ADP-ribose) polymerase increase antibody class switching.
1993
Formation and resealing of intercalator-induced DNA strand breaks in permeabilized L1210 cells without the stimulated synthesis of poly(ADP-ribose).
1982 StandoutNobel
Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism
1999
DNA strand breaks and ADP-ribosyl transferase activation during cell differentiation
1982 Nature
Molecular Mechanisms of Mammalian DNA Repair and the DNA Damage Checkpoints
2004 StandoutNobel
γ-Radiation induced ADP-ribosyl transferase activity and mammalian longevity
1985
NAD(+)-dependent repair of damaged DNA by human cell extracts.
1993 StandoutNobel
Hydrogen peroxide-induced injury of cells and its prevention by inhibitors of poly(ADP-ribose) polymerase.
1986
Overproduction of the poly(ADP-ribose) polymerase DNA-binding domain blocks alkylation-induced DNA repair synthesis in mammalian cells.
1993
Mechanisms and Genes of Cellular Suicide
1995 StandoutScience
Disturbances in DNA precursor metabolism associated with exposure to an inhibitor of poly(ADP-ribose) synthetase
1986
Works of Robert C. Benjamin being referenced
The Complete Nucleotide Sequence of Bacteriophage HP1 DNA
1996
Identification of enzymatic activities which process protein bound mono(ADP-ribose)
1985
Poly(ADP-ribose) synthesis in vitro programmed by damaged DNA. A comparison of DNA molecules containing different types of strand breaks.
1980
Characterization of recognition sites on bacteriophage HP1c1 DNA which interact with the DNA uptake system of Haemophilus influenzae Rd
1984
ADP-ribosylation in mammalian cell ghosts. Dependence of poly(ADP-ribose) synthesis on strand breakage in DNA.
1980
Quantitative studies of inhibitors of ADP-ribosylation in vitro and in vivo
1989