Citation Impact
Citing Papers
Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation
2001 StandoutScienceNobel
Comprehensive computational design of ordered peptide macrocycles
2017 StandoutScienceNobel
Mouse model for noninvasive imaging of HIF prolyl hydroxylase activity: Assessment of an oral agent that stimulates erythropoietin production
2005 StandoutNobel
Expansive discovery of chemically diverse structured macrocyclic oligoamides
2024 StandoutScienceNobel
Concordant Regulation of Gene Expression by Hypoxia and 2-Oxoglutarate-dependent Dioxygenase Inhibition
2006 StandoutNobel
Genome-wide Association of Hypoxia-inducible Factor (HIF)-1α and HIF-2α DNA Binding with Expression Profiling of Hypoxia-inducible Transcripts
2009 StandoutNobel
Lipoic acid metabolism and mitochondrial redox regulation
2017
C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation
2001 StandoutNobel
Isolation and Biochemical Characterization of Hypophosphite/ 2-Oxoglutarate Dioxygenase
2002
Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain
2016 StandoutNatureNobel
Mechanisms of Topoisomerase I Inhibition by Anticancer Drugs
1994 StandoutNobel
The enzymology of clavam and carbapenem biosynthesis
2005
Site-directed Mutagenesis of 2,4-Dichlorophenoxyacetic Acid/α-Ketoglutarate Dioxygenase
2000
The Radical SAM Superfamily
2008
The human SUMF1 gene, required for posttranslational sulfatase modification, defines a new gene family which is conserved from pro- to eukaryotes
2003
Oxygen sensing by HIF hydroxylases
2004 StandoutNobel
Expanding the Enzyme Universe: Accessing Non‐Natural Reactions by Mechanism‐Guided Directed Evolution
2015 StandoutNobel
Studies on the active site of deacetoxycephalosporin C synthase
1999
Linaclotide Inhibits Colonic Nociceptors and Relieves Abdominal Pain via Guanylate Cyclase-C and Extracellular Cyclic Guanosine 3′,5′-Monophosphate
2013
New reactions in clavulanic acid biosynthesis
2002
Structural and mechanistic studies on 2-oxoglutarate-dependent oxygenases and related enzymes
1999
Enzymatic assembly of carbon–carbon bonds via iron-catalysed sp3 C–H functionalization
2018 StandoutNatureNobel
Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage
2002 StandoutNatureNobel
Differential Sensitivity of Hypoxia Inducible Factor Hydroxylation Sites to Hypoxia and Hydroxylase Inhibitors
2011 StandoutNobel
Crystal structure of a clavaminate synthase–Fe(II)–2‐oxoglutarate–substrate–NO complex: evidence for metal centred rearrangements
2002
Histone demethylation by a family of JmjC domain-containing proteins
2005 StandoutNature
Differential Function of the Prolyl Hydroxylases PHD1, PHD2, and PHD3 in the Regulation of Hypoxia-inducible Factor
2004 StandoutNobel
Regulation of angiogenesis by hypoxia: role of the HIF system
2003 StandoutNobel
The use of dioxygen by HIF prolyl hydroxylase (PHD1)
2002 StandoutNobel
Chemistry and biosynthesis of clavulanic acid and other clavams
1997
Identification of Strictly Conserved Histidine and Arginine Residues as Part of the Active Site in Petunia hybrida Flavanone 3β‐Hydroxylase
1997
Structure of proline 3‐hydroxylase
2001
Characterization of an altered DNA catalysis of a camptothecin-resistant eukaryotic topoisomerase I
1993
Specific interaction of camptothecin, a topoisomerase I inhibitor, with guanine residues of DNA detected by photoactivation at 365 nm
1993 StandoutNobel
Camptothecin inhibits both the cleavage and religation reactions of eukaryotic DNA topoisomerase I
1992
Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis
2019 StandoutNobel
The iron(II) and 2-oxoacid-dependent dioxygenases and their role in metabolism (1967 to 1999)
2000
Hypoxia-inducible Factor (HIF) Asparagine Hydroxylase Is Identical to Factor Inhibiting HIF (FIH) and Is Related to the Cupin Structural Family
2002 StandoutNobel
Asparaginyl Hydroxylation of the Notch Ankyrin Repeat Domain by Factor Inhibiting Hypoxia-inducible Factor
2007 StandoutNobel
Stalking intermediates in oxygen activation by iron enzymes: Motivation and method
2006
Enzymatic functionalization of carbon–hydrogen bonds
2010 StandoutNobel
Cellular Determinants of Sensitivity and Resistance to DNA Topoisomerase Inhibitors
1994 StandoutNobel
Structure of Factor-inhibiting Hypoxia-inducible Factor (HIF) Reveals Mechanism of Oxidative Modification of HIF-1α
2003 StandoutNobel
Induction of cleavage in topoisomerase I c-DNA by topoisomerase I enzymes from calf thymus and wheat germ in the presence and absence of camptothecin
1993 StandoutNobel
Native structure of photosystem II at 1.95 Å resolution viewed by femtosecond X-ray pulses
2014 StandoutNature
The Retinoblastoma Binding Protein RBP2 Is an H3K4 Demethylase
2007 StandoutNobel
Effects of Uracil Incorporation, DNA Mismatches, and Abasic Sites on Cleavage and Religation Activities of Mammalian Topoisomerase I
1997 StandoutNobel
Fe(II)/α-Ketoglutarate-Dependent Hydroxylases and Related Enzymes
2004
Structural origins of the selectivity of the trifunctional oxygenase clavaminic acid synthase.
2000
Function, Attachment and Synthesis of Lipoic Acid in Escherichia coli
2005
Trends in peptide drug discovery
2021
Spectroscopic and electronic structure studies of aromatic electrophilic attack and hydrogen-atom abstraction by non-heme iron enzymes
2006
Chemical Topology: Complex Molecular Knots, Links, and Entanglements
2011 StandoutNobel
Orally Absorbed Cyclic Peptides
2017
Estimation of response spectra and peak accelerations from western North American earthquakes; an interim report
1993
Crystal Structures of Human Topoisomerase I in Covalent and Noncovalent Complexes with DNA
1998 Science
Synthesis, functionalization, and properties of intercalation compounds
2003
Investigation of theStreptomyces clavuligerusCephamycin C Gene Cluster and Its Regulation by the CcaR Protein
1998
Mechanism-Based Inactivation of the Human Prolyl-4-hydroxylase by 5-Oxaproline-Containing Peptides: Evidence for a Prolyl Radical Intermediate
1999
RadicalS-Adenosylmethionine Enzymes
2014
Non-Heme Fe(IV)–Oxo Intermediates
2007 Standout
Molecular Modeling Studies of the DNA−Topoisomerase I Ternary Cleavable Complex with Camptothecin
1998 StandoutNobel
A Structural Model for the Ternary Cleavable Complex Formed between Human Topoisomerase I, DNA, and Camptothecin
2001
Mechanism of Taurine: α‐Ketoglutarate Dioxygenase (TauD) from Escherichia coli
2005
Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor
2002 StandoutNobel
Interaction of an alkylating camptothecin derivative with a DNA base at topoisomerase I-DNA cleavage sites.
1995 StandoutNobel
Posttranslational hydroxylation of ankyrin repeats in IκB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)
2006 StandoutNobel
Effect of local DNA sequence on topoisomerase I cleavage in the presence or absence of camptothecin.
1991 StandoutNobel
Tumor Cell Death Induced by Topoisomerase-Targeting Drugs
2001
Liquid Exfoliation of Layered Materials
2013 StandoutScience
Fluorophore Targeting to Cellular Proteins via Enzyme-Mediated Azide Ligation and Strain-Promoted Cycloaddition
2012 StandoutNobel
AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination
2009 StandoutNobel
S-Adenosylmethionine: A Wolf in Sheep's Clothing, or a Rich Man's Adenosylcobalamin?
2003
Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism
2010 StandoutNobel
Direct spectroscopic detection of a C-H-cleaving high-spin Fe(IV) complex in a prolyl-4-hydroxylase
2006
Site-specific chemical modification of recombinant proteins produced in mammalian cells by using the genetically encoded aldehyde tag
2009 StandoutNobel
Dioxygen Activation at Mononuclear Nonheme Iron Active Sites: Enzymes, Models, and Intermediates
2004 Standout
Enzymatic Chemistry of Cyclopropane, Epoxide, and Aziridine Biosynthesis
2011
Enzymatic construction of highly strained carbocycles
2018 StandoutScienceNobel
Two interconverting Fe(IV) intermediates in aliphatic chlorination by the halogenase CytC3
2007
Spectroscopic Studies of Substrate Interactions with Clavaminate Synthase 2, a Multifunctional α-KG-Dependent Non-Heme Iron Enzyme: Correlation with Mechanisms and Reactivities
2001
Copper induces cell death by targeting lipoylated TCA cycle proteins
2022 StandoutScience
Non-heme iron enzymes: Contrasts to heme catalysis
2003
Response of High-Rise and Base-Isolated Buildings to a Hypothetical M w 7.0 Blind Thrust Earthquake
1995 StandoutScience
Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy
2014 StandoutNobel
Structure of an HIF-1α-pVHL Complex: Hydroxyproline Recognition in Signaling
2002 StandoutScienceNobel
Chemomimetic Biocatalysis: Exploiting the Synthetic Potential of Cofactor-Dependent Enzymes To Create New Catalysts
2015 StandoutNobel
Role of the nonheme Fe(II) center in the biosynthesis of the plant hormone ethylene
1999
Reversal of DNA alkylation damage by two human dioxygenases
2002 StandoutNobel
Hypoxic retinal Müller cells promote vascular permeability by HIF-1–dependent up-regulation of angiopoietin-like 4
2013 StandoutNobel
Spectroscopic and Computational Evaluation of the Structure of the High-Spin Fe(IV)-Oxo Intermediates in Taurine: α-Ketoglutarate Dioxygenase from Escherichia coli and Its His99Ala Ligand Variant
2007
C–C bond forming radical SAM enzymes involved in the construction of carbon skeletons of cofactors and natural products
2018
Cloning of Chinese hamster DNA topoisomerase I cDNA and identification of a single point mutation responsible for camptothecin resistance.
1993
Molecular Mechanisms of Mammalian DNA Repair and the DNA Damage Checkpoints
2004 StandoutNobel
Quantum Chemical Studies of Mechanisms for Metalloenzymes
2014
β-Secondary Kinetic Isotope Effects in the Clavaminate Synthase-Catalyzed Oxidative Cyclization of Proclavaminic Acid and in Related Azetidinone Model Reactions
1999
Product-substrate engineering by bacteria: Studies on clavaminate synthase, a trifunctional dioxygenase
1999
Works of Robert Busby being referenced
Linaclotide, through activation of guanylate cyclase C, acts locally in the gastrointestinal tract to elicit enhanced intestinal secretion and transit
2010
Linaclotide is a potent and selective guanylate cyclase C agonist that elicits pharmacological effects locally in the gastrointestinal tract
2010
A Strategy for Identifying Novel, Mechanistically Unique Inhibitors of Topoisomerase I
1992
Expression and Purification of Two Isozymes of Clavaminate Synthase and Initial Characterization of the Iron Binding Site
1995
Pharmacologic Properties, Metabolism, and Disposition of Linaclotide, a Novel Therapeutic Peptide Approved for the Treatment of Irritable Bowel Syndrome with Constipation and Chronic Idiopathic Constipation
2012
A single monomeric iron center in clavaminate synthase catalyzes three nonsuccessive oxidative transformations
1996
Lipoic Acid Biosynthesis: LipA Is an Iron−Sulfur Protein
1999
Circular Dichroism and Magnetic Circular Dichroism Spectroscopic Studies of the Non-Heme Ferrous Active Site in Clavaminate Synthase and Its Interaction with α-Ketoglutarate Cosubstrate
1998
Probable Role of Clavaminic Acid as the Terminal Intermediate in the Common Pathway to Clavulanic Acid and the Antipodal Clavam Metabolites
1997
Observations of Loma Prieta aftershocks from a dense array in Sunnyvale, California
1991
Irreversible trapping of the DNA-topoisomerase I covalent complex. Affinity labeling of the camptothecin binding site.
1990
Identification, cloning, sequencing, and overexpression of the gene encoding proclavaminate amidino hydrolase and characterization of protein function in clavulanic acid biosynthesis
1995
Escherichia coli LipA Is a Lipoyl Synthase: In Vitro Biosynthesis of Lipoylated Pyruvate Dehydrogenase Complex from Octanoyl-Acyl Carrier Protein
2000
Site-Directed Mutagenesis and Biochemical Analysis of the Endogenous Ligands in the Ferrous Active Site of Clavaminate Synthase. The His-3 Variant of the 2-His-1-Carboxylate Model
2000