Standout Papers
Citation Impact
Citing Papers
An Msh2 Point Mutation Uncouples DNA Mismatch Repair and Apoptosis
2004
The role of hMLH1, hMSH3, and hMSH6 defects in cisplatin and oxaliplatin resistance: correlation with replicative bypass of platinum-DNA adducts.
1998
Mismatch Repair-dependent Iterative Excision at Irreparable O6-Methylguanine Lesions in Human Nuclear Extracts
2006 StandoutNobel
Mismatch Repair Processing of Carcinogen-DNA Adducts Triggers Apoptosis
1999
Mismatch repair deficiency associated with overexpression of the MSH3 gene
1998
Hallmarks of Cancer: The Next Generation
2011 Standout
A Naturally Occurring hPMS2 Mutation Can Confer a Dominant Negative Mutator Phenotype
1998 StandoutNobel
Methotrexate induces oxidative DNA damage and is selectively lethal to tumour cells with defects in the DNA mismatch repair gene MSH2
2009
Extended weekly dose-dense paclitaxel/carboplatin is feasible and active in heavily pre-treated platinum-resistant recurrent ovarian cancer
2009
Reconstitution of Yeast Nucleotide Excision Repair with Purified Rad Proteins, Replication Protein A, and Transcription Factor TFIIH
1995
Kinetics of the Action of Thymine DNA Glycosylase
1998
MGMT: Key node in the battle against genotoxicity, carcinogenicity and apoptosis induced by alkylating agents
2007
Homologous Recombination Rescues Mismatch-Repair-Dependent Cytotoxicity of SN1-Type Methylating Agents in S. cerevisiae
2005
Strand-specific Mismatch Repair in Mammalian Cells
1997 StandoutNobel
Cisplatin: mode of cytotoxic action and molecular basis of resistance
2003 Standout
Mismatch repair and DNA damage signalling
2004
Epigenetics in human disease and prospects for epigenetic therapy
2004 StandoutNature
Ovarian cancer
2014 Standout
MutS homologs in mammalian cells
1997
Molecular mechanisms of drug resistance
2005
Order of Assembly of Human DNA Repair Excision Nuclease
1999 StandoutNobel
Selective recognition of a cisplatin-DNA adduct by human mismatch repair proteins
1997
Reconstitution of 5′-Directed Human Mismatch Repair in a Purified System
2005
Role of hMLH1 promoter hypermethylation in drug resistance to 5‐fluorouracil in colorectal cancer cell lines
2003
Direct Visualization of Asymmetric Adenine Nucleotide-Induced Conformational Changes in MutLα
2008 StandoutNobel
Structure and function of the N-terminal 40 kDa fragment of human PMS2: a monomeric GHL ATPase
2001
Cancer drug resistance: an evolving paradigm
2013 Standout
NUCLEOTIDE EXCISION REPAIR
1993 StandoutNobel
The mismatch-repair protein hMSH2 binds selectively to DNA adducts of the anticancer drug cisplatin
1996
The resurgence of platinum-based cancer chemotherapy
2007 Standout
Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
1998 StandoutNatureNobel
The power and the promise of DNA methylation markers
2003
Characterization of Reaction Intermediates of Human Excision Repair Nuclease
1997 StandoutNobel
Interactions of Human Mismatch Repair Proteins MutSα and MutLα with Proteins of the ATR-Chk1 Pathway
2009 StandoutNobel
When Checkpoints Fail
1997 StandoutNobel
Hydrolytic function of Exo1 in mammalian mismatch repair
2014 StandoutNobel
Measurement of chemoresistance markers in patients with stage iii non–small cell lung cancer: a novel approach for patient selection
2003
Expression ofMsx-2 during development, regeneration, and wound healing in axolotl limbs
1998
TRIBE: Hijacking an RNA-Editing Enzyme to Identify Cell-Specific Targets of RNA-Binding Proteins
2016 StandoutNobel
DNA damage recognition during nucleotide excision repair in mammalian cells
1999
Mismatch-, MutS-, MutL-, and Helicase II-dependent Unwinding from the Single-strand Break of an Incised Heteroduplex
1998 StandoutNobel
RPA involvement in the damage-recognition and incision steps of nucleotide excision repair
1995 Nature
Endonucleolytic Function of MutLα in Human Mismatch Repair
2006 StandoutNobel
Epigenetics in Cancer
2008 Standout
Plasticity of Retrovirus-Labelled Myotubes in the Newt Limb Regeneration Blastema
2000
Metagenomic biomarker discovery and explanation
2011 Standout
Human Exonuclease I Is Required for 5′ and 3′ Mismatch Repair
2002 StandoutNobel
Identifying DNA Methylation Biomarkers of Cancer Drug Response
2005
Human Ku Autoantigen Binds Cisplatin-damaged DNA but Fails to Stimulate Human DNA-activated Protein Kinase
1996
Enrichment for DNA mismatch repair-deficient cells during treatment with cisplatin
1998
Cellular and molecular determinants of cisplatin resistance
1998
Structures of Human Exonuclease 1 DNA Complexes Suggest a Unified Mechanism for Nuclease Family
2011 StandoutNobel
Expression ofMsx genes in regenerating and developing limbs of axolotl
1998
MutS Preferentially Recognizes Cisplatin- over Oxaliplatin-modified DNA
2002
Preferential binding of the xeroderma pigmentosum group A complementing protein to damaged DNA
1993
Eukaryotic mismatch repair: an update
1998
Differential human nucleotide excision repair of paired and mispaired cisplatin-DNA adducts
1997
DNA Polymerase δ Is Required for Human Mismatch Repair in Vitro
1997 StandoutNobel
Resistance to 6-thioguanine in mismatch repair-deficient human cancer cell lines correlates with an increase in induced mutations at the HPRT locus
1998
Different forms of TFIIH for transcription and DNA repair: Holo-TFIIH and a nucleotide excision repairosome
1995 StandoutNobel
Electron Crystal Structure of the Transcription Factor and DNA Repair Complex, Core TFIIH
2000 StandoutNobel
The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage
1999 StandoutNatureNobel
A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations
2010 Standout
Sensory Nerves in Lung and Airways
2014
Role of DNA mismatch repair in apoptotic responses to therapeutic agents
2004
High-Resolution Microtubule Structures Reveal the Structural Transitions in αβ-Tubulin upon GTP Hydrolysis
2014 StandoutNobel
Microtubule-binding agents: a dynamic field of cancer therapeutics
2010 Standout
Microsatellite Instability in Human Cancer: A Prognostic Marker for Chemotherapy?
1999
DDP-induced cytotoxicity is not influenced by p53 in nine human ovarian cancer cell lines with different p53 status
1997
Dual role of TFIIH in DNA excision repair and in transcription by RNA polymerase II
1994 StandoutNatureNobel
Reconstitution of Human Excision Nuclease with Recombinant XPF-ERCC1 Complex
1997 StandoutNobel
Adenosine nucleotide modulates the physical interaction between hMSH2 and BRCA1
2001
Ongoing and unsaid on oxaliplatin: the hope
1998
Mechanisms of tolerance to DNA damaging therapeutic drugs
2001
Discrete in vivo roles for the MutL homologs Mlh2p and Mlh3p in the removal of frameshift intermediates in budding yeast
2000
Aberrant Epigenetic Landscape in Cancer: How Cellular Identity Goes Awry
2010
The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores
2009 Standout
Functions of MutLα, Replication Protein A (RPA), and HMGB1 in 5′-Directed Mismatch Repair
2009 StandoutNobel
Mismatch Repair in Human Nuclear Extracts
2002
Cancer epigenomics: DNA methylomes and histone-modification maps
2007 Standout
Piezo2 senses airway stretch and mediates lung inflation-induced apnoea
2016 StandoutNatureNobel
Driver mutations in TP53 are ubiquitous in high grade serous carcinoma of the ovary
2010
In Vivo Imaging Indicates Muscle Fiber Dedifferentiation Is a Major Contributor to the Regenerating Tail Blastema
2001
Mechanism of 5′-Directed Excision in Human Mismatch Repair
2003 StandoutNobel
Identification of hMutLβ, a Heterodimer of hMLH1 and hPMS1
1999
Mammalian DNA nucleotide excision repair reconstituted with purified protein components
1995
Specific Binding of Human MSH2·MSH6 Mismatch-Repair Protein Heterodimers to DNA Incorporating Thymine- or Uracil-containing UV Light Photoproducts Opposite Mismatched Bases
1999
Molecular mechanism of nucleotide excision repair
1999
Strategies for reversing drug resistance
2003
NF-κB Mediates FGF Signal Regulation of msx-1 Expression
2001
Enhancement of Cisplatin Sensitivity in High Mobility Group 2 cDNA‐transfected Human Lung Cancer Cells
1999
Methylator resistance mediated by mismatch repair deficiency in a glioblastoma multiforme xenograft.
1997 StandoutNobel
BRCA Mutation Frequency and Patterns of Treatment Response in BRCA Mutation–Positive Women With Ovarian Cancer: A Report From the Australian Ovarian Cancer Study Group
2012
Mammalian DNA Mismatch Repair
1999
Inferring tumour purity and stromal and immune cell admixture from expression data
2013 Standout
DNA MISMATCH REPAIR AND GENETIC INSTABILITY
2000
162 Differential sensitivity of P53+ and P53- cells to caffeine-induced radiosensitization and override of G2 delay
1995
Quality Control by DNA Repair
1999 StandoutScienceNobel
The role of mismatch repair in DNA damage-induced apoptosis.
1999
The fluxgate magnetometer
1979
Localization of the binding region of high mobility group protein 2 to cisplatin-damaged DNA.
1993
A gene hypermethylation profile of human cancer.
2001 Standout
DNA Mismatch Repair: Functions and Mechanisms
2005 StandoutNobel
DNA Mismatch Repair: Molecular Mechanisms and Biological Function
2003
Human MutSalpha recognizes damaged DNA base pairs containing O6-methylguanine, O4-methylthymine, or the cisplatin-d(GpG) adduct.
1996 StandoutNobel
Tumor Microsatellite-Instability Status as a Predictor of Benefit from Fluorouracil-Based Adjuvant Chemotherapy for Colon Cancer
2003 Standout
New Strategies in the Treatment of Ovarian Cancer: Current Clinical Perspectives and Future Potential
2013
Epigenetic regulation of the MGMT and hMSH6 DNA repair genes in cells resistant to methylating agents
2000
Low magnetic flux noise observed in laser-deposited in situ films of YB2Cu3Oy and implications for high- Tc SQUIDs
1989 StandoutNatureNobel
p53-dependent and -independent responses to cisplatin in mouse testicular teratocarcinoma cells
1998
Structure, Recognition, and Processing of Cisplatin−DNA Adducts
1999 Standout
Functional Studies on the Candidate ATPase Domains of Saccharomyces cerevisiae MutLα
2000
Post-Transcriptional Controls by Ribonucleoprotein Complexes in the Acquisition of Drug Resistance
2013
Functional specificity of MutL homologs in yeast: Evidence for three Mlh1-based heterocomplexes with distinct roles during meiosis in recombination and mismatch correction
1999
Assembly, subunit composition, and footprint of human DNA repair excision nuclease
1998 StandoutNobel
Dependence of the Cytotoxicity of DNA-Damaging Agents on the Mismatch Repair Status of Human Cells
2004
The Impact of High-Temperature Superconductivity on SQUID Magnetometers
1988 StandoutScienceNobel
Cisplatin−DNA Binding Specificity of Calf High-Mobility Group 1 Protein
1996
Cellular and Molecular Regulation of Muscle Regeneration
2004 Standout
Biallelic inactivation of hMLH 1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers
1998 StandoutNobel
Human DNA Repair Genes
2001 StandoutScienceNobel
Interaction of mismatch repair protein PMS2 and the p53-related transcription factor p73 in apoptosis response to cisplatin
2003
Translocation of a UV-damaged DNA binding protein into a tight association with chromatin after treatment of mammalian cells with UV light
1997
Role of the hMLH1 DNA mismatch repair protein in fluoropyrimidine-mediated cell death and cell cycle responses.
2001
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
1997 StandoutScienceNobel
hMutSα- and hMutLα-dependent phosphorylation of p53 in response to DNA methylator damage
1999 StandoutNobel
Disruption of p53 function sensitizes breast cancer MCF-7 cells to cisplatin and pentoxifylline.
1995 StandoutNobel
Cytokines Inhibit p53-Mediated Apoptosis but Not p53-Mediated G1 Arrest
1995
Involvement of the Mismatch Repair System in Temozolomide-Induced Apoptosis
1998
REPLICATION PROTEIN A: A Heterotrimeric, Single-Stranded DNA-Binding Protein Required for Eukaryotic DNA Metabolism
1997
Biochemistry and genetics of eukaryotic mismatch repair.
1996
Recognition and Repair of Compound DNA Lesions (Base Damage and Mismatch) by Human Mismatch Repair and Excision Repair Systems
1997 StandoutNobel
Works of Robert Brown being referenced
Novel Molecular Subtypes of Serous and Endometrioid Ovarian Cancer Linked to Clinical Outcome
2008
Ovarian Cancer Stem Cell–Like Side Populations Are Enriched Following Chemotherapy and Overexpress EZH2
2011
Inactivation of HOXA Genes by Hypermethylation in Myeloid and Lymphoid Malignancy is Frequent and Associated with Poor Prognosis
2007
Prognostic DNA Methylation Biomarkers in Ovarian Cancer
2006
Dual repair modulation reverses Temozolomide resistance in vitro
2004
Epigenetics as a mechanism driving polygenic clinical drug resistance
2006
Cisplatin-DNA damage recognition proteins in human tumour extracts
1993
Epigenetic inactivation ofMCJ (DNAJD1) in malignant paediatric brain tumours
2005
Expression and activity of the newt Msx-1 gene in relation to limb regeneration
1995
Signalling cell cycle arrest and cell death through the MMR System
2005
hMLH1 expression and cellular responses of ovarian tumour cells to treatment with cytotoxic anticancer agents
1997
The Acquisition of hMLH1 Methylation in Plasma DNA after Chemotherapy Predicts Poor Survival for Ovarian Cancer Patients
2004
A role for methylation of the hMLH1 promoter in loss of hMLH1 expression and drug resistance in ovarian cancer
1999
‘Air hunger’ arising from increased PCO2 in mechanically ventilated quadriplegics
1989
A role for mismatch repair in control of DNA ploidy following DNA damage
2001
Cisplatin and Adriamycin Resistance Are Associated with MutLα and Mismatch Repair Deficiency in an Ovarian Tumor Cell Line
1996 StandoutNobel
Critical evaluation of p53 as a prognostic marker in ovarian cancer
2004
Binding activities of cis‐platin‐damage‐recognition proteins in human tumour cell lines
1993
The epigenetics of ovarian cancer drug resistance and resensitization
2004
Dependence on RAD52 and RAD1 for anticancer drug resistance mediated by inactivation of mismatch repair genes
1999
HOXA5 is targeted by cell-type-specific CpG island methylation in normal cells and during the development of acute myeloid leukaemia
2006
Increased accumulation of p53 protein in cisplatin‐resistant ovarian cell lines
1993
Binding of human single-stranded DNA binding protein to DNA damaged by the anticancer drug cis-diamminedichloroplatinum (II).
1992
Methylation microarray analysis of late-stage ovarian carcinomas distinguishes progression-free survival in patients and identifies candidate epigenetic markers.
2002
A miniature fluxgate magnetometer with sub-gamma noise
1972
Phase I and Pharmacodynamic Trial of the DNA Methyltransferase Inhibitor Decitabine and Carboplatin in Solid Tumors
2007
Reversal of drug resistance in human tumor xenografts by 2'-deoxy-5-azacytidine-induced demethylation of the hMLH1 gene promoter.
2000
Reduced MLH1 Expression in Breast Tumors After Primary Chemotherapy Predicts Disease-Free Survival
2000
Microsatellite instability, apoptosis, and loss of p53 function in drug-resistant tumor cells.
1996
Modulation of drug resistance mediated by loss of mismatch repair by the DNA polymerase inhibitor aphidicolin.
1999
Cell cycle arrests and radiosensitivity of human tumor cell lines: dependence on wild-type p53 for radiosensitivity.
1994
Recent advances in fluxgate magnetometry
1972
Pharmacogenetic Assessment of Toxicity and Outcome After Platinum Plus Taxane Chemotherapy in Ovarian Cancer: The Scottish Randomised Trial in Ovarian Cancer
2007