Citation Impact
Citing Papers
Multiplex Genome Engineering Using CRISPR/Cas Systems
2013 StandoutScience
Anti-Markovnikov alkene oxidation by metal-oxo–mediated enzyme catalysis
2017 StandoutScienceNobel
C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector
2016 StandoutScience
RNA-Guided Human Genome Engineering via Cas9
2013 StandoutScience
A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity
2012 StandoutScienceNobel
Direct and Catalytic C ‐Glycosylation of Arenes: Expeditious Synthesis of the Remdesivir Nucleoside**
2021 StandoutNobel
Structures of the RNA-guided surveillance complex from a bacterial immune system
2011 StandoutNatureNobel
DNA interrogation by the CRISPR RNA-guided endonuclease Cas9
2014 StandoutNatureNobel
Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
2006 StandoutNature
Inhibition of the G2 DNA Damage Checkpoint and of Protein Kinases Chk1 and Chk2 by the Marine Sponge Alkaloid Debromohymenialdisine
2001
Paradigms of ribosome synthesis: Lessons learned from ribosomal proteins
2014
Photochemical Reactions as Key Steps in Natural Product Synthesis
2011
Bacillus subtilis trp Leader RNA
2009
High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects
2016 StandoutNature
Mechanism Targeted Discovery of Antitumor Marine Natural Products
2004
Marine natural products
1990 Standout
Protein kinase inhibition of clinically important staurosporine analogues
2010
Life in cellulose houses: symbiotic bacterial biosynthesis of ascidian drugs and drug leads
2010
New CRISPR–Cas systems from uncultivated microbes
2016 StandoutNatureNobel
Marine natural products
2009
Maturation and degradation of RNA in bacteria
2007
Marine pharmacology in 2003–2004: Anti-tumour and cytotoxic compounds
2006
CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III
2011 StandoutNatureNobel
DTX5c, a new OA sulphate ester derivative from cultures of Prorocentrum belizeanum
2006
Deep-sea natural products
2008
Foreign DNA capture during CRISPR–Cas adaptive immunity
2015 StandoutNatureNobel
The CRISPR-associated DNA-cleaving enzyme Cpf1 also processes precursor CRISPR RNA
2016 StandoutNatureNobel
Chapter 15 Assay of Bacillus subtilis Ribonucleases In Vitro
2008
In vivo genome editing using Staphylococcus aureus Cas9
2015 StandoutNature
RNA-guided genetic silencing systems in bacteria and archaea
2012 StandoutNatureNobel
Synthesis and structure–activity relationships of N-6 substituted analogues of 9-hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of Wee1 and Chk1 checkpoint kinases
2007
Bis-imide granulatimide analogues as potent Checkpoint 1 kinase inhibitors
2006
Phosphorylation of CpgA Protein Enhances Both Its GTPase Activity and Its Affinity for Ribosome and Is Crucial for Bacillus subtilis Growth and Morphology
2012
Diterpenes from gorgonian corals
2009
Biology and Applications of CRISPR Systems: Harnessing Nature’s Toolbox for Genome Engineering
2016 StandoutNobel
Intermolecular Radical Carbofluorination of Non‐activated Alkenes
2014
Integrase-mediated spacer acquisition during CRISPR–Cas adaptive immunity
2015 StandoutNatureNobel
The Biology of CRISPR-Cas: Backward and Forward
2018 StandoutNobel
CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes
2013 StandoutNobel
Enzymatic Synthesis of Optically Active Tertiary Alcohols: Expanding the Biocatalysis Toolbox
2008
Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection
2016 StandoutNatureNobel
The Impact of the Mukaiyama Aldol Reaction in Total Synthesis
2013
Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression
2013 StandoutNobel
A Fluorogenic Aryl Fluorosulfate for Intraorganellar Transthyretin Imaging in Living Cells and in Caenorhabditis elegans
2015 StandoutNobel
Applications of Continuous-Flow Photochemistry in Organic Synthesis, Material Science, and Water Treatment
2016
In vivo 3′-to-5′ exoribonuclease targetomes of Streptococcus pyogenes
2018 StandoutNobel
The structure of LepA, the ribosomal back translocase
2008 StandoutNobel
Monofluorination of Organic Compounds: 10 Years of Innovation
2015 Standout
Copper-Mediated Coupling Reactions and Their Applications in Natural Products and Designed Biomolecules Synthesis
2008 Standout
SuFEx Click Chemistry Enabled Late-Stage Drug Functionalization
2018 StandoutNobel
A Cas9–guide RNA complex preorganized for target DNA recognition
2015 StandoutScienceNobel
Synthesis and Biological Evaluation of 10,11-Dihydrodictyostatin, a Potent Analogue of the Marine Anticancer Agent Dictyostatin
2007
Drug Discovery and Natural Products: End of an Era or an Endless Frontier?
2009 StandoutScience
Radicals: Reactive Intermediates with Translational Potential
2016
Functions of Ribosomal Proteins in Assembly of Eukaryotic Ribosomes In Vivo
2015
Synthesis of Granulatimide Positional Analogues.
2003
Formal fluorine atom transfer radical addition: silver-catalyzed carbofluorination of unactivated alkenes with ketones in aqueous solution
2014
A cooperative allylic fluorination: combination of nucleophilic and electrophilic fluorine sources
2014
The Hitchhiker’s Guide to Flow Chemistry
2017 Standout
Synthesis, in vitro antiproliferative activities, and Chk1 inhibitory properties of dipyrrolo[3,4-a:3,4-c]carbazole-triones
2006
Synthesis of isogranulatimides A and B analogues possessing a 7-azaindole unit instead of an indole moiety
2003
Synthesis of aminopyrimidylindoles structurally related to meridianins
2007
The new frontier of genome engineering with CRISPR-Cas9
2014 StandoutScienceNobel
Catalytic fluorination of unactivated C(sp3)–H bonds
2014
Synthesis of Rebeccamycin and 11-Dechlororebeccamycin
1999
RNA Degradation inStaphylococcus aureus: Diversity of Ribonucleases and Their Impact
2015
Selective fluorination of alkyl C–H bonds via photocatalysis
2014
Occurrence, Biogenesis, and Synthesis of Biologically Active Carbazole Alkaloids
2012 Standout
Silver-Catalyzed Radical Fluorination of Alkylboronates in Aqueous Solution
2014
A bacterial Argonaute with noncanonical guide RNA specificity
2016 StandoutNobel
Recent advances in the synthesis of tetrahydrofurans and applications in total synthesis
2016
A Journey Under the Sea: The Quest for Marine Anti-Cancer Alkaloids
2011
Programmed DNA destruction by miniature CRISPR-Cas14 enzymes
2018 StandoutScienceNobel
The medicinal chemist's toolbox for late stage functionalization of drug-like molecules
2015
Osmosensory signaling in Mycobacterium tuberculosis mediated by a eukaryotic-like Ser/Thr protein kinase
2013 StandoutNobel
Synthesis of N-alkyl substituted bioactive indolocarbazoles related to Gö6976
2006
Azine Activation via Silylium Catalysis
2021 StandoutNobel
Flow Synthesis of Fluorinated α‐Amino Acids
2015
Kinetic Resolution of Homoaldols via Catalytic Asymmetric Transacetalization
2010 StandoutNobel
New Synthetic Route to Granulatimide and Its Structural Analogues.
2002
Synthesis of Aryl- and Heteroaryl[a]pyrrolo[3,4-c]carbazoles
2003
Synthesis of two series of pyrazolic analogues of the marine alkaloids granulatimide and isogranulatimide as potent Checkpoint 1 kinase inhibitors
2010
A Small-Footprint, High-Capacity Flow Reactor for UV Photochemical Synthesis on the Kilogram Scale
2016
Diastereodivergent Hydroxyfluorination of Cyclic and Acyclic Allylic Amines: Synthesis of 4-Deoxy-4-fluorophytosphingosines
2012
Large-Scale Applications of Transition Metal-Catalyzed Couplings for the Synthesis of Pharmaceuticals
2011 Standout
Synthesis of naphthopyrrolo[3,4-c]carbazoles
2001
Evolution of a molecular switch: universal bacterial GTPases regulate ribosome function
2001
Transition Metal Complexes in Organic Synthesis, Part 73. Synthetic Routes to Naturally Occurring Furocarbazoles
2004
Synthesis of granulatimide bis-imide analogues
2005
Messenger RNA Degradation in Bacterial Cells
2014
Alkaloids from Marine Ascidians
2011
Synthesis and biological evaluation of novel analogues of dictyostatin
2007
Site-Selective Aliphatic C–H Chlorination Using N-Chloroamides Enables a Synthesis of Chlorolissoclimide
2015
Determination of Relative Configuration in Organic Compounds by NMR Spectroscopy and Computational Methods
2007
Structure and assembly model for the Trypanosoma cruzi 60S ribosomal subunit
2016 StandoutNobel
Asymmetric Total Synthesis of (+)-Hexachlorosulfolipid, a Cytotoxin Isolated from Adriatic Mussels
2010
Briarane, Erythrane, and Aquariane Diterpenoids from the Caribbean Gorgonian Erythropodium caribaeorum
2003
Synthetic Approaches and Pharmacological Activity of 1,3,4-Oxadiazoles: A Review of the Literature from 2000–2012
2012
Navigating the Chiral Pool in the Total Synthesis of Complex Terpene Natural Products
2017
Synthesis of granulatimide analogues bearing a maleimide instead of an imidazole heterocycle
2003
Molecular orbital calculations, experimental and theoretical UV spectra of granulatimides and didemnimides, biologically active polycyclic heteroaromatic alkaloids from the ascidian Didemnum granulatum
2001
Synthesis of isogranulatimide analogues possessing a pyrrole moiety instead of an imidazole heterocycle
2003
Strong and Confined Acids Enable a Catalytic Asymmetric Nazarov Cyclization of Simple Divinyl Ketones
2019 StandoutNobel
5 Marine natural products
2003
Solar Synthesis: Prospects in Visible Light Photocatalysis
2014 StandoutScience
First synthesis of symmetrical and non-symmetrical aza indolocarbazoles derivatives
2002
Rewriting a genome
2013 StandoutNatureNobel
Photocatalyzed Benzylic Fluorination: Shedding “Light” on the Involvement of Electron Transfer
2014
Lamellarins and Related Pyrrole-Derived Alkaloids from Marine Organisms
2007 Standout
Visible Light Photocatalysis: Applications and New Disconnections in the Synthesis of Pharmaceutical Agents
2016
Isolation and Synthesis of Biologically Active Carbazole Alkaloids
2002 Standout
Confinement-Controlled, Either syn- or anti-Selective Catalytic Asymmetric Mukaiyama Aldolizations of Propionaldehyde Enolsilanes
2021 StandoutNobel
Direct Access to β‐Fluorinated Aldehydes by Nitrite‐Modified Wacker Oxidation
2016 Nobel
Catalytic Asymmetric Vinylogous Prins Cyclization: A Highly Diastereo- and Enantioselective Entry to Tetrahydrofurans
2016 StandoutNobel
Enantioselective Total Synthesis of Nigelladine A via Late-Stage C–H Oxidation Enabled by an Engineered P450 Enzyme
2017 StandoutNobel
Works of Robert Britton being referenced
Functional domains of the 50S subunit mature late in the assembly process
2013
Total Synthesis and Configurational Assignment of (−)‐Dictyostatin, a Microtubule‐Stabilizing Macrolide of Marine Sponge Origin
2004
Total Synthesis of (−)‐Reidispongiolide A, an Actin‐Targeting Marine Macrolide
2007
Total Synthesis of Ascospiroketal A Through a AgI‐Promoted Cyclization Cascade
2014
Total Synthesis and Structural Revision of Laurefurenynes A and B
2013
Total Synthesis of (−)‐Reidispongiolide A, an Actin‐Targeting Macrolide Isolated from the Marine Sponge Reidispongia coerulea
2008
Cell cycle arrest in Era GTPase mutants: a potential growth rate‐regulated checkpoint in Escherichia coli
1998
A Convenient Photocatalytic Fluorination of Unactivated CH Bonds
2014
Stereochemical determination of dictyostatin, a novel microtubule-stabilising macrolide from the marine sponge Corallistidae sp.Electronic supplementary information (ESI) available: copies of 1D and 2D NMR spectra, tables of spectral data and calculated torsion angles. See http://www.rsc.org/suppdata/cc/b3/b316390c/
2004
Synthesis of antimicrofilament marine macrolides: Synthesis and configurational assignment of a C 5 –C 16 degradation fragment of reidispongiolide A
2004
High-throughput assay for G2 checkpoint inhibitors and identification of the structurally novel compound isogranulatimide.
1998
A Convenient Photocatalytic Fluorination of Unactivated CH Bonds
2014
A short de novo synthesis of nucleoside analogs
2020 Science
Total Synthesis of (−)‐Reidispongiolide A, an Actin‐Targeting Marine Macrolide
2007
A Practical Synthesis of 5-Lipoxygenase Inhibitor MK-0633
2010
Regioselective and Stereoselective Cyclizations of Chloropolyols in Water: Rapid Synthesis of Hydroxytetrahydrofurans
2010
Granulatimide and 6-Bromogranulatimide, Minor Alkaloids of the Brazilian Ascidian Didemnum granulatum
2001
Synthetic Transformations of Eleutherobin Reveal New Features of Its Microtubule-Stabilizing Pharmacophore
2001
Granulatimide and Isogranulatimide, Aromatic Alkaloids with G2 Checkpoint Inhibition Activity Isolated from the Brazilian Ascidian Didemnum granulatum: Structure Elucidation and Synthesis
1998
Development of a Concise and General Enantioselective Approach to 2,5-Disubstituted-3-hydroxytetrahydrofurans
2009
Maturation of the 5′ end of Bacillus subtilis 16S rRNA by the essential ribonuclease YkqC/RNase J1
2006
Multiple GTPases Participate in the Assembly of the Large Ribosomal Subunit in Bacillus subtilis
2006
Improved Synthesis of Isogranulatimide, a G2 Checkpoint Inhibitor. Syntheses of Didemnimide C, Isodidemnimide A, Neodidemnimide A, 17-Methylgranulatimide, and Isogranulatimides A−C
1999
Inhibition of Chk1 by the G2 DNA damage checkpoint inhibitor isogranulatimide
2004
Antimitotic diterpenoids from Erythropodium caribaeorum : isolation artifacts and putative biosynthetic intermediates
2001
A General Method for the Synthesis of Nonracemic trans-Epoxides: Concise Syntheses of trans-Epoxide-Containing Insect Sex Pheromones
2007
Direct photocatalytic fluorination of benzylic C–H bonds with N-fluorobenzenesulfonimide
2015
Asymmetric Organozincate Additions to Ethyl 2,2,2-Trifluoropyruvate
2007
New Okadaic Acid Analogues from the Marine Sponge Merriamum oxeato and Their Effect on Mitosis
2003
Development of a Direct Photocatalytic C–H Fluorination for the Preparative Synthesis of Odanacatib
2015
The Kondrat’eva Reaction in Flow: Direct Access to Annulated Pyridines
2013