Citation Impact
Citing Papers
Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Insig renders sorting signal in Scap inaccessible to COPII proteins
2007 Nobel
The Atg5–Atg12 conjugate associates with innate antiviral immune responses
2007
IRE1 Signaling Affects Cell Fate During the Unfolded Protein Response
2007 Science
γ-Secretase Cleavage and Nuclear Localization of ErbB-4 Receptor Tyrosine Kinase
2001 Science
In vitro reconstitution of ER-stress induced ATF6 transport in COPII vesicles
2009 StandoutNobel
Accurate computational design of multipass transmembrane proteins
2018 StandoutScienceNobel
Signal integration in the endoplasmic reticulum unfolded protein response
2007 Standout
Computational design of soluble and functional membrane protein analogues
2024 StandoutNatureNobel
Hepatitis B virus X protein (HBx) activates ATF6 and IRE1-XBP1 pathways of unfolded protein response
2006
Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells.
1997
Nicastrin Functions as a γ-Secretase-Substrate Receptor
2005 StandoutNobel
Substrate Specificity of Rhomboid Intramembrane Proteases Is Governed by Helix-Breaking Residues in the Substrate Transmembrane Domain
2003
Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals
2001
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA
2002 StandoutNature
Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL
2002 StandoutNatureNobel
Behavioral and neurobiological implications of sex‐determining factors inDrosophila
1994 StandoutNobel
A trip to the ER: coping with stress
2003
Promoter Analysis of the Mouse Sterol Regulatory Element-binding Protein-1c Gene
2000
Genetic Interactions Due to Constitutive and Inducible Gene Regulation Mediated by the Unfolded Protein Response in C. elegans
2005
Male-specific fruitless specifies the neural substrates of Drosophila courtship behaviour
2005 StandoutNatureNobel
Three-dimensional structure of human γ-secretase
2014 Nature
The SREBP Pathway: Regulation of Cholesterol Metabolism by Proteolysis of a Membrane-Bound Transcription Factor
1997 StandoutNobel
γ-Secretase: proteasome of the membrane?
2004
Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
2007 Standout
Caenorhabditis elegans pathways that surveil and defend mitochondria
2014 StandoutNatureNobel
Drosophila Rhomboid-1 Defines a Family of Putative Intramembrane Serine Proteases
2001
A Genetic Screen to Identify Components of the sina Signaling Pathway in Drosophila Eye Development
1998
Gene Discovery Using Computational and Microarray Analysis of Transcription in the Drosophila melanogaster Testis
2000
A transgenic mouse model for monitoring endoplasmic reticulum stress
2003
ER stress and the unfolded protein response
2004
Intramembrane-cleaving proteases: controlled liberation of proteins and bioactive peptides
2003
Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells.
1997 Nobel
Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide
2007 Standout
Uncoupled Packaging of Amyloid Precursor Protein and Presenilin 1 into Coat Protein Complex II Vesicles
2004 StandoutNobel
Cleavage of the membrane‐bound transcription factor OASIS in response to endoplasmic reticulum stress
2006
Cleavage Site for Sterol-regulated Protease Localized to a Leu-Ser Bond in the Lumenal Loop of Sterol Regulatory Element-binding Protein-2
1997 Nobel
Regulated Step in Cholesterol Feedback Localized to Budding of SCAP from ER Membranes
2000
The ubiquitin-proteasome proteolytic pathway
1994 StandoutNobel
Signalling Pathways in the Unfolded Protein Response: Development from Yeast to Mammals
2009
Genome-scale approaches for discovering novel nonconventional splicing substrates of the Ire1 nuclease
2004
The unfolded protein response sensor IRE1α is required at 2 distinct steps in B cell lymphopoiesis
2005
SREBP transcriptional activity is mediated through an interaction with the CREB-binding protein.
1996
Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides1Published on the World Wide Web on 17 August 1999.1
1999
Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a.
1996
Sterol Regulatory Element Binding Proteins (SREBPs): Controllers of Lipid Synthesis and Cellular Uptake
2009
Endoplasmic Reticulum Stress Activates Cleavage of CREBH to Induce a Systemic Inflammatory Response
2006
Conditional Forebrain Inactivation of Nicastrin Causes Progressive Memory Impairment and Age-Related Neurodegeneration
2009 StandoutNobel
Unveiling the roles of autophagy in innate and adaptive immunity
2007
Tumor Necrosis Factor α (TNFα) Induces the Unfolded Protein Response (UPR) in a Reactive Oxygen Species (ROS)-dependent Fashion, and the UPR Counteracts ROS Accumulation by TNFα
2005
XBP1 mRNA Is Induced by ATF6 and Spliced by IRE1 in Response to ER Stress to Produce a Highly Active Transcription Factor
2001 Standout
Neurotrophins and their receptors: A convergence point for many signalling pathways
2003 Standout
Differential Contributions of ATF6 and XBP1 to the Activation of Endoplasmic Reticulum Stress-Responsive cis-Acting Elements ERSE, UPRE and ERSE-II
2004
Orchestrating the unfolded protein response in health and disease
2002
New reproductive anomalies in fruitless‐mutant Drosophila males: Extreme lengthening of mating durations and infertility correlated with defective serotonergic innervation of reproductive organs
2001 StandoutNobel
Endoplasmic reticulum stress: cell life and death decisions
2005 Standout
Bioactive small molecules reveal antagonism between the integrated stress response and sterol-regulated gene expression
2005
Coupling endoplasmic reticulum stress to the cell death program
2004
A Role for Presenilin-1 in Nuclear Accumulation of Ire1 Fragments and Induction of the Mammalian Unfolded Protein Response
1999
Regulation of gene expression by SREBP and SCAP
2000
Drosophila S2 cells: an alternative infection model for Listeria monocytogenes
2003
The endoplasmic reticulum stress response in immunity and autoimmunity
2008
Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1.
1998
Viral interactions with macroautophagy: A double-edged sword
2010
Transcriptional Induction of Mammalian ER Quality Control Proteins Is Mediated by Single or Combined Action of ATF6α and XBP1
2007
Presenilin-dependent Intramembrane Proteolysis of CD44 Leads to the Liberation of Its Intracellular Domain and the Secretion of an Aβ-like Peptide
2002
Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease
2010 Standout
Characterization of Drosophila fruitless‐gal4 transgenes reveals expression in male‐specific fruitless neurons and innervation of male reproductive structures
2004
Two Distinct Stress Signaling Pathways Converge Upon the CHOP Promoter During the Mammalian Unfolded Protein Response
2002
ER chaperone functions during normal and stress conditions
2004
Deletion of Presenilin 1 Hydrophilic Loop Sequence Leads to Impaired γ-Secretase Activity and Exacerbated Amyloid Pathology
2006
Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes
2003 StandoutNatureNobel
Membranes in Balance: Mechanisms of Sphingolipid Homeostasis
2010
Mammalian APH-1 Interacts with Presenilin and Nicastrin and Is Required for Intramembrane Proteolysis of Amyloid-β Precursor Protein and Notch
2002
Roles of CHOP/GADD153 in endoplasmic reticulum stress
2003 Standout
ATF6α Optimizes Long-Term Endoplasmic Reticulum Function to Protect Cells from Chronic Stress
2007
Increased Levels of Nuclear SREBP-1c Associated with Fatty Livers in Two Mouse Models of Diabetes Mellitus
1999
From endoplasmic-reticulum stress to the inflammatory response
2008 StandoutNature
A Glimpse of Structural Biology through X-Ray Crystallography
2014
Crystal structure of a rhomboid family intramembrane protease
2006 Nature
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
2002 StandoutNobel
A Time-Dependent Phase Shift in the Mammalian Unfolded Protein Response
2003
Regulation of apoptosis by endoplasmic reticulum pathways
2003
Adaptation to ER Stress Is Mediated by Differential Stabilities of Pro-Survival and Pro-Apoptotic mRNAs and Proteins
2006
SREBP Activity Is Regulated by mTORC1 and Contributes to Akt-Dependent Cell Growth
2008
Cellular and Molecular Mechanisms of Pain
2009 StandoutNobel
Switching and Signaling at the Telomere
2001 StandoutNobel
IRE1-Independent Gain Control of the Unfolded Protein Response
2004
SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation
2001 Nobel
Two Tandem Binding Sites for Sterol Regulatory Element Binding Proteins Are Required for Sterol Regulation of Fatty-acid Synthase Promoter
1996
The role of the unfolded protein response in tumour development: friend or foe?
2004
The Luminal Domain of ATF6 Senses Endoplasmic Reticulum (ER) Stress and Causes Translocation of ATF6 from the ER to the Golgi
2002
Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene.
1997
Delineation of a Negative Feedback Regulatory Loop That Controls Protein Translation during Endoplasmic Reticulum Stress
2003
ATF6 modulates SREBP2‐mediated lipogenesis
2004
Control of Male Sexual Behavior and Sexual Orientation in Drosophila by the fruitless Gene
1996 StandoutNobel
Differential Stimulation of Cholesterol and Unsaturated Fatty Acid Biosynthesis in Cells Expressing Individual Nuclear Sterol Regulatory Element-binding Proteins
1998 Nobel
Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1
2002 StandoutNobel
GRP78 expression inhibits insulin and ER stress–induced SREBP-1c activation and reduces hepatic steatosis in mice
2009
Nuclear Sterol Regulatory Element-binding Proteins Activate Genes Responsible for the Entire Program of Unsaturated Fatty Acid Biosynthesis in Transgenic Mouse Liver
1998
The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability
2001 StandoutNobel
Microarray Analysis and Organization of Circadian Gene Expression in Drosophila
2001 StandoutNobel
Instruction of Distinct CD4 T Helper Cell Fates by Different Notch Ligands on Antigen-Presenting Cells
2004 StandoutNobel
Obesity and the Regulation of Energy Balance
2001 Standout
A Conserved GXXXG Motif in APH-1 Is Critical for Assembly and Activity of the γ-Secretase Complex
2004
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
2015 Standout
Misfolded proteins, endoplasmic reticulum stress and neurodegeneration
2004
Notch Signaling: From the Outside In
2000
Complementary Signaling Pathways Regulate the Unfolded Protein Response and Are Required for C. elegans Development
2001
Nitric oxide induces coupling of mitochondrial signalling with the endoplasmic reticulum stress response
2004
Amyloid Precursor Protein Processing in Sterol Regulatory Element-binding Protein Site 2 Protease-deficient Chinese Hamster Ovary Cells
1998
TRF1 promotes parallel pairing of telomeric tracts in vitro
1998
Requirements for Signal Peptide Peptidase-Catalyzed Intramembrane Proteolysis
2002
Repair of telomeric DNA prior to replicative senescence
2000
IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response
2002
Sterol Resistance in CHO Cells Traced to Point Mutation in SREBP Cleavage–Activating Protein
1996 Nobel
ER Stress Regulation of ATF6 Localization by Dissociation of BiP/GRP78 Binding and Unmasking of Golgi Localization Signals
2002
Gcn4p and Novel Upstream Activating Sequences Regulate Targets of the Unfolded Protein Response
2004
Roles for Proteolysis and Trafficking in Notch Maturation and Signal Transduction
1998
Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases
2000
A ubiquitin-like system mediates protein lipidation
2000 StandoutNatureNobel
Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity
1999 StandoutNature
The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity
2001
Partial Purification and Characterization of γ-Secretase from Post-mortem Human Brain
2003
The unfolded protein response—a stress signaling pathway of the endoplasmic reticulum
2004
Autophagy Counterbalances Endoplasmic Reticulum Expansion during the Unfolded Protein Response
2006
A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain
1999 StandoutNature
Transmembrane bZIP Transcription Factors in ER Stress Signaling and the Unfolded Protein Response
2007
How Transmembrane Proteins Sense Endoplasmic Reticulum Stress
2007
Endoplasmic Reticulum Stress and Oxidative Stress: A Vicious Cycle or a Double-Edged Sword?
2007
The Endoplasmic Reticulum: Folding, Calcium Homeostasis, Signaling, and Redox Control
2006
Peptidomimetic Probes and Molecular Modeling Suggest That Alzheimer's γ-Secretase Is an Intramembrane-Cleaving Aspartyl Protease
1999
pXBP1(U) encoded in XBP1 pre-mRNA negatively regulates unfolded protein response activator pXBP1(S) in mammalian ER stress response
2006
Transient Cerebral Ischemia Activates Processing of xbp1 Messenger RNA Indicative of Endoplasmic Reticulum Stress
2003
Clues from cell metabolism
2010 StandoutNatureNobel
Heat induces the splicing by IRE1 of a mRNA encoding a transcription factor involved in the unfolded protein response in Arabidopsis
2011
Intracellular Signaling by the Unfolded Protein Response
2006
Degradation of Proteins with Acetylated Amino Termini by the Ubiquitin System
1989 StandoutScienceNobel
Activation of Mammalian Unfolded Protein Response Is Compatible with the Quality Control System Operating in the Endoplasmic Reticulum
2004
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
2002 StandoutNobel
Structure of the STRA6 receptor for retinol uptake
2016 StandoutScienceNobel
The muscle of Lawrence in Drosophila : A case of repeated evolutionary loss
1997 StandoutNobel
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
2002 StandoutScience
γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2
2003
Regulation of Receptor Fate by Ubiquitination of Activated β 2 -Adrenergic Receptor and β-Arrestin
2001 StandoutScienceNobel
Presenilin-dependent γ-secretase activity modulates thymocyte development
2001
A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood
1999 Nobel
Nitric Oxide and Endoplasmic Reticulum Stress
2006
Sexual orientation in Drosophila is altered by the satori mutation in the sex-determination gene fruitless that encodes a zinc finger protein with a BTB domain.
1996
Orchestrating the unfolded protein response in health and disease
2002
Mechanism of the cleavage specificity of Alzheimer’s disease γ-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein
1999
The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation
2011 StandoutScience
The unfolded protein response sensor IRE1α is required at 2 distinct steps in B cell lymphopoiesis
2005
THE MAMMALIAN UNFOLDED PROTEIN RESPONSE
2005 Standout
Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability
2009 StandoutNobel
XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response
2003 Standout
The Berkeley Drosophila Genome Project Gene Disruption Project: Single P-Element Insertions Mutating 25% of Vital Drosophila Genes
1999
The fruitless Gene Is Required for the Proper Formation of Axonal Tracts in the Embryonic Central Nervous System of Drosophila
2002
Luman/CREB3 Induces Transcription of the Endoplasmic Reticulum (ER) Stress Response Protein Herp through an ER Stress Response Element
2006
Downregulation of PS1 expression in neurons decreases beta-amyloid production: a biochemical link between the two major familial Alzheimer's disease genes
1998
PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation
2008
Decreased lipid synthesis in livers of mice with disrupted Site-1 protease gene
2001 Nobel
Molecular Genetic Dissection of the Sex-Specific and Vital Functions of the Drosophila melanogaster Sex Determination Gene fruitless
2001 StandoutNobel
Aberrant Splicing and Altered Spatial Expression Patterns in fruitless Mutants of Drosophila melanogaster
2000 StandoutNobel
NOTCH AND PRESENILIN : Regulated Intramembrane Proteolysis Links Development and Degeneration
2003
Alzheimer's Disease: Molecular Understanding Predicts Amyloid-Based Therapeutics
2003
COURTSHIP INDROSOPHILA
2000
Abnormalities of Male-Specific FRU Protein and Serotonin Expression in the CNS offruitlessMutants inDrosophila
2001 StandoutNobel
The Host Defense of Drosophila melanogaster
2007 StandoutNobel
Selective activation of the transcription factor ATF6 mediates endoplasmic reticulum proliferation triggered by a membrane protein
2011
Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response
2009 StandoutNobel
IRE1 and efferent signaling from the endoplasmic reticulum
2000
Mammalian subtilisin/kexin isozyme SKI-1: A widely expressed proprotein convertase with a unique cleavage specificity and cellular localization
1999
The Mating of a Fly
1994 StandoutScienceNobel
Structural Motifs Involved in Ubiquitin-Mediated Processing of the NF-κB Precursor p105: Roles of the Glycine-Rich Region and a Downstream Ubiquitination Domain
1999 StandoutNobel
Identification of Signal Peptide Peptidase, a Presenilin-Type Aspartic Protease
2002 Science
Stable Binding of ATF6 to BiP in the Endoplasmic Reticulum Stress Response
2005
BBF2H7, a Novel Transmembrane bZIP Transcription Factor, Is a New Type of Endoplasmic Reticulum Stress Transducer
2006
Sterol regulatory element-binding proteins
1999
Role of Disulfide Bridges Formed in the Luminal Domain of ATF6 in Sensing Endoplasmic Reticulum Stress
2006
Recurrent G-to-A substitution in a single codon of SREBP cleavage-activating protein causes sterol resistance in three mutant Chinese hamster ovary cell lines
1996 Nobel
Mammalian Transcription Factor ATF6 Is Synthesized as a Transmembrane Protein and Activated by Proteolysis in Response to Endoplasmic Reticulum Stress
1999 Standout
THE UBIQUITIN SYSTEM
1998 StandoutNobel
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
2009 StandoutScience
Sex-specific differentiation of a male-specific abdominal muscle, the Muscle of Lawrence, is abnormal in hydroxyurea-treated and in fruitless male flies
1995
ADD1/SREBP1 activates PPARγ through the production of endogenous ligand
1998
Asparagine-proline sequence within membrane-spanning segment of SREBP triggers intramembrane cleavage by Site-2 protease
2000 Nobel
Works of Robert B. Rawson being referenced
Sterol-Regulated Release of SREBP-2 from Cell Membranes Requires Two Sequential Cleavages, One Within a Transmembrane Segment
1996 Nobel
Failure to Cleave Sterol Regulatory Element-binding Proteins (SREBPs) Causes Cholesterol Auxotrophy in Chinese Hamster Ovary Cells with Genetic Absence of SREBP Cleavage-activating Protein
1999 Nobel
The SREBP pathway — insights from insigs and insects
2003
Mutant Mammalian Cells as Tools to Delineate the Sterol Regulatory Element-Binding Protein Pathway for Feedback Regulation of Lipid Synthesis
2002 Nobel
Regulated Intramembrane Proteolysis
2000
Isolation of Cholesterol-requiring Mutant Chinese Hamster Ovary Cells with Defects in Cleavage of Sterol Regulatory Element-binding Proteins at Site 1
1998 Nobel
COPI Activity Coupled with Fatty Acid Biosynthesis Is Required for Viral Replication
2006
The SREBP Pathway in Drosophila
2002 Nobel
Molecular Identification of the Sterol-Regulated Luminal Protease that Cleaves SREBPs and Controls Lipid Composition of Animal Cells
1998 Nobel
ER Stress Induces Cleavage of Membrane-Bound ATF6 by the Same Proteases that Process SREBPs
2000
Fatty acid auxotrophy in Drosophila larvae lacking SREBP
2006
Complementation Cloning of , a Gene Encoding a Putative Metalloprotease Required for Intramembrane Cleavage of SREBPs
1997 Nobel
Membrane Topology of S2P, a Protein Required for Intramembranous Cleavage of Sterol Regulatory Element-binding Proteins
1999 Nobel
Toward a molecular genetic analysis of spermatogenesis in Drosophila melanogaster: characterization of male-sterile mutants generated by single P element mutagenesis.
1993
Regulation of SREBP Processing and Membrane Lipid Production by Phospholipids in Drosophila
2002 ScienceNobel
UbcD1, a Drosophila ubiquitin-conjugating enzyme required for proper telomere behavior.
1997
Regulated intramembrane proteolysis: from the endoplasmic reticulum to the nucleus
2002