Citation Impact
Citing Papers
Filopodia formation mediated by receptor tyrosine kinase Ror2 is required for Wnt5a-induced cell migration
2006
Wnt5a–Ror–Dishevelled signaling constitutes a core developmental pathway that controls tissue morphogenesis
2012
Hydrogen Peroxide Is Essential for Estrogen-Deficiency Bone Loss and Osteoclast Formation
2004
Hormone replacement therapy in rheumatoid arthritis is associated with lower serum levels of soluble IL-6 receptor and higher insulin-like growth factor 1
2003
Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness
2017 Standout
Investigation of multipotent postnatal stem cells from human periodontal ligament
2004 Standout
Integrative approaches to the prediction of protein functions based on the feature selection
2009
WNT5A mutations in patients with autosomal dominant Robinow syndrome
2009
Estrogen deficiency and bone loss: an inflammatory tale
2006
Transient Increase in the Levels of T-Helper 1 Cytokines in Postmenopausal Women and the Effects of Hormone Replacement Therapy
2001
The complexities of skeletal biology
2003 StandoutNature
Estradiol reverses renal injury in Alb/TGF-β1 transgenic mice
2004
Biological mediators for periodontal regeneration
1999
Cellular and Gene Expression Responses Involved in the Rapid Growth Inhibition of Human Cancer Cells by RNA Interference-mediated Depletion of Telomerase RNA
2005 StandoutNobel
Inflammation and cancer
2002 StandoutNature
Physical Principles of Membrane Shape Regulation by the Glycocalyx
2019 StandoutNobel
Mutation of the gene encoding the ROR2 tyrosine kinase causes autosomal recessive Robinow syndrome
2000
Exosomes/microvesicles: mediators of cancer-associated immunosuppressive microenvironments
2011
Pathways of Egr-1-Mediated Gene Transcription in Vascular Biology
1999
Interleukin-1β and tumor necrosis factor-α, but not interleukin-6, stimulate osteoprotegerin ligand gene expression in human osteoblastic cells
1999
Promoter structure of mouse RANKL/TRANCE/OPGL/ODF gene
1999
Deciphering skeletal patterning: clues from the limb
2003 Nature
17β-Estradiol Induces Apoptosis in the Preosteoclastic FLG 29.1 Cell Line
1999
INHIBITORY EFFECT OF PHYSIOLOGICAL CONCENTRATIONS OF CORTISOL BUT NOT ESTRADIOL ON INTERLEUKIN (IL)-6 PRODUCTION BY HUMAN OSTEOBLAST-LIKE CELL LINES WITH DIFFERENT CONSTITUTIVE IL-6 EXPRESSION
2001
Expression of the Osteoblast Differentiation Factor RUNX2 (Cbfa1/AML3/Pebp2αA) Is Inhibited by Tumor Necrosis Factor-α
2002
ADRENAL AND GONADAL STEROIDS INHIBIT IL-6 SECRETION BY HUMAN MARROW CELLS
2001
Regulatory mechanisms in the pathways of cartilage and bone formation
2001
The Receptor Tyrosine Kinase Ror2 Associates with and Is Activated by Casein Kinase Iϵ
2004
Adhesion events in angiogenesis
2001
Osteomyelitis
1997 Standout
osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification
1998 Standout
Bone morphogenetic protein-6 production in human osteoblastic cell lines. Selective regulation by estrogen.
1998
Interleukin 7 and estrogen-induced bone loss
2003
Role of cytokines in bone resorption
1995
Wnt signaling in osteoblasts and bone diseases
2004
Differential Effects of Estradiol on the Adrenocorticotropin Responses to Interleukin-6 and Interleukin-1 in the Monkey1
2001
Genomic deletion of a long-range bone enhancer misregulates sclerostin in Van Buchem disease
2005
Tumor Necrosis Factor-α Blockade: A Novel Therapy for Rheumatic Disease
2002
Bone Quality — The Material and Structural Basis of Bone Strength and Fragility
2006 Standout
Osteoporosis: now and the future
2011 Standout
Cytokine production in the bone marrow microenvironment: failure to demonstrate estrogen regulation in early postmenopausal women.
1996
Bone-Resorbing Cytokines from Peripheral Blood Mononuclear Cells after Hormone Replacement Therapy: A Longitudinal Study
2001
Novel functions for NFκB: inhibition of bone formation
2010
Effects of Raloxifene on Bone Mineral Density, Serum Cholesterol Concentrations, and Uterine Endometrium in Postmenopausal Women
1997 Standout
WNT signaling in bone homeostasis and disease: from human mutations to treatments
2013 Standout
Transgenic mice expressing soluble tumor necrosis factor-receptor are protected against bone loss caused by estrogen deficiency.
1997
Regulatory effects of estrogen on acute lung inflammation in mice
2005
Regulation of osteoclast activity
1999
Identification of Putative Target Genes of the Transcription Factor RUNX2
2013 StandoutNobel
Wnt/β-Catenin Signaling and Disease
2012 Standout
Estrogen deficiency induces bone loss by enhancing T-cell production of TNF-α
2000
Bone Marrow, Cytokines, and Bone Remodeling — Emerging Insights into the Pathophysiology of Osteoporosis
1995
Raloxifene (LY139481 HCI) prevents bone loss and reduces serum cholesterol without causing uterine hypertrophy in ovariectomized rats.
1994
Circletail, a New Mouse Mutant with Severe Neural Tube Defects: Chromosomal Localization and Interaction with the Loop-Tail Mutation
2001
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis
1999 StandoutNature
Immunity, Inflammation, and Cancer
2010 Standout
The MicroRNA miR-1 Regulates a MEF-2-Dependent Retrograde Signal at Neuromuscular Junctions
2008 StandoutNobel
Cytokines, bone remodeling, and estrogen deficiency: a 1998 update
1998
Expression and subcellular localization of Ror tyrosine kinase receptors are developmentally regulated in cultured hippocampal neurons
2003
Endocrine Regulation of Energy Metabolism by the Skeleton
2007 Standout
HORMONAL MODULATION OF INTERLEUKIN-6, TUMOR NECROSIS FACTOR AND ASSOCIATED RECEPTOR SECRETION IN POSTMENOPAUSAL WOMEN
2002
Building strong bones: molecular regulation of the osteoblast lineage
2011
Osteoclast differentiation and activation
2003 StandoutNature
Human Trophoblast-Derived Exosomal Fibronectin Induces Pro-Inflammatory Il-1β Production by Macrophages
2011
Estrogen decreases TNF gene expression by blocking JNK activity and the resulting production of c-Jun and JunD
1999
THE PATHOPHYSIOLOGY AND TREATMENT OF POSTMENOPAUSAL OSTEOPOROSIS
1997
Requirement for NF-κB in osteoclast and B-cell development
1997
The receptor tyrosine kinase Ror2 is involved in non‐canonical Wnt5a/JNK signalling pathway
2003
The Deleted in Brachydactyly B Domain of ROR2 Is Required for Receptor Activation by Recruitment of Src
2008
Similarities and distinctions in the mode of action of different classes of antioestrogens.
2000
TNF-α induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand
2000
Receptor Tyrosine Kinase Ror2 Mediates Wnt5a-induced Polarized Cell Migration by Activating c-Jun N-terminal Kinase via Actin-binding Protein Filamin A
2008
Telomere length in leukocytes correlates with bone mineral density and is shorter in women with osteoporosis
2007
Macrophage plasticity and polarization: in vivo veritas
2012 Standout
Environmental Enrichment Reduces Aβ Levels and Amyloid Deposition in Transgenic Mice
2005 Standout
Glypican-1 identifies cancer exosomes and detects early pancreatic cancer
2015 StandoutNature
Estrogen Modulates the Hypothalamic-Pituitary-Adrenal and Inflammatory Cytokine Responses to Endotoxin in Women1
2001
NF-κB: a key role in inflammatory diseases
2001 Standout
The Ror Receptor Tyrosine Kinase CAM-1 Is Required for ACR-16-Mediated Synaptic Transmission at the C. elegans Neuromuscular Junction
2005
Production and Actions of Estrogens
2002 Standout
Systematic analysis of genes required for synapse structure and function
2005 StandoutNatureNobel
The effect of 17β-estradiol on production of cytokines in cultures of peripheral blood
2001
Lipopolysaccharide-stimulated osteoclastogenesis is mediated by tumor necrosis factor via its P55 receptor.
1997
The TNF and TNF Receptor Superfamilies
2001 Standout
Osteoclast-derived activity in the coupling of bone formation to resorption
2005
Estrogen’s bone-protective effects may involve differential IL-1 receptor regulation in human osteoclast-like cells
1999
Regulation of interleukin-6, osteoclastogenesis, and bone mass by androgens. The role of the androgen receptor.
1995
Acute-Phase Proteins and Other Systemic Responses to Inflammation
1999 Standout
Ror‐family receptor tyrosine kinases in noncanonical Wnt signaling: Their implications in developmental morphogenesis and human diseases
2009
Immune responses and bone loss: the estrogen connection
2005
The Role of IL‐6 Type Cytokines and Their Receptors in Boneaa
1998
PhyloGene server for identification and visualization of co-evolving proteins using normalized phylogenetic profiles
2015 StandoutNobel
Matrix Elasticity Directs Stem Cell Lineage Specification
2006 Standout
Update on Wnt signaling in bone cell biology and bone disease
2011
Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities
2017 Standout
Sec24b selectively sorts Vangl2 to regulate planar cell polarity during neural tube closure
2009 StandoutNobel
The TRAF Family of Signal Transducers Mediates NF-κB Activation by the TRANCE Receptor
1998 StandoutNobel
Hormonal Regulation of Osteoclast Function
1998
Inflammasomes in health and disease
2012 StandoutNature
Genetic regulation of osteoclast development and function
2003
The Complex Role of Estrogens in Inflammation
2007 Standout
Fibrosis, not cell size, delineates β-myosin heavy chain reexpression during cardiac hypertrophy and normal aging in vivo
2006 StandoutNobel
Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)
2013 Standout
Tumor Necrosis Factor-α Mediates Osteopenia Caused by Depletion of Antioxidants
2004
Augmentation of T Cell Levels and Responses Induced by Androgen Deprivation
2004 StandoutNobel
Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes
2016 Standout
Estrogen, cytokines, and pathogenesis of postmenopausal osteoporosis
1996
Magnesium in Man: Implications for Health and Disease
2014 Standout
The Roles of Osteoprotegerin and Osteoprotegerin Ligand in the Paracrine Regulation of Bone Resorption
2000
Interleukin-1 Receptor Signaling Mediates Atherosclerosis Associated With Bacterial Exposure and/or a High-Fat Diet in a Murine Apolipoprotein E Heterozygote Model
2004
Interleukin-18 (Interferon-γ–inducing Factor) Is Produced by Osteoblasts and Acts Via Granulocyte/Macrophage Colony-stimulating Factor and Not Via Interferon-γ to Inhibit Osteoclast Formation
1997
Telomere length is paternally inherited and is associated with parental lifespan
2007 StandoutNobel
In Vitro Secretion of Cytokines by Human Bone Marrow: Effects of Age and Estrogen Status1
1998
Bone Resorption by Osteoclasts
2000 StandoutScience
Estrogen Reduces the Depth of Resorption Pits by Disturbing the Organic Bone Matrix Degradation Activity of Mature Osteoclasts
2001
Tumor Necrosis Factor α Regulatesα vβ5 Integrin Expression by Osteoclast Precursors in Vitro and in Vivo1
2000
TNFα Potently Activates Osteoclasts, through a Direct Action Independent of and Strongly Synergistic with RANKL
2002
Multiple roles ofHoxa11andHoxd11in the formation of the mammalian forelimb zeugopod
2003 StandoutNobel
Toward simpler and faster genome-wide mutagenesis in mice
2007 StandoutNobel
Cellular and molecular mechanisms of osteoporosis
1998
17β-Estradiol Stimulates Expression of Osteoprotegerin by a Mouse Stromal Cell Line, ST-2, via Estrogen Receptor-α*
2001
Birth and Death of Bone Cells: Basic Regulatory Mechanisms and Implications for the Pathogenesis and Treatment of Osteoporosis*
2000 Standout
Changes in Proinflammatory Cytokine Activity after Menopause
2002
The impact of chronic estrogen deprivation on immunologic parameters in the ovariectomized rhesus monkey (Macaca mulatta) model of menopause
2001
A Chimeric Form of Osteoprotegerin Inhibits Hypercalcemia and Bone Resorption Induced by IL-1β, TNF-α, PTH, PTHrP, and 1,25(OH)2D3
1999
A c-fms tyrosine kinase inhibitor, Ki20227, suppresses osteoclast differentiation and osteolytic bone destruction in a bone metastasis model
2006
Update in New Anabolic Therapies for Osteoporosis
2010
Estrogen inhibits interleukin-6 production and gene expression in a human osteoblastic cell line with high levels of estrogen receptors
1996
The Role of Estrogen in the Control of Rat Osteocyte Apoptosis
1998
Estradiol repression of tumor necrosis factor-α transcription requires estrogen receptor activation function-2 and is enhanced by coactivators
1999
Increased B-lymphopoiesis by interleukin 7 induces bone loss in mice with intact ovarian function: Similarity to estrogen deficiency
1997
Marrow Stromal Cells as Stem Cells for Nonhematopoietic Tissues
1997 StandoutScience
Endogenous bone-resorbing factors in estrogen deficiency: Cooperative effects of IL-1 and IL-6
1995
Rational Design of Bisphosphonate Lipid-like Materials for mRNA Delivery to the Bone Microenvironment
2022 StandoutNobel
Transcriptional Induction of Cyclooxygenase-2 in Osteoblasts Is Involved in Interleukin-6-Induced Osteoclast Formation*
1997
Differential Ligand Activation of Estrogen Receptors ERα and ERβ at AP1 Sites
1997 StandoutScience
Mice lacking tartrate-resistant acid phosphatase (Acp 5) have disrupted endochondral ossification and mild osteopetrosis
1996 StandoutNobel
Skeletal Growth Factors
2010
Palaeoproteomic evidence identifies archaic hominins associated with the Châtelperronian at the Grotte du Renne
2016 StandoutNobel
17β-Estradiol Antagonizes Effects of 1α,25-Dihydroxyvitamin D3 on Interleukin-6 Production and Osteoclast-Like Cell Formation in Mouse Bone Marrow Primary Cultures*
1997
Therapeutic Approaches to Bone Diseases
2000 Science
Filopodia: The Fingers That Do the Walking
2007
Age-Associated Increased Interleukin-6 Gene Expression, Late-Life Diseases, and Frailty
2000
Works of Robert B. Kimble being referenced
Interleukin-1 receptor antagonist and tumor necrosis factor binding protein decrease osteoclast formation and bone resorption in ovariectomized mice.
1994
Ror2, encoding a receptor-like tyrosine kinase, is required for cartilage and growth plate development
2000
Estrogen Deficiency Increases the Ability of Stromal Cells to Support Murine Osteoclastogenesis via an Interleukin-1and Tumor Necrosis Factor-mediated Stimulation of Macrophage Colony-stimulating Factor Production
1996
Skeletal Overexpression of Noggin Results in Osteopenia and Reduced Bone Formation
2003
Persistent bone-sparing effect of interleukin-1 receptor antagonist: A hypothesis on the role of IL-1 in ovariectomy-induced bone loss
1994
Estrogen blocks M-CSF gene expression and osteoclast formation by regulating phosphorylation of Egr-1 and its interaction with Sp-1.
1998
Dominant mutations in ROR2, encoding an orphan receptor tyrosine kinase, cause brachydactyly type B
2000
Interleukin-1 receptor antagonist decreases bone loss and bone resorption in ovariectomized rats.
1994
Simultaneous block of interleukin-1 and tumor necrosis factor is required to completely prevent bone loss in the early postovariectomy period
1995
Dual-energy x-ray absorptiometry of the rat: Accuracy, precision, and measurement of bone loss
1993
Monocytic secretion of interleukin-1 receptor antagonist in normal and osteoporotic women: effects of menopause and estrogen/progesterone therapy.
1993
The Functional Block of TNF but Not of IL-6 Prevents Bone Loss in Ovariectomized Mice
1997
Simultaneous block of interleukin-1 and tumor necrosis factor is required to completely prevent bone loss in the early postovariectomy period.
1995
Ligand binding to monocyte alpha 5 beta 1 integrin activates the alpha 2 beta 1 receptor via the alpha 5 subunit cytoplasmic domain and protein kinase C.
1994