Citation Impact
Citing Papers
Role of Ced-3/ICE-family proteases in staurosporine-induced programmed cell death.
1996
Targeted cell killing by reconstituted caspases
2007 StandoutNobel
Strategy for Dual-Analyte Luciferin Imaging: In Vivo Bioluminescence Detection of Hydrogen Peroxide and Caspase Activity in a Murine Model of Acute Inflammation
2013 StandoutNobel
Activation of Caspase-2 in Apoptosis
1997
Cross Talk between ERK and PKA Is Required for Ca2+ Stimulation of CREB-Dependent Transcription and ERK Nuclear Translocation
1998
Functional Characterization of the Prodomain of Interleukin1β-converting Enzyme
1996
Processing of the Nedd2 precursor by ICE‐like proteases and granzyme B
1996
Fas-induced Activation of the Cell Death-related Protease CPP32 Is Inhibited by Bcl-2 and by ICE Family Protease Inhibitors
1996
A conformational switch controls hepatitis delta virus ribozyme catalysis
2004 StandoutNatureNobel
Identification of a signal for rapid export of proteins from the nucleus
1995 StandoutNobel
Murine Caspase-11, an ICE-Interacting Protease, Is Essential for the Activation of ICE
1998
Spatio-temporal dynamics of cyclic AMP signals in an intact neural circuit
1996 StandoutNatureNobel
Signal transduction by cGMP-dependent protein kinases and their emerging roles in the regulation of cell adhesion and gene expression
2005
Signaling from Synapse to Nucleus: Postsynaptic CREB Phosphorylation during Multiple Forms of Hippocampal Synaptic Plasticity
1996
Molecular Ordering of Apoptotic Mammalian CED-3/ICE-like Proteases
1996
Involvement of Caspase-1 and Caspase-3 in the Production and Processing of Mature Human Interleukin 18 in Monocytic THP.1 Cells
1997
Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
1998 StandoutNatureNobel
Cytotoxic T-cell-derived granzyme B activates the apoptotic protease ICE-LAP3
1996
Genetic and Pharmacological Evidence for a Novel, Intermediate Phase of Long-Term Potentiation Suppressed by Calcineurin
1998 StandoutNobel
Substrate Specificities of Caspase Family Proteases
1997
Bcl-2 regulates activation of apoptotic proteases in a cell-free system
1996
Control of Apoptosis by Proteases
1997
ICE Family Proteases: Mediators of All Apoptotic Cell Death?
1996
ERICE, a Novel FLICE-activatable Caspase
1998
Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c
1996 Standout
ICE/CED-3 proteasesin apoptosis
1996
Activation of a CrmA-insensitive, p35-sensitive Pathway in Ionizing Radiation-induced Apoptosis
1997
ICE-LAP6, a Novel Member of the ICE/Ced-3 Gene Family, Is Activated by the Cytotoxic T Cell Protease Granzyme B
1996
Proteolytic cleavage during chemotherapy-induced apoptosis
1996
The biochemistry of apoptosis
2000 StandoutNature
Quantitative studies of the effect of HTLV-I Tax protein on CREB protein - DNA binding
1994
A Tripartite Array of Transcription Factor Binding Sites Mediates cAMP Induction of Phosphoenolpyruvate Carboxykinase Gene Transcription and Its Inhibition by Insulin
1998
Spodoptera frugiperda Caspase-1, a Novel Insect Death Protease That Cleaves the Nuclear Immunophilin FKBP46, Is the Target of the Baculovirus Antiapoptotic Protein p35
1997
Sequential activation of three distinct ICE‐like activities in Fas‐ligated Jurkat cells
1996
Proteasome inhibitors induce mitochondria‐independent apoptosis in human glioma cells
1999 StandoutNobel
The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease.
1996 StandoutNobel
Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract
1996
The C. elegans Protein EGL-1 Is Required for Programmed Cell Death and Interacts with the Bcl-2–like Protein CED-9
1998 StandoutNobel
A Single BIR Domain of XIAP Sufficient for Inhibiting Caspases
1998
Protein kinases and phosphatases: The Yin and Yang of protein phosphorylation and signaling
1995 Standout
Bcl-2 acts upstream of the PARP protease and prevents its activation
1997
Molecular Ordering of the Cell Death Pathway
1996
The Death Receptors
1999
Involvement of the Ca2+-dependent Phosphatase Calcineurin in Gene Transcription That Is Stimulated by cAMP through cAMP Response Elements
1995
Substrate and Inhibitor Specificity of Interleukin-1β-converting Enzyme and Related Caspases
1997
Different Subcellular Distribution of Caspase-3 and Caspase-7 following Fas-induced Apoptosis in Mouse Liver
1998
Two CD95 (APO-1/Fas) signaling pathways
1998 Standout
Caenorhabditis elegans CED-9 protein is a bifunctional cell-death inhibitor
1997 StandoutNatureNobel
FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex
1996 Standout
Functional Activation of Nedd2/ICH-1 (Caspase-2) Is an Early Process in Apoptosis
1997
Caspases: killer proteases
1997 Standout
A fluorescent indicator for visualizing cAMP-induced phosphorylation in vivo
2000
ICE/CED3-like Proteases as Therapeutic Targets for the Control of Inappropriate Apoptosis
1996
cAMP-Dependent Regulation of Gene Transcription by cAMP Response Element-Binding Protein and cAMP Response Element Modulator
1995
Heteronuclear Ribonucleoproteins C1 and C2, Components of the Spliceosome, Are Specific Targets of Interleukin 1β-converting Enzyme-like Proteases in Apoptosis
1996
CREB and the formation of long-term memory
1996
cAMP Response Element-binding Protein Monomers Cooperatively Assemble to Form Dimers on DNA
1998
The Ced-3/Interleukin 1β Converting Enzyme-like Homolog Mch6 and the Lamin-cleaving Enzyme Mch2α Are Substrates for the Apoptotic Mediator CPP32
1996
Adaptor-mediated Recruitment of RNA Polymerase II to a Signal-dependent Activator
1996
Processing and Activation of CMH-1 by Granzyme B
1996
Activation of the Native 45-kDa Precursor Form of Interleukin-1-converting Enzyme
1996
Molecular characterization of mitochondrial apoptosis-inducing factor
1999 StandoutNature
Activation of Multiple Interleukin-1β Converting Enzyme Homologues in Cytosol and Nuclei of HL-60 Cells during Etoposide-induced Apoptosis
1997
Involvement of Cellular Proteolytic Machinery in Apoptosis
1997
CREB1 Encodes a Nuclear Activator, a Repressor, and a Cytoplasmic Modulator that Form a Regulatory Unit Critical for Long-Term Facilitation
1998 StandoutNobel
Specific Cleavage of α-Fodrin during Fas- and Tumor Necrosis Factor-induced Apoptosis Is Mediated by an Interleukin-1β-converting Enzyme/Ced-3 Protease Distinct from the Poly(ADP-ribose) Polymerase Protease
1996
The cell-death machine
1996
The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis
1996
FLICE Induced Apoptosis in a Cell-free System
1997
Translocation of calmodulin to the nucleus supports CREB phosphorylation in hippocampal neurons
1998 Nature
The role of the bcl-2/ced-9 gene family in cancer and general implications of defects in cell death control for tumourigenesis and resistance to chemotherapy
1997
Transcriptional regulation by the phosphorylation-dependent factor CREB
2001 Standout
Mutational Analysis of the Caenorhabditis elegans Cell-Death Gene ced-3
1999 StandoutNobel
The TRA-1A Sex Determination Protein of C. elegans Regulates Sexually Dimorphic Cell Deaths by Repressing the egl-1 Cell Death Activator Gene
1999 StandoutNobel
Crystal Structure of a Procaspase-7 Zymogen
2001
Genetic Demonstration of a Role for PKA in the Late Phase of LTP and in Hippocampus-Based Long-Term Memory
1997 StandoutNobel
FLICE is activated by association with the CD95 death-inducing signaling complex (DISC)
1997
Protease Involvement in Fodrin Cleavage and Phosphatidylserine Exposure in Apoptosis
1996
Insulin disrupts β-adrenergic signalling to protein kinase A in adipocytes
2005 StandoutNatureNobel
Localization of the cell death genes CPP32 and Mch-2 to human Chromosome 4q
1997
FLICE Is Predominantly Expressed as Two Functionally Active Isoforms, Caspase-8/a and Caspase-8/b
1997
Function of caspases in regulating apoptosis caused by erythropoietin deprivation in erythroid progenitors
1999
Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice
1996 StandoutNature
Defects in the Ubiquitin Pathway Induce Caspase-independent Apoptosis Blocked by Bcl-2
1998 StandoutNobel
Commitment to cell death measured by loss of clonogenicity is separable from the appearance of apoptotic markers
1998
Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death
2001 StandoutScience
Impaired apoptosis, extended duration of immune responses, and a lupus-like autoimmune disease in IEX-1-transgenic mice
2002 StandoutNobel
Heat-stable inhibitors of cAMP-dependent protein kinase carry a nuclear export signal.
1994 StandoutNobel
Transition from Caspase-dependent to Caspase-independent Mechanisms at the Onset of Apoptotic Execution
1998
Recombinant cyclic AMP response element binding protein (CREB) phosphorylated on Ser-133 is transcriptionally active upon its introduction into fibroblast nuclei.
1994
Dissecting processing and apoptotic activity of a cysteine protease by mutant analysis.
1996
The CREB family of activators is required for endochondral bone development
2001
TRANSCRIPTIONAL REGULATION BY CYCLIC AMP
1997
The Bcl-2 Protein Family: Arbiters of Cell Survival
1998 StandoutScience
Proteasome regulation of activation-induced T cell death
1997 StandoutNobel
Genetically encoded reporters of protein kinase A activity reveal impact of substrate tethering
2001 StandoutNobel
Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis
1995 StandoutScience
Dismantling Cell–Cell Contacts during Apoptosis Is Coupled to a Caspase-dependent Proteolytic Cleavage of β-Catenin
1997
FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2.
1996
Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked
1997 StandoutScience
DNA-dependent protein kinase catalytic subunit: a target for an ICE-like protease in apoptosis.
1996
Activation of CPP32 and Mch3α in wild-type p53-induced apoptosis
1997
Lamin proteolysis facilitates nuclear events during apoptosis.
1996
The CED-3/ICE-like Protease Mch2 Is Activated during Apoptosis and Cleaves the Death Substrate Lamin A
1996
The Dynamics of the Transcriptional Response to Cyclic Adenosine 3′,5′-Monophosphate: Recurrent Inducibility and Refractory Phase
1997
A Dominant Role for the Raf-MEK Pathway in Forskolin, 12-O-Tetradecanoyl-phorbol Acetate, and Platelet-Derived Growth Factor-Induced CREB (cAMP-Responsive Element-Binding Protein) Activation, Uncoupled from Serine 133 Phosphorylation in NIH 3T3 Cells
1999
Pivotal role of a DEVD-sensitive step in etoposide-induced and Fas-mediated apoptotic pathways.
1996
Resistance of actin to cleavage during apoptosis
1997
Processing/Activation of At Least Four Interleukin-1β Converting Enzyme–like Proteases Occurs during the Execution Phase of Apoptosis in Human Monocytic Tumor Cells
1997
Death Receptors: Signaling and Modulation
1998 StandoutScience
A Drosophila CREB/CREM Homolog Encodes Multiple Isoforms, Including a Cyclic AMP-Dependent Protein Kinase-Responsive Transcriptional Activator and Antagonist
1995
Neural Science
2000 StandoutNobel
Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis.
1996
Inducible Binding of Cyclic Adenosine 3′,5′-Monophosphate (cAMP)-Responsive Element Binding Protein (CREB) to a cAMP-Responsive Promoter in Vivo
1999
CREB AND MEMORY
1998
The role of proteases during apoptosis
1996
Expression of a peptide inhibitor of protein phosphatase 1 increases phosphorylation and activity of CREB in NIH 3T3 fibroblasts.
1994
Molecular ordering of the Fas-apoptotic pathway: The Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases
1996
Fas Preassociation Required for Apoptosis Signaling and Dominant Inhibition by Pathogenic Mutations
2000 StandoutScienceNobel
A novel function for serotonin-mediated short-term facilitation in Aplysia : Conversion of a transient, cell-wide homosynaptic Hebbian plasticity into a persistent, protein synthesis-independent synapse-specific enhancement
2000 StandoutNobel
Distinct effects of cAMP and mitogenic signals on CREB-binding protein recruitment impart specificity to target gene activation via CREB
2001
The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis
1997 StandoutScience
Caspases Are Activated in a Branched Protease Cascade and Control Distinct Downstream Processes in Fas-induced Apoptosis
1998
Proteolytic Activation of Protein Kinase C δ by an ICE/CED 3-like Protease Induces Characteristics of Apoptosis
1996
Activation of the cell death program by inhibition of proteasome function
1997
Inhibition of Ced-3/ICE-related Proteases Does Not Prevent Cell Death Induced by Oncogenes, DNA Damage, or the Bcl-2 Homologue Bak
1997
Spatiotemporal dynamics of guanosine 3′,5′-cyclic monophosphate revealed by a genetically encoded, fluorescent indicator
2001 StandoutNobel
Caspases: the executioners of apoptosis
1997 Standout
Purification and cDNA cloning of a second apoptosis-related cysteine protease that cleaves and activates sterol regulatory element binding proteins.
1996 Nobel
Altered behavior and long-term potentiation in type I adenylyl cyclase mutant mice.
1995
Interleukin 1β-converting Enzyme Related Proteases/Caspases Are Involved in TRAIL-induced Apoptosis of Myeloma and Leukemia Cells
1997
Multiple protein kinase A-regulated events are required for transcriptional induction by cAMP.
1995
Mitochondria and Apoptosis
1998 StandoutScience
Mammalian Caspases: Structure, Activation, Substrates, and Functions During Apoptosis
1999 Standout
MATURE T LYMPHOCYTE APOPTOSIS—Immune Regulation in a Dynamic and Unpredictable Antigenic Environment
1999
Neuroscience: Breaking Down Scientific Barriers to the Study of Brain and Mind
2000 StandoutScienceNobel
Genetically encoded fluorescent reporters of protein tyrosine kinase activities in living cells
2001 StandoutNobel
Thermostable inhibitor of cAMP-dependent protein kinase enhances the rate of export of the kinase catalytic subunit from the nucleus.
1994 StandoutNobel
In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains.
1996
CREB: A Stimulus-Induced Transcription Factor Activated by A Diverse Array of Extracellular Signals
1999 Standout
Bcl-2 Expression in Neural Cells Blocks Activation of ICE/CED-3 Family Proteases during Apoptosis
1996
Multiple species of CPP32 and Mch2 are the major active caspases present in apoptotic cells
1997
THE UBIQUITIN SYSTEM
1998 StandoutNobel
Caspases: Enemies Within
1998 StandoutScience
Movement of the free catalytic subunit of cAMP-dependent protein kinase into and out of the nucleus can be explained by diffusion.
1993 StandoutNobel
Purification and Characterization of an Interleukin-1β-converting Enzyme Family Protease That Activates Cysteine Protease P32 (CPP32)
1996
Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32
1996
Phosphorylation of CREB at Ser-133 Induces Complex Formation with CREB-Binding Protein via a Direct Mechanism
1996
Impaired hippocampal plasticity in mice lacking the Cbeta1 catalytic subunit of cAMP-dependent protein kinase.
1996 StandoutNobel
Works of Robert Armstrong being referenced
Regulation of somatostatin gene transcription by cyclic adenosine monophosphate
1996
Mch3, a novel human apoptotic cysteine protease highly related to CPP32.
1995
Coupling of hormonal stimulation and transcription via the cyclic AMP-responsive factor CREB is rate limited by nuclear entry of protein kinase A.
1993
A Refractory Phase in Cyclic AMP-Responsive Transcription Requires Down Regulation of Protein Kinase A
1995
Coupling of Hormonal Stimulation and Transcription via the Cyclic AMP-Responsive Factor CREB Is Rate Limited by Nuclear Entry of Protein Kinase A
1993 StandoutNobel