Citation Impact
Citing Papers
Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4
1993
Tumor Induction and Tissue Atrophy in Mice Lacking E2F-1
1996
Chromosome 13 homozygosity in osteosarcoma without retinoblastoma.
1986
Stepwise progression of B lineage differentiation supported by interleukin 7 and other stromal cell molecules.
1990
Expression and amplification of the N-myc gene in primary retinoblastoma
1984 Nature
Effects of an Rb mutation in the mouse
1992 StandoutNature
SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene
1988 Standout
Essential role of mouse telomerase in highly proliferative organs
1998 StandoutNatureNobel
Transplantation of Normal and Leukemic Human Bone Marrow into Immune‐Deficient Mice: Development of Animal Models for Human Hematopoiesis
1991
At least four different chromosomal regions are involved in loss of heterozygosity in human breast carcinoma
1989
DP and E2F proteins: coordinating transcription with cell cycle progression
1994
Leukemia and the disruption of normal hematopoiesis
1991
Loss of constitutional heterozygosity in colon carcinoma from patients with familial polyposis coli
1988 Nature
Expression of transcription factor E2F1 induces quiescent cells to enter S phase
1993 Nature
A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F
1992
The retinoblastoma susceptibility gene product undergoes cell cycle-dependent dephosphorylation and binding to and release from SV40 large T
1990
RAG-1-deficient mice have no mature B and T lymphocytes
1992 StandoutNobel
A case of synovial sarcoma with abnormal expression of the human retinoblastoma susceptibility gene
1988
Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis
1992 Nature
The SCID Mouse Mutant: Definition, Characterization, and Potential Uses
1991
A molecular basis for familial hypertrophic cardiomyopathy: A β cardiac myosin heavy chain gene missense mutation
1990 Standout
Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation, and suppress tumor cell growth
1998 StandoutNobel
The V(D)J recombination activating gene, RAG-1
1989 Nobel
An N-Terminal transformation-governing sequence of SV40 large T antigen contributes to the binding of both p110 and a second cellular protein, p120
1989
Coexpression of cdk2/cdc2 and retinoblastoma gene products in colorectal cancer
1995
A cell initiating human acute myeloid leukaemia after transplantation into SCID mice
1994 StandoutNature
Retinoblastoma gene mutations in primary human bladder cancer
1995
A genetic model for colorectal tumorigenesis
1990 Standout
The recombination activating gene-1 (RAG-1) transcript is present in the murine central nervous system
1991 Nobel
An internal deletion within an 11p13 zinc finger gene contributes to the development of Wilms' tumor
1990
Molecular Analysis of the Short Arm of Chromosome 3 in Small-Cell and Non-Small-Cell Carcinoma of the Lung
1987
Loss of heterozygosity of chromosome 3p markers in small-cell lung cancer
1987 Nature
Molecular and cellular origins of B lymphocyte diversity
1991
Evidence for a new tumour suppressor locus (DBM) in human B–cell neoplasia telomeric to the retinoblastoma gene
1993
The retinoblastoma protein is phosphorylated during specific phases of the cell cycle
1989
Molecular characterization of the retinoblastoma susceptibility gene
1993
Amplification of the E2F1 transcription factor gene in the HEL erythroleukemia cell line
1995
Preferential mutation of paternally derived RB gene as the initial event in sporadic osteosarcoma
1989 Nature
Mutations in the DNA ligase I gene of an individual with immunodeficiencies and cellular hypersensitivity to DNA-damaging agents
1992 StandoutNobel
A human immunoglobulin gene reduces the incidence of lymphomas in c-Myc-bearing transgenic mice
1988 Nature
Distinct RB1 gene mutations with low penetrance in hereditary retinoblastoma
1994
Tumor suppressor genes
1991 Standout
Cellular targets for transformation by the adenovirus E1A proteins
1989
Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product
1988 StandoutNature
Cyclin A-kinase regulation of E2F-1 DNA binding function underlies suppression of an S phase checkpoint
1995
Role of the retinoblastoma protein in the pathogenesis of human cancer.
1997 StandoutNobel
Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumping
1990 StandoutNature
xRB as a modulator of transcription
1996
Development of multiple endocrine neoplasia type 2A does not involve substantial deletions of chromosome 10
1989
Early loss of the retinoblastoma gene is associated with impaired growth inhibitory innervation during melanotroph carcinogenesis in Rb+/- mice.
1996
SV40 T antigen induced chromosomal changes reflect a process that is both clastogenic and aneuploidogenic and is ongoing throughout neoplastic progression of human fibroblasts
1992
Biological basis of germline mutation: Comparisons of spontaneous germline mutation rates among drosophila, mouse, and human
1995
The candidate Wilms' tumour gene is involved in genitourinary development
1990 Nature
Retinoblastoma gene structure and product expression in human gastric carcinomas
1994
A major segment of the neurofibromatosis type 1 gene: cDNA sequence, genomic structure, and point mutations
1990 Standout
Oncogenic Point Mutations in the Human Retinoblastoma Gene: Their Application to Genetic Counseling
1989
Familial predisposition to Wilms' tumour does not map to the short arm of chromosome 11
1988 Nature
Growth inhibition by TGF-β linked to suppression of retinoblastoma protein phosphorylation
1990
An analysis of abnormalities of the retinoblastoma gene in human ovarian and endometrial carcinoma
1990
Retinoblastoma cancer suppressor gene product is a substrate of the cell cycle regulator cdc2 kinase.
1991
Early B-cell precursors in scid mice: Normal numbers of cells transformable with abelson murine leukemia virus (A-MuLV)
1988
Genomic organization, chromosomal localization, and independent expression of human cyclin D genes
1992
A pre-B cell nuclear protein that specifically interacts with the immunoglobulin V-J recombination sequences
1987
Chromosomal localization of the human rhabdomyosarcoma locus by mitotic recombination mapping
1987 Nature
Identification of cellular proteins that can interact specifically with the T/ElA-binding region of the retinoblastoma gene product
1991 StandoutNobel
Reduction to homozygosity is the predominant spontaneous mutational event in cultured human lymphoblastoid cells
1991
Amino-terminal domains of c-myc and N-myc proteins mediate binding to the retinoblastoma gene product
1991 Nature
Genes specifically expressed at growth arrest of mammalian cells
1988
Allelic loss of the retinoblastoma gene in primary human prostatic adenocarcinomas
1995
The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle
1991
Loss of alleles on chromosome 18 and on the short arm of chromosome 17 in polyploid colorectal carcinomas
1988
Selective expression of RAG-2 in chicken B cells undergoing immunoglobulin gene conversion
1991 Nobel
Paternal origin of new mutations in Von Recklinghausen neurofibromatosis
1990 Nature
Inhibitors of mammalian G1 cyclin-dependent kinases.
1995 Standout
Restriction fragment length polymorphism studies show consistent loss of chromosome 3p alleles in small cell lung cancer patients' tumors.
1988
RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement
1992 Standout
The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element
1989
Genetic Alterations during Colorectal-Tumor Development
1988 Standout
The retinoblastoma protein as a transcriptional repressor
1993
G1/S phosphorylation of the retinoblastoma protein is associated with an altered affinity for the nuclear compartment
1991
Recent advances in the growth and isolation of primitive human haemopoietic progenitor cells
1992
The Retinoblastoma Susceptibility Gene Product Represses Transcription When Directly Bound to the Promoter
1995
Experimental Models for Understanding B Lymphocyte Formation
1987
SV40 large T antigen binds preferentially to an underphosphorylated member of the retinoblastoma susceptibility gene product family
1989
Extrathymic positive selection of αβ T-cell precursors in nude mice
1992 StandoutNatureNobel
Functional interactions of the retinoblastoma protein with mammalian D-type cyclins
1993 Standout
The defect in murine severe combined immune deficiency: Joining of signal sequences but not coding segments in V(D)J recombination
1988
Mammalian G1 cyclins
1993 Standout
The retinoblastoma protein copurifies with E2F-I, an E1A-regulated inhibitor of the transcription factor E2F
1991
T-lymphocyte development in scid mice is arrested shortly after the initiation of T-cell receptor delta gene recombination.
1991
B lymphocyte lineage-restricted expression of mb-1, a gene with CD3-like structural properties.
1988
Loss of alleles of loci on the short arm of chromosome 3 in renal cell carcinoma
1987 Nature
The pRB-related protein p107 contains two growth suppression domains: independent interactions with E2F and cyclin/cdk complexes.
1995
Differential DNA sequence deletions from chromosomes 3, 11, 13, and 17 in squamous-cell carcinoma, large-cell carcinoma, and adenocarcinoma of the human lung.
1989
Sustained expression of the human protooncogene MYCN rescues rat embryo cells from senescence.
1988 StandoutNobel
Point Mutational Inactivation of the Retinoblastoma Antioncogene
1989 Science
The biologic significance of alloreactivity. The ontogeny of T-cell sets specific for alloantigens or modified self antigens
1978 StandoutNobel
The Drosophila RBP-J kappa gene encodes the binding protein for the immunoglobulin J kappa recombination signal sequence.
1991 StandoutNobel
Oncogenic point mutations in exon 20 of the RB1 gene in families showing incomplete penetrance and mild expression of the retinoblastoma phenotype.
1992
Common Pathogenetic Mechanism for Three Tumor Types in Bilateral Acoustic Neurofibromatosis
1987 Science
Identification of a growth suppression domain within the retinoblastoma gene product.
1992 StandoutNobel
Distinct sub-populations of the retinoblastoma protein show a distinct pattern of phosphorylation.
1994
Checkpoints: Controls That Ensure the Order of Cell Cycle Events
1989 StandoutScienceNobel
Homozygosity of Chromosome 13 in Retinoblastoma
1984
Genetic mechanisms of tumor-specific loss of 11p DNA sequences in Wilms tumor.
1987
Antibodies specific for the human retinoblastoma protein identify a family of related polypeptides.
1991
Cyclin D1 transgene impedes lymphocyte maturation and collaborates in lymphomagenesis with the myc gene.
1994
Expression of a foreign gene in myeloid and lymphoid cells derived from multipotent haematopoietic precursors
1985 Nature
An appraisal of the application of recombinant DNA techniques to chromosome defects
1985
A link between double-strand break-related repair and V(D)J recombination: the scid mutation.
1991
Cancer-prone hereditary diseases with DNA processing abnormalities
1986
Trends in oncogenes
1985 StandoutNobel
Familial, EsD-linked, retinoblastoma with reduced penetrance and variable expressivity
1983
Frequent inactivation of the retinoblastoma anti-oncogene is restricted to a subset of human tumor cells.
1990
Human Retinoblastoma Susceptibility Gene: Cloning, Identification, and Sequence
1987 StandoutScience
Interactions of the p107 and Rb proteins with E2F during the cell proliferation response.
1993
T-cell receptor gene rearrangements in functional T-cell clones from severe combined immune deficient (scid) mice: reversion of the scid phenotype in individual lymphocyte progenitors.
1990
Differentiation of growth signal requirement of B lymphocyte precursor is directed by expression of immunoglobulin.
1991 StandoutNobel
Altering the Genome by Homologous Recombination
1989 StandoutScienceNobel
Prediction of Familial Predisposition to Retinoblastoma
1986
Strand breaks without DNA rearrangement in V (D)J recombination.
1991
Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system
1974 StandoutNatureNobel
The retinoblastoma protein physically associates with the human cdc2 kinase.
1992
THE MOLECULAR GENETICS OF CELLULAR ONCOGENES
1984
A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites.
1995 StandoutNobel
ANTI-ONCOGENES
1985
Amplification of N- myc in Untreated Human Neuroblastomas Correlates with Advanced Disease Stage
1984 StandoutScienceNobel
Isolation of coordinately regulated genes that are expressed in discrete stages of B-cell development.
1990
Allele Loss at the Retinoblastoma Locus in Human Ovarian Cancer
1991
Tumor Suppressor Genes: The Puzzle and the Promise
1989 Science
Tumor Suppressor Genes
1991 Science
Loss of the retinoblastoma susceptibility gene (RB1) is a frequent and early event in prostatic tumorigenesis
1994
An E2F-binding site mediates cell-cycle regulated repression of mouse B-myb transcription.
1993
Regulation of p16CDKN2 Expression and Its Implications for Cell Immortalization and Senescence
1996
Expression and state of phosphorylation of the retinoblastoma susceptibility gene product in cycling and noncycling human hematopoietic cells.
1990
Propagation of human blastic myeloid leukemias in the SCID mouse
1992
The scid gene encodes a trans-acting factor that mediates the rejoining event of Ig gene rearrangement.
1988
Cancer Cell Cycles
1996 StandoutScience
Bone marrow from children in relapse with pre-B acute lymphoblastic leukemia proliferates and disseminates rapidly in scid mice
1991
Isolation of scid pre-B cells that rearrange kappa light chain genes: formation of normal signal and abnormal coding joins.
1989
Cell Cycle Control and Cancer
1994 StandoutScienceNobel
Amplification and Rearrangement of Hu- ets -1 in Leukemia and Lymphoma with Involvement of 11q23
1986 Science
Tumor-specific loss of 11p15.5 alleles in del11p13 Wilms tumor and in familial adrenocortical carcinoma.
1989
Abnormalities in Structure and Expression of the Human Retinoblastoma Gene in SCLC
1988 Science
Molecular Etiology of Low-Penetrance Retinoblastoma in Two Pedigrees
1994
Isolation of human chromosome 13-specific DNA sequences cloned from flow sorted chromosomes and potentially linked to the retinoblastoma locus
1984
The regions of the retinoblastoma protein needed for binding to adenovirus E1A or SV40 large T antigen are common sites for mutations.
1990
Engraftment of Immune-Deficient Mice with Human Hematopoietic Stem Cells
1988 Science
Loss of a Harvey ras allele in sporadic Wilms' tumour
1984 Nature
Mitotic recombination of chromosome 17 in astrocytomas.
1989
Loss of alleles at polymorphic loci on chromosome 2 in uveal melanoma
1986
Establishment of an interleukin-5-dependent subclone from an interleukin-3-dependent murine hemopoietic progenitor cell line, LyD9, and its malignant transformation by autocrine secretion of interleukin-5.
1990 StandoutNobel
Development of homozygosity for chromosome 11p markers in Wilms' tumour
1984 Nature
Chronic lymphocytic leukemia cells with allelic deletions at 13q14 commonly have one intact RB1 gene: evidence for a role of an adjacent locus.
1993
p53 functions as a cell cycle control protein in osteosarcomas.
1990
Linkage of Genes for Human Esterase D and Hereditary Retinoblastoma
1984
The Transcription Factor E2F-1 Is a Downstream Target of RB Action
1995 StandoutNobel
Nonrandom loss of chromosome 15 in Syrian hamster tumours induced by v-Ha-ras plus v-myc oncogenes
1985 Nature
Evolution of tumours and the impact of molecular oncology
1985 Nature
Purification, biochemical characterization, and biological function of human esterase D.
1986
Germ-line transmission of genes introduced into cultured pluripotential cells by retroviral vector
1986 StandoutNatureNobel
Molecular cloning of the human esterase D gene, a genetic marker of retinoblastoma.
1986
Apoptosis or retinoblastoma: alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence of p53.
1994
Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein.
1993
Enzymatic Amplification of β-Globin Genomic Sequences and Restriction Site Analysis for Diagnosis of Sickle Cell Anemia
1985 StandoutScienceNobel
Loss of alleles at loci on human chromosome 11 during genesis of Wilms' tumour
1984 Nature
Extensive contribution of Rb-deficient cells to adult chimeric mice with limited histopathological consequences.
1994
Differential regulation of E2F transactivation by cyclin/cdk2 complexes.
1994
Recombination of exogenous interleukin 2 receptor gene flanked by immunoglobulin recombination signal sequences in a pre-B cell line and transgenic mice.
1991 StandoutNobel
Deletion of a splice donor site ablates expression of the following exon and produces an unphosphorylated RB protein unable to bind SV40 T antigen.
1990
Somatic deletion and duplication of genes on chromosome 11 in Wilms' tumours
1984 Nature
Retinoblastoma: Clues to Human Oncogenesis
1984 Science
CELL INTERACTIONS BETWEEN HISTOINCOMPATIBLE T AND B LYMPHOCYTES
1973 StandoutNobel
Loss of genes on the short arm of chromosome 11 in bladder cancer
1985 Nature
E2F-4, a new member of the E2F transcription factor family, interacts with p107.
1994
Regions of the Retinoblastoma Gene Product Required for its Interaction with the E2F Transcription Factor are Necessary for E2 Promoter Repression and pRb-Mediated Growth Suppression
1993
Suppression of the Neoplastic Phenotype by Replacement of the RB Gene in Human Cancer Cells
1988 Science
Insertion of a bacterial gene into the mouse germ line using an infectious retrovirus vector.
1985
Molecular detection of deletions involving band q14 of chromosome 13 in retinoblastomas.
1986
Surface Antigen Expression and Immunoglobulin Gene Rearrangement During Mouse pre‐B Cell Development
1983
Structural Rearrangement of the Retinoblastoma Gene in Human Breast Carcinoma
1988 Science
Distribution of horseradish peroxidase (HRP)-anti-HRP immune complexes in mouse spleen with special reference to follicular dendritic cells.
1978 StandoutNobel
Genomic organization of mouse J kappa recombination signal binding protein (RBP-J kappa) gene.
1992 StandoutNobel
p53: A Frequent Target for Genetic Abnormalities in Lung Cancer
1989 StandoutScience
Loss of genes on chromosome 22 in tumorigenesis of human acoustic neuroma
1986 Nature
Definition of the minimal simian virus 40 large T antigen- and adenovirus E1A-binding domain in the retinoblastoma gene product.
1990 StandoutNobel
A protein synthesis-dependent increase in E2F1 mRNA correlates with growth regulation of the dihydrofolate reductase promoter.
1993 StandoutNobel
Expression of Dominant-Negative Mutant DP-1 Blocks Cell Cycle Progression in G1
1996
Expression of N-myc and c-src during the development of fetal human brain.
1987
Hypervariable ‘minisatellite’ regions in human DNA
1985 StandoutNature
Clonal Analysis of Human Colorectal Tumors
1987 Science
Analysis of Lymphoid Population in Scid Mice; Detection of a Potential B Lymphocyte Progenitor Population Present at Normal Levels in Scid Mice by Three Color Flow Cytometry With B220 and S7
1989
The analysis of malignancy by cell fusion: the position in 1988.
1988
The Molecular Genetics of Cancer
1987 StandoutScienceNobel
Cell Cycle Analysis of E2F in Primary Human T Cells Reveals Novel E2F Complexes and Biochemically Distinct Forms of Free E2F
1993
Brca2 is required for embryonic cellular proliferation in the mouse.
1997 StandoutNobel
Reduction to Homozygosity of Genes on Chromosome 11 in Human Breast Neoplasia
1987 Science
DNA restriction fragment length polymorphisms and heterozygosity in the human genome
1984
Nonfunctional mutants of the retinoblastoma protein are characterized by defects in phosphorylation, viral oncoprotein association, and nuclear tethering.
1991
Wild-type V(D)J recombination in scid pre-B cells.
1990
Structure and expression of the murine retinoblastoma gene and characterization of its encoded protein.
1989
Loss of heterozygosity on chromosomes 3, 13, and 17 in small-cell carcinoma and on chromosome 3 in adenocarcinoma of the lung.
1987
Molecular Characterization of the Lymphoid V(D) J Recombination Activity
1989
Genetic Suppression of Tumor Formation
1985
Deletion of the human retinoblastoma gene in primary leukemias
1990
Inactivation of the retinoblastoma gene in human lymphoid neoplasms
1991
Collaboration of G1 cyclins in the functional inactivation of the retinoblastoma protein.
1994
Induction versus progression of brain tumor development: differential functions for the pRB- and p53-targeting domains of simian virus 40 T antigen.
1994
Low incidence of loss of chromosome 10 in sporadic and hereditary human medullary thyroid carcinoma.
1989
Loss of heterozygosity in three embryonal tumours suggests a common pathogenetic mechanism
1985 Nature
Oncogene Amplification in Tumor Cells
1986
A single amino acid substitution results in a retinoblastoma protein defective in phosphorylation and oncoprotein binding.
1990
scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair.
1991
Tumorigenicity in Human Melanoma Cell Lines Controlled by Introduction of Human Chromosome 6
1990 Science
Hereditary cancer, oncogenes, and antioncogenes.
1985 Standout
B cell ontogeny in murine embryo studied by a culture system with the monolayer of a stromal cell clone, ST2: B cell progenitor develops first in the embryonal body rather than in the yolk sac.
1988
Clonal genomic alterations in glioma malignancy stages.
1988
A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma
1986 StandoutNature
Targeted disruption of p107: functional overlap between p107 and Rb.
1996
Cloning and characterization of human cyclin D3, a cDNA closely related in sequence to the PRAD1/cyclin D1 proto-oncogene.
1992
Independent regions of adenovirus E1A are required for binding to and dissociation of E2F-protein complexes.
1993
Defect of Scid Mouse Revealed in In Vitro Culture Systems
1989
Regulation of the Ets-Related Transcription Factor Elf-1 by Binding to the Retinoblastoma Protein
1993 StandoutScienceNobel
A Protein Synthesis-Dependent Increase in E2F1 mRNA Correlates with Growth Regulation of the Dihydrofolate Reductase Promoter
1993 StandoutNobel
Deletions of a DNA sequence in retinoblastomas and mesenchymal tumors: organization of the sequence and its encoded protein.
1987
Cytogenetics of Bloom's syndrome
1986
Two distinct and frequently mutated regions of retinoblastoma protein are required for binding to SV40 T antigen.
1990
Genetics and biochemistry of collagen binding-triggered glandular differentiation in a human colon carcinoma cell line.
1988
Genetic control of cytolytic T-lymphocyte responses. I. Ir gene control of the specificity of cytolytic T-lymphocyte responses to trinitrophenyl-modified syngeneic cells.
1978 StandoutNobel
Some retinoblastomas, osteosarcomas, and soft tissue sarcomas may share a common etiology.
1988
Inactivation of the Retinoblastoma Susceptibility Gene in Human Breast Cancers
1988 Science
A null allele of esterase D is a marker for genetic events in retinoblastoma formation
1987
E2F: a Link Between the Rb Tumor Suppressor Protein and Viral Oncoproteins
1992 Science
Nonrandom chromosomal changes in untreated retinoblastomas
1983
The Human Papilloma Virus-16 E7 Oncoprotein Is Able to Bind to the Retinoblastoma Gene Product
1989 StandoutScience
Allelotype of Colorectal Carcinomas
1989 Science
Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein.
1993
Functional interaction between E2F-4 and p130: evidence for distinct mechanisms underlying growth suppression by different retinoblastoma protein family members.
1995
Mechanisms of p53 loss in human sarcomas.
1990
Identification of distinct roles for separate E1A domains in disruption of E2F complexes.
1993
Structural Evidence for the Authenticity of the Human Retinoblastoma Gene
1987 Science
Normal recombination substrate VH to DJH rearrangements in pre-B cell lines from scid mice.
1990
Cytokine Stimulation of Multilineage Hematopoiesis from Immature Human Cells Engrafted in SCID Mice
1992 Science
Expression and rearrangement of the alpha, beta, and gamma chain genes of the T cell receptor in cloned murine large granular lymphocyte lines. No correlation with the cytotoxic spectrum.
1986 StandoutNobel
Works of Robert A. Phillips being referenced
The retinoblastoma protein and cell cycle regulation
1992
Preferential germline mutation of the paternal allele in retinoblastoma
1989 Nature
Mechanisms of loss of heterozygosity in retinoblastoma
1992
A physical map around the retinoblastoma gene
1990
Unraveling the Function of the Retinoblastoma Gene
1993
The scid mutation in mice causes a general defect in DNA repair
1990 Nature
The scid defect affects the final step of the immunoglobulin VDJ recombinase mechanism
1988
Isochromosome 6p, a unique chromosomal abnormality in retinoblastoma: Verification by standard staining techniques, new densitometric methods, and somatic cell hybridization
1984
Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency
1986
Expression of recessive alleles by chromosomal mechanisms in retinoblastoma
1983 StandoutNature
A QUANTITATIVE ASSAY FOR THE PROGENITORS OF BONE MARROW-ASSOCIATED LYMPHOCYTES
1972
Direct Transcriptional Repression by pRB and Its Reversal by Specific Cyclins
1995
RESTRICTION OF SPECIFICITY IN THE PRECURSORS OF BONE MARROW-ASSOCIATED LYMPHOCYTES
1973
Pleiotropic Effects of the scid Mutation: Effects on Lymphoid Differentiation and on Repair of Radiation Damage
1989
A detailed analysis of chromosomal changes in heritable and non-heritable retinoblastoma
1985
Mutations in the RB1 gene and their effects on transcription.
1989
Molecular cloning and characterization of the mouse RB1 promoter.
1993
An expanded population of natural killer cells in mice with severe combined immunodeficiency (SCID) lack rearrangement and expression of T cell receptor genes.
1986
Cloning of the esterase D gene: a polymorphic gene probe closely linked to the retinoblastoma locus on chromosome 13.
1986
Quantitative Studies of the Activation of Cytotoxic Lymphocyte Precursor Cells
1977
The Effect of the scid Mutation on Mechanism and Control of Immunoglobulin Heavy and Light Chain Gene Rearrangement
1989
Transcriptional repression of the E2-containing promoters EIIaE, c-myc, and RB1 by the product of the RB1 gene.
1992
Infrequent genomic rearrangement and normal expression of the putative RB1 gene in retinoblastoma tumors.
1988
Mutations in the RB1 Gene and Their Effects on Transcription
1989
Identification of Germline and Somatic Mutations Affecting the Retinoblastoma Gene
1988 Science
Hyperphosphorylation of the retinoblastoma gene product is determined by domains outside the simian virus 40 large-T-antigen-binding regions.
1990
B‐Lymphocyte Subpopulations in the Mouse
1975
Osteosarcoma and retinoblastoma: a shared chromosomal mechanism revealing recessive predisposition.
1985
A Model of Human Acute Lymphoblastic Leukemia in Immune-Deficient SCID Mice
1989 Science
INHIBITION OF THE IMMUNE RESPONSE BY 7S ANTIBODY
1973
Generation of purified stromal cell cultures that support lymphoid and myeloid precursors
1986
Expression of human adenosine deaminase in murine haematopoietic progenitor cells following retroviral transfer
1986 Nature
Multiple karyotypic changes in retinoblastoma tumor cells: Presence of normal chromosome No. 13 in most tumors
1982
Retinoma: Spontaneous regression of retinoblastoma or benign manifestation of the mutation?
1982
Speculations on the roles of RB1 in tissue‐specific differentiation, tumor initiation, and tumor progression
1993
Separation of cells by velocity sedimentation
1969
In Vitro Differentiation of B Lymphocytes from Pre-B Cells
1979
Infrequent Genomic Rearrangement and Normal Expression of the Putative RB1 Gene in Retinoblastoma Tumors
1988
pRb controls proliferation, differentiation, and death of skeletal muscle cells and other lineages during embryogenesis.
1996
Initiation of Antibody Production to Sheep Erythrocytes in Vitro: Replacement of the Requirement for T-Cells with a Cell-Free Factor Isolated from Cultures of Lymphoid Cells
1972
Genetic manipulation of hematopoietic stem cells with retrovirus vectors
1986
Natural killer (NK) cells are present in mice with severe combined immunodeficiency (scid).
1985
Tumour induction by the retinoblastoma mutation is independent of N-myc expression
1986 Nature
Fibroblasts from Retinoblastoma patients: Enhanced growth in fetal calf serum and a normal response to ionizing radiation
1982
Genetic Origin of Mutations Predisposing to Retinoblastoma
1985 Science
Somatic inactivation of genes on chromosome 13 is a common event in retinoblastoma
1983 Nature
Transcriptional Repression of the E2-Containing Promoters EIIaE, c-myc, and RB1 by the Product of the RB1 Gene
1992
Introduction of a selectable gene into primitive stem cells capable of long-term reconstitution of the hemopoietic system of W/W mice
1985
Retrovirus transfer of a bacterial gene into mouse haematopoietic progenitor cells
1983 Nature