Robert A. O’Reilly

Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors

Fatty acid binding to plasma albumin

Pharmacology and Management of the Vitamin K Antagonists

Mechanisms of Thrombus Formation

Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration

A Clinical Trial of Vena Caval Filters in the Prevention of Pulmonary Embolism in Patients with Proximal Deep-Vein Thrombosis

Intracerebral haemorrhage

Pharmacodynamic resistance to warfarin associated with a Val66Met substitution in vitamin K epoxide reductase complex subunit 1

Warfarin Maintenance Dosing Patterns in Clinical Practice

Valvular Heart Disease Associated with Fenfluramine–Phentermine

Predicting plasma protein binding of drugs: a new approach

Posaconazole or Fluconazole for Prophylaxis in Severe Graft-versus-Host Disease

Adverse Drug Reactions to Systemic Antifungals Prevention and Management

Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2

Catalytic Asymmetric Intramolecular Michael Reaction of Aldehydes

Herb-drug interactions

A Randomized Trial Comparing 5-mg and 10-mg Warfarin Loading Doses

Maternal characteristics and risk of severe neonatal thrombocytopenia and intracranial hemorrhage in pregnancies complicated by autoimmune thrombocytopenia

Oral Anticoagulant Therapy

Effects of Computerized Clinical Decision Support Systems on Practitioner Performance and Patient Outcomes

Cushing's syndrome

Drug Interactions with Fluconazole

Comparison of a daily fixed 2.5-mg warfarin dose with a 5-mg, international normalized ratio adjusted, warfarin dose initially following heart valve replacement

Induction of Human CYP2C9 by Rifampicin, Hyperforin, and Phenobarbital Is Mediated by the Pregnane X Receptor

Emergency Hospitalizations for Adverse Drug Events in Older Americans

Subcutaneous Low-Molecular-Weight Heparin Compared with Continuous Intravenous Heparin in the Treatment of Proximal-Vein Thrombosis

A Randomized Comparison of a Computer-Based Dosing Program with a Manual System to Monitor Oral Anticoagulant Therapy

Organocatalytic Asymmetric Michael Reaction of Cyclic 1,3‐Dicarbonyl Compounds and α,β‐Unsaturated Ketones—A Highly Atom‐Economic Catalytic One‐Step Formation of Optically Active Warfarin Anticoagulant

The Management of Thrombosis in the Antiphospholipid-Antibody Syndrome

Gout

The inflammasome, autoinflammatory diseases, and gout

A New Equation to Estimate Glomerular Filtration Rate

Tuberculosis in Patients with Human Immunodeficiency Virus Infection

Dabigatran versus Warfarin in the Treatment of Acute Venous Thromboembolism

Acetaminophen and Other Risk Factors for Excessive Warfarin Anticoagulation

Treatment of invasive aspergillosis with itraconazole

Anticoagulant-related bleeding: Clinical epidemiology, prediction, and prevention

Immune Thrombocytopenic Purpura

Population pharmacokinetic-pharmacodynamic analysis of fluindione in patients*

The Clinical Course of Pulmonary Embolism

Genomic assignment of the warfarin resistance locus, Rw, in the rat

Antithrombotic Therapy for Venous Thromboembolic Disease

Nonsteroidal Antiinflammatory Drugs — Differences and Similarities

Oral Anticoagulants

Low-Molecular-Weight Heparin versus a Coumarin for the Prevention of Recurrent Venous Thromboembolism in Patients with Cancer

Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis

Effect of ginkgo and ginger on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects

Oral Anticoagulants: Mechanism of Action, Clinical Effectiveness, and Optimal Therapeutic Range

Cytochrome P4502C9: an enzyme of major importance in human drug metabolism

Suppression of hemostatic system activation by oral anticoagulants in the blood of patients with thrombotic diatheses.

Rivaroxaban versus Enoxaparin for Thromboprophylaxis after Hip Arthroplasty

Interactions with Aromatic Rings in Chemical and Biological Recognition

Prevention and treatment of bleeding complications in patients receiving vitamin K antagonists, Part 1: Prevention

Systematic Overview of Warfarin and Its Drug and Food Interactions

Molecular and Cellular Biology of Blood Coagulation

Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse

Antifungal and Surgical Treatment of Invasive Aspergillosis: Review of 2,121 Published Cases

The Pharmacology and Management of the Vitamin K Antagonists

Antithrombotic Therapy for Venous Thromboembolic Disease

Does heart failure exacerbation increase response to warfarin?A critical review of the literature

Oral Anticoagulant Drugs

Topographic diversity of fungal and bacterial communities in human skin

External validity of randomised controlled trials: “To whom do the results of this trial apply?”

Results of an open-label, prospective study of anticoagulant therapy for atrial fibrillation in an outpatient anticoagulation clinic

Treatment of coumarin‐associated coagulopathy: a systematic review and proposed treatment algorithms

Evaluation of a computer-assisted method for individualized anticoagulation: Retrospective and prospective studies with a pharmacodynamic model

Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events (ACTIVE W): a randomised controlled trial

The Effects of Danshen (Salvia miltiorrhiza) on Warfarin Pharmacodynamics and Pharmacokinetics of Warfarin Enantiomers in Rats

Interaction of Dietary Factors with Oral Anticoagulants

Pharmacology and toxicity of high-dose ketoconazole

Optimal Therapeutic Level of Heparin Therapy in Patients With Venous Thrombosis

The Effect of Ketoconazole on Amphotericin B in a Model of Disseminated Aspergillosis

A Computer Generated Induction System for Hospitalized Patients Starting on Oral Anticoagulant Therapy

Mechanism of coumarin action: significance of vitamin K epoxide reductase inhibition

The Use of Ketoconazole as an Inhibitor of Steroid Production

Understanding the Dose-Effect Relationship

Ketoconazole-Induced Increase in Estradiol-Testosterone Ratio

Intracerebral Hemorrhage Associated With Oral Anticoagulant Therapy

Ketoconazole and Other Imidazole Derivatives as Inhibitors of Steroidogenesis

Pharmacogenetic differences between warfarin, acenocoumarol and phenprocoumon

Determination of the Tryptophan Content of Proteins by Ion Exchange Chromatography of Alkaline Hydrolysates

Catalytic Asymmetric Epoxidation of Cyclic Enones

Pregnancy-associated thrombocytopenia: pathogenesis and management

Strategies in Herbivory by Mammals: The Role of Plant Secondary Compounds

Serum Albumin

Initial Experience in Therapy for Progressive Mycoses with Itraconazole, the First Clinically Studied Triazole

Electroreductive Dimerization of Coumarin and Coumarin Analogues at Carbon Cathodes

American Heart Association/American College of Cardiology Foundation Guide to Warfarin Therapy

Prevention of arterial thromboembolism with acetylsalicylic acid

Low Dose Oral Vitamin K to Reverse Acenocoumarol-induced Coagulopathy: A Randomized Controlled Trial

Guide to anticoagulant therapy. Part 2: Oral anticoagulants. American Heart Association.

Pharmacokinetics of fluconazole in cerebrospinal fluid and serum in human coccidioidal meningitis

Organocatalytic Asymmetric Michael Reaction of Cyclic 1,3‐Dicarbonyl Compounds and α,β‐Unsaturated Ketones—A Highly Atom‐Economic Catalytic One‐Step Formation of Optically Active Warfarin Anticoagulant

Pharmacokinetics of absorption, distribution and elimination of fenfluramine and its main metabolite in man

Clinical Pharmacokinetics of Oral Anticoagulants

The Chemical Defenses of Plants to Pathogens and Herbivores

Two-Step Warfarin Therapy

Initiation of warfarin therapy

Warfarin STEREOCHEMICAL ASPECTS OF ITS METABOLISM AND THE INTERACTION WITH PHENYLBUTAZONE

Warfarin

ACC/AHA 2006 Guidelines for the Management of Patients With Valvular Heart Disease

Polycyclic Polyprenylated Acylphloroglucinols

A molecular mechanism for genetic warfarin resistance in the rat

American Heart Association/American College of Cardiology Foundation guide to warfarin therapy11The American Heart Association makes every effort to avoid any actual or potential conflicts of interest that may arise as a result of an outside relationship or a personal, professional, or business interest of a member of the writing panel. Specifically, all members of the writing group are required to complete and submit a Disclosure Questionnaire showing all such relationships that might be perceived as real or potential conflicts of interest.This statement has been co-published in the April 1, 2003, issue of Circulation.This statement was approved by the American Heart Association Science Advisory and Coordinating Committee in October 2002 and by the American College of Cardiology Board of Trustees in February 2003. A single reprint is available by calling 800-242-8721 (US only) or writing the American Heart Association, Public Information, 7272 Greenville Ave, Dallas, TX 75231-4596. Ask for reprint No. 71-0254. To purchase additional reprints: up to 999 copies, call 800-611-6083 (US only) or fax 413-665-2671; 1000 or more copies, call 410-528-4426, fax 410-528-4264, or e-mail klbradle@lww.com. To make photocopies for personal or educational use, call the Copyright Clearance Center, 978-750-8400.

Resource Availability and Plant Antiherbivore Defense

Atom‐Economic Synthesis of Optically Active Warfarin Anticoagulant over a Chiral MOF Organocatalyst

Pharmacokinetics of the enantiomers of acenocoumarol in man.

Clinical Pharmacokinetics of Systemic Antifungal Drugs

Relationship Between Drug Concentration in Plasma or Serum and Amount of Drug in the Body

Age as a determinant of sensitivity to warfarin.

Interaction of Ketoconazole with Rifampin and Isoniazid

Evolution of serum albumin

Kinetic parameters and renal clearances of plasma adenosine 3′,5′-monophosphate and guanosine 3′,5′-monophosphate in man

Homozygosity mapping of a second gene locus for hereditary combined deficiency of vitamin K–dependent clotting factors to the centromeric region of chromosome 16

Synthetic Organic Electrochemical Methods Since 2000: On the Verge of a Renaissance

2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation

Analysis of macromolecule-ligand binding by determination of stepwise equilibrium constants

[14] Microcalorimetry for biological chemistry: Experimental design, data analysis, and interpretation

Reduction of Substituted Phenyl 2-Chloroacetates at Silver Cathodes: Electrosynthesis of Coumarins

Systemic Antifungal Agents

A gene-anchored map position of the rat warfarin-resistance locus, Rw, and its orthologs in mice and humans

A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor.

INCREASING ACTIVITY OF SULFONAMIDES WITH DISPLACING AGENTS: A REVIEW

A Review of Enzyme Induction of Warfarin Metabolism with Recommendations for Patient Management

Photopharmacology: Beyond Proof of Principle

Effect of Mode of Administration on Drug Distribution in a Two-Compartment Open System

Metal–Organic Frameworks for Heterogeneous Basic Catalysis

Antithrombotic Therapy for Venous Thromboembolic Disease

The Effect of Low-Dose Warfarin on the Risk of Stroke in Patients with Nonrheumatic Atrial Fibrillation

Drug Prescribing in Renal Failure: Dosing Guidelines for Adults.

Cytokine-induced radiation protection and sensitization

Mechanisms of the stereoselective interaction between miconazole and racemic warfarin in human subjects

Prospective Evaluation of Anticoagulant Reversal With Oral Vitamin K1 While Continuing Warfarin Therapy Unchanged

The mechanism of the interaction between amiodarone and warfarin in humans

The mechanism of the warfarin-rifampin drug interaction in humans

Hereditary Transmission of Exceptional Resistance to Coumarin Anticoagulant Drugs

Vitamin K and the Oral Anticoagulant Drugs

IMPACT OF ASPIRIN AND CHLORTHALIDONE ON THE PHARMACODYNAMICS OF ORAL ANTICOAGULANT DRUGS IN MAN*

Studies on Coumarin Anticoagulant Drugs

Dynamic interaction between disulfiram and separated enantiomorphs of racemic warfarin

Racemic Warfarin and Trimethoprim-Sulfamethoxazole Interaction in Humans

Spironolactone and warfarin interaction

Pharmacokinetic analysis of the effect of barbiturate on the anticoagulant action of warfarin in man

Studies on the Interaction of Warfarin and Clofibrate in Man

COVERT ANTICOAGULANT INGESTION: STUDY OF 25 PATIENTS AND REVIEW OF WORLD LITERATURE

Immunologic Thrombocytopenic Purpura and Pregnancy

Interaction of the anticoagulant drug warfarin and its metabolites with human plasma albumin

Comparative Interaction of Cimetidine and Ranitidine With Racemic Warfarin in Man

Effect of heptabarbital on the response to bishydroxycoumarin in man.

HEREDITARY RESISTANCE TO COUMARIN ANTICOAGULANT DRUGS IN MAN AND RAT*

Interaction of secobarbital with warfarin pseudoracemates

Interaction of Several Coumarin Compounds with Human and Canine Plasma Albumin

Interaction of Chronic Daily Warfarin Therapy and Rifampin

Bioavailability of Warfarin in a Patient with Severe Short Bowel Syndrome

Phase I study of recombinant human interleukin-1 beta (rhIL-1 beta) in patients with bone marrow failure.

Comparative Pharmacokinetics of Coumarin Anticoagulants IV

Stereoselective interaction of sulfinpyrazone with racemic warfarin and its separated enantiomorphs in man.

Kinetics of pharmacologic effects in man: The anticoagulant action of warfarin

Pharmacokinetics of warfarin enantiomers: A search for intrasubject correlations

Interaction of amiodarone with racemic warfarin and its separated enantiomorphs in humans

Interaction of Sodium Warfarin and Disulfiram (Antabuse®) in Man

Stereoselective Interaction of Phenylbutazone with [12C/13C]Warfarin Pseudoracemates in Man

Studies on the Coumarin Anticoagulant Drugs : The Assay of Warfarin and its Biologic Application

Comparative Pharmacokinetics of Coumarin Anticoagulants XXXV: Examination of Possible Pharmacokinetic Interaction between (R)-(+)- and (S)-(−)-Warfarin in Humans

Stereoselective Interaction of Trimethoprim-Sulfamethoxazole with the Separated Enantiomorphs of Racemic Warfarin in Man

HEREDITARY RESISTANCE TO COUMARIN ANTICOAGULANT DRUGS IN MAN AND RAT*

Interaction of Sodium Warfarin and Rifampin

Studies on Coumarin Anticoagulant Drugs

The Stereoselective Interaction of Warfarin and Metronidazole in Man

The Second Reported Kindred with Hereditary Resistance to Oral Anticoagulant Drugs

Disposition of ketoconazole, an oral antifungal, in humans

Potentiation of Anticoagulant Effect of Warfarin by Phenylbutazone

Warfarin Metabolism and Drug-Drug Interactions

STUDIES ON THE COUMARIN ANTICOAGULANT DRUGS: THE PHARMACODYNAMICS OF WARFARIN IN MAN*

Metabolic Fate of Phenprocoumon in Humans

Lack of effect of mealtime wine on the hypoprothrombinemia of oral anticoagulants

Phenylbutazone‐warfarin interaction in man: further stereochemical and metabolic considerations.

THE BINDING OF SODIUM WARFARIN TO PLASMA ALBUMIN AND ITS DISPLACEMENT BY PHENYLBUTAZONE*

The warfarin-sulfinpyrazone interaction: stereochemical considerations

Lack of Effect of Fortified Wine Ingested During Fasting and Anticoagulant Therapy

Studies on the Coumarin Anticoagulant Drugs: Interaction of Human Plasma Albumin and Warfarin Sodium*

DETERMINANTS OF THE RESPONSE TO ORAL ANTICOAGULANT DRUGS IN MAN