Citation Impact
Citing Papers
Antiemetics: American Society of Clinical Oncology Clinical Practice Guideline Update
2011 Standout
Pathophysiology of Migraine: A Disorder of Sensory Processing
2017 Standout
Tachykinin NK1 receptor antagonists act centrally to inhibit emesis induced by the chemotherapeutic agent cisplatin in ferrets
1996
Correlation of Neurokinin (NK) 1 Receptor Occupancy in Gerbil Striatum with Behavioral Effects of NK1 Antagonists
2002
A Bioluminescent Assay for Agonist Activity at Potentially Any G-Protein-Coupled Receptor
1997
The novel NK1 receptor antagonist MK–0869 (L–754,030) and its water soluble phosphoryl prodrug, L–758,298, inhibit acute and delayed cisplatin-induced emesis in ferrets
2000
Is there still a future for neurokinin 3 receptor antagonists as potential drugs for the treatment of psychiatric diseases?
2011
Predictors of posttraumatic stress disorder and symptoms in adults: A meta-analysis.
2003 Standout
Substance P receptor antagonists in the therapy of migraine
2001
Neural regulation of endocrine and autonomic stress responses
2009 Standout
Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval
2000 StandoutNature
The tachykinin NK1 receptor. Part I: Ligands and mechanisms of cellular activation
1997
THE METABOLIC DISPOSITION OF APREPITANT, A SUBSTANCE P RECEPTOR ANTAGONIST, IN RATS AND DOGS
2004
Physiology and Neurobiology of Stress and Adaptation: Central Role of the Brain
2007 Standout
The role of substance P in stress and anxiety responses
2006
Mechanical, thermal and formalin-induced nociception is differentially altered in 5-HT1A−/−, 5-HT1B−/−, 5-HT2A−/−, 5-HT3A−/− and 5-HTT−/− knock-out male mice
2007 StandoutNobel
Anandamide – the other side of the coin
2000 StandoutNobel
The tachykinin NK1 receptor. Part II: Distribution and pathophysiological roles
1998
Introduction of Fluorine and Fluorine‐Containing Functional Groups
2013 Standout
Central sensitization: Implications for the diagnosis and treatment of pain
2010 Standout
5-Hydroxytryptamine-interacting drugs in animal models of anxiety disorders: More than 30 years of research
1995
Modulation of amphetamine-induced striatal dopamine release by ketamine in humans: implications for schizophrenia
2000 StandoutNobel
The Non-Antiemetic Uses of Serotonin 5-HT3 Receptor Antagonists
1997
Cellular and behavioural profile of the novel, selective neurokinin1 receptor antagonist, vestipitant: A comparison to other agents
2008
Blockade by oral or parenteral RPR 100893 (a non‐peptide NK1 receptor antagonist) of neurogenic plasma protein extravasation within guinea‐pig dura mater and conjunctiva
1994
Modulation of hypoglossal motoneuron excitability by NK1 receptor activation in neonatal mice in vitro
2001
Anxiogenic-like effect of chronic corticosterone in the light-dark emergence task in mice.
2006
Drug repurposing: progress, challenges and recommendations
2018 Standout
Regional Brain Activity Changes Associated with Fentanyl Analgesia Elucidated by Positron Emission Tomography
1997
Chemotherapy-Induced Nausea and Vomiting
2008 Standout
Behavioural pharmacology of 5-HT3 receptor ligands
1992
Rolapitant (SCH 619734): A potent, selective and orally active neurokinin NK1 receptor antagonist with centrally-mediated antiemetic effects in ferrets
2012
Tachykinins: receptor to effector
1996
Physiology and Pathophysiology of Purinergic Neurotransmission
2007 Standout
The Role of the Amygdala in Fear and Anxiety
1992 Standout
Serotonin receptors: Subtypes, functional responses and therapeutic relevance
1995
Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model
2002 Standout
Probing the Structure and Function of the Tachykinin Neurokinin-2 Receptor through Biosynthetic Incorporation of Fluorescent Amino Acids at Specific Sites
1996
5-hydroxytryptamine is a fast excitatory transmitter at 5-HT3 receptors in rat amygdala
1992
Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia
2003 Standout
Tachykinin receptor antagonists in clinical trials
2009
Excessive placental secretion of neurokinin B during the third trimester causes pre-eclampsia
2000 Nature
Peptidergic sensory neurons in the control of vascular functions: Mechanisms and significance in the cutaneous and splanchnic vascular beds
2005
Reversal of behavioural and electrophysiological correlates of experimental peripheral neuropathy by the NK1 receptor antagonist GR205171 in rats
1998
Receptor localization in the mammalian dorsal horn and primary afferent neurons
1997
The Tachykinin Peptide Family
2002
The integration of negative affect, pain and cognitive control in the cingulate cortex
2011 Standout
Impaired recognition of emotion in facial expressions following bilateral damage to the human amygdala
1994 StandoutNature
Circulating Angiogenic Factors and the Risk of Preeclampsia
2004 Standout
Neurokinin‐1 receptor antagonism in a human model of visceral hypersensitivity
2007
PREDICT modeling and in‐silico screening for G‐protein coupled receptors
2004
Neuropathic Pain Activates the Endogenous κ Opioid System in Mouse Spinal Cord and Induces Opioid Receptor Tolerance
2004 StandoutNobel
Toward high-resolution prediction and design of transmembrane helical protein structures
2007 StandoutNobel
Fluoroolefin dipeptide isosteres -II.
1990
Latest Advances in Understanding Preeclampsia
2005 StandoutScience
Fluorine in medicinal chemistry
2007 Standout
Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)
2013 Standout
Solid-Phase Intramolecular N-Acyliminium Pictet−Spengler Reactions as Crossroads to Scaffold Diversity
2004 StandoutNobel
Design and structure of a novel Neurokinin A receptor antagonist cyclo(-Met1-Asp2-Trp3-Phe4-Dap5-Leu6-)cyclo(2β-5β)
1995
Neurotransmitter regulation of dopamine neurons in the ventral tegmental area
1993
Electrochemical Cyclization of Dipeptides To Form Novel Bicyclic, Reverse-Turn Peptidomimetics. 2. Synthesis and Conformational Analysis of 6,5-Bicyclic Systems
1996
The 5-HT3Subtype of Serotonin Receptor Contributes to Nociceptive Processing via a Novel Subset of Myelinated and Unmyelinated Nociceptors
2002 StandoutNobel
Marine Indole Alkaloids: Potential New Drug Leads for the Control of Depression and Anxiety
2010 Standout
2-Amino-3-oxohexahydroindolizino[8,7-b]indole-5-carboxylate derivatives as new scaffolds for mimicking β-turn secondary structures. Molecular dynamics and stereoselective synthesis
1995
Design, Synthesis, and Conformational Analysis of a Proposed Type I β-Turn Mimic
1998
Regional Brain Activity Changes Associated with Fentanyl Analgesia Elucidated by Positron Emission Tomography
1997
Inactivation of a Serotonin-Gated Ion Channel by a Polypeptide Toxin from Marine Snails
1998 StandoutScienceNobel
Fluoroolefin dipeptide isosteres — I.
1990
Nervous system distribution of the serotonin 5-HT3 receptor mRNA.
1993 StandoutNobel
Implicit Solvation Models: Equilibria, Structure, Spectra, and Dynamics
1999 Standout
Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas
2016 Standout
Conceptual Density Functional Theory
2003 Standout
Synaptic Control of Motoneuronal Excitability
2000
Neurobiology of fear responses: the role of the amygdala
1997
β-Peptides: From Structure to Function
2001 Standout
Spinal and Supraspinal Factors in Human Muscle Fatigue
2001 Standout
Olefin Metathesis and Beyond
2000 Standout
Recommendations for the Use of Antiemetics: Evidence-Based, Clinical Practice Guidelines
1999
Placebo and Opioid Analgesia-- Imaging a Shared Neuronal Network
2002 StandoutScience
Randomized Phase II Study of the Neurokinin 1 Receptor Antagonist CJ-11,974 in the Control of Cisplatin-Induced Emesis
1999
Prolactin: Structure, Function, and Regulation of Secretion
2000 Standout
Cyclizations of N-Acyliminium Ions
2004 Standout
Pathophysiology of Sleep Apnea
2010 Standout
The Combinatorial Synthesis of Bicyclic Privileged Structures or Privileged Substructures
2003 Standout
Brain Corticosteroid Receptor Balance in Health and Disease*
1998 Standout
Conformationally constrained thyroliberin analogs: a novel electrochemical route to a key rigid Pro-Phe building block
1992
Serotonin Receptors
2008
Conformational Analysis of Reverse-Turn Constraints by N-Methylation and N-Hydroxylation of Amide Bonds in Peptides and Non-Peptide Mimetics
1998
A cell protection screen reveals potent inhibitors of multiple stages of the hepatitis C virus life cycle
2010 StandoutNobel
Synthesis of a Substance P Antagonist with a Somatostatin Scaffold: Factors Affecting Agonism/Antagonism at GPCRs and the Role of Pseudosymmetry
2000
Nonpeptide Tachykinin Receptor Antagonists. II. Pharmacological and Pharmacokinetic Profile of SB-222200, a Central Nervous System Penetrant, Potent and Selective NK-3 Receptor Antagonist
2000
Discovery and Biological Characterization of (2R,4S)-1′-Acetyl-N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-2-(4-fluoro-2-methylphenyl)-N-methyl-4,4′-bipiperidine-1-carboxamide as a New Potent and Selective Neurokinin 1 (NK1) Receptor Antagonist Clinical Candidate
2011
Association of Anxiety-Related Traits with a Polymorphism in the Serotonin Transporter Gene Regulatory Region
1996 StandoutScience
Seeing the Machinery of Live Cells
1998 StandoutScienceNobel
Neuronal Plasticity: Increasing the Gain in Pain
2000 StandoutScience
The Oral Neurokinin-1 Antagonist Aprepitant for the Prevention of Chemotherapy-Induced Nausea and Vomiting: A Multinational, Randomized, Double-Blind, Placebo-Controlled Trial in Patients Receiving High-Dose Cisplatin—The Aprepitant Protocol 052 Study Group
2003 Standout
American Society of Clinical Oncology Treatment of Unresectable Non–Small-Cell Lung Cancer Guideline: Update 2003
2003 Standout
Substance P induced by peripheral nerve injury in primary afferent sensory neurons and its effect on dorsal column nucleus neurons
1995
Specific Recruitment of Antigen-presenting Cells by Chemerin, a Novel Processed Ligand from Human Inflammatory Fluids
2003 Standout
Both Protein Kinase A and Mitogen-Activated Protein Kinase Are Required in the Amygdala for the Macromolecular Synthesis-Dependent Late Phase of Long-Term Potentiation
2000 StandoutNobel
Works of R.M. Hagan being referenced
[3H] GR67330, a very high affinity ligand for 5-HT3 receptors
1990
Anxiolytic activity of tachykinin NK2 receptor antagonists in the mouse light-dark box
1993
The pharmacology of GR203040, a novel, potent and selective non‐peptide tachykinin NK1 receptor antagonist
1995
Interactions between 5-HT3 receptors and cerebral dopamine function: implications for the treatment of schizophrenia and psychoactive substance abuse
1993
The anxiolytic-like activity of GR159897, a non-peptide NK2 receptor antagonist, in rodent and primate models of anxiety
1995
Receptors mediating tachykinin‐induced contractile responses in guinea‐pig trachea
1991
Behavioural and biochemical responses following activation of midbrain dopamine pathways by receptor selective neurokinin agonists
1991
Potent and highly selective neurokinin antagonists
1990
Ontogeny and characterization of [125I]Bolton Hunter-Eledoisin binding sites in rat spinal cord by quantitative autoradiography
1992
GR138676, a novel peptidic tachykinin antagonist which is potent at NK3 receptors
1994
Receptor-selective, peptidase-resistant agonists at neurokinin NK-1 and NK-2 receptors: New tools for investigating neurokinin function
1991
Recent developments in tachykinin NK1receptor antagonists: prospects for the treatment of migraine headache
1995
Investigation into species variants in tachykinin NK1 receptors by use of the non‐peptide antagonist, CP‐96,345
1991
Effect of 5‐HT3 receptor antagonists on responses to selective activation of mesolimbic dopaminergic pathways in the rat
1990
Effects of intrathecal NK-1 and NK-2 antagonists on xylene-induced cystitis in rat
1993
Low molecular weight neurokinin NK2 antagonists
1993
Opioid receptor sub-types involved in the control of transmitter release in cortex of the brain of the rat
1984