Citation Impact
Citing Papers
Expanded therapeutic potential in activity space of next-generation 5-nitroimidazole antimicrobials with broad structural diversity
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C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector
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Species Interactions in a Parasite Community Drive Infection Risk in a Wildlife Population
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Requirement of bic/microRNA-155 for Normal Immune Function
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Chagas disease
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Challenges and opportunities for primary, secondary, and tertiary prevention of Chagas’ disease
2009
Functional diversity of helper T lymphocytes
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2014
Susceptibility to Trypanosoma cruzi is modified by a previous non‐related infection
1999
Plasmodium activates the innate immune response of Anopheles gambiae mosquitoes
1997
Parasite polyclonal activators: new targets for vaccination approaches?
2001
Role of C-C chemokine receptor type 7 and its ligands during neuroinflammation
2012
Trypanosoma cruzi surface mucins: host-dependent coat diversity
2006
The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA
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Chagas disease in Spain, the United States and other non-endemic countries
2009
High-resolution cryo-electron microscopy structure of the Trypanosoma brucei ribosome
2013 StandoutNatureNobel
Developments in Quantitative PCR
1998
CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity
2002 StandoutNature
Trypanosoma cruzi: parasite shed vesicles increase heart parasitism and generate an intense inflammatory response
2008
Chapter 7 Glycobiology of Trypanosoma cruzi
2009
Programmable RNA Tracking in Live Cells with CRISPR/Cas9
2016 StandoutNobel
A new mathematical model for relative quantification in real-time RT-PCR
2001 Standout
Chemokines, inflammation and Trypanosoma cruzi infection
2002
Nitric oxide-induced apoptotic cell death in the acute phase of Trypanosoma cruzi infection in mice
1998
Usefulness of PCR-based assays to assess drug efficacy in Chagas disease chemotherapy: value and limitations
2009
Dominant T- and B-cell epitopes in an autoantigen linked to Chagas’ disease
2001
CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III
2011 StandoutNatureNobel
Genomic organization and expression profile of the mucin-associated surface protein (masp) family of the human pathogen Trypanosoma cruzi
2009
Induction of cardiac autoimmunity in Chagas heart disease: A case for molecular mimicry
2006
Biosynthesis of Glycosylphosphatidylinositols in Mammals and Unicellular Microbes
1999
Mass Spectrometry Based Glycoproteomics—From a Proteomics Perspective
2010
CD36 is a sensor of diacylglycerides
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A Broad-Spectrum Inhibitor of CRISPR-Cas9
2017 StandoutNobel
The development of allergic inflammation
2008 StandoutNature
Programmable RNA recognition and cleavage by CRISPR/Cas9
2014 StandoutNatureNobel
The involvement of CD4+CD25+ T cells in the acute phase of Trypanosoma cruzi infection
2008
RNA-Guided RNA Cleavage by a CRISPR RNA-Cas Protein Complex
2009
Structure of mammalian eIF3 in the context of the 43S preinitiation complex
2015 StandoutNatureNobel
Trypanosoma cruzi trans-sialidase as a multifunctional enzyme in Chagas’ disease
2012
Cytokines and cell adhesion receptors in the regulation of immunity to Trypanosoma cruzi
2007
RNA-guided genetic silencing systems in bacteria and archaea
2012 StandoutNatureNobel
Trans-sialidase and mucins of Trypanosoma cruzi: an important interplay for the parasite
2011
Sialic Acid Glycobiology Unveils Trypanosoma cruzi Trypomastigote Membrane Physiology
2016 StandoutNobel
The importance of aberrant T-cell responses in Chagas disease
2005
Genomic Analyses, Gene Expression and Antigenic Profile of the Trans-Sialidase Superfamily of Trypanosoma cruzi Reveal an Undetected Level of Complexity
2011
Rationale and design of a randomized placebo-controlled trial assessing the effects of etiologic treatment in Chagas' cardiomyopathy: The BENznidazole Evaluation For Interrupting Trypanosomiasis (BENEFIT)
2008
Chagas disease and the US blood supply
2008
Fexinidazole: A Potential New Drug Candidate for Chagas Disease
2012
Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores
2016 StandoutNature
Significance of inducible nitric oxide synthase in acute myocarditis caused by Trypanosoma cruzi (Tulahuen strain)
2002
The Repetitive Cytoskeletal Protein H49 of Trypanosoma cruzi Is a Calpain-Like Protein Located at the Flagellum Attachment Zone
2011
Role of the Toll/interleukin‐1 receptor signaling pathway in host resistance and pathogenesis during infection with protozoan parasites
2004
Chagas Heart Disease Pathogenesis: One Mechanism or Many?
2008
Biology and Applications of CRISPR Systems: Harnessing Nature’s Toolbox for Genome Engineering
2016 StandoutNobel
Instruction of Distinct CD4 T Helper Cell Fates by Different Notch Ligands on Antigen-Presenting Cells
2004 StandoutNobel
Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease
2002 StandoutNature
Real time PCR strategy for the identification of major lineages of Trypanosoma cruzi directly in chronically infected human tissues
2004
In the Absence of IL-12, CD4+ T Cell Responses to Intracellular Pathogens Fail to Default to a Th2 Pattern and Are Host Protective in an IL-10−/− Setting
2002
Killer lymphocytes use granulysin, perforin and granzymes to kill intracellular parasites
2016
Comparative glycoproteomics: approaches and applications
2008
Evaluation and Treatment of Chagas Disease in the United States
2007
Regulation of Immunity to Parasites by T Cells and T Cell-Derived Cytokines
1992 Standout
Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection
2016 StandoutNatureNobel
TcTASV-C, a Protein Family in Trypanosoma cruzi that Is Predominantly Trypomastigote-Stage Specific and Secreted to the Medium
2013
Inferences, questions and possibilities in Toll-like receptor signalling
2004 StandoutNatureNobel
Pathogen Recognition and Innate Immunity
2006 Standout
Structure of the Mammalian Ribosomal 43S Preinitiation Complex Bound to the Scanning Factor DHX29
2013 StandoutNobel
Type I interferons suppress CD4+ T‐cell‐dependent parasite control during blood‐stage Plasmodium infection
2011
RNA-guided complex from a bacterial immune system enhances target recognition through seed sequence interactions
2011 StandoutNobel
Evidence that Development of Severe Cardiomyopathy in Human Chagas' Disease Is Due to a Th1-Specific Immune Response
2003
Regulation of Trypanosoma cruzi infections in vitro and in vivo by transforming growth factor beta (TGF-beta).
1991
RTP4 inhibits IFN-I response and enhances experimental cerebral malaria and neuropathology
2020 StandoutNobel
Trypanosoma cruziInduces Regulatory Dendritic Cells In Vitro
2008
Chagas heart disease: pathophysiologic mechanisms, prognostic factors and risk stratification
2009
Trypanocide treatment among adults with chronic Chagas disease living in Santa Fe city (Argentina), over a mean follow-up of 21 years: parasitological, serological and clinical evolution
2007
Long-Term Cardiac Outcomes of Treating Chronic Chagas Disease with Benznidazole versus No Treatment
2006
CD8+ T Cell Effector Mechanisms in Resistance to Infection
2000
Side effects of benznidazole as treatment in chronic Chagas disease: fears and realities
2009
Proliferation of multipotent hematopoietic cells controlled by a truncated erythropoietin receptor transgene.
1996 StandoutNobel
Structures of the CRISPR-Cmr complex reveal mode of RNA target positioning
2015 StandoutScienceNobel
The new frontier of genome engineering with CRISPR-Cas9
2014 StandoutScienceNobel
Preferential Localization of Effector Memory Cells in Nonlymphoid Tissue
2001 StandoutScience
Implications of genetic variability of Trypanosoma cruzi for the pathogenesis of Chagas disease
2007
Neglected Tropical Diseases: Multi-Target-Directed Ligands in the Search for Novel Lead Candidates against Trypanosoma and Leishmania
2009
CasA mediates Cas3-catalyzed target degradation during CRISPR RNA-guided interference
2014 StandoutNobel
Interleukin-12 mediates resistance to Trypanosoma cruzi in mice and is produced by murine macrophages in response to live trypomastigotes
1996
Development of T H 1 CD4 + T Cells Through IL-12 Produced by Listeria -Induced Macrophages
1993 StandoutScience
Immunopathology of Chagas disease
1999
Activation of Toll-Like Receptor-2 by Glycosylphosphatidylinositol Anchors from a Protozoan Parasite
2001
Pathogenesis of Chronic Chagas Heart Disease
2007
Inositol 1,4,5‐trisphosphate receptor regulates replication, differentiation, infectivity and virulence of the parasitic protist T rypanosoma cruzi
2013
Regulation of Trypanosoma cruzi-Induced Myocarditis by Programmed Death Cell Receptor 1
2011 StandoutNobel
Accurate Identification of Deamidated Peptides in Global Proteomics Using a Quadrupole Orbitrap Mass Spectrometer
2013
Intracellular Adhesion Molecule 1 Plays a Key Role in Acquired Immunity to Salmonellosis
2003
The biology , function , and biomedical applications of exosomes
2020 StandoutScience
The effects of nitric oxide on the immune system during Trypanosoma cruzi infection
2009
Innate and Acquired Immunity in the Pathogenesis of Chagas Disease
2004
A chemical approach to unraveling the biological function of the glycosylphosphatidylinositol anchor
2007 StandoutNobel
CRISPR/Cas, the Immune System of Bacteria and Archaea
2010 StandoutScience
The pathogenesis of Chagas' disease: when autoimmune and parasite-specific immune responses meet
2001
Trypanosoma cruzitrans-Sialidase Prevents Elicitation of Th1 Cell Response via Interleukin 10 and Downregulates Th1 Effector Cells
2015
Gamma Interferon Modulates CD95 (Fas) and CD95 Ligand (Fas-L) Expression and Nitric Oxide-Induced Apoptosis during the Acute Phase ofTrypanosoma cruziInfection: a Possible Role in Immune Response Control
1999
Extracellular vesicles in parasitic diseases
2014
Formation and Remodeling of Inositolphosphoceramide during Differentiation of Trypanosoma cruzi from Trypomastigote to Amastigote
2003
Multigene Families in Trypanosoma cruzi and Their Role in Infectivity
2012
Structure and assembly model for the Trypanosoma cruzi 60S ribosomal subunit
2016 StandoutNobel
Molecular diversity of theTrypanosoma cruziTcSMUG family of mucin genes and proteins
2011
Altering mice by homologous recombination using embryonic stem cells.
1994 StandoutNobel
Interleukin 10 and interferon gamma regulation of experimental Trypanosoma cruzi infection.
1992
Diagnosis of Chagas disease: what has been achieved? What remains to be done with regard to diagnosis and follow up studies?
2009
Phylogenetic Perspectives in Innate Immunity
1999 StandoutScienceNobel
Palaeoproteomic evidence identifies archaic hominins associated with the Châtelperronian at the Grotte du Renne
2016 StandoutNobel
PROTEASES IN PARASITIC DISEASES
2006
CTLA-4 Blockage Increases Resistance to Infection with the Intracellular Protozoan Trypanosoma cruzi
2004
The role of IL-12 in experimental Trypanosoma cruzi infection
1998
Chemical Glycoproteomics
2016 StandoutNobel
Mechanisms of pathogenesis in Chagas disease
2006
Immunization of Mice with a TolA-Like Surface Protein ofTrypanosoma cruziGenerates CD4+T-Cell-Dependent Parasiticidal Activity
1999
Generation of Anti-trypanosomal Agents through Concise Synthesis and Structural Diversification of Sesquiterpene Analogues
2011 StandoutNobel
Works of Rick L. Tarleton being referenced
Cutting Edge: Dysfunctional CD8+ T Cells Reside in Nonlymphoid Tissues During Chronic Trypanosoma cruzi Infection
2003
Stable CD8+ T Cell Memory during Persistent Trypanosoma cruzi Infection
2008
Chronic Human Infection with Trypanosoma cruzi Drives CD4+ T Cells to Immune Senescence
2009
Evaluation of high efficiency gene knockout strategies for Trypanosoma cruzi
2009
Widespread, focal copy number variations (CNV) and whole chromosome aneuploidies in Trypanosoma cruzi strains revealed by array comparative genomic hybridization
2011
A Heuristic Method for Assigning a False-discovery Rate for Protein Identifications from Mascot Database Search Results
2005
Susceptibility of β2-microglobulin-deficient mice to Trypanosoma cruzi infection
1992 Nature
Trypanosoma cruzi: Cytokine effects on macrophage trypanocidal activity
1991
CD8+ T cells in Trypanosoma cruzi infection
2009
Characterization of cytokine production in murine Trypanosoma cruzi infection by in situ immunocytochemistry: Lack of association between susceptibility and type 2 cytokine production
1996
Human infection with Trypanosoma cruzi induces parasite antigen-specific cytotoxic T lymphocyte responses.
1998
The role of T-cell subpopulations in experimental Chagas' disease
1991
Chromosome level assembly of the hybrid Trypanosoma cruzi genome
2009
Persistent Production of Inflammatory and Anti-inflammatory Cytokines and Associated MHC and Adhesion Molecule Expression at the Site of Infection and Disease in ExperimentalTrypanosoma cruziInfections
1996
The Challenges of Chagas Disease— Grim Outlook or Glimmer of Hope?
2007
Proteomic analysis of the Trypanosoma cruzi ribosomal proteins
2009
The role of T cells in Trypanosoma cruzi infections
1995
Chagas Disease Etiology: Autoimmunity or Parasite Persistence?
1999
Parasite Persistence Correlates with Disease Severity and Localization in Chronic Chagas' Disease
1999
Rapid quantitation of Trypanosoma cruzi in host tissue by real-time PCR
2003
Polyfunctional T Cell Responses in Children in Early Stages of Chronic Trypanosoma cruzi Infection Contrast with Monofunctional Responses of Long-term Infected Adults
2013
Chagas disease: a role for autoimmunity?
2003
In vitro Culture of Cardiac Mast Cells from Mice Experimentally Infected with <i>Trypanosoma cruzi</i>
1994
Trypanosoma cruzi modulates the profile of memory CD8+ T cells in chronic Chagas' disease patients
2006
Immune system recognition of Trypanosoma cruzi
2007
The relative contribution of antibody production and CD8+ T cell function to immune control of Trypanosoma cruzi
1998
Identification of Contractile Vacuole Proteins in Trypanosoma cruzi
2011
Proteins with Glycosylphosphatidylinositol (GPI) Signal Sequences Have Divergent Fates during a GPI Deficiency
1997
TGF‐β regulates pathology but not tissue CD8+ T cell dysfunction during experimental Trypanosoma cruzi infection
2007
Regulation of immunity in Trypanosoma cruzi infection
1991
Genetic immunization with LYT1 or a pool of trans-sialidase genes protects mice from lethal Trypanosoma cruzi infection
2003
Interleukin 1 activity in haemolymph from strains of the snail biomphalaria glabrata varying in susceptibility to the human blood fluke, Schistosoma mansoni: presence, differential expression, and biological function
1994
Parasite persistence in the aetiology of Chagas disease
2001
Kinetoplastids: related protozoan pathogens, different diseases
2008
Eliminating Chagas disease: challenges and a roadmap
2009
Frequency of Interferon‐γ–Producing T Cells Specific forTrypanosoma cruziInversely Correlates with Disease Severity in Chronic Human Chagas Disease
2004
CD8+ T-Cell Responses to Trypanosoma cruzi Are Highly Focused on Strain-Variant trans-Sialidase Epitopes
2006
Construction and use of a multi-competitor gene for quantitative RT-PCR using existing primer sets
1995
Initial induction of immunity, followed by suppression of responses to parasite antigens during Trypanosoma cruzi infection of mice
1987
Endogenous CD4+CD25+Regulatory T Cells Have a Limited Role in the Control ofTrypanosoma cruziInfection in Mice
2006
Depletion of CD8+ T cells increases susceptibility and reverses vaccine-induced immunity in mice infected with Trypanosoma cruzi.
1990
CD8+ T Cells Specific for Immunodominant Trans-Sialidase Epitopes Contribute to Control of Trypanosoma cruzi Infection but Are Not Required for Resistance
2010
Genetic Immunization Elicits Antigen-Specific Protective Immune Responses and Decreases Disease Severity inTrypanosoma cruziInfection
2002
Identification of Trypanosoma cruzi trans-sialidase family members as targets of protective CD8+ TC1 responses.
1997
Depletion of T-cell subpopulations results in exacerbation of myocarditis and parasitism in experimental Chagas' disease
1994
The Trypanosoma cruzi Proteome
2005 Science
Epigenetic Regulation of Transcription and Virulence in Trypanosoma cruzi by O-Linked Thymine Glucosylation of DNA
2011
Amastigote Surface Proteins ofTrypanosoma cruziAre Targets for CD8+ CTL
1998
Generation ofTrypanosoma cruzi-Specific CD8+T-Cell Immunity Is Unaffected by the Absence of Type I Interferon Signaling
2010
Glycosylphosphatidylinositols are required for the development of Trypanosoma cruzi amastigotes
1997
Restoration of in vitro immune responses of spleen cells from mice infected with Trypanosoma cruzi by supernatants containing interleukin 2.
1984
Trypanosoma cruzi-induced suppression of IL-2 production. II. Evidence for a role for suppressor cells.
1988
Increased Susceptibility of Stat4-Deficient and Enhanced Resistance in Stat6-Deficient Mice to Infection withTrypanosoma cruzi
2000
Differential control of IFN-gamma and IL-2 production during Trypanosoma cruzi infection.
1991
Antigen-Specific Th1 But Not Th2 Cells Provide Protection from Lethal Trypanosoma cruzi Infection in Mice
2001
“Autoimmune rejection” of neonatal heart transplants in experimental Chagas disease is a parasite-specific response to infected host tissue
1997
Glycoproteomics ofTrypanosoma cruziTrypomastigotes Using Subcellular Fractionation, Lectin Affinity, and Stable Isotope Labeling
2006
Vaccination with Trypomastigote Surface Antigen 1-Encoding Plasmid DNA Confers Protection against LethalTrypanosoma cruziInfection
1998
Tumour necrosis factor (cachectin) production during experimental Chagas' disease.
1988
Generation, specificity, and function of CD8+ T cells in Trypanosoma cruzi infection
2004
The identification and molecular characterization of Trypanosoma cruzi amastigote surface protein-1, a member of the trans-sialidase gene super-family1Note: Nucleotide sequence data reported in this paper is available in the GenBank data base under the Accession no. U74494.1
1997