Citation Impact
Citing Papers
Cytochrome P450 and Non–Cytochrome P450 Oxidative Metabolism: Contributions to the Pharmacokinetics, Safety, and Efficacy of Xenobiotics
2016
Lineage-Specific Changes in Biomarkers in Great Apes and Humans
2015 StandoutNobel
Development of a Microscale Cell Culture Analog To Probe Naphthalene Toxicity
2004
Targeting hypoxia in cancer therapy
2011 Standout
Role of residue 87 in substrate selectivity and regioselectivity of drug-metabolizing cytochrome P450 CYP102A1 M11
2011
Synthesis and utility of fluorogenic acetoxymethyl ethers
2010
True
2000
Methods for Predicting Human Drug Metabolism
2006
Evolution of the cytochrome P450 superfamily: sequence alignments and pharmacogenetics
1998
Engaging neuroscience to advance translational research in brain barrier biology
2011
Structure and function of the blood–brain barrier
2009 Standout
Cytochrome P-450 Polymorphisms and Response to Clopidogrel
2008 Standout
Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P‐glycoprotein: Implications for drug delivery and activity in cancer chemotherapy
1995
Clinical Significance of the Cytochrome P450 2C19 Genetic Polymorphism
2002
Facile and General Synthesis of Photoactivatable Xanthene Dyes
2011 StandoutNobel
Mismatch repair and nucleotide excision repair proteins cooperate in the recognition of DNA interstrand crosslinks
2009 StandoutNobel
WITHDRAWN—a resource for withdrawn and discontinued drugs
2015
Cells on chips
2006 StandoutNature
Mechanism-Based Inhibition: Deriving KI and kinact Directly from Time-Dependent IC50 Values
2009
Libraries of hybrid proteins from distantly related sequences
2001 StandoutNobel
Colorectal cancer
2013 Standout
Catalytic Assays for Human Cytochrome P450
2003
DrugBank: a knowledgebase for drugs, drug actions and drug targets
2007 Standout
Characterization of Substrate Binding to Cytochrome P450 1A1 Using Molecular Modeling and Kinetic Analyses: Case of Residue 382
2003
P2X7 receptors in the nervous system
2006
The Chemistry of Small-Molecule Fluorogenic Probes
2012
Exploiting tumour hypoxia in cancer treatment
2004 Standout
Metabolic profiling, metabolomic and metabonomic procedures for NMR spectroscopy of urine, plasma, serum and tissue extracts
2007 Standout
The Substrate Binding Site of Human Liver Cytochrome P450 2C9: An Approach Using Designed Tienilic Acid Derivatives and Molecular Modeling
1995
Cytochrome P450 Substrate Specificities, Substrate Structural Templates and Enzyme Active Site Geometries
1999
Development, maintenance and disruption of the blood-brain barrier
2013 Standout
Cancer Chemopreventive Activity of Resveratrol
2002
Polyphenols: food sources and bioavailability
2004 Standout
The role of human cytochrome P450 enzymes in the metabolism of anticancer agents: implications for drug interactions.
1995
Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression
2001 Standout
The immunology of stroke: from mechanisms to translation
2011 Standout
Covalent binding of the anticancer drug ellipticine to DNA in V79 cells transfected with human cytochrome P450 enzymes
2002
Systematic Meta-Analyses and Field Synopsis of Genetic Association Studies in Colorectal Cancer
2012
Modification of Clinical Presentation of Prostate Tumors by a Novel Genetic Variant in CYP3A4
1998
The role of the blood–CNS barrier in CNS disorders and their treatment
2009
The ChEMBL database in 2017
2016 Standout
Liaisons dangereuses: P2X7 and the inflammasome
2007
Involvement of human cytochromes P450 (CYP) in the reductive metabolism of AQ4N, a hypoxia activated anthraquinone DI-N-oxide prodrug
1998
DNA adduct formation by the anticancer drug ellipticine in rats determined by 32P postlabeling
2003
Human Cytochrome P450 Enzymes: A Status Report Summarizing Their Reactions, Substrates, Inducers, and Inhibitors
1997
Hematological and serum biochemical values in cynomolgus monkeys anesthetized with ketamine hydrochloride
2005
The role of shear stress in Blood-Brain Barrier endothelial physiology
2011
The anticancer agent ellipticine on activation by cytochrome P450 forms covalent DNA adducts☆
2001
The Ontogeny of Human Drug-Metabolizing Enzymes: Phase I Oxidative Enzymes
2002
Comparative modelling of cytochromes P450
2002
Nucleoside transporters: molecular biology and implications for therapeutic development
1999
Current concepts of blood-brain barrier development
2011
Asymmetric Multicomponent Reactions (AMCRs): The New Frontier
2005 Standout
Evaluation of alkoxyresorufins as fluorescent substrates for cytochrome P450 BM3 and site-directed mutants
2005
Developmental Pharmacology — Drug Disposition, Action, and Therapy in Infants and Children
2003 Standout
Fingerprinting food: current technologies for the detection of food adulteration and contamination
2012 Standout
A Fluorogenic Aryl Fluorosulfate for Intraorganellar Transthyretin Imaging in Living Cells and in Caenorhabditis elegans
2015 StandoutNobel
Sulfatase-activated fluorophores for rapid discrimination of mycobacterial species and strains
2013 StandoutNobel
SuFEx Click Chemistry Enabled Late-Stage Drug Functionalization
2018 StandoutNobel
Cu and Cu-Based Nanoparticles: Synthesis and Applications in Catalysis
2016 Standout
Challenges and Opportunities for the Application of Boron Clusters in Drug Design
2016
The Anticancer Drug Ellipticine Forms Covalent DNA Adducts, Mediated by Human Cytochromes P450, through Metabolism to 13-Hydroxyellipticine and EllipticineN2-Oxide
2004
Enantioselective α-Hydroxylation of 2-Arylacetic Acid Derivatives and Buspirone Catalyzed by Engineered Cytochrome P450 BM-3
2006 StandoutNobel
Nanozymes: Classification, Catalytic Mechanisms, Activity Regulation, and Applications
2019 Standout
Molecular Physiology of P2X Receptors
2002 Standout
Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis
2016 Standout
Recent advances in the synthesis of pyrroles by multicomponent reactions
2014 Standout
Applications of Poly(Ethylene)Glycol (PEG) in Separation Science
2015
Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas
2016 Standout
Occurrence, Biogenesis, and Synthesis of Biologically Active Carbazole Alkaloids
2012 Standout
Stereoselective Enzymatic Synthesis of Heteroatom-Substituted Cyclopropanes
2018 StandoutNobel
RESPONSE: Re: Modification of Clinical Presentation of Prostate Tumors by a Novel Genetic Variant in CYP3A4
1999
Formation and Repair of Interstrand Cross-Links in DNA
2005
ProTox-II: a webserver for the prediction of toxicity of chemicals
2018 Standout
Formaldehyde in the Indoor Environment
2010 Standout
Green and Sustainable Solvents in Chemical Processes
2018 Standout
Lung cancer detection by proton transfer reaction mass-spectrometric analysis of human breath gas
2007
Activation of C−H Bonds by Metal Complexes
1997 Standout
Homochiral α-d - and β-d -Isoxazolidinylthymidines via 1,3-Dipolar Cycloaddition
1999
Spectroscopic and Statistical Techniques for Information Recovery in Metabonomics and Metabolomics
2008
Fluorescent Chemosensors Based on Spiroring-Opening of Xanthenes and Related Derivatives
2011 Standout
Update on the Development of Antagonists of Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells (CRTH2). From Lead Optimization to Clinical Proof-of-Concept in Asthma and Allergic Rhinitis
2012
Design and Synthesis of Molecular Umbrellas
1997
De Novo Carborane-Containing Macrocyclic Peptides Targeting Human Epidermal Growth Factor Receptor
2019 StandoutNobel
Biomedical Importance of Indoles
2013 Standout
Chemistry and Biology Of Multicomponent Reactions
2012 Standout
Pharmacogenomics: Translating Functional Genomics into Rational Therapeutics
1999 StandoutScience
Transcriptomic and Quantitative Proteomic Analysis of Transporters and Drug Metabolizing Enzymes in Freshly Isolated Human Brain Microvessels
2011
Mechanism of Oxidation Reactions Catalyzed by Cytochrome P450 Enzymes
2004 Standout
High-Throughput Screening in Drug Metabolism and Pharmacokinetic Support of Drug Discovery
2000
Design Strategies for Water-Soluble Small Molecular Chromogenic and Fluorogenic Probes
2013 Standout
About Supramolecular Assemblies of π-Conjugated Systems
2005 Standout
Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design
2011 Standout
Flavylium Polymethine Fluorophores for Near‐ and Shortwave Infrared Imaging
2017 StandoutNobel
Physiology of Microglia
2011 Standout
Computational design of a red fluorophore ligase for site-specific protein labeling in living cells
2014 StandoutNobel
Metal-Free Multicomponent Syntheses of Pyridines
2014 Standout
Bright Ideas for Chemical Biology
2008
Structure and Chemistry of Cytochrome P450
2005 Standout
Works of Richard Weaver being referenced
Xenobiotic metabolising enzyme expression in colonic neoplasia.
1993
ABC transporters, cytochromes P450 and their main transcription factors: expression at the human blood–brain barrier
2008
Expression and transcriptional regulation of ABC transporters and cytochromes P450 in hCMEC/D3 human cerebral microvascular endothelial cells
2008
A comparative study of constitutive and induced alkoxyresorufin O-dealkylation and individual cytochrome P450 forms in cynomolgus monkey (Macaca fascicularis), human, mouse, rat and hamster liver microsomes
1994
An approach to use an unusual adenosine transporter to selectively deliver polyamine analogues to trypanosomes
1998
The expression of cytochrome P-450, epoxide hydrolase, and glutathione s-transferase in hepatocellular carcinoma
1993
Cytochrome P450 2C9 is responsible for hydroxylation of the naphthoquinone antimalarial drug 58C80 in human liver
1993
Cytochrome P450 specificities of alkoxyresorufin O-dealkylation in human and rat liver
1994
Molecular modelling of human CYP2C subfamily enzymes CYP2C9 and CYP2C19: rationalization of substrate specificity and site-directed mutagenesis experiments in the CYP2C subfamily
1998
Cytochrome P450 expression is a common molecular event in soft tissue sarcomas
1993
The immunohistochemical localization of drug‐metabolizing enzymes in prostate cancer
1995
Expression of cytochrome P450IA in breast cancer
1991
Discovery of small molecule human C5a receptor antagonists
2009
Determining the best animal model for human cytochrome P450 activities: a comparison of mouse, rat, rabbit, dog, micropig, monkey and man
2000
Expression of xenobiotic metabolizing enzymes in breast cancer
1993
Identification and reduction of ion suppression effects on pharmacokinetic parameters by polyethylene glycol 400
2006
Risk assessment and mitigation strategies for reactive metabolites in drug discovery and development
2010
Discovery of potent CRTh2 (DP2) receptor antagonists
2006
Hit-to-Lead studies: The discovery of potent adamantane amide P2X7 receptor antagonists
2003
CYTOCHROME P450 INHIBITION USING RECOMBINANT PROTEINS AND MASS SPECTROMETRY/MULTIPLE REACTION MONITORING TECHNOLOGY IN A CASSETTE INCUBATION
2003
Cytochrome P450IA expression in adult and fetal human liver
1992
Cytochrome P450 expression in oesophageal cancer.
1994
Isosteres of nucleoside triphosphates
1996
Virtual Chromatographic Resolution Enhancement in Cryoflow LC−NMR Experiments via Statistical Total Correlation Spectroscopy
2007
Time-dependent CYP inhibition
2007
Conjugation of a Polyamine to the Bifunctional Alkylating Agent Chlorambucil Does Not Alter the Preferred Crosslinking Site in Duplex DNA
1995
The design and synthesis of nucleoside triphosphate isosteres as potential inhibitors of HIV reverse transcriptase
1997
Localization of microsomal epoxide hydrolase in normal and neoplastic human kidney.
1995