Standout Papers
- Cloning of two mouse genes encoding alpha 2-adrenergic receptor subtypes and identification of a single amino acid in the mouse alpha 2-C10 homolog responsible for an interspecies variation in antagonist binding. (1992)
- Targeted inactivation of the gene encoding the mouse alpha 2c-adrenoceptor homolog. (1995)
- Cloning and expression of the mouse homolog of the human α2-C2 adrenergic receptor (1992)
- Primary structure of the mouse β1-adrenergic receptor gene (1993)
- Genetic Alteration of α2C-Adrenoceptor Expression in Mice: Influence on Locomotor, Hypothermic, and Neurochemical Effects of Dexmedetomidine, a Subtype-Nonselective α2-Adrenoceptor Agonist (1997)
- Cardiovascular Regulation in Mice Lacking α 2 -Adrenergic Receptor Subtypes b and c (1996)
- Subtype-specific differences in the intracellular sorting of G protein-coupled receptors. (1993)
Citation Impact
Citing Papers
A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein
2007 StandoutNobel
High-Resolution Crystal Structure of an Engineered Human β 2 -Adrenergic G Protein–Coupled Receptor
2007 StandoutScienceNobel
Potent Induction of Tumor Immunity by Combining Tumor Cryoablation with Anti–CTLA-4 Therapy
2011 StandoutNobel
Spinophilin Blocks Arrestin Actions in Vitro and in Vivo at G Protein-Coupled Receptors
2004 StandoutScienceNobel
International Union of Pharmacology nomenclature of adrenoceptors.
1994 StandoutNobel
Adrenergic α2C-Receptors Modulate the Acoustic Startle Reflex, Prepulse Inhibition, and Aggression in Mice
1998 StandoutNobel
Cardiovascular and Metabolic Alterations in Mice Lacking Both β1- and β2-Adrenergic Receptors
1999 StandoutNobel
Transgenic models of α2-adrenergic receptor subtype function
2008
Switching of the coupling of the β2-adrenergic receptor to different G proteins by protein kinase A
1997 StandoutNatureNobel
Gene Substitution/Knockout to Delineate the Role of α2‐Adrenoceptor Subtypes in Mediating Central Effects of Catecholamines and Imidazolines
1999 StandoutNobel
The Third Intracellular Loop of α2-Adrenergic Receptors Determines Subtype Specificity of Arrestin Interaction
2002
Role of α2C‐adrenoceptor subtype in spatial working memory as revealed by mice with targeted disruption of the α2C‐adrenoceptor gene
1999
EGL-10 Regulates G Protein Signaling in the C. elegans Nervous System and Shares a Conserved Domain with Many Mammalian Proteins
1996 StandoutNobel
Nitrous Oxide Produces Antinociceptive Response via α2Band/or α2CAdrenoceptor Subtypes in Mice
1999
Evaluation of the effects of a specific α2-adrenoceptor antagonist, atipamezole, on α1- and α2-adrenoceptor subtype binding, brain neurochemistry and behaviour in comparison with yohimbine
1997
Cell Surface Expression of α1D-Adrenergic Receptors Is Controlled by Heterodimerization with α1B-Adrenergic Receptors
2004
Localization ofα2c-adrenergic receptor immunoreactivity in catecholaminergic neurons in the rat central nervous system
1998
Cell-type Specific Targeting of the α2c-Adrenoceptor
2000 StandoutNobel
High-resolution crystal structure of human protease-activated receptor 1
2012 StandoutNatureNobel
Adrenergic Receptors From Molecular Structure to in vivo function
1997 StandoutNobel
Receptor subtype and dose dependence of dexmedetomidine-induced accumulation of [14C]glutamine in astrocytes suggests glial involvement in its hypnotic-sedative and anesthetic-sparing effects
2000
Association of distinct α 2 adrenoceptor and serotonin transporter polymorphisms with constipation and somatic symptoms in functional gastrointestinal disorders
2004
Distribution of α2-adrenergic receptor subtype gene expression in rat brain
1994
Receptor Subtype-specific Regulation of Muscarinic Acetylcholine Receptor Sequestration by Dynamin
1998
The Three α2-Adrenergic Receptor Subtypes Achieve Basolateral Localization in Madin-Darby Canine Kidney II Cells via Different Targeting Mechanisms
1996
Alpha2C-adrenoceptor overexpression disrupts execution of spatial and non-spatial search patterns
1999 StandoutNobel
Subtype-Specific Intracellular Trafficking of α2-Adrenergic Receptors
1997 StandoutNobel
A Novel Interaction between Adrenergic Receptors and the α-Subunit of Eukaryotic Initiation Factor 2B
1997 StandoutNobel
Agonist-regulated Interaction between α2-Adrenergic Receptors and Spinophilin
2001
Abnormal Regulation of the Sympathetic Nervous System in α2A-Adrenergic Receptor Knockout Mice
1999 StandoutNobel
Adrenergic receptor signal transduction and regulation
1995 StandoutNobel
Gene targeting — homing in on α2-adrenoceptor-subtype function
1997 StandoutNobel
Further characterization of human α2-adrenoceptor subtypes: [3H]RX821002 binding and definition of additional selective drugs
1994
Distribution of ?2C-adrenergic receptor-like immunoreactivity in the rat central nervous system
1996
Two functionally distinct α2-adrenergic receptors regulate sympathetic neurotransmission
1999 StandoutNatureNobel
The structure and function of G-protein-coupled receptors
2009 StandoutNatureNobel
Enterochromaffin Cells Are Gut Chemosensors that Couple to Sensory Neural Pathways
2017 StandoutNobel
Presynaptic ?2-autoreceptors in mouse heart atria: evidence for the ?2D subtype
1996
Prevention of Venous Thromboembolism
2004 Standout
α2C-Adrenoceptor-Overexpressing Mice Are Impaired in Executing Nonspatial and Spatial Escape Strategies
1998 StandoutNobel
Effect of Cell Type on the Subcellular Localization of the Thyrotropin-Releasing Hormone Receptor
1997
Subclassification of presynaptic ?2-adrenoceptors: ?2D-autoreceptors in mouse brain
1995
Behavioral and neurochemical characterization of α2A-adrenergic receptor knockout mice
2002 StandoutNobel
Structure, function, and regulation of adrenergic receptors
1993
The Role of Sequestration in G Protein-coupled Receptor Resensitization
1997 StandoutNobel
Importance of quantitative genetic variations in the etiology of hypertension
2000 StandoutNobel
Heterotrimeric C proteins: Organizers of transmembrane signals
1995
Genetic alteration of the α2-adrenoceptor subtype c in mice affects the development of behavioral despair and stress-induced increases in plasma corticosterone levels
1999 StandoutNobel
Cardiovascular effects of rilmenidine, moxonidine and clonidine in conscious wild‐type and D79N α2A‐adrenoceptor transgenic mice
1999
A re-investigation of questionable subclassifications of presynaptic α2-autoreceptors: rat vena cava, rat atria, human kidney and guinea-pig urethra
1997
EXPRESSION OF α 2 -ADRENERGIC RECEPTOR SUBTYPES IN THE MOUSE BRAIN: EVALUATION OF SPATIAL AND TEMPORAL INFORMATION IMPARTED BY 3 kb OF 5′ REGULATORY SEQUENCE FOR THE α 2A AR-RECEPTOR GENE IN TRANSGENIC ANIMALS
1996
d-amphetamine and l-5-hydroxytryptophan-induced behaviours in mice with genetically-altered expression of the α2C-adrenergic receptor subtype
1998 StandoutNobel
Role of Arrestins in Endocytosis and Signaling of α2-Adrenergic Receptor Subtypes
1999
Characterization of a new radioiodinated probe for the α2C adrenoceptor in the mouse brain
2000
The Clavien-Dindo Classification of Surgical Complications
2009 Standout
Synergistic interactions between two α 2-adrenoceptor agonists, dexmedetomidine and ST-91, in two substrains of Sprague–Dawley rats
2000
Ligand Efficacy and Potency at Recombinant α2 Adrenergic Receptors
1998
Down-regulation of Transforming Growth Factor-β Receptors: Cooperativity between the Types I, II, and III Receptors and Modulation at the Cell Surface
1999
In Vivo Mutation of the α2A-Adrenergic Receptor by Homologous Recombination Reveals the Role of This Receptor Subtype in Multiple Physiological Processes
1997
A highly conserved tyrosine residue in G protein-coupled receptors is required for agonist-mediated beta 2-adrenergic receptor sequestration.
1994 StandoutNobel
Dual modulation of cell survival and cell death by β 2 -adrenergic signaling in adult mouse cardiac myocytes
2001 StandoutNobel
βAR Signaling Required for Diet-Induced Thermogenesis and Obesity Resistance
2002 StandoutScienceNobel
Antagonist-dependent and -independent steps in the mechanism of adrenergic receptor internalization
1994 StandoutNobel
β 2 -Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein
1998 StandoutNobel
Cholesterol increases kinetic, energetic, and mechanical stability of the human β2-adrenergic receptor
2012 StandoutNobel
Intracellular targeting and trafficking of thrombin receptors. A novel mechanism for resensitization of a G protein-coupled receptor.
1994 StandoutNobel
β-Arrestin-Dependent Formation of β 2 Adrenergic Receptor-Src Protein Kinase Complexes
1999 StandoutScienceNobel
Diabetic nephropathy is markedly enhanced in mice lacking the bradykinin B2 receptor
2004 StandoutNobel
Genetically increased angiotensin I-converting enzyme level and renal complications in the diabetic mouse
2001 StandoutNobel
Myocyte Adrenoceptor Signaling Pathways
2003 StandoutScienceNobel
Moxonidine, a Selective α2-Adrenergic and Imidazoline Receptor Agonist, Produces Spinal Antinociception in Mice
1999
Heterozygous α 2A -adrenergic receptor mice unveil unique therapeutic benefits of partial agonists
2002 StandoutNobel
Decreased blood pressure response in mice deficient of the α 1b -adrenergic receptor
1997
The peptide product of a 5' leader cistron in the beta 2 adrenergic receptor mRNA inhibits receptor synthesis.
1994 StandoutNobel
G Protein-Coupled Receptors: Functional and Mechanistic Insights Through Altered Gene Expression
1998 StandoutNobel
The α2A-Adrenergic Receptor Plays a Protective Role in Mouse Behavioral Models of Depression and Anxiety
2001
Multiple endocytic pathways of G protein-coupled receptors delineated by GIT1 sensitivity
2000 StandoutNobel
Mutation of the α2A-Adrenoceptor Impairs Working Memory Performance and Annuls Cognitive Enhancement by Guanfacine
2002 StandoutNobel
Recent Advances in Cardiac β2-Adrenergic Signal Transduction
1999
Targeting the Receptor-G q Interface to Inhibit in Vivo Pressure Overload Myocardial Hypertrophy
1998 StandoutScienceNobel
Targeted disruption of the mouse beta1-adrenergic receptor gene: developmental and cardiovascular effects.
1996 StandoutNobel
Antinociceptive Action of Nitrous Oxide Is Mediated by Stimulation of Noradrenergic Neurons in the Brainstem and Activation of α2BAdrenoceptors
2000 StandoutNobel
Structure-based discovery of β 2 -adrenergic receptor ligands
2009 StandoutNobel
Central Hypotensive Effects of the α 2a -Adrenergic Receptor Subtype
1996 Science
Overexpression of Alpha2C-adrenoceptors impairs water maze navigation
1999
Receptor and Gβγ isoform-specific interactions with G protein-coupled receptor kinases
1997 StandoutNobel
In vivo gene modification elucidates subtype-specific functions of alpha(2)-adrenergic receptors.
2000
The alpha(2a)-adrenergic receptor plays a protective role in mouse behavioral models of depression and anxiety.
2001
Identification of the endophilins (SH3p4/p8/p13) as novel binding partners for the β1-adrenergic receptor
1999 StandoutNobel
The PDZ-binding motif of the β 2 -adrenoceptor is essential for physiologic signaling and trafficking in cardiac myocytes
2003 StandoutNobel
INSIGHTS FROM IN VIVO MODIFICATION OF ADRENERGIC RECEPTOR GENE EXPRESSION
1998 StandoutNobel
S18616, a highly potent spiroimidazoline agonist at alpha(2)-adrenoceptors: II. Influence on monoaminergic transmission, motor function, and anxiety in comparison with dexmedetomidine and clonidine.
2000
Gene targeting — homing in on α2-adrenoceptor-subtype function
1997 StandoutNobel
The effect of eight V2 vasopressin receptor mutations on stimulation of adenylyl cyclase and binding to vasopressin.
1994
Sympathoinhibitory Function of the α2A-Adrenergic Receptor Subtype
1999
Why are there so many adrenoceptor subtypes?
1994
Role of endocytosis in the activation of the extracellular signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors
2000 StandoutNobel
ß-Arrestin 2 Mediates Endocytosis of Type III TGF-ß Receptor and Down-Regulation of Its Signaling
2003 StandoutScienceNobel
Desensitization, internalization, and signaling functions of β-arrestins demonstrated by RNA interference
2003 StandoutNobel
Works of Richard E. Link being referenced
Assessment of the role of α2‐adrenoceptor subtypes in the antinociceptive, sedative and hypothermic action of dexmedetomidine in transgenic mice
1997
Primary structure of the mouse β1-adrenergic receptor gene
1993 StandoutNobel
Cloning and expression of the mouse homolog of the human α2-C2 adrenergic receptor
1992 StandoutNobel
Genetic Alteration of α2C-Adrenoceptor Expression in Mice: Influence on Locomotor, Hypothermic, and Neurochemical Effects of Dexmedetomidine, a Subtype-Nonselective α2-Adrenoceptor Agonist
1997 StandoutNobel
Cost Analysis of Open, Laparoscopic, and Percutaneous Treatment Options for Nephron-Sparing Surgery
2006
CLASSIFICATION AND TRENDS OF PERIOPERATIVE MORBIDITIES FOLLOWING LAPAROSCOPIC RADICAL PROSTATECTOMY
2005
Complications of 2,775 Urological Laparoscopic Procedures: 1993 to 2005
2007
Cloning of two mouse genes encoding alpha 2-adrenergic receptor subtypes and identification of a single amino acid in the mouse alpha 2-C10 homolog responsible for an interspecies variation in antagonist binding.
1992 StandoutNobel
Cardiovascular Regulation in Mice Lacking α 2 -Adrenergic Receptor Subtypes b and c
1996 StandoutScienceNobel
Targeted inactivation of the gene encoding the mouse alpha 2c-adrenoceptor homolog.
1995 StandoutNobel
Subtype-specific differences in the intracellular sorting of G protein-coupled receptors.
1993 StandoutNobel