Citation Impact
Citing Papers
Structure of apo-CAP reveals that large conformational changes are necessary for DNA binding
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On the mechanism of sensing unfolded protein in the endoplasmic reticulum
2005
A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein
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Crystal Structure of a Mammalian Voltage-Dependent Shaker Family K + Channel
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Reconstitution of invertebrate glutamate receptor function depends on stargazin-like proteins
2006
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De novo design of transmembrane β barrels
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In vitro reconstitution of ER-stress induced ATF6 transport in COPII vesicles
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Cytoplasmic ankyrin repeats of transient receptor potential A1 (TRPA1) dictate sensitivity to thermal and chemical stimuli
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Structural basis for cAMP-mediated allosteric control of the catabolite activator protein
2009
Sculpting conducting nanopore size and shape through de novo protein design
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Structure and Mechanism of Kainate Receptor Modulation by Anions
2007
A Role for Extracellular Na+in the Channel Gating of Native and Recombinant Kainate Receptors
2003
Two Regions in the N-terminal Domain of Ionotropic Glutamate Receptor 3 Form the Subunit Oligomerization Interfaces That Control Subtype-specific Receptor Assembly
2005
Flip and Flop: A Molecular Determinant for AMPA Receptor Channel Opening
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A Transmembrane Accessory Subunit that Modulates Kainate-Type Glutamate Receptors
2009
Full Domain Closure of the Ligand-binding Core of the Ionotropic Glutamate Receptor iGluR5 Induced by the High Affinity Agonist Dysiherbaine and the Functional Antagonist 8,9-Dideoxyneodysiherbaine
2009
Interface Interactions Modulating Desensitization of the Kainate-Selective Ionotropic Glutamate Receptor Subunit GluR6
2006
De novo design of allosterically switchable protein assemblies
2024 StandoutNatureNobel
Domain organization and function in GluK2 subtype kainate receptors
2010
Block of Kainate Receptor Desensitization Uncovers a Key Trafficking Checkpoint
2006
Ionotropic and metabotropic glutamate receptor structure and pharmacology
2005
Molecular Determinants Responsible for Differences in Desensitization Kinetics of AMPA Receptor Splice Variants
2004
Engineering a high-affinity allosteric binding site for divalent cations in kainate receptors
2008
Mapping the Interaction Sites between AMPA Receptors and TARPs Reveals a Role for the Receptor N-Terminal Domain in Channel Gating
2014
Ligand Binding Is a Critical Requirement for Plasma Membrane Expression of Heteromeric Kainate Receptors
2004
Energetics of glutamate receptor ligand binding domain dimer assembly are modulated by allosteric ions
2009
Crystal structure of the kainate receptor GluR5 ligand‐binding core in complex with (S)‐glutamate
2005
Crystal Structures of the Kainate Receptor GluR5 Ligand Binding Core Dimer with Novel GluR5-Selective Antagonists
2006
Crystal Structures of the GluR5 and GluR6 Ligand Binding Cores: Molecular Mechanisms Underlying Kainate Receptor Selectivity
2005
Amino-Acid Residues Involved in Glutamate Receptor 6 Kainate Receptor Gating and Desensitization
2003
Selective agonist binding of (S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA) and 2S-(2α,3β,4β)-2-carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid (kainate) receptors: a molecular modeling study
2003
A Nondesensitizing Kainate Receptor Point Mutant
2009
Channel gating of NMDA receptors
2002
Binding of spermine and ifenprodil to a purified, soluble regulatory domain of theN‐methyl‐d‐aspartate receptor
2008
Ampakines and the threefold path to cognitive enhancement
2006
Glutamate receptor ion channels
2005 Standout
The open pore conformation of potassium channels
2002 StandoutNatureNobel
Gating motions underlie AMPA receptor secretion from the endoplasmic reticulum
2008
Structure of a mammalian ryanodine receptor
2014 StandoutNatureNobel
Electrophysiological Properties of AMPA Receptors Are Differentially Modulated Depending on the Associated Member of the TARP Family
2007
Glutamate Receptor Ion Channels: Structure, Regulation, and Function
2010 Standout
Understanding Synapses: Past, Present, and Future
2008 StandoutNobel
Stargazin Reduces Desensitization and Slows Deactivation of the AMPA-Type Glutamate Receptors
2005
Interferons, interferon‐like cytokines, and their receptors
2004
Single-Molecule Discrimination of Discrete Perisynaptic and Distributed Sites of Actin Filament Assembly within Dendritic Spines
2010 StandoutNobel
Glutamate receptors at atomic resolution
2006 Nature
α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Channels Lacking the N-terminal Domain
2002
Structural biology of glutamate receptor ion channel complexes
2016
Conformational Changes in the Ligand-binding Domain of a Functional Ionotropic Glutamate Receptor
2005
Solution X-ray Scattering Evidence for Agonist- and Antagonist-induced Modulation of Cleft Closure in a Glutamate Receptor Ligand-binding Domain
2005
Structural aspects of AMPA receptor activation, desensitization and deactivation
2007
Effects of theLurcherMutation on GluR1 Desensitization and Activation Kinetics
2004
3-Hydroxypyridazine 1-oxides as carboxylate bioisosteres: A new series of subtype-selective AMPA receptor agonists
2006
Kynurenic acid has a dual action on AMPA receptor responses
2006
A Role of the Transient Receptor Potential Domain of Vanilloid Receptor I in Channel Gating
2007
Channel opening and gating mechanism in AMPA-subtype glutamate receptors
2017 StandoutNatureNobel
Gating Reaction Mechanisms for NMDA Receptor Channels
2005
Measurement of Conformational Changes accompanying Desensitization in an Ionotropic Glutamate Receptor
2006
Modulation of the Dimer Interface at Ionotropic Glutamate-Like Receptor δ2 by d-Serine and Extracellular Calcium
2009
X-ray structure of a voltage-dependent K+ channel
2003 StandoutNatureNobel
Regulation of AMPA Receptor Gating by Ligand Binding Core Dimers
2004
Voltage-dependent Gating of Hyperpolarization-activated, Cyclic Nucleotide-gated Pacemaker Channels
2004
Capturing cyclic nucleotides in action: snapshots from crystallographic studies
2006
AMPA Receptor Trafficking at Excitatory Synapses
2003
Interaction of the M4 Segment with Other Transmembrane Segments Is Required for Surface Expression of Mammalian α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors
2011
The Quaternary Structure of a Calcium-Permeable AMPA Receptor: Conservation of Shape and Symmetry across Functionally Distinct Subunit Assemblies
2008
Crystal structure and mechanism of a calcium-gated potassium channel
2002 StandoutNatureNobel
AMPA Receptor Binding Cleft Mutations That Alter Affinity, Efficacy, and Recovery from Desensitization
2005
Structural Basis for AMPA Receptor Activation and Ligand Selectivity: Crystal Structures of Five Agonist Complexes with the GluR2 Ligand-binding Core
2002
Subunit-Specific Roles of Glycine-Binding Domains in Activation of NR1/NR3 N-Methyl-d-aspartate Receptors
2006
Cysteine regulation of protein function – as exemplified by NMDA-receptor modulation
2002
Identification of a Site in GluR1 and GluR2 That Is Important for Modulation of Deactivation and Desensitization
2003
Sensitizing Anthrax Lethal Toxin-resistant Macrophages to Lethal Toxin-induced Killing by Tumor Necrosis Factor-α
2003 StandoutNobel
Pheromonal communication in vertebrates
2006 Nature
Stargazin Interaction with α-Amino-3-hydroxy-5-methyl-4-isoxazole Propionate (AMPA) Receptors Is Critically Dependent on the Amino Acid at the Narrow Constriction of the Ion Channel
2007
SynCAM 1 Adhesion Dynamically Regulates Synapse Number and Impacts Plasticity and Learning
2010 StandoutNobel
Assembly and Stoichiometry of the AMPA Receptor and Transmembrane AMPA Receptor Regulatory Protein Complex
2010
The Expanding Social Network of Ionotropic Glutamate Receptors: TARPs and Other Transmembrane Auxiliary Subunits
2011
TARPs differentially decorate AMPA receptors to specify neuropharmacology
2010
The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers
2008 StandoutNature
Structure-Based Rational Design of Chemical Ligands for AMPA-Subtype Glutamate Receptors
2003
Probing Intersubunit Interfaces in AMPA-subtype Ionotropic Glutamate Receptors
2016
Issues in T‐helper 1 development – resolved and unresolved
2004
Is the Isolated Ligand Binding Domain a Good Model of the Domain in the Native Receptor?
2003
Two Families of TARP Isoforms that Have Distinct Effects on the Kinetic Properties of AMPA Receptors and Synaptic Currents
2007
Allosteric modulators of NR2B‐containing NMDA receptors: molecular mechanisms and therapeutic potential
2009
Molecular mechanism of ligand recognition by NR3 subtype glutamate receptors
2008
A Bivalent Tarantula Toxin Activates the Capsaicin Receptor, TRPV1, by Targeting the Outer Pore Domain
2010 StandoutNobel
LTP Requires a Unique Postsynaptic SNARE Fusion Machinery
2013 StandoutNobel
AMPA Receptor Ligand Binding Domain Mobility Revealed by Functional Cross Linking
2009
Stargazin interacts functionally with the AMPA receptor glutamate-binding module
2006
The sequence of events that underlie quantal transmission at central glutamatergic synapses
2007
A Site in the Fourth Membrane-associated Domain of the N-Methyl-d-aspartate Receptor Regulates Desensitization and Ion Channel Gating
2002
Block of AMPA Receptor Desensitization by a Point Mutation outside the Ligand-Binding Domain
2004
Structural Basis of Inward Rectification
2002 StandoutNobel
Coupled Control of Desensitization and Gating by the Ligand Binding Domain of Glutamate Receptors
2012
TARP Subtypes Differentially and Dose-Dependently Control Synaptic AMPA Receptor Gating
2007
Role of the Microbiota in Immunity and Inflammation
2014 Standout
Structural Rearrangements of NR1/NR2A NMDA Receptors during Allosteric Inhibition
2008
Developmentally Regulated, Combinatorial RNA Processing Modulates AMPA Receptor Biogenesis
2006
Structure-Based Functional Design of Chemical Ligands for AMPA-Subtype Glutamate Receptors
2004
Transforming growth factor-β induces development of the TH17 lineage
2006 StandoutNature
The VGL-Chanome: A Protein Superfamily Specialized for Electrical Signaling and Ionic Homeostasis
2004
Conformational restriction blocks glutamate receptor desensitization
2006
Four Different Subunits Are Essential for Expressing the Synaptic Glutamate Receptor at Neuromuscular Junctions ofDrosophila
2005
A Novel Conus Snail Polypeptide Causes Excitotoxicity by Blocking Desensitization of AMPA Receptors
2009
Mechanism of Positive Allosteric Modulators Acting on AMPA Receptors
2005
Competitive AMPA receptor antagonists
2006
Site within N-Methyl-D-aspartate Receptor Pore Modulates Channel Gating
2004
Modulation of Triheteromeric NMDA Receptors by N-Terminal Domain Ligands
2005
TRP channels as cellular sensors
2003 StandoutNature
Mechanism of Partial Agonist Action at the NR1 Subunit of NMDA Receptors
2005
Evolution of glutamate interactions during binding to a glutamate receptor
2005
Crystal Structure of the GluR2 Amino-Terminal Domain Provides Insights into the Architecture and Assembly of Ionotropic Glutamate Receptors
2009
Structure and Rearrangements in the Carboxy-Terminal Region of SpIH Channels
2007
Immunity, Inflammation, and Cancer
2010 Standout
TRPV1 structures in distinct conformations reveal activation mechanisms
2013 StandoutNatureNobel
Novel Single Chain cAMP Sensors for Receptor-induced Signal Propagation
2004
The Three-dimensional Structure of an Ionotropic Glutamate Receptor Reveals a Dimer-of-dimers Assembly
2004
Tyr702 Is an Important Determinant of Agonist Binding and Domain Closure of the Ligand-Binding Core of GluR2
2005
Molecular Mechanism of AMPA Receptor Noncompetitive Antagonism
2005
Structure and assembly of pore-forming proteins
2010
MHC peptides and the sensory evaluation of genotype
2005
Structure and gating of the glutamate receptor ion channel
2004
TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action
2016 StandoutNatureNobel
Three-dimensional structure of an AMPA receptor without associated stargazin/TARP proteins
2006
A Domain Linking the AMPA Receptor Agonist Binding Site to the Ion Pore Controls Gating and CauseslurcherProperties when Mutated
2007
The Pore Structure of the Closed RyR1 Channel
2005
ThermoTRP channels as modular proteins with allosteric gating
2007
Structure and different conformational states of native AMPA receptor complexes
2005 Nature
Appropriate NR1-NR1 Disulfide-linked Homodimer Formation Is Requisite for Efficient Expression of Functional, Cell Surface N-Methyl-D-aspartate NR1/NR2 Receptors
2004
β2-Adrenergic Receptor Signaling and Desensitization Elucidated by Quantitative Modeling of Real Time cAMP Dynamics
2007 StandoutNobel
A biological role for prokaryotic ClC chloride channels
2002 Nature
Identification of a Tetramerization Domain in the C Terminus of the Vanilloid Receptor
2004
Mechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ligand-binding core
2003
Structure and Dynamics of AMPA Receptor GluA2 in Resting, Pre-Open, and Desensitized States
2014
Control of NMDA Receptor Function by the NR2 Subunit Amino-Terminal Domain
2009
Dangerous liaisons: STAT3 and NF-κB collaboration and crosstalk in cancer
2009
Benzamide-Type AMPA Receptor Modulators Form Two Subfamilies with Distinct Modes of Action
2002
Folding and assembly of β-barrel membrane proteins
2004
Structural and Single-Channel Results Indicate That the Rates of Ligand Binding Domain Closing and Opening Directly Impact AMPA Receptor Gating
2008
Activation of NR1/NR2B NMDA receptors
2003
Mechanism of differential control of NMDA receptor activity by NR2 subunits
2009 Nature
Pore-forming toxins: ancient, but never really out of fashion
2015
Comparative analysis of the pharmacology of GluR1 in complex with transmembrane AMPA receptor regulatory proteins γ2, γ3, γ4, and γ8
2008
Stargazin Modulates Native AMPA Receptor Functional Properties by Two Distinct Mechanisms
2005
C-terminal Domains of Transmembrane α-Amino-3-hydroxy-5-methyl-4-isoxazole Propionate (AMPA) Receptor Regulatory Proteins Not Only Facilitate Trafficking but Are Major Modulators of AMPA Receptor Function
2009
AMPA Receptor Tetramerization Is Mediated by Q/R Editing
2003
PHENIX: a comprehensive Python-based system for macromolecular structure solution
2010 Standout
The Outer Pore of the Glutamate Receptor Channel Has 2-Fold Rotational Symmetry
2004
Glutamate-based therapeutic approaches: ampakines
2005
A light-gated, potassium-selective glutamate receptor for the optical inhibition of neuronal firing
2010
Partial Agonism and Antagonism of the Ionotropic Glutamate Receptor iGLuR5
2007
Structural basis for partial agonist action at ionotropic glutamate receptors
2003
X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor
2009 Nature
Structure and function of AMPA receptors
2003
Structural Bases of Desensitization in AMPA Receptor-Auxiliary Subunit Complexes
2017 StandoutNobel
The voltage-gated potassium channels and their relatives
2002 Nature
Molecular determinants of ligand discrimination in the glutamate-binding pocket of the NMDA receptor
2004
The Structure of a Mixed GluR2 Ligand-binding Core Dimer in Complex with (S)-Glutamate and the Antagonist (S)-NS1209
2006
Glutamate Receptor Gating
2004
Surprises and pitfalls arising from (pseudo)symmetry
2007
Roles of the N-terminal Domain on the Function and Quaternary Structure of the Ionotropic Glutamate Receptor
2005
The Relationship between Agonist Potency and AMPA Receptor Kinetics
2006
Point Mutations in Anthrax Protective Antigen That Block Translocation
2001
LRRC8 Proteins Form Volume-Regulated Anion Channels that Sense Ionic Strength
2016 StandoutNobel
A Molecular Determinant of Subtype-Specific Desensitization in Ionotropic Glutamate Receptors
2016
Distinct Structural Pathways Coordinate the Activation of AMPA Receptor-Auxiliary Subunit Complexes
2016
Trimeric Architecture of Homomeric P2X2 and Heteromeric P2X1+2 Receptor Subtypes
2004
A Hot-Sensing Cold Receptor: C-Terminal Domain Determines Thermosensation in Transient Receptor Potential Channels
2006
Subunit arrangement and function in NMDA receptors
2005 Nature
Ligand-Gated Ion Channels: New Insights into Neurological Disorders and Ligand Recognition
2012
Elucidation of AMPA receptor–stargazin complexes by cryo–electron microscopy
2016 StandoutScienceNobel
Mechanism of Activation and Selectivity in a Ligand-Gated Ion Channel: Structural and Functional Studies of GluR2 and Quisqualate,
2002
Mapping the Binding Site of the Neuroprotectant Ifenprodil on NMDA Receptors
2002
Structural determinants of agonist-specific kinetics at the ionotropic glutamate receptor 2
2005
The multifaceted subunit interfaces of ionotropic glutamate receptors
2014
Structure and organization of heteromeric AMPA-type glutamate receptors
2016 Science
Structure of an agonist-bound ionotropic glutamate receptor
2014 Science
Pore-forming activity and structural autoinhibition of the gasdermin family
2016 StandoutNature
RIM-Binding Protein, a Central Part of the Active Zone, Is Essential for Neurotransmitter Release
2011 StandoutScienceNobel
Olfactory neurons expressing transient receptor potential channel M5 (TRPM5) are involved in sensing semiochemicals
2007 StandoutNobel
TRPV1 Channels Are Intrinsically Heat Sensitive and Negatively Regulated by Phosphoinositide Lipids
2013 StandoutNobel
Genetic Analysis of Brain Circuits Underlying Pheromone Signaling
2006
The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation
2011 StandoutScience
A steroid modulatory domain on NR2B controlsN-methyl-d -aspartate receptor proton sensitivity
2004
Subnanometer-resolution electron cryomicroscopy-based domain models for the cytoplasmic region of skeletal muscle RyR channel
2008
Properties of Quantal Transmission at CA1 Synapses
2004
Mechanism for phosphoinositide selectivity and activation of TRPV1 ion channels
2015
Architecture of fully occupied GluA2 AMPA receptor–TARP complex elucidated by cryo-EM
2016 Nature
Interferon-Stimulated Genes: A Complex Web of Host Defenses
2014 StandoutNobel
The role of AMPA receptor-mediated excitotoxicity in ALS: Is deficient RNA editing to blame?
2009
Conserved SOL-1 proteins regulate ionotropic glutamate receptor desensitization
2006
Reversible Photocontrol of Biological Systems by the Incorporation of Molecular Photoswitches
2013 StandoutNobel
Two amino acid residues determine 2-APB sensitivity of the ion channels TRPV3 and TRPV4
2009 StandoutNobel
Multiple Molecular Determinants for Allosteric Modulation of Alternatively Spliced AMPA Receptors
2003
Bruchpilot Promotes Active Zone Assembly, Ca 2+ Channel Clustering, and Vesicle Release
2006 StandoutScienceNobel
How AMPA Receptor Desensitization Depends on Receptor Occupancy
2003
Functional Insights from Glutamate Receptor Ion Channel Structures
2012
X-ray structures of AMPA receptor–cone snail toxin complexes illuminate activation mechanism
2014 Science
Structure and gating of tetrameric glutamate receptors
2013
Studies of NMDA Receptor Function and Stoichiometry with Truncated and Tandem Subunits
2003
Emerging structural explanations of ionotropic glutamate receptor function
2004
Correlating AMPA Receptor Activation and Cleft Closure across Subunits: Crystal Structures of the GluR4 Ligand-Binding Domain in Complex with Full and Partial Agonists
2008
Emerging Targets in Photopharmacology
2016 StandoutNobel
Competitive Antagonism of AMPA Receptors by Ligands of Different Classes: Crystal Structure of ATPO Bound to the GluR2 Ligand-Binding Core, in Comparison with DNQX
2002
Determination of solution structures of proteins up to 40 kDa using CS-Rosetta with sparse NMR data from deuterated samples
2012 StandoutNobel
LRET Investigations of Conformational Changes in the Ligand Binding Domain of a Functional AMPA Receptor
2008
A Eukaryotic Specific Transmembrane Segment is Required for Tetramerization in AMPA Receptors
2013
Tuning activation of the AMPA-sensitive GluR2 ion channel by genetic adjustment of agonist-induced conformational changes
2003
Microsecond-to-Millisecond Conformational Dynamics Demarcate the GluR2 Glutamate Receptor Bound to Agonists Glutamate, Quisqualate, and AMPA
2005
Dissection of the components for PIP 2 activation and thermosensation in TRP channels
2007
Different Gating Mechanisms in Glutamate Receptor and K+Channels
2003
SOL-1 is an auxiliary subunit that modulates the gating of GLR-1 glutamate receptors inCaenorhabditis elegans
2006
Structure of the kainate receptor subunit GluR6 agonist-binding domain complexed with domoic acid
2005
Role of dimer interface in activation and desensitization in AMPA receptors
2010
Salt Bridges and Gating in the COOH-terminal Region of HCN2 and CNGA1 Channels
2004
Mechanisms of Antagonism of the GluR2 AMPA Receptor: Structure and Dynamics of the Complex of Two Willardiine Antagonists with the Glutamate Binding Domain
2009
Structural basis for gating charge movement in the voltage sensor of a sodium channel
2011 StandoutNobel
Works of Rich Olson being referenced
Crystal Structure of the Vibrio cholerae Cytolysin (VCC) Pro-toxin and its Assembly into a Heptameric Transmembrane Pore
2005
Mechanisms for ligand binding to GluR0 ion channels: crystal structures of the glutamate and serine complexes and a closed apo state
2001
Mechanism of glutamate receptor desensitization
2002 Nature
Structure of a Pheromone Receptor-Associated MHC Molecule with an Open and Empty Groove
2005
Glycan Specificity of the Vibrio vulnificus Hemolysin Lectin Outlines Evolutionary History of Membrane Targeting by a Toxin Family
2014
STATs Dimerize in the Absence of Phosphorylation
2003
Structural basis for modulation and agonist specificity of HCN pacemaker channels
2003 Nature
Crystal structure of staphylococcal LukF delineates conformational changes accompanying formation of a transmembrane channel.
1999
Crystal structure of the Vibrio cholerae cytolysin heptamer reveals common features among disparate pore-forming toxins
2011
Vibrio cholerae Cytolysin Recognizes the Heptasaccharide Core of Complex N-Glycans with Nanomolar Affinity
2012