Citation Impact
Citing Papers
Loss of conformational entropy in protein folding calculated using realistic ensembles and its implications for NMR-based calculations
2014 StandoutNobel
SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase
2019 StandoutNobel
Catalysis by dihydrofolate reductase and other enzymes arises from electrostatic preorganization, not conformational motions
2011 StandoutNobel
Sulfur [ 18 F]Fluoride Exchange Click Chemistry Enabled Ultrafast Late-Stage Radiosynthesis
2021 StandoutNobel
Diversity oriented clicking delivers β-substituted alkenyl sulfonyl fluorides as covalent human neutrophil elastase inhibitors
2022 StandoutNobel
Genetic Ablation of the Fatty Acid–Binding Protein FABP5 Suppresses HER2-Induced Mammary Tumorigenesis
2013
Saturated fatty acids regulate retinoic acid signalling and suppress tumorigenesis by targeting fatty acid-binding protein 5
2015
Effect of probucol on LDL oxidation and atherosclerosis in LDL receptor-deficient mice
1998
The human fatty acid-binding protein family: Evolutionary divergences and functions
2011
Small-molecule inhibitors of FABP4/5 ameliorate dyslipidemia but not insulin resistance in mice with diet-induced obesity
2011
Structural analysis of ibuprofen binding to human adipocyte fatty-acid binding protein (FABP4)
2015
Decarboxylative alkenylation
2017 Nature
Alternative M2 Activation of Kupffer Cells by PPARδ Ameliorates Obesity-Induced Insulin Resistance
2008
Abdominal obesity and metabolic syndrome
2006 StandoutNature
MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity
2006 Standout
Dynamic personalities of proteins
2007 StandoutNature
Inflammation and metabolic disorders
2006 StandoutNature
The substrate specificity of tocopherol cyclase
1996
AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism
2005 Standout
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
The role of vitamin E in atherosclerosis
2003
Fatty acid binding proteins in adipose tissue: A promising link between metabolic syndrome and atherosclerosis?
2008
Mechanisms linking obesity with cardiovascular disease
2006 StandoutNature
Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy volunteers: a randomised, single-blind, placebo-controlled, phase 1 trial
2013
Dietary and pharmacological antioxidants in atherosclerosis
1999
Circulating Levels of Fatty Acid-Binding Protein Family and Metabolic Phenotype in the General Population
2013
Use of antioxidant vitamins for the prevention of cardiovascular disease: meta-analysis of randomised trials
2003
Coenzyme Q10 supplementation inhibits aortic lipid oxidation but fails to attenuate intimal thickening in balloon-injured New Zealand white rabbits
2003
Dissociation of atherogenesis from aortic accumulation of lipid hydro(pero)xides in Watanabe heritable hyperlipidemic rabbits
1999
Redistribution and loss of side chain entropy upon formation of a calmodulin-peptide complex.
2000
Microscopic origins of entropy, heat capacity and the glass transition in proteins
2001 Nature
Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43
2009 StandoutNature
Effect of dietary catechin and vitamin E on aortic fatty streak accumulation in hypercholesterolemic hamsters
1998
Inflammation, stress, and diabetes
2005 Standout
Mechanisms of the components of the metabolic syndrome that predispose to diabetes and atherosclerotic CVD
2007
Human nutrition, the gut microbiome and the immune system
2011 StandoutNature
The stress-activated protein kinase subfamily of c-Jun kinases
1994 StandoutNature
Enzymatic assembly of carbon–carbon bonds via iron-catalysed sp3 C–H functionalization
2018 StandoutNatureNobel
A Role of Mixed‐Function Oxidation Reactions in the Accumulation of Altered Enzyme Forms During Aging
1987
Antioxidants and Atherosclerotic Heart Disease
1997 Standout
Double-Stranded RNA-Dependent Protein Kinase Links Pathogen Sensing with Stress and Metabolic Homeostasis
2010
Role of Oxidative Modifications in Atherosclerosis
2004 Standout
Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II
1988 Nature
Cigarette Smoke Decreases Airway Epithelial FABP5 Expression and Promotes Pseudomonas aeruginosa Infection
2013
Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease
2010 Standout
Lipid signalling in disease
2008
Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance
2010
The adipocyte fatty acid-binding protein aP2 is required in allergic airway inflammation
2006
In vivo genome editing using Staphylococcus aureus Cas9
2015 StandoutNature
Mechanisms linking obesity to insulin resistance and type 2 diabetes
2006 StandoutNature
Targeting Fatty Acid Binding Protein (FABP) Anandamide Transporters – A Novel Strategy for Development of Anti-Inflammatory and Anti-Nociceptive Drugs
2012
Atherosclerosis — An Inflammatory Disease
1999 Standout
Origin and physiological roles of inflammation
2008 StandoutNature
Reactive oxygen species have a causal role in multiple forms of insulin resistance
2006 StandoutNature
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
Hydrogen Sulfide Promotes Adipogenesis in 3T3L1 Cells
2015
Structural Basis for Ligand Regulation of the Fatty Acid-binding Protein 5, Peroxisome Proliferator-activated Receptor β/δ (FABP5-PPARβ/δ) Signaling Pathway
2014
The role of senescent cells in ageing
2014 StandoutNature
Macrophage biology in development, homeostasis and disease
2013 StandoutNature
Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets
2008
Obesity is associated with macrophage accumulation in adipose tissue
2003 Standout
Identification of a Lipokine, a Lipid Hormone Linking Adipose Tissue to Systemic Metabolism
2008
A crucial role for adipose tissue p53 in the regulation of insulin resistance
2009
Effect of vitamin E on aortic lipid oxidation and intimal proliferation after arterial injury in cholesterol-fed rabbits
2001
Autophagy in immunity and inflammation
2011 StandoutNature
Comparison of the effects of α-tocopherol, ubiquinone-10 and probucol at therapeutic doses on atherosclerosis in WHHL rabbits
2002
Adenosine Monophosphate-Activated Protein Kinase: A Central Regulator of Metabolism with Roles in Diabetes, Cancer, and Viral Infection
2011
Regulation of bovine kidney branched-chain 2-oxoacid dehydrogenase complex by reversible phosphorylation
1984 StandoutNobel
Interleukin-10 Associates With Adiponectin Predominantly in Subjects With Metabolic Syndrome
2007
SuFEx Click Chemistry Enabled Late-Stage Drug Functionalization
2018 StandoutNobel
Catalytic Asymmetric Dearomatizing Redox Cross Coupling of Ketones with Aryl Hydrazines Giving 1,4-Diketones
2015 StandoutNobel
A genetic variant at the fatty acid-binding protein aP2 locus reduces the risk for hypertriglyceridemia, type 2 diabetes, and cardiovascular disease
2006
Regulation of Cholesterol Biosynthesis
1986
Protein Oxidation and Aging
1992 StandoutScience
Effect of Iron Overload and Iron Deficiency on Atherosclerosis in the Hypercholesterolemic Rabbit
1997
Dynamical Contributions to Enzyme Catalysis: Critical Tests of A Popular Hypothesis
2006 StandoutNobel
Regulation of synthesis and degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase by low density lipoprotein and 25-hydroxycholesterol in UT-1 cells.
1982 StandoutNobel
Dietary Cosupplementation With Vitamin E and Coenzyme Q 10 Inhibits Atherosclerosis in Apolipoprotein E Gene Knockout Mice
2001
The Emerging Functions and Mechanisms of Mammalian Fatty Acid–Binding Proteins
2008
Evidence indicating that inactivation of 3-hydroxy-3-methylglutaryl coenzyme A reductase by low density lipoprotein or by 25-hydroxycholesterol requires mediator protein(s) with rapid turnover rate.
1981
Microscopic Insights into the NMR Relaxation-Based Protein Conformational Entropy Meter
2013
Intermolecular Enolate Heterocoupling: Scope, Mechanism, and Application
2008
Tocopherol‐mediated peroxidation of lipoproteins: implications for vitamin E as a potential antiatherogenic supplement
1999
Increase in membrane cholesterol: A possible trigger for degradation of HMG CoA reductase and crystalloid endoplasmic reticulum in UT-1 cells
1984 StandoutNobel
Identification of The Tocopherol‐Cyclase in the Blue‐Green Algae Anabaena variabilis KÜTZING (Cyanobacteria)
1993
Catalytic Asymmetric Hydroalkoxylation of C–C Multiple Bonds
2021 StandoutNobel
Hyperresistinemia Is Associated With Coexistence of Hypertension and Type 2 Diabetes
2008
A Receptor-Mediated Pathway for Cholesterol Homeostasis
1986 StandoutScienceNobel
Molecular cloning of 3-hydroxy-3-methylglutaryl coenzyme a reductase and evidence for regulation of its mRNA.
1982 StandoutNobel
Oxidation of proteins by mixed-function oxidation systems: implication in protein turnover, ageing and neutrophil function
1986
Fast Time Scale Dynamics of Protein Backbones: NMR Relaxation Methods, Applications, and Functional Consequences
2006
Isolation and characterization of cells resistant to ML236B (compactin) with increased levels of 3-hydroxy-3-methylglutaryl coenzyme A reductase.
1981
Development of a therapeutic monoclonal antibody that targets secreted fatty acid–binding protein aP2 to treat type 2 diabetes
2015
Identification of simple arylfluorosulfates as potent agents against resistant bacteria
2021 StandoutNobel
Altered insulin secretion associated with reduced lipolytic efficiency in aP2-/- mice.
1999
Regulation of cholesterol biosynthesis in enucleated cells.
1981
Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth
2011 Standout
Appearance of crystalloid endoplasmic reticulum in compactin-resistant Chinese hamster cells with a 500-fold increase in 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
1982 StandoutNobel
Obesity is associated with macrophage accumulation in adipose tissue
2003 Standout
The Metabolic Syndrome
2008 Standout
Membrane-bound domain of HMG CoA reductase is required for sterol-enhanced degradation of the enzyme
1985 StandoutNobel
Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue
2016 StandoutNobel
Active and inactive forms of 3-hydroxy-3-methylglutaryl coenzyme A reductase in the liver of the rat. Comparison with the rate of cholesterol synthesis in different physiological states.
1979 StandoutNobel
NMR Characterization of the Dynamics of Biomacromolecules
2004
Identification and Characterization of a Small Molecule Inhibitor of Fatty Acid Binding Proteins
2009
“Inverse Drug Discovery” Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates
2017 StandoutNobel
Reversible modulation of liver hydroxymethylglutaryl CoA reductase
1978
Works of Rex A. Parker being referenced
Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2
2007 Nature
Hypocholesterolemic activity of synthetic and natural tocotrienols.
1992
Dissection of the Endogenous Cellular Pathways of PCSK9-induced Low Density Lipoprotein Receptor Degradation
2009
Potent and selective biphenyl azole inhibitors of adipocyte fatty acid binding protein (aFABP)
2006
Lack of macrophage fatty-acid–binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis
2001
Relation of Vascular Oxidative Stress, α-Tocopherol, and Hypercholesterolemia to Early Atherosclerosis in Hamsters
1995
Phosphorylation of microsomal HMG CoA reductase increases susceptibility to proteolytic degradation
1984
Short-term regulation of hydroxymethylglutaryl coenzyme a reductase by reversible phosphorylation: Modulation of reductase phosphatase in rat hepatocytes
1982
Role of the Fatty Acid Binding Protein mal1 in Obesity and Insulin Resistance
2003
Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes
2005
Activation of the branched-chain α-ketoacid dehydrogenase complex by a broad specificity protein phosphatase
1982
Backbone and Side Chain Dynamics of Uncomplexed Human Adipocyte and Muscle Fatty Acid-Binding Proteins
1998
Reversible modulation of the activities of both liver microsomal hydroxymethylglutaryl coenzyme a reductase and its inactivating enzyme. Evidence for regulation by phosphorylation-dephosphorylation
1978