Citation Impact
Citing Papers
17-Hydroxy-jolkinolide B Inhibits Signal Transducers and Activators of Transcription 3 Signaling by Covalently Cross-Linking Janus Kinases and Induces Apoptosis of Human Cancer Cells
2009
A Phase I First-in-Human Trial of Bardoxolone Methyl in Patients with Advanced Solid Tumors and Lymphomas
2012
Targeting Nrf2 with the triterpenoid CDDO- imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice
2008
Nrf2 Activation Protects against Solar-Simulated Ultraviolet Radiation in Mice and Humans
2015
Ferroptosis regulation by the NGLY1/NFE2L1 pathway
2022 StandoutNobel
Anti-inflammatory Triterpenoid Blocks Immune Suppressive Function of MDSCs and Improves Immune Response in Cancer
2010
Bardoxolone methyl (BARD) ameliorates ischemic AKI and increases expression of protective genes Nrf2, PPARγ, and HO-1
2011
Cancer Chemoprevention Mechanisms Mediated Through the Keap1–Nrf2 Pathway
2010
Triterpenoid modulation of IL-17 and Nrf-2 expression ameliorates neuroinflammation and promotes remyelination in autoimmune encephalomyelitis
2011
The multifaceted role of Nrf2 in mitochondrial function
2016
Nrf2 the rescue: Effects of the antioxidative/electrophilic response on the liver
2010
Active NF-E2-related Factor (Nrf2) Contributes to Keep Endothelial NO Synthase (eNOS) in the Coupled State
2009
Keap1, the cysteine-based mammalian intracellular sensor for electrophiles and oxidants
2016
A split, conditionally active mimetic of IL-2 reduces the toxicity of systemic cytokine therapy
2022 StandoutNobel
Bardoxolone Methyl and Kidney Function in CKD with Type 2 Diabetes
2011
NRF2 Cysteine Residues Are Critical for Oxidant/Electrophile-Sensing, Kelch-Like ECH-Associated Protein-1-Dependent Ubiquitination-Proteasomal Degradation, and Transcription Activation
2009
Targeting the KEAP1-NRF2 System to Prevent Kidney Disease Progression
2017 Standout
Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease
2015
An Exceptionally Potent Inducer of Cytoprotective Enzymes
2010
Transcriptional Regulation of Renal Cytoprotective Genes by Nrf2 and Its Potential Use as a Therapeutic Target to Mitigate Cisplatin-Induced Nephrotoxicity
2010
Inflammation and cancer
2002 StandoutNature
The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores Nrf2 activity and attenuates oxidative stress, inflammation, and fibrosis in rats with chronic kidney disease
2013
Nrf2: friend or foe for chemoprevention?
2009
The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis
2005 StandoutNobel
Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards
2016 Standout
Nrf2–Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species
2006 Standout
The clinical toxicity profile of vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor (VEGFR) targeting angiogenesis inhibitors; A review
2006
Mechanisms Underlying Inflammation in Neurodegeneration
2010 Standout
Nrf2-dependent protection from LPS induced inflammatory response and mortality by CDDO-Imidazolide
2006
Methyl‐substituted diindolylmethanes as inhibitors of estrogen‐induced growth of T47D cells and mammary tumors in rats
2001
Impaired liver regeneration in Nrf2 knockout mice: role of ROS‐mediated insulin/IGF‐1 resistance
2007
Mechanochemistry: opportunities for new and cleaner synthesis
2011 Standout
Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-Imidazolide
2009
Actions of TGF-β as tumor suppressor and pro-metastatic factor in human cancer
2006
NRF2 and cancer: the good, the bad and the importance of context
2012
Cancer Cell Growth Is Differentially Affected by Constitutive Activation of NRF2 by KEAP1 Deletion and Pharmacological Activation of NRF2 by the Synthetic Triterpenoid, RTA 405
2015
Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications
2022 Standout
T Lymphocyte–Specific Activation of Nrf2 Protects from AKI
2015
Targeting the transcription factor Nrf2 to ameliorate oxidative stress and inflammation in chronic kidney disease
2013
PPAR influences susceptibility to DMBA-induced mammary, ovarian and skin carcinogenesis
2004
Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway
2011 Standout
Regulation and role of transforming growth factor-β in immune tolerance induction and inflammation
2004
C151 in KEAP1 is the main cysteine sensor for the cyanoenone class of NRF2 activators, irrespective of molecular size or shape
2018
Structure of the BTB Domain of Keap1 and Its Interaction with the Triterpenoid Antagonist CDDO
2014
Celastrols as Inducers of the Heat Shock Response and Cytoprotection
2004 Standout
Pharmacokinetics and pharmacodynamics of orally administered acetylenic tricyclic bis (cyanoenone), a highly potent Nrf2 activator with a reversible covalent mode of action
2015
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease
2014 Standout
Natural product-derived pharmacological modulators of Nrf2/ARE pathway for chronic diseases
2013
The Triterpenoid CDDO-Imidazolide Confers Potent Protection against Hyperoxic Acute Lung Injury in Mice
2009
ROS Function in Redox Signaling and Oxidative Stress
2014 Standout
Transcriptional responses to oxidative stress: Pathological and toxicological implications
2009
Genetic or Pharmacologic Amplification of Nrf2 Signaling Inhibits Acute Inflammatory Liver Injury in Mice
2008
The cytoprotective role of the Keap1–Nrf2 pathway
2011
Triterpenoids CDDO-ethyl amide and CDDO-trifluoroethyl amide improve the behavioral phenotype and brain pathology in a transgenic mouse model of Huntington's disease
2010
Use of the Peroxisome Proliferator-Activated Receptor (PPAR) γ Ligand Troglitazone as Treatment for Refractory Breast Cancer: A Phase II Study
2003
Keap1 inhibition attenuates glomerulosclerosis
2014
Reactive oxygen species (ROS) as pleiotropic physiological signalling agents
2020 Standout
The Nrf2 triterpenoid activator, CDDO-imidazolide, protects kidneys from ischemia–reperfusion injury in mice
2013
Parkinson's disease
2015 Standout
Risk Factors for Heart Failure in Patients With Type 2 Diabetes Mellitus and Stage 4 Chronic Kidney Disease Treated With Bardoxolone Methyl
2014
ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis
2007 Standout
Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine
2016 StandoutNobel
PPARγ signaling exacerbates mammary gland tumor development
2004
The synthetic triterpenoid, RTA 405, increases the glomerular filtration rate and reduces angiotensin II–induced contraction of glomerular mesangial cells
2012
The tumour microenvironment as a target for chemoprevention
2007
Bardoxolone Methyl Decreases Megalin and Activates Nrf2 in the Kidney
2012
Tumor-infiltrating myeloid cells induce tumor cell resistance to cytotoxic T cells in mice
2011
The Discovery and Development of Selective Estrogen Receptor Modulators (SERMs) for Clinical Practice
2013
Lenvatinib versus Placebo in Radioiodine-Refractory Thyroid Cancer
2015 Standout
Mitochondrial Membrane Permeabilization in Cell Death
2007 Standout
STATs in cancer inflammation and immunity: a leading role for STAT3
2009 Standout
TGFβ in Cancer
2008 Standout
PPARγ signaling and metabolism: the good, the bad and the future
2013 Standout
Functional mapping and annotation of genetic associations with FUMA
2017 Standout
Inflammation and the development of pancreatic cancer
2002
Molecular basis of the Keap1–Nrf2 system
2015
Synthetic Oleanane Triterpenoids: Multifunctional Drugs with a Broad Range of Applications for Prevention and Treatment of Chronic Disease
2012
Molecular Basis of Electrophilic and Oxidative Defense: Promises and Perils of Nrf2
2012
Coordinated induction of Nrf2 target genes protects against iron nitrilotriacetate (FeNTA)-induced nephrotoxicity
2008
Critical Cysteine Residues of Kelch-Like ECH-Associated Protein 1 in Arsenic Sensing and Suppression of Nuclear Factor Erythroid 2-Related Factor 2
2009
In vivo modulation of the Parkinsonian phenotype by Nrf2
2006
Dysregulation of apoptosis genes in hematopoietic malignancies
2002
What We Talk About When We Talk About Fat
2014 Standout
Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities
2008 Standout
Keap1 as the redox sensor of the antioxidant response
2016
Aflatoxin: A 50-Year Odyssey of Mechanistic and Translational Toxicology
2010
An Inducible Pathway for Degradation of FLIP Protein Sensitizes Tumor Cells to TRAIL-induced Apoptosis
2002
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
2015 Standout
Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases
2019 Standout
CDDO-Im protects from acetaminophen hepatotoxicity through induction of Nrf2-dependent genes
2009
Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice
2009
Palbociclib and Letrozole in Advanced Breast Cancer
2016 Standout
Can We Target Tubular Damage to Prevent Renal Function Decline in Diabetes?
2012
BI-1 Regulates an Apoptosis Pathway Linked to Endoplasmic Reticulum Stress
2004 StandoutNobel
NF-E2-related factor 2 promotes compensatory liver hypertrophy after portal vein branch ligation in mice
2014
Antiinflammatory profiles during primary SIV infection in African green monkeys are associated with protection against AIDS
2005 StandoutNobel
Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer
2007
Theoretical Basis, Experimental Design, and Computerized Simulation of Synergism and Antagonism in Drug Combination Studies
2006 Standout
The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores endothelial function impaired by reduced Nrf2 activity in chronic kidney disease
2013
Neuroinflammation in Parkinson's disease: Its role in neuronal death and implications for therapeutic intervention
2009
Mechanisms Contributing to Adverse Cardiovascular Events in Patients with Type 2 Diabetes Mellitus and Stage 4 Chronic Kidney Disease Treated with Bardoxolone Methyl
2014
Long Non-coding RNA NEAT1: A Novel Target for Diagnosis and Therapy in Human Tumors
2018
Dose-dependent deleterious and salutary actions of the Nrf2 inducer dh404 in chronic kidney disease
2015
Protein Sequence Editing of SKN-1A/Nrf1 by Peptide:N-Glycanase Controls Proteasome Gene Expression
2019 StandoutNobel
Tumor Angiogenesis
2008 Standout
Characterization of novel small-molecule NRF2 activators: Structural and biochemical validation of stereospecific KEAP1 binding
2016
Stattic: A Small-Molecule Inhibitor of STAT3 Activation and Dimerization
2006
Roles of PPARs in health and disease
2000 StandoutNature
Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution
2011
Gene regulation by long non-coding RNAs and its biological functions
2020 Standout
Nrf2: control of sensitivity to carcinogens
2011
Targeting Nrf2-Mediated Gene Transcription by Extremely Potent Synthetic Triterpenoids Attenuate Dopaminergic Neurotoxicity in the MPTP Mouse Model of Parkinson's Disease
2012
An Overview of the Advantages of KEAP1-NRF2 System Activation During Inflammatory Disease Treatment
2017
Capsaicin Induces Heme Oxygenase-1 Expression in HepG2 Cells Via Activation of PI3K-Nrf2 Signaling: NAD(P)H:Quinone Oxidoreductase as a Potential Target
2007
Basic Principles and Emerging Concepts in the Redox Control of Transcription Factors
2011
1,1-Bis(3′-Indolyl)-1-(p-Substitutedphenyl)methanes Induce Apoptosis and Inhibit Renal Cell Carcinoma Growth
2007
Nrf2, the Master Regulator of Anti-Oxidative Responses
2017
Xenobiotic-Activated Receptors: From Transcription to Drug Metabolism to Disease
2008
Role of Nrf2 in Oxidative Stress and Toxicity
2013 Standout
Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2-regulated genes
2007
Bis- and Trisindolylmethanes (BIMs and TIMs)
2009 Standout
Heme Oxygenases in Cardiovascular Health and Disease
2016
Nrf2 Neh5 domain is differentially utilized in the transactivation of cytoprotective genes
2007
Human broadly neutralizing antibodies to the envelope glycoprotein complex of hepatitis C virus
2012 StandoutNobel
Fat and Beyond: The Diverse Biology of PPARγ
2008 Standout
Inhibition of angiogenesis and vascular leakiness by angiopoietin-related protein 4.
2003
Potent Protection against Aflatoxin-Induced Tumorigenesis through Induction of Nrf2-Regulated Pathways by the Triterpenoid 1-[2-Cyano-3-,12-Dioxooleana-1,9(11)-Dien-28-Oyl]Imidazole
2006
Synthesis, cellular evaluation, and mechanism of action of piperlongumine analogs
2012
New Synthetic Triterpenoids: Potent Agents for Prevention and Treatment of Tissue Injury Caused by Inflammatory and Oxidative Stress
2011
Complete Protection against Aflatoxin B1-Induced Liver Cancer with a Triterpenoid: DNA Adduct Dosimetry, Molecular Signature, and Genotoxicity Threshold
2014
Synthesis, Chemical Reactivity as Michael Acceptors, and Biological Potency of Monocyclic Cyanoenones, Novel and Highly Potent Anti-inflammatory and Cytoprotective Agents
2012
The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis
2018 Standout
Adapting Proteostasis for Disease Intervention
2008 StandoutScience
Fibrosis — A Common Pathway to Organ Injury and Failure
2015 Standout
Ferroptosis as a target for protection against cardiomyopathy
2019 Standout
Myeloid Lineage–Specific Deletion of Antioxidant System Enhances Tumor Metastasis
2014
Enantioselective direct aldol reaction: the blossoming of modern organocatalysis
2007
A Heck–Matsuda Process for the Synthesis of β‐Arylethenesulfonyl Fluorides: Selectively Addressable Bis‐electrophiles for SuFEx Click Chemistry
2016 StandoutNobel
Antiinflammatory profiles during primary SIV infection in African green monkeys are associated with protection against AIDS
2005 StandoutNobel
Hypoxic retinal Müller cells promote vascular permeability by HIF-1–dependent up-regulation of angiopoietin-like 4
2013 StandoutNobel
Cul3-mediated Nrf2 ubiquitination and antioxidant response element (ARE) activation are dependent on the partial molar volume at position 151 of Keap1
2009
NRF2-mediated Notch pathway activation enhances hematopoietic reconstitution following myelosuppressive radiation
2014
Highly Potent Activation of Nrf2 by Topical Tricyclic Bis(Cyano Enone): Implications for Protection against UV Radiation during Thiopurine Therapy
2012
Chaperone-mediated autophagy is involved in the execution of ferroptosis
2019
Euphorbia Diterpenes: Isolation, Structure, Biological Activity, and Synthesis (2008–2012)
2014 Standout
Palladium‐Catalyzed Fluorosulfonylvinylation of Organic Iodides
2017 StandoutNobel
Stress-Activated Cap'n'collar Transcription Factors in Aging and Human Disease
2010
Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy
2016 Standout
Derivative of Bardoxolone Methyl, dh404, in an Inverse Dose-Dependent Manner Lessens Diabetes-Associated Atherosclerosis and Improves Diabetic Kidney Disease
2014
KEAP1 inhibition is neuroprotective and suppresses the development of epilepsy
2018
Disruption of Nrf2 Synergizes with High Glucose to Cause Heightened Myocardial Oxidative Stress and Severe Cardiomyopathy in Diabetic Mice
2013
Salutary effect of pre-treatment with an Nrf2 inducer on ischemia reperfusion injury in the rat liver.
2014
Systemic Activation of NRF2 Alleviates Lethal Autoimmune Inflammation in Scurfy Mice
2017 StandoutNobel
Lack of Association between Nuclear Factor Erythroid-Derived 2-Like 2 Promoter Gene Polymorphisms and Oxidative Stress Biomarkers in Amyotrophic Lateral Sclerosis Patients
2014
Works of Renee Risingsong being referenced
Synthetic Triterpenoids Prolong Survival in a Transgenic Mouse Model of Pancreatic Cancer
2010
The Synthetic Triterpenoid CDDO-Methyl Ester Delays Estrogen Receptor–Negative Mammary Carcinogenesis in Polyoma Middle T Mice
2012
Synthetic triterpenoids enhance transforming growth factor beta/Smad signaling.
2003
The triterpenoid, CDDO-methyl ester, and the rexinoid, LG100268, synergize in the prevention of mammary tumors in a mouse model of estrogen receptor-negative breast cancer.
2006
CDDO-Methyl Ester Delays Breast Cancer Development in Brca1-Mutated Mice
2011
Neuroprotective Effects of the Triterpenoid, CDDO Methyl Amide, a Potent Inducer of Nrf2-Mediated Transcription
2009
Neuroprotective effect of Nrf2/ARE activators, CDDO ethylamide and CDDO trifluoroethylamide, in a mouse model of amyotrophic lateral sclerosis
2011
Dimethyl fumarate and the oleanane triterpenoids, CDDO-imidazolide and CDDO-methyl ester, both activate the Nrf2 pathway but have opposite effects in the A/J model of lung carcinogenesis
2015
Design, synthesis, and anti-inflammatory activity both in vitro and in vivo of new betulinic acid analogues having an enone functionality in ring A
2006
Novel semisynthetic analogues of betulinic acid with diverse cytoprotective, antiproliferative, and proapoptotic activities
2007
Triterpenoids CDDO-Methyl Ester or CDDO-Ethyl Amide and Rexinoids LG100268 or NRX194204 for Prevention and Treatment of Lung Cancer in Mice
2009
A Novel Acetylenic Tricyclic bis-(Cyano Enone) Potently Induces Phase 2 Cytoprotective Pathways and Blocks Liver Carcinogenesis Induced by Aflatoxin
2008
The Synthetic Triterpenoids CDDO-Methyl Ester and CDDO-Ethyl Amide Prevent Lung Cancer Induced by Vinyl Carbamate in A/J Mice
2007
The Synthetic Triterpenoid CDDO-Imidazolide Suppresses STAT Phosphorylation and Induces Apoptosis in Myeloma and Lung Cancer Cells
2006
The Selective Estrogen Receptor Modulator Arzoxifene and the Rexinoid LG100268 Cooperate to Promote Transforming Growth Factor β-Dependent Apoptosis in Breast Cancer
2004
The rexinoid LG100268 and the synthetic triterpenoid CDDO-methyl amide are more potent than erlotinib for prevention of mouse lung carcinogenesis
2008
Prevention and Treatment of Experimental Estrogen Receptor–Negative Mammary Carcinogenesis by the Synthetic Triterpenoid CDDO-Methyl Ester and the Rexinoid LG100268
2008
The Synthetic Triterpenoids, CDDO and CDDO-Imidazolide, Are Potent Inducers of Heme Oxygenase-1 and Nrf2/ARE Signaling
2005
Design and Synthesis of Tricyclic Compounds with Enone Functionalities in Ring A and C: A Novel Class of Highly Active Inhibitors of Nitric Oxide Production in Mouse Macrophages
2003
The Combination of the Rexinoid, LG100268, and a Selective Estrogen Receptor Modulator, Either Arzoxifene or Acolbifene, Synergizes in the Prevention and Treatment of Mammary Tumors in an Estrogen Receptor–Negative Model of Breast Cancer
2006
Prevention and treatment of experimental breast cancer with the combination of a new selective estrogen receptor modulator, arzoxifene, and a new rexinoid, LG 100268.
2002
A new ligand for the peroxisome proliferator-activated receptor-gamma (PPAR-gamma), GW7845, inhibits rat mammary carcinogenesis.
1999
Extremely potent triterpenoid inducers of the phase 2 response: Correlations of protection against oxidant and inflammatory stress
2005
Design and Synthesis of Tricyclic Compounds with Enone Functionalities in Rings A and C: A Novel Class of Highly Active Inhibitors of Nitric Oxide Production in Mouse Macrophages
2002
The novel synthetic triterpenoid, CDDO-imidazolide, inhibits inflammatory response and tumor growth in vivo.
2003