Citation Impact
Citing Papers
The Endogenous Tryptophan Metabolite and NAD+ Precursor Quinolinic Acid Confers Resistance of Gliomas to Oxidative Stress
2013
Extensive Profiling of the Expression of the Indoleamine 2,3-Dioxygenase 1 Protein in Normal and Tumoral Human Tissues
2014
A TDO2-AhR Signaling Axis Facilitates Anoikis Resistance and Metastasis in Triple-Negative Breast Cancer
2015
Tryptophan Catabolites from Microbiota Engage Aryl Hydrocarbon Receptor and Balance Mucosal Reactivity via Interleukin-22
2013 Standout
An Aryl Hydrocarbon Receptor-Mediated Amplification Loop That Enforces Cell Migration in ER−/PR−/Her2− Human Breast Cancer Cells
2016
From stress to inflammation and major depressive disorder: A social signal transduction theory of depression.
2014 Standout
Dendritic cells in cancer immunology and immunotherapy
2019 Standout
Kynurenines in the mammalian brain: when physiology meets pathology
2012
High-Throughput Fluorescence-Based Screening Assays for Tryptophan-Catabolizing Enzymes
2014
Persistent kallikrein 5 activation induces atopic dermatitis-like skin architecture independent of PAR2 activity
2017 StandoutNobel
Cyclooxygenase inhibition targets neurons to prevent early behavioural decline in Alzheimer’s disease model mice
2016
IDO in the Tumor Microenvironment: Inflammation, Counter-Regulation, and Tolerance
2016
Safety and clinical activity of pembrolizumab for treatment of recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-012): an open-label, multicentre, phase 1b trial
2016 Standout
A multi-substrate screening approach for the identification of a broadly applicable Diels–Alder catalyst
2019 StandoutNobel
Cancer Immunotherapy by Targeting IDO1/TDO and Their Downstream Effectors
2015
Approaches to treat immune hot, altered and cold tumours with combination immunotherapies
2019 Standout
Mammalian phosphoinositide kinases and phosphatases
2009 StandoutNobel
Tryptophan-2,3-Dioxygenase (TDO) deficiency is associated with subclinical neuroprotection in a mouse model of multiple sclerosis
2017
An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor
2011 StandoutNature
Myeloid-derived suppressor cells in the era of increasing myeloid cell diversity
2021 Standout
xCell: digitally portraying the tissue cellular heterogeneity landscape
2017 Standout
The biology and function of fibroblasts in cancer
2016 Standout
Host Indoleamine 2,3-Dioxygenase: Contribution to Systemic Acquired Tumor Tolerance
2012
The road to fully programmable protein catalysis
2022 StandoutNatureNobel
Immunological hallmarks of stromal cells in the tumour microenvironment
2015
Introduction of Fluorine and Fluorine‐Containing Functional Groups
2013 Standout
Emil Knoevenagel and the Roots of Aminocatalysis
2010 StandoutNobel
Molecular docking as a popular tool in drug design, an in silico travel
2016
Targeting phosphoinositide 3-kinase—Moving towards therapy
2007
The tumor microenvironment
2020 Standout
Targeting the phosphoinositide 3-kinase pathway in cancer
2009 Standout
The Catalytic Asymmetric Knoevenagel Condensation
2011 StandoutNobel
Delivery technologies for cancer immunotherapy
2019 Standout
An expanding range of targets for kynurenine metabolites of tryptophan
2012
Tissue Kallikrein Inhibitors Based on the Sunflower Trypsin Inhibitor Scaffold – A Potential Therapeutic Intervention for Skin Diseases
2016 StandoutNobel
Concise synthesis of ricciocarpin A and discovery of a more potent analogue
2009 StandoutNobel
Probiotics and prebiotics in intestinal health and disease: from biology to the clinic
2019
Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression
2015 Standout
Organocatalytic umpolung: N-heterocyclic carbenes and beyond
2012 Standout
Tryptophan metabolism: entering the field of aging and age-related pathologies
2013
The stress kinase GCN2 does not mediate suppression of antitumor T cell responses by tryptophan catabolism in experimental melanomas
2016
The Emerging Hallmarks of Cancer Metabolism
2016 Standout
Targeting the indoleamine 2,3-dioxygenase pathway in cancer
2015
Expression of Tryptophan 2,3-Dioxygenase and Production of Kynurenine Pathway Metabolites in Triple Transgenic Mice and Human Alzheimer's Disease Brain
2013
Copper‐Catalyzed Difluoromethylation of β,γ‐Unsaturated Carboxylic Acids: An Efficient Allylic Difluoromethylation
2012
Regioselective synthesis of isocoumarins by ruthenium-catalyzed aerobic oxidative cyclization of aromatic acids with alkynes
2011
Understanding the Intersections between Metabolism and Cancer Biology
2017 Standout
Coinhibitory Receptor Expression and Immune Checkpoint Blockade: Maintaining a Balance in CD8+ T Cell Responses to Chronic Viral Infections and Cancer
2017 StandoutNobel
Suppression of Th1 differentiation by tryptophan supplementation in vivo
2017
Big opportunities for small molecules in immuno-oncology
2015
Three-component synthesis and anticancer evaluation of polycyclic indenopyridines lead to the discovery of a novel indenoheterocycle with potent apoptosis inducing properties
2007
Identification of Interferon-Stimulated Genes with Antiretroviral Activity
2016 StandoutNobel
Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond
2019 Standout
Trial watch: IDO inhibitors in cancer therapy
2014
Indoleamine 2,3 dioxygenase and metabolic control of immune responses
2012
Accumulation of an Endogenous Tryptophan-Derived Metabolite in Colorectal and Breast Cancers
2015
Structural insights into substrate and inhibitor binding sites in human indoleamine 2,3-dioxygenase 1
2017
Tryptophan 2,3-dioxygenase and indoleamine 2,3-dioxygenase 1 make separate, tissue-specific contributions to basal and inflammation-induced kynurenine pathway metabolism in mice
2016
Gut microbiota in human metabolic health and disease
2020 Standout
Recent advances in Sonogashira reactions
2011 Standout
Modulation of Cancer-Specific Immune Responses by Amino Acid Degrading Enzymes
2016
Iron Catalysis in Organic Synthesis
2015 Standout
3d Transition Metals for C–H Activation
2018 Standout
Biological and clinical significance of tryptophan-catabolizing enzymes in cutaneous T-cell lymphomas
2017
Copper-Catalyzed Direct C-2 Difluoromethylation of Furans and Benzofurans: Access to C-2 CF2H Derivatives
2014
Role of indoleamine 2,3-dioxygenase in health and disease
2015
Challenges in the Discovery of Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors
2015
Room-Temperature Ionic Liquids: Solvents for Synthesis and Catalysis. 2
2011 Standout
Synthesis of Heterocycles via Electrophilic Cyclization of Alkynes Containing Heteroatom
2011 Standout
The Catalytic Asymmetric Mukaiyama–Michael Reaction of Silyl Ketene Acetals with α,β‐Unsaturated Methyl Esters
2017 StandoutNobel
Cancer Immunotherapy: Selected Targets and Small‐Molecule Modulators
2016
The Hitchhiker’s Guide to Flow Chemistry
2017 Standout
Amino acid catabolism: a pivotal regulator of innate and adaptive immunity
2012
Suppression of TDO-mediated tryptophan catabolism in glioblastoma cells by a steroid-responsive FKBP52-dependent pathway
2014
Discovery of IDO1 Inhibitors: From Bench to Bedside
2017
Iminium Catalysis
2007
Synergistic Transcutaneous Immunotherapy Enhances Antitumor Immune Responses through Delivery of Checkpoint Inhibitors
2016
Chromone: A Valid Scaffold in Medicinal Chemistry
2014 Standout
Toward the First Class of Suicide Inhibitors of Kallikreins Involved in Skin Diseases
2014
Nanotechnology for Multimodal Synergistic Cancer Therapy
2017 Standout
Full Selectivity Control in Cobalt(III)‐Catalyzed C−H Alkylations by Switching of the C−H Activation Mechanism
2017
Solution-Phase Synthesis of a Diverse Isocoumarin Library
2009
Molecular Docking: Shifting Paradigms in Drug Discovery
2019 Standout
A New Reagent for Direct Difluoromethylation
2012
Indoleamine 2,3-Dioxygenase and Its Therapeutic Inhibition in Cancer
2017
Liquid phase oxidation chemistry in continuous-flow microreactors
2015
Tryptophan PET Imaging of the Kynurenine Pathway in Patient-Derived Xenograft Models of Glioblastoma
2016
Delaying aging and the aging-associated decline in protein homeostasis by inhibition of tryptophan degradation
2012
Chromatographic analysis of tryptophan metabolites
2017
The Janus-Faced Nature of Ido1 in Infectious Diseases: Challenges and Therapeutic Opportunities
2015
Carboxylate-Assisted Ruthenium-Catalyzed Alkyne Annulations by C–H/Het–H Bond Functionalizations
2013 Standout
Ruthenium(II)-Catalyzed C–H Bond Activation and Functionalization
2012 Standout
Tryptophan Catabolism in Cancer: Beyond IDO and Tryptophan Depletion
2012
Chemomimetic Biocatalysis: Exploiting the Synthetic Potential of Cofactor-Dependent Enzymes To Create New Catalysts
2015 StandoutNobel
Advances in Synthetic Applications of Hypervalent Iodine Compounds
2016 Standout
Iron-Promoted C–C Bond Cleavage of 1,3-Diketones: A Route to 1,2-Diketones under Mild Reaction Conditions
2011
A patent review of IDO1 inhibitors for cancer
2018
T cell exclusion, immune privilege, and the tumor microenvironment
2015 StandoutScience
Asymmetric Catalysis of the Carbonyl-Amine Condensation: Kinetic Resolution of Primary Amines
2017 StandoutNobel
Aromatic Trifluoromethylation with Metal Complexes
2011 Standout
The Halogen Bond
2016 Standout
Design, Structure−Activity Relationships, X-ray Crystal Structure, and Energetic Contributions of a Critical P1 Pharmacophore: 3-Chloroindole-7-yl-Based Factor Xa Inhibitors
2008
Tryptophan-2,3-dioxygenase (TDO) inhibition ameliorates neurodegeneration by modulation of kynurenine pathway metabolites
2016
Indoleamine 2,3-dioxygenase is a critical resistance mechanism in antitumor T cell immunotherapy targeting CTLA-4
2013 StandoutNobel
Tryptophan‐2,3‐dioxygenase is regulated by prostaglandin E2 in malignant glioma via a positive signaling loop involving prostaglandin E receptor‐4
2015
Aerobic C–H Olefination of Indoles via a Cross-Dehydrogenative Coupling in Continuous Flow
2014
Metal-Free Multicomponent Syntheses of Pyridines
2014 Standout
Copper‐Catalyzed Preparation of γ‐Alkylidenebutenolides and Isocoumarins under Mild Palladium‐Free Conditions
2009
Works of Raphaël Frédérick being referenced
Synthesis, crystal structures and electronic properties of isomers of chloro-pyridinylvinyl-1H-indoles
2012
Synthesis, biological evaluation and molecular modelling of sulfonohydrazides as selective PI3K p110α inhibitors
2007
Indoleamine 2,3-dioxygenase inhibitory activity of derivatives of marine alkaloid tsitsikammamine A
2012
Synthesis and inhibition study of monoamine oxidase, indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase by 3,8-substituted 5H-indeno[1,2-c]pyridazin-5-one derivatives
2011
Coumarin and Isocoumarin as Serine Protease Inhibitors
2004
Intestinal Sucrase as a Novel Target Contributing to the Regulation of Glycemia by Prebiotics
2016
Indoleamine 2,3-dioxygenase inhibitors: a patent review (2008 – 2012)
2013
Thiosemicarbazide, a fragment with promising indolamine-2,3-dioxygenase (IDO) inhibition properties
2014
Indol-2-yl ethanones as novel indoleamine 2,3-dioxygenase (IDO) inhibitors
2010
Pyrazolo[4,3-c]isoquinolines as potential inhibitors of NF-κB activation
2010
Investigation of mechanism-based thrombin inhibitors: Implications of a highly conserved water molecule for the binding of coumarins within the S pocket
2006
Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase
2012
Synthesis, Structural Reassignment, and Biological Activity of Type B MAO Inhibitors Based on the 5H-Indeno[1,2-c]pyridazin-5-one Core
2006
3,6-Disubstituted Coumarins as Mechanism-Based Inhibitors of Thrombin and Factor Xa
2005
Tryptophan 2,3-Dioxygenase (TDO) Inhibitors. 3-(2-(Pyridyl)ethenyl)indoles as Potential Anticancer Immunomodulators
2011
Mechanism-Based Thrombin Inhibitors: Design, Synthesis, and Molecular Docking of a New Selective 2-Oxo-2H-1-benzopyran Derivative
2007
Synthesis and Biological Evaluation of Novel Analogues of the Pan Class I Phosphatidylinositol 3-Kinase (PI3K) Inhibitor 2-(Difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1H-benzimidazole (ZSTK474)
2011
Discovery and preliminary SARs of keto-indoles as novel indoleamine 2,3-dioxygenase (IDO) inhibitors
2011