Citation Impact
Citing Papers
Contextual Synthetic Lethality of Cancer Cell Kill Based on the Tumor Microenvironment
2010
Epigenetic Repression of DNA Mismatch Repair by Inflammation and Hypoxia in Inflammatory Bowel Disease–Associated Colorectal Cancer
2009 StandoutNobel
Generation of knock-in primary human T cells using Cas9 ribonucleoproteins
2015 StandoutNobel
Effects of Acute versus Chronic Hypoxia on DNA Damage Responses and Genomic Instability
2010
Roles of DNA repair and reductase activity in the cytotoxicity of the hypoxia-activated dinitrobenzamide mustard PR-104A
2009
In Vivo Profiling of Hypoxic Gene Expression in Gliomas Using the Hypoxia Marker EF5 and Laser-capture Microdissection
2011
Chimeric antigen receptor -T cell therapy: Applications and challenges in treatment of allergy and asthma
2019
Gene array of VHL mutation and hypoxia shows novel hypoxia-induced genes and that cyclin D1 is a VHL target gene
2004 StandoutNobel
Hypoxia-inducible factor-2 regulates vascular tumorigenesis in mice
2008
On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models
2016 StandoutNatureNobel
Treatment of kidney cancer
2009 StandoutNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
The role of hypoxia-inducible factors in tumorigenesis
2008
Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m 6 A-demethylation of NANOG mRNA
2016 StandoutNobel
Contrasting Properties of Hypoxia-Inducible Factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-Associated Renal Cell Carcinoma
2005 StandoutNobel
Human mismatch repair gene, MLH1, is transcriptionally repressed by the hypoxia-inducible transcription factors, DEC1 and DEC2
2008
Hypoxia-Inducible Factors in Physiology and Medicine
2012 StandoutNobel
Hypoxia-inducible factors in the kidney
2006
Hypoxia, DNA repair and genetic instability
2008
Targeting hypoxia in cancer therapy
2011 Standout
Single-Stranded DNA Orchestrates an ATM-to-ATR Switch at DNA Breaks
2009
HIF-α Effects on c-Myc Distinguish Two Subtypes of Sporadic VHL-Deficient Clear Cell Renal Carcinoma
2008
APE1/Ref-1Role in Redox Signaling: Translational Applications of Targeting the Redox Function of the DNA Repair/Redox Protein APE1/Ref-1
2011
Targeting HIF-1 for cancer therapy
2003 StandoutNobel
Two levels of protection for the B cell genome during somatic hypermutation
2008 Nature
The SIN3A histone deacetylase complex is required for a complete transcriptional response to hypoxia
2017 StandoutNobel
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation
2012 StandoutNatureNobel
DNA repair pathways as targets for cancer therapy
2008
HIF-1α Induces Genetic Instability by Transcriptionally Downregulating MutSα Expression
2005 StandoutNobel
The von Hippel-Lindau Gene, Kidney Cancer, and Oxygen Sensing
2003 StandoutNobel
EZH2 Promotes Expansion of Breast Tumor Initiating Cells through Activation of RAF1-β-Catenin Signaling
2011
Common genetic variants at the 11q13.3 renal cancer susceptibility locus influence binding of HIF to an enhancer of cyclin D1 expression
2012 StandoutNobel
Hypoxic gene expression and metastasis
2004
Bystander Effects of Bioreductive Drugs: Potential for Exploiting Pathological Tumor Hypoxia with Dinitrobenzamide Mustards
2007
VHL, the story of a tumour suppressor gene
2014
Repression of RAD51 gene expression by E2F4/p130 complexes in hypoxia
2006
The von Hippel–Lindau protein, HIF hydroxylation, and oxygen sensing
2005 StandoutNobel
Efficient Ablation of Genes in Human Hematopoietic Stem and Effector Cells using CRISPR/Cas9
2014
Hypoxic Tumors and Their Effect on Immune Cells and Cancer Therapy
2010
Hypoxia, gene expression, and metastasis
2007
Oxygen Sensing, Homeostasis, and Disease
2011 StandoutNobel
Regulation of Metabolism by Hypoxia-Inducible Factor 1
2011 StandoutNobel
Cancer-related inflammation
2008 StandoutNature
Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth
2003
Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1
2011 StandoutNobel
Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
2009 StandoutNobel
Evaluation of HIF-1 inhibitors as anticancer agents
2007 StandoutNobel
Digoxin inhibits development of hypoxic pulmonary hypertension in mice
2012 StandoutNobel
Computational design of a synthetic PD-1 agonist
2021 StandoutNobel
HIF-1α is required for development of the sympathetic nervous system
2019 StandoutNobel
Life with Oxygen
2007 StandoutScienceNobel
Accumulation of the FACT complex, as well as histone H3.3, serves as a target marker for somatic hypermutation
2013 StandoutNobel
Digoxin and other cardiac glycosides inhibit HIF-1α synthesis and block tumor growth
2008 StandoutNobel
Reconstitution of RPA-covered single-stranded DNA-activated ATR-Chk1 signaling
2010 StandoutNobel
Nonimmunoglobulin target loci of activation-induced cytidine deaminase (AID) share unique features with immunoglobulin genes
2012 StandoutNobel
von Hippel-Lindau Disease
2006 StandoutNobel
Decrease in topoisomerase I is responsible for activation-induced cytidine deaminase (AID)-dependent somatic hypermutation
2011 StandoutNobel
Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1α to promote cell-cycle progression
2014 StandoutNobel
Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation
2011 StandoutNobel
The von Hippel-Lindau tumor suppressor protein sensitizes renal cell carcinoma cells to tumor necrosis factor-induced cytotoxicity by suppressing the nuclear factor-kappaB-dependent antiapoptotic pathway.
2003
Targeting Hypoxic Cells through the DNA Damage Response
2010
AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination
2009 StandoutNobel
Hypoxia-inducible factor 1-dependent expression of adenosine receptor 2B promotes breast cancer stem cell enrichment
2018 StandoutNobel
Kinase requirements in human cells: III. Altered kinase requirements inVHL−/− cancer cells detected in a pilot synthetic lethal screen
2008 StandoutNobel
The C-terminal region of activation-induced cytidine deaminase is responsible for a recombination function other than DNA cleavage in class switch recombination
2009 StandoutNobel
pVHL suppresses kinase activity of Akt in a proline-hydroxylation–dependent manner
2016 StandoutScienceNobel
Metabolic reprogramming and cancer progression
2020 StandoutScience
von Hippel-Lindau Protein-Mediated Repression of Tumor Necrosis Factor Alpha Translation Revealed through Use of cDNA Arrays
2003
Differential regulation of S-region hypermutation and class-switch recombination by noncanonical functions of uracil DNA glycosylase
2014 StandoutNobel
BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1α activation
2018 StandoutNobel
Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression
2012 StandoutNobel
Hypoxia Causes Downregulation of Mismatch Repair System and Genomic Instability in Stem Cells
2008
Hypoxic retinal Müller cells promote vascular permeability by HIF-1–dependent up-regulation of angiopoietin-like 4
2013 StandoutNobel
The von Hippel-Lindau Tumor Suppressor Protein and Clear Cell Renal Carcinoma
2007 StandoutNobel
Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutation
2011 StandoutNobel
Chemotherapy triggers HIF-1–dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype
2015 StandoutNobel
APE1 is dispensable for S-region cleavage but required for its repair in class switch recombination
2014 StandoutNobel
Inhibition of the oxygen sensor PHD2 in the liver improves survival in lactic acidosis by activating the Cori cycle
2015 StandoutNobel
Role ofVHLGene Mutation in Human Cancer
2004 StandoutNobel
Hypoxia-inducible factor 1 transcriptional activity in endothelial cells is required for acute phase cardioprotection induced by ischemic preconditioning
2012 StandoutNobel
Works of Ranjit S. Bindra being referenced
Hypoxia-Induced Down-regulation of BRCA1 Expression by E2Fs
2005
Regulation of DNA repair in hypoxic cancer cells
2007
Introduction to the Yale Precision Medicine Tumor Board
2017
Genetic instability and the tumor microenvironment: towards the concept of microenvironment-induced mutagenesis
2004
Hypoxia down-regulates DNA double strand break repair gene expression in prostate cancer cells
2005
Alterations in DNA Repair Gene Expression under Hypoxia: Elucidating the Mechanisms of Hypoxia‐Induced Genetic Instability
2005
Targeted Disruption of the CCR5 Gene in Human Hematopoietic Stem Cells Stimulated by Peptide Nucleic Acids
2011
Co-repression of mismatch repair gene expression by hypoxia in cancer cells: Role of the Myc/Max network
2007
Hypoxia-induced genetic instability—a calculated mechanism underlying tumor progression
2006
Krebs-cycle-deficient hereditary cancer syndromes are defined by defects in homologous-recombination DNA repair
2018
Hypoxia-Induced Phosphorylation of Chk2 in an Ataxia Telangiectasia Mutated–Dependent Manner
2005
Chronic Hypoxia Decreases Synthesis of Homologous Recombination Proteins to Offset Chemoresistance and Radioresistance
2008
Decreased Expression of the DNA Mismatch Repair Gene Mlh1 under Hypoxic Stress in Mammalian Cells
2003
Down-Regulation of Rad51 and Decreased Homologous Recombination in Hypoxic Cancer Cells
2004
VHL-mediated hypoxia regulation of cyclin D1 in renal carcinoma cells.
2002
CHK2-Dependent Phosphorylation of BRCA1 in Hypoxia
2006
Inhibition of poly(ADP-ribose) polymerase down-regulates BRCA1 and RAD51 in a pathway mediated by E2F4 and p130
2010