Citation Impact
Citing Papers
Reconstituting Organ-Level Lung Functions on a Chip
2010 StandoutScience
The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin
2005 StandoutScience
CYP2A6: genetics, structure, regulation, and function
2012
Murine liver repair via transient activation of regenerative pathways in hepatocytes using lipid nanoparticle-complexed nucleoside-modified mRNA
2021 StandoutNobel
Keratinocyte serum-free medium maintains long-term liver gene expression and function in cultured rat hepatocytes by preventing the loss of liver-enriched transcription factors
2006
Regulation of Type II Transmembrane Serine Proteinase TMPRSS6 by Hypoxia-inducible Factors
2010 StandoutNobel
Pan-Genotype Hepatitis E Virus Replication in Stem Cell–Derived Hepatocellular Systems
2017 StandoutNobel
Evaluation of mRNA expression of human drug-metabolizing enzymes and transporters in chimeric mouse with humanized liver
2005
Hepatocyte Growth Factor Reduces Free Cholesterol‐Mediated Lipotoxicity in Primary Hepatocytes by Countering Oxidative Stress
2016
Oxidant/anti-oxidant dynamics in patients with advanced cervical cancer: correlation with treatment response
2010
Characterization of lipid and lipoprotein metabolism in primary human hepatocytes
2012
Profiling Induction of Cytochrome P450 Enzyme Activity by Statins Using a New Liquid Chromatography-Tandem Mass Spectrometry Cocktail Assay in Human Hepatocytes
2010
Genetic Predictors of Interindividual Variability in Hepatic CYP3A4 Expression
2009
The third dimension bridges the gap between cell culture and live tissue
2007 Standout
Oxidative stress, inflammation, and cancer: How are they linked?
2010 Standout
Identification of a Novel Polymorphic Enhancer of the Human CYP3A4 Gene
2004
Completion of the entire hepatitis C virus life cycle in genetically humanized mice
2013 StandoutNatureNobel
The missing linkage: what pharmacogenetic associations are left to find inCYP3A?
2009
Microglia-mediated neurotoxicity: uncovering the molecular mechanisms
2006 Standout
Vascularized and functional human liver from an iPSC-derived organ bud transplant
2013 StandoutNature
C/EBPβ and Its Binding Element Are Required for NFκB-induced COX2 Expression Following Hypertonic Stress
2005
Direct Lineage Conversion of Terminally Differentiated Hepatocytes to Functional Neurons
2011 StandoutNobel
Molecular Mechanism of Basal CYP3A4 Regulation by Hepatocyte Nuclear Factor 4α: Evidence for Direct Regulation in the Intestine
2007
Interindividual Variability and Tissue-Specificity in the Expression of Cytochrome P450 3A mRNA
2002
Regulation of CYP3A genes in the human respiratory tract
2005
Sex Differences in the Expression of Hepatic Drug Metabolizing Enzymes
2009
Drug-Induced Liver Injury in Humans: The Case of Ximelagatran
2009
Cancer, Inflammation, and Therapy: Effects on Cytochrome P450–Mediated Drug Metabolism and Implications for Novel Immunotherapeutic Agents
2014
Gene-Specific Effects of Inflammatory Cytokines on Cytochrome P450 2C, 2B6 and 3A4 mRNA Levels in Human Hepatocytes
2007
A Mitochondrial Protein Compendium Elucidates Complex I Disease Biology
2008 Standout
Organoid Models and Applications in Biomedical Research
2015 Standout
Cytokines Associated with Amyloid Plaques in Alzheimer's Disease Brain Stimulate Human Glial and Neuronal Cell Cultures to Secrete Early Complement Proteins, But Not C1-Inhibitor
1999
Guide to drug porphyrogenicity prediction and drug prescription in the acute porphyrias
2007
A Humanized Mouse Model to Study Hepatitis C Virus Infection, Immune Response, and Liver Disease
2011 StandoutNobel
Porphyrias
2010 Standout
An overview of tissue and whole organ decellularization processes
2011 Standout
Human hepatocyte culture systems for the in vitro evaluation of cytochrome P450 expression and regulation
2001
Robust expansion of human hepatocytes in Fah−/−/Rag2−/−/Il2rg−/− mice
2007
Post-transcriptional Regulation of Human Pregnane X Receptor by Micro-RNA Affects the Expression of Cytochrome P450 3A4
2008
EXPRESSION OF HUMAN CYTOCHROMES P450 IN CHIMERIC MICE WITH HUMANIZED LIVER
2004
THP-1 cell line: An in vitro cell model for immune modulation approach
2014 Standout
COMPARISON OF PRIMARY HUMAN HEPATOCYTES AND HEPATOMA CELL LINE HEPG2 WITH REGARD TO THEIR BIOTRANSFORMATION PROPERTIES
2003
Synergistically Enhanced CYP2B6 Inducibility between a Polymorphic Mutation in CYP2B6 Promoter and Pregnane X Receptor Activation
2010
Toxic effects of the non-steroidal anti-inflammatory drug diclofenac
2004
Membrane vesicles as conveyors of immune responses
2009 Standout
Nonalcoholic Fatty Liver Disease: Modulating Gut Microbiota to Improve Severity?
2020
Recent Advances in Human Hepatocyte Culture Systems
2000
WoLF PSORT: protein localization predictor
2007 Standout
IN VIVO INDUCTION OF HUMAN CYTOCHROME P450 ENZYMES EXPRESSED IN CHIMERIC MICE WITH HUMANIZED LIVER
2005
From Krebs to clinic: glutamine metabolism to cancer therapy
2016 Standout
Transcription Factor Binding to a Putative Double E-Box Motif Represses CYP3A4 Expression in Human Lung Cells
2007
Discriminative Quantification of Cytochrome P4502D6 and 2D7/8 Pseudogene Expression by TaqMan Real-Time Reverse Transcriptase Polymerase Chain Reaction
2002
Non-alcoholic fatty liver disease
2021 Standout
Role of Oxidative Modifications in Atherosclerosis
2004 Standout
Liver-specific Deletion of the NADPH-Cytochrome P450 Reductase Gene
2003
Pluripotent stem cell-derived hepatocyte-like cells
2014
An artificial liver sinusoid with a microfluidic endothelial‐like barrier for primary hepatocyte culture
2007
Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation
2008
Genetic polymorphism of hepatocyte nuclear factor‐4α influences human cytochrome P450 2D6 activity†
2008
INVOLVEMENT OF HEPATOCYTE NUCLEAR FACTOR 4α IN THE DIFFERENT EXPRESSION LEVEL BETWEEN CYP2C9 AND CYP2C19 IN THE HUMAN LIVER
2006
The role of intracellular signaling in insulin-mediated regulation of drug metabolizing enzyme gene and protein expression
2006
Microfluidic organs-on-chips
2014 Standout
The orphan nuclear receptor HNF4α determines PXR- and CAR-mediated xenobiotic induction of CYP3A4
2003
Xenobiotic-Induced Transcriptional Regulation of Xenobiotic Metabolizing Enzymes of the Cytochrome P450 Superfamily in Human Extrahepatic Tissues
2008
Antisense glutaminase inhibition decreases glutathione antioxidant capacity and increases apoptosis in Ehrlich ascitic tumour cells
2004
Involvement of Cell Junctions in Hepatocyte Culture Functionality
2006
A New Mouse Liver-specific Gene, Encoding a Protein Homologous to Human Antimicrobial Peptide Hepcidin, Is Overexpressed during Iron Overload
2001 Standout
The IFN-λ-IFN-λR1-IL-10Rβ Complex Reveals Structural Features Underlying Type III IFN Functional Plasticity
2017 StandoutNobel
Drugs Mediate the Transcriptional Activation of the 5-Aminolevulinic Acid Synthase (ALAS1) Gene via the Chicken Xenobiotic-sensing Nuclear Receptor (CXR)
2002
PPARA: A Novel Genetic Determinant of CYP3A4 In Vitro and In Vivo
2012
Establishment of a humanized model of liver using NOD/Shi-scid IL2Rgnull mice
2008
Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids
2018 StandoutNobel
Mouse liver repopulation with hepatocytes generated from human fibroblasts
2014 Nature
Molecular mechanisms of genetic variation and transcriptional regulation of CYP2C19
2012
Primary Hepatocytes: Current Understanding of the Regulation of Metabolic Enzymes and Transporter Proteins, and Pharmaceutical Practice for the Use of Hepatocytes in Metabolism, Enzyme Induction, Transporter, Clearance, and Hepatotoxicity Studies
2007
Significance of the Minor Cytochrome P450 3A Isoforms
2006
REGULATION OF DRUG TRANSPORTERS: DURING INFECTION AND INFLAMMATION
2007
Does Hepatic Steatosis Affect Drug Metabolizing Enzymes in the Liver?
2011
Method for the decellularization of intact rat liver
2010
DLPC and SAMe combined prevent leptin‐stimulated TIMP‐1 production in LX‐2 human hepatic stellate cells by inhibiting H2O2‐mediated signal transduction
2005
Hepatogenic differentiation of human mesenchymal stem cells from adipose tissue in comparison with bone marrow mesenchymal stem cells
2006
Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling
2017 StandoutNatureNobel
IL-6 and related cytokines as the critical lynchpins between inflammation and cancer
2014
The Ligands of Estrogen Receptor α Regulate Cytochrome P4502C9 (CYP2C9) Expression
2011
The Transcriptional Regulation of the Human CYP2C Genes
2009
Induced pluripotent stem cell–derived hepatocytes have the functional and proliferative capabilities needed for liver regeneration in mice
2010 StandoutNobel
Polymorphic Cytochrome P450 2D6: Humanized Mouse Model and Endogenous Substrates
2004
Evolving concepts in liver tissue modeling and implications forin vitrotoxicology
2008
Direct Reprogramming of Human Fibroblasts to Functional and Expandable Hepatocytes
2014
Organotypic liver culture models: Meeting current challenges in toxicity testing
2012
Cerebral organoids model human brain development and microcephaly
2013 StandoutNature
An update on in vitro test methods in human hepatic drug biotransformation research: pros and cons
2003
Contribution of Hepatocyte Nuclear Factor-4 to Down-Regulation of CYP2D6 Gene Expression by Nitric Oxide
2002
A Mammalian Organelle Map by Protein Correlation Profiling
2006
The CYP2D6 Humanized Mouse: Effect of the Human CYP2D6 Transgene and HNF4 on the Disposition of Debrisoquine in the Mouse
2001
Micropatterned coculture of primary human hepatocytes and supportive cells for the study of hepatotropic pathogens
2015 StandoutNobel
Oral Glutamine Reduces Radiation Morbidity in Breast Conservation Surgery
2013
HepaRG human hepatic cell line utility as a surrogate for primary human hepatocytes in drug metabolism assessment in vitro
2010
In Vivo Analysis of Aicda Gene Regulation: A Critical Balance between Upstream Enhancers and Intronic Silencers Governs Appropriate Expression
2013 StandoutNobel
Foxa2 integrates the transcriptional response of the hepatocyte to fasting
2005
Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation
2013 Standout
Pathway-Targeted Pharmacogenomics of CYP1A2 in Human Liver
2010
Normal and cancer-related functions of the p160 steroid receptor co-activator (SRC) family
2009
Novel CYP2C9 Promoter Variants and Assessment of Their Impact on Gene Expression
2008
Zonation related function and ubiquitination regulation in human hepatocellular carcinoma cells in dynamic vs. static culture conditions
2012
Pyrazinamide clearance is impaired among HIV/tuberculosis patients with high levels of systemic immune activation
2017 StandoutNobel
Toxicology of antisense therapeutics
2004
Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver
2008 Standout
Stem cell-derived polarized hepatocytes
2020 StandoutNobel
NF-κB, inflammation, immunity and cancer: coming of age
2018 Standout
Role of Nitric Oxide in Down-Regulation of CYP2B1 Protein, but Not RNA, in Primary Cultures of Rat Hepatocytes
2001
c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism
2009 StandoutNature
Mechanisms of implantation: strategies for successful pregnancy
2012 Standout
New Insights into the Regulation of CYP2C9 Gene Expression: The Role of the Transcription Factor GATA-4
2009
Extracellular vesicles: Exosomes, microvesicles, and friends
2013 Standout
Adipose-Derived Stem Cells for Regenerative Medicine
2007 Standout
Cytochrome P4502C9 genotype in Southeast Anatolia and possible relation with some serum tumour markers and cytokines.
2001
Adipose-Derived Stem Cells for Future Regenerative System Medicine
2012
Oral Rivaroxaban for Symptomatic Venous Thromboembolism
2010 Standout
Modeling host interactions with hepatitis B virus using primary and induced pluripotent stem cell-derived hepatocellular systems
2014 StandoutNobel
Regulation of Nitric Oxide-Sensitive Guanylyl Cyclase
2003
Aggregation-Induced Emission: Together We Shine, United We Soar!
2015 Standout
Erythropoietin mediates hepcidin expression in hepatocytes through EPOR signaling and regulation of C/EBPα
2008
Human serum leads to differentiation of human hepatoma cells, restoration of very-low-density lipoprotein secretion, and a 1000-fold increase in HCV Japanese fulminant hepatitis type 1 titers
2013 StandoutNobel
Identification of the xenosensors regulating human 5-aminolevulinate synthase
2004
Electrochemiluminescence (ECL)
2004 Standout
Therapeutic Targeting of the Interleukin-6 Receptor
2011
Pharmaceuticals of Emerging Concern in Aquatic Systems: Chemistry, Occurrence, Effects, and Removal Methods
2019 Standout
Liver cell models in in vitro toxicology.
1998
Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles
2014 Standout
Persistent hepatitis C virus infection in microscale primary human hepatocyte cultures
2010 StandoutNobel
REGULATION OF DRUG-METABOLIZING ENZYMES AND TRANSPORTERS IN INFLAMMATION
2005
Oligonucleotide-Modified Gold Nanoparticles for Intracellular Gene Regulation
2006 StandoutScience
Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes
2008
Mechanism of Oxidation Reactions Catalyzed by Cytochrome P450 Enzymes
2004 Standout
Intrinsic Sexually Dimorphic Expression of the Principal Human CYP3A4 Correlated with Suboptimal Activation of GH/Glucocorticoid-Dependent Transcriptional Pathways in Men
2011
CLINICAL AND TOXICOLOGICAL RELEVANCE OF CYP2C9: Drug-Drug Interactions and Pharmacogenetics
2005
The Induction of Cytochrome P450 3A5 (CYP3A5) in the Human Liver and Intestine Is Mediated by the Xenobiotic Sensors Pregnane X Receptor (PXR) and Constitutively Activated Receptor (CAR)
2004
Works of Ramiro Jover being referenced
Transcriptional Regulation and Expression of CYP3A4 in Hepatocytes
2007
Human mesenchymal stem cells from adipose tissue: Differentiation into hepatic lineage
2006
Cytochrome P450 regulation by hepatocyte nuclear factor 4 in human hepatocytes: A study using adenovirus-mediated antisense targeting
2001
Protective effect of quercetin on high-fat diet-induced non-alcoholic fatty liver disease in mice is mediated by modulating intestinal microbiota imbalance and related gut-liver axis activation
2016
Role of hepatocyte nuclear factor 3γ in the expression of human CYP2C genes
2004
Transcriptional Regulation of the Human Hepatic CYP3A4: Identification of a New Distal Enhancer Region Responsive to CCAAT/Enhancer-Binding Protein β Isoforms (Liver Activating Protein and Liver Inhibitory Protein)
2005
Hepatic cytochrome P450 down-regulation during aseptic inflammation in the mouse is interleukin 6 dependent
2000
Limited heme synthesis in porphobilinogen deaminase‐deficient mice impairs transcriptional activation of specific cytochrome P450 genes by phenobarbital
2000
Transcriptional Regulation of Cytochrome P450 Genes by the Nuclear Receptor Hepatocyte Nuclear Factor 4-Alpha
2009
Semi-automatic quantitative RT-PCR to measure CYP induction by drugs in human hepatocytes
2003
Intracellular glutathione in human hepatocytes incubated with S- and GSH-depleting drugs
1991
Human Hepatocytes in Primary Culture: The Choice to Investigate Drug Metabolism in Man
2004
Cytochrome P450 and Steatosis
2009
Transcriptional Activation of CYP2C9, CYP1A1, and CYP1A2 by Hepatocyte Nuclear Factor 4α Requires Coactivators Peroxisomal Proliferator Activated Receptor-γ Coactivator 1α and Steroid Receptor Coactivator 1
2006
Human Hepatocytes as a Tool for Studying Toxicity and Drug Metabolism
2003
Evaluation of the cytotoxicity of ten chemicals on human cultured hepatocytes: Predictability of human toxicity and comparison with rodent cell culture systems
1992
Hepatocyte cell lines: their use, scope and limitations in drug metabolism studies
2006
Quantitative RT-PCR Measurement of Human Cytochrome P-450s: Application to Drug Induction Studies
2000
Induction of 5-Aminolevulinate Synthase by Drugs Is Independent of Increased Apocytochrome P450 Synthesis
1996
Role of glutathione in the induction of apoptosis and c-fos and c-jun mRNAs by oxidative stress in tumor cells
2004
Expression of Liver Specific-Genes in Hepatocytes Cultured in Collagen Gel Matrix
2000
Re‐expression of C/EBPα induces CYP2B6, CYP2C9 and CYP2D6 genes in HepG2 cells
1998
Transcriptional Regulation of Human CYP3A4 Basal Expression by CCAAT Enhancer-Binding Protein α and Hepatocyte Nuclear Factor-3γ
2003
Human Hepatocyte Growth Factor Down-regulates the Expression of Cytochrome P450 Isozymes in Human Hepatocytes in Primary Culture
1998
Functional Interactions between Gut Microbiota Transplantation, Quercetin, and High‐Fat Diet Determine Non‐Alcoholic Fatty Liver Disease Development in Germ‐Free Mice
2019
Measurement of intracellular LDH activity in 96-well cultures: A rapid and automated assay for cytotoxicity studies
1991
Down‐regulation of human CYP3A4 by the inflammatory signal interleukin 6: molecular mechanism and transcription factors involved
2002
Nitric Oxide-Mediated Inhibition of Cytochrome P450 by Interferon-γ in Human Hepatocytes
1997
Diclofenac Toxicity to Hepatocytes: A Role for Drug Metabolism in Cell Toxicity
1999
Long-term expression of differentiated functions in hepatocytes cultured in three-dimensional collagen matrix
1998
Nitric oxide-mediated inhibition of cytochrome P450 by interferon-gamma in human hepatocytes.
1997
Expression and induction of a large set of drug‐metabolizing enzymes by the highly differentiated human hepatoma cell line BC2
2001
Oncostatin M Down-regulates Basal and Induced Cytochromes P450 in Human Hepatocytes
1998