Citation Impact
Citing Papers
Wild-Type KRAS Is Required for Panitumumab Efficacy in Patients With Metastatic Colorectal Cancer
2008 Standout
Metformin Is an AMP Kinase–Dependent Growth Inhibitor for Breast Cancer Cells
2006
EglN2 associates with the NRF 1‐ PGC 1α complex and controls mitochondrial function in breast cancer
2015 StandoutNobel
Ado-trastuzumab Emtansine (T-DM1): An Antibody–Drug Conjugate (ADC) for HER2-Positive Breast Cancer
2014
De novo design and directed folding of disulfide-bridged peptide heterodimers
2022 StandoutNobel
Clinical pharmacology of trastuzumab emtansine (T-DM1): an antibody–drug conjugate in development for the treatment of HER2-positive cancer
2012
The Preclinical Profile of the Duocarmycin-Based HER2-Targeting ADC SYD985 Predicts for Clinical Benefit in Low HER2-Expressing Breast Cancers
2015
DS-8201a, A Novel HER2-Targeting ADC with a Novel DNA Topoisomerase I Inhibitor, Demonstrates a Promising Antitumor Efficacy with Differentiation from T-DM1
2016
Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality
2009 StandoutNobel
The cryptophycins as potent payloads for antibody drug conjugates
2015
Antibody-drug conjugates for cancer therapy: The technological and regulatory challenges of developing drug-biologic hybrids
2015
Antibody–Drug Conjugate Payloads
2013
A view on drug resistance in cancer
2019 StandoutNature
Reducing hydrophobicity of homogeneous antibody-drug conjugates improves pharmacokinetics and therapeutic index
2015
Cancer nanomedicine: progress, challenges and opportunities
2016 Standout
Urea dependence of thiol-disulfide equilibria in thioredoxin: confirmation of the linkage relationship and a sensitive assay for structure
1989
Dynamic Covalent Chemistry
2002 StandoutNobel
Cancer nanotechnology: The impact of passive and active targeting in the era of modern cancer biology
2013 Standout
EMT and Dissemination Precede Pancreatic Tumor Formation
2012 Standout
Insulin-like growth factors and neoplasia
2004
The antibody-drug conjugate: an enabling modality for natural product-based cancer therapeutics
2013
Principles of nanoparticle design for overcoming biological barriers to drug delivery
2015 Standout
Recombinant Human Retinol-Binding Protein Refolding, Native Disulfide Formation, and Characterization
1998
Antibody-targeted drugs and drug resistance—Challenges and solutions
2014
Exploring the effects of linker composition on site-specifically modified antibody–drug conjugates
2014
Cutting-edge mass spectrometry methods for the multi-level structural characterization of antibody-drug conjugates
2015
Calcineurin Promotes Hypoxia-inducible Factor 1α Expression by Dephosphorylating RACK1 and Blocking RACK1 Dimerization
2007 StandoutNobel
Lowering Homocysteine in Patients With Ischemic Stroke to Prevent Recurrent Stroke, Myocardial Infarction, and Death
2004 Standout
Stimuli-responsive nanocarriers for drug delivery
2013 Standout
Biological Chemistry of Thiols in the Vasculature and in Vascular-related Disease
2009
The importance of selenium to human health
2000 Standout
Antibody–drug conjugates: targeted drug delivery for cancer
2010
Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes
2005 StandoutNature
Theoretical Insights into the Mechanism for Thiol/Disulfide Exchange
2003
Antibody–drug conjugates: current status and future directions
2013
A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations
2010 Standout
Flotillin-Dependent Clustering of the Amyloid Precursor Protein Regulates Its Endocytosis and Amyloidogenic Processing in Neurons
2008 StandoutNobel
The clinical impact of glycobiology: targeting selectins, Siglecs and mammalian glycans
2021 StandoutNobel
Amplification of Dynamic Chiral Crown Ether Complexes During Cyclic Acetal Formation
2003 StandoutNobel
α-Selenoconotoxins, a New Class of Potent α7 Neuronal Nicotinic Receptor Antagonists
2006
Strategies and challenges for the next generation of antibody–drug conjugates
2017 Standout
Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer
2017 StandoutNature
Pancreatic Cancer
2010 Standout
The Role of Thiols and Disulfides on Protein Stability
2009
Dual‐Responsive Breakdown of Nanostructures with High Doxorubicin Payload for Apoptotic Anticancer Therapy
2012
Fusobacterium nucleatum Promotes Chemoresistance to Colorectal Cancer by Modulating Autophagy
2017 Standout
Antibody‐Drug Conjugates for the Treatment of Cancer
2012
Visualization of Molecular Activities Inside Living Cells with Fluorescent Labels
2004
Investigating Mitochondrial Redox Potential with Redox-sensitive Green Fluorescent Protein Indicators
2004 StandoutNobel
Engineered Nanoparticles for Drug Delivery in Cancer Therapy
2014 Standout
Antibody–Drug Conjugates: An Emerging Concept in Cancer Therapy
2014
Genetics and biology of pancreatic ductal adenocarcinoma
2006
Insulin-Like Growth Factor 1 Receptor Targeted Therapeutics: Novel Compounds and Novel Treatment Strategies for Cancer Medicine
2008
Selenium metabolism, selenoproteins and mechanisms of cancer prevention: complexities with thioredoxin reductase
1999
Redox-Sensitive Materials for Drug Delivery: Targeting the Correct Intracellular Environment, Tuning Release Rates, and Appropriate Predictive Systems
2013
Antibody–Drug Conjugates for Tumor Targeting—Novel Conjugation Chemistries and the Promise of non-IgG Binding Proteins
2015
Design and Preparation of Porous Polymers
2012 Standout
Iron Catalysis in Organic Synthesis
2015 Standout
Introducing Glycolinkers for the Functionalization of Cytotoxic Drugs and Applications in Antibody–Drug Conjugation Chemistry
2016
Photothermal therapy and photoacoustic imaging via nanotheranostics in fighting cancer
2018 Standout
“Green” Atom Transfer Radical Polymerization: From Process Design to Preparation of Well-Defined Environmentally Friendly Polymeric Materials
2007
Self-Assembled Monolayers of Thiolates on Metals as a Form of Nanotechnology
2005 Standout
Oxidative Coupling between Two Hydrocarbons: An Update of Recent C–H Functionalizations
2015 Standout
Copper Active Sites in Biology
2014 Standout
Formation of a Macrobicyclic Tris(disulfide) by Molecular Self-Assembly
1999
Insight into the Fluid-Phase Miscibility of Ester and Ether Phospholipids through Analysis of Nearest-Neighbor Recognition
1996
Mechanisms of Resistance to Antibody–Drug Conjugates
2016
Selenocysteine, identified as the penultimate C-terminal residue in human T-cell thioredoxin reductase, corresponds to TGA in the human placental gene.
1996
Advances in targeted therapeutic agents
2010
Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release
2016 Standout
The Sonogashira Reaction: A Booming Methodology in Synthetic Organic Chemistry
2007 Standout
Dynamic Combinatorial Chemistry
2006 Standout
Maintaining Biological Activity by Using Triazoles as Disufide Bond Mimetics
2011 StandoutNobel
Investigational CD33-targeted therapeutics for acute myeloid leukemia
2018
Polymer Brushes via Surface-Initiated Controlled Radical Polymerization: Synthesis, Characterization, Properties, and Applications
2009 Standout
Enzymatic Surface-Initiated Polymerization: A Novel Approach for the in Situ Solid-Phase Synthesis of Biocompatible Polymer Poly(3-hydroxybutyrate)
2004
Nanotechnology for Multimodal Synergistic Cancer Therapy
2017 Standout
N-Heterocyclic Carbenes in Late Transition Metal Catalysis
2009 Standout
Selenium and Sulfur in Exchange Reactions: A Comparative Study
2010
Site-Specific Antibody–Drug Conjugation through Glycoengineering
2014
Microfluidics in the selection of affinity reagents for the detection of cancer: paving a way towards future diagnostics
2016
Trapping lithium polysulfides of a Li–S battery by forming lithium bonds in a polymer matrix
2015 StandoutNobel
De novo design of covalently constrained mesosize protein scaffolds with unique tertiary structures
2017 StandoutNobel
Kinetic Resolution of Homoaldols via Catalytic Asymmetric Transacetalization
2010 StandoutNobel
Antibody-Drug Conjugates in Cancer Therapy
2012
Natural product and natural product derived drugs in clinical trials
2014 Standout
Chemistry of Biologically Important Synthetic Organoselenium Compounds
2001 Standout
From Anthramycin to Pyrrolobenzodiazepine (PBD)‐Containing Antibody–Drug Conjugates (ADCs)
2016
Fluorosulfuryl Isocyanate Enabled SuFEx Ligation of Alcohols and Amines
2021 StandoutNobel
Mechanism of SN2 Disulfide Bond Cleavage by Phosphorus Nucleophiles. Implications for Biochemical Disulfide Reducing Agents
2007
Light-Controlled Radical Polymerization: Mechanisms, Methods, and Applications
2016 Standout
Synthesis of a Biotin-Derived Alkyne for Pd-Catalyzed Coupling Reactions
2006
Spectral, Kinetic, and Thermodynamic Properties of Cu(I) and Cu(II) Binding by Methanobactin from Methylosinus trichosporium OB3b
2006
Palladium-Catalyzed C–H Alkenylation of Arenes Using Thioethers as Directing Groups
2012
Chemoresistant Colorectal Cancer Cells, the Cancer Stem Cell Phenotype, and Increased Sensitivity to Insulin-like Growth Factor-I Receptor Inhibition
2009
The type I insulin-like growth factor receptor pathway: a key player in cancer therapeutic resistance
2008
A Polar Sulfamide Spacer Significantly Enhances the Manufacturability, Stability, and Therapeutic Index of Antibody–Drug Conjugates
2018
Insulin-Like Growth Factor I Controls a Mutually Exclusive Association of RACK1 with Protein Phosphatase 2A and β1 Integrin To Promote Cell Migration
2006
Design of Coltuximab Ravtansine, a CD19-Targeting Antibody–Drug Conjugate (ADC) for the Treatment of B-Cell Malignancies: Structure–Activity Relationships and Preclinical Evaluation
2015
Photopharmacology: Beyond Proof of Principle
2014 StandoutNobel
Emerging Droplet Microfluidics
2017 Standout
Characterization of Mammalian Selenoproteomes
2003 StandoutScience
Nearest-Neighbor Recognition in Phospholipid Membranes
1997
Design Strategies for Water-Soluble Small Molecular Chromogenic and Fluorogenic Probes
2013 Standout
A Robust and Versatile Photoinduced Living Polymerization of Conjugated and Unconjugated Monomers and Its Oxygen Tolerance
2014 Standout
Orthogonal Cysteine–Penicillamine Disulfide Pairing for Directing the Oxidative Folding of Peptides
2015
The Redox Potential of Selenocystine in Unconstrained Cyclic Peptides
1997
The Structural Diversity of Phthalides from the Apiaceae
2007
PK Assays for Antibody–Drug Conjugates: Case Study with Ado-Trastuzumab Emtansine
2013
Thiol-ene “click” reactions and recent applications in polymer and materials synthesis
2009
Works of Rajeeva Singh being referenced
IMGN853, a Folate Receptor-α (FRα)–Targeting Antibody–Drug Conjugate, Exhibits Potent Targeted Antitumor Activity against FRα-Expressing Tumors
2015
Antibody-Maytansinoid Conjugates Designed to Bypass Multidrug Resistance
2010
A New Class of Antibody–Drug Conjugates with Potent DNA Alkylating Activity
2016
Antibody–Cytotoxic Agent Conjugates: Preparation and Characterization
2008
Catalysis of Reduction of Disulfide by Selenol
1995
Reductive unfolding and oxidative refolding of a Bowman–Birk inhibitor from horsegram seeds (Dolichos biflorus): evidence for ‘hyperreactive’ disulfide bonds and rate-limiting nature of disulfide isomerization in folding
2002
A novel pathway for maytansinoid release from thioether linked antibody–drug conjugates (ADCs) under oxidative conditions
2011
Targeting of Insulin-like Growth Factor-I Receptor with a Monoclonal Antibody Inhibits Growth of Hepatic Metastases from Human Colon Carcinoma in Mice
2007
Labeling of Antibodies by in Situ Modification of Thiol Groups Generated from Selenol-Catalyzed Reduction of Native Disulfide Bonds
2002
An Amplified Assay for Thiols Based on Reactivation of Papain
1993
Structural stability of human α-thrombin studied by disulfide reduction and scrambling
2003
Formation of N-Substituted 2-Iminothiolanes When Amino Groups in Proteins and Peptides Are Modified by 2-Iminothiolane
1996
[14] Reagents for rapid reduction of disulfide bonds
1995
Disulfide-Linked Antibody−Maytansinoid Conjugates: Optimization of In Vivo Activity by Varying the Steric Hindrance at Carbon Atoms Adjacent to the Disulfide Linkage
2011
Abstract B126: Potent antigen-specific anti-tumor activity observed with antibody-drug conjugates (ADCs) made using a new class of DNA-crosslinking agents
2009
Degenerate intermolecular thiolate-disulfide interchange involving cyclic five-membered disulfides is faster by .apprx.103 than that involving six- or seven-membered disulfides
1990
An anti-insulin-like growth factor I receptor antibody that is a potent inhibitor of cancer cell proliferation.
2003
Abstract B120: Designing potent antibody-drug conjugates: The impact of lysosomal processing efficiency and conjugate linker selection on anticancer activity
2009
A reagent for reduction of disulfide bonds in proteins that reduces disulfide bonds faster than does dithiothreitol
1991
Design of Antibody−Maytansinoid Conjugates Allows for Efficient Detoxification via Liver Metabolism
2011
A Sensitive Assay for Maleimide Groups
1994
Sensitive ELISA Method for the Measurement of Catabolites of Antibody–Drug Conjugates (ADCs) in Target Cancer Cells
2015
Tumor Delivery and In Vivo Processing of Disulfide-Linked and Thioether-Linked Antibody−Maytansinoid Conjugates
2009
Measurement of thiol-disulfide interchange reactions and thiol pKa values
1987
Down-regulation of Insulin Receptor by Antibodies against the Type I Insulin-Like Growth Factor Receptor: Implications for Anti–Insulin-Like Growth Factor Therapy in Breast Cancer
2006
Synthesis and Evaluation of Hydrophilic Linkers for Antibody–Maytansinoid Conjugates
2011