Citation Impact
Citing Papers
Peptide/Protein Stapling and Unstapling: Introduction of s -Tetrazine, Photochemical Release, and Regeneration of the Peptide/Protein
2015
Membrane curvature regulates the spatial distribution of bulky glycoproteins
2022 StandoutNobel
The Organization, Promoter Analysis, and Expression of the Human PPARγ Gene
1997 Standout
Significance of Pro12Ala Mutation in Peroxisome Proliferator-Activated Receptor-γ2 in Korean Diabetic and Obese Subjects*
2000
PPARγ3 mRNA: a distinct PPARγ mRNA subtype transcribed from an independent promoter
1998
Activators of the nuclear receptor PPARγ enhance colon polyp formation
1998
The Synthesis of Cystine Peptides by Iodine Oxidation of S‐Trityl‐cysteine and S‐Acetamidomethyl‐cysteine Peptides
1980
Organic Vanadium Chelators Potentiate Vanadium-Evoked Glucose Metabolism In Vitro and In Vivo: Establishing Criteria for Optimal Chelators
2000
Thiazolidinediones
2004 Standout
L-764406 Is a Partial Agonist of Human Peroxisome Proliferator-activated Receptor γ
1999
Nuclear Association of the Cytoplasmic Tail of MUC1 and β-Catenin
2003
Amino acids that specify structure through hydrophobic clustering and histidine-aromatic interactions lead to biologically active peptidomimetics
1994
Peroxovanadium compounds: Biolgoical actions and mechanism of insulin-mimesis
1995
Liver fibrosis
2005 Standout
Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain
2016 StandoutNatureNobel
Peroxisome proliferator-activated receptor gene expression in human tissues. Effects of obesity, weight loss, and regulation by insulin and glucocorticoids.
1997
Thiazolidinediones: an update
2000
Activators of peroxisome proliferator-activated receptor gamma have depot-specific effects on human preadipocyte differentiation.
1997
Newly Synthesized Phosphatidylinositol Phosphates Are Required for Synaptic Norepinephrine but Not Glutamate or γ-Aminobutyric Acid (GABA) Release
1998 StandoutNobel
Plasma Adiponectin Levels and Risk of Myocardial Infarction in Men
2004 Standout
Control of Human Muscle-type Carnitine Palmitoyltransferase I Gene Transcription by Peroxisome Proliferator-activated Receptor
1998
Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas
2004 StandoutNobel
Mechanisms Controlling Mitochondrial Biogenesis and Respiration through the Thermogenic Coactivator PGC-1
1999 Standout
Adipocytes as regulators of energy balance and glucose homeostasis
2006 StandoutNature
Pro12Ala Missense Mutation of the Peroxisome Proliferator Activated Receptor γ and Diabetes Mellitus
1999
Towards models of vanadate-dependent haloperoxidases: the hydroxyl side chain
2000
l-Glutamic Acid γ-Monohydroxamate
1999
A one‐variable topographical descriptor for the β‐turns of peptides and proteins
1990
Differential Response of Estrogen Receptor α and Estrogen Receptor β to Partial Estrogen Agonists/Antagonists
1998
Characterization of a membrane‐associated phosphotyrosyl protein phosphatase from the A431 human epidermoid carcinoma cell line
1989
Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats.
1998
Antidiabetic thiazolidinediones inhibit collagen synthesis and hepatic stellate cell activation in vivo and in vitro
2002
Stimulation of 125I-transferrin binding and 59Fe uptake in rat adipocytes by vanadate: Treatment time determines apparent tissue sensitivity
1998
Protein kinases and phosphatases: The Yin and Yang of protein phosphorylation and signaling
1995 Standout
A PPARγ mutant serves as a dominant negative inhibitor of PPAR signaling and is localized in the nucleus
2000
The peroxisome proliferator activated receptorφ2 (PPARφ2) Pro12Ala variant: lack of association with type 2 diabetes in obese and non obese Tunisian patients
2005
Chromosomal Localization and Partial Genomic Structure of the Human Peroxisome Proliferator Activated Receptor-Gamma (hPPARγ) Gene
1997
A Unique PPARγ Ligand with Potent Insulin-Sensitizing yet Weak Adipogenic Activity
2001
Hepatic over-expression of peroxisome proliferator activated receptor γ2 in the ob/ob mouse model of non‐insulin dependent diabetes mellitus
2001
Design of a selective insulin receptor tyrosine kinase inhibitor and its effect on glucose uptake and metabolism in intact cells
1989
In VivoEffects of Pioglitazone on Uncoupling Protein-2 and -3 mRNA Levels in Skeletal Muscle of Hyperglycemic KK Mice
1998
Ulcerative colitis
2016 Standout
Mice Lacking Adiponectin Show Decreased Hepatic Insulin Sensitivity and Reduced Responsiveness to Peroxisome Proliferator-activated Receptor γ Agonists
2005
Regulation of Gene Expression by Activation of the Peroxisome Proliferator-Activated Receptor γ with Rosiglitazone (BRL 49653) in Human Adipocytes
1999
Peroxisome Proliferator-activated Receptor-γ Ligands Inhibit Adipocyte 11β-Hydroxysteroid Dehydrogenase Type 1 Expression and Activity
2001
CH/π interaction in the conformation of peptides. A database study † †This paper is dedicated to the memory of the late Professor Sir Derek H. R. Barton, the founder of the concept of conformation. The authors sincerely regret the immeasurable loss of an outstanding figure in the world of science.
1999
Continuous spectrophotometric assay of protein tyrosine phosphatase using phosphotyrosine
1992 StandoutNobel
Interactions with Aromatic Rings in Chemical and Biological Recognition
2003 Standout
Peroxisome proliferator-activated receptor agonists
1997
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ
2004 StandoutNature
Mechanisms of fatty acid-induced inhibition of glucose uptake.
1994 Standout
Macrophage plasticity and polarization: in vivo veritas
2012 Standout
What We Talk About When We Talk About Fat
2014 Standout
Reduction in the evolution of murine type II collagen–induced arthritis by treatment with rosiglitazone, a ligand of the peroxisome proliferator–activated receptor γ
2003
Distribution of peroxisome proliferator-activated receptors (PPARs) in human skeletal muscle and adipose tissue: relation to insulin action
2000
Interdomain communication regulating ligand binding by PPAR-γ
1998 Nature
Cell and Molecular Biology of the Incretin Hormones Glucagon-Like Peptide-I and Glucose-Dependent Insulin Releasing Polypeptide
1995
The Hydrogen Bond in the Solid State
2002 Standout
Activation of PPARδ alters lipid metabolism in db/db mice
2000
Conformational constraints: Nonpeptide β‐turn mimics
1990
Metabolic effects of vanadyl sulfate in humans with non—insulin-dependent diabetes mellitus: In vivo and in vitro studies
2000
Roles of PPARs in health and disease
2000 StandoutNature
Induction of Adipocyte Complement-Related Protein of 30 Kilodaltons by PPARγ Agonists: A Potential Mechanism of Insulin Sensitization
2002
Atrial natriuretic factor elicits an endothelium-independent relaxation and activates particulate guanylate cyclase in vascular smooth muscle.
1984 StandoutNobel
Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator–activated receptor-γ
2005
General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids.
1985
Glyoxylic Acid and MP-Glyoxylate: Efficient Formaldehyde Equivalents in the 3-CC of 2-Aminoazines, Aldehydes, and Isonitriles
2004
β-Turn mimetic library synthesis: scaffolds and applications
2001
CH/π interaction: Implications in organic chemistry
1989
Protein phosphotyrosine phosphatase purified from the particulate fraction of human placenta dephosphorylates insulin and growth-factor receptors
1988
CD45, an integral membrane protein tyrosine phosphatase. Characterization of enzyme activity.
1990 StandoutNobel
Type 2 diabetes: principles of pathogenesis and therapy
2005 Standout
Identification of multiple binding sites for atrial natriuretic factor by affinity cross-linking in cultured endothelial cells.
1986 StandoutNobel
Hydroamination: Direct Addition of Amines to Alkenes and Alkynes
2008 Standout
The Mechanisms of Action of PPARs
2002 Standout
Design, Synthesis, and Conformational Analysis of a Proposed Type I β-Turn Mimic
1998
Troglitazone Induces GLUT4 Translocation in L6 Myotubes
2001
Amino acid sequence of homologous rat atrial peptides: natriuretic activity of native and synthetic forms.
1984
Medicinal Chemistry in the Golden Age of Biology: Lessons from Steroid and Peptide Research
1991
Heterozygous α 2A -adrenergic receptor mice unveil unique therapeutic benefits of partial agonists
2002 StandoutNobel
Recent Developments in Isocyanide Based Multicomponent Reactions in Applied Chemistry
2005 Standout
A Transgenic Model of Visceral Obesity and the Metabolic Syndrome
2001 StandoutScience
Dose-Response Effect of Pioglitazone on Insulin Sensitivity and Insulin Secretion in Type 2 Diabetes
2002
Reverse Turns in Peptides and Protein
1980
The Cation−π Interaction
1997 Standout
Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics.
1994
Dictionary of protein secondary structure: Pattern recognition of hydrogen‐bonded and geometrical features
1983 Standout
Distinct Properties and Advantages of a Novel Peroxisome Proliferator-Activated Protein γ Selective Modulator
2003
Bioactive Conformation of Luteinizing Hormone-Releasing Hormone: Evidence from a Conformationally Constrained Analog
1980 Science
Rational Tuning of Fluorobenzene Probes for Cysteine‐Selective Protein Modification
2018 StandoutNobel
A Field Guide to Foldamers
2001 Standout
The Chemistry and Biochemistry of Vanadium and the Biological Activities Exerted by Vanadium Compounds
2004 Standout
Mechanisms of vanadium action: insulin-mimetic or insulin-enhancing agent?
2000
Cloning of the gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsin
1986 StandoutNatureNobel
Bile Acids: Natural Ligands for an Orphan Nuclear Receptor
1999 StandoutScience
Target-Oriented and Diversity-Oriented Organic Synthesis in Drug Discovery
2000 StandoutScience
Atrial natriuretic factor selectively activates particulate guanylate cyclase and elevates cyclic GMP in rat tissues.
1984 StandoutNobel
Crystal structure of leucine-enkephalin
1983 StandoutNatureNobel
Cloning, characterization, and expression of a novel GDP dissociation inhibitor isoform from skeletal muscle.
1994 StandoutNobel
Opiate receptor subclasses differ in their conformational requirements
1982 Nature
The Combinatorial Synthesis of Bicyclic Privileged Structures or Privileged Substructures
2003 Standout
Regulation of Peroxisome Proliferator-Activated Receptor γ Expression by Adipocyte Differentiation and Determination Factor 1/Sterol Regulatory Element Binding Protein 1: Implications for Adipocyte Differentiation and Metabolism
1999
Modulation of Receptor and Receptor Subtype Affinities Using Diastereomeric and Enantiomeric Monosaccharide Scaffolds as a Means to Structural and Biological Diversity. A New Route to Ether Synthesis
1998
Peroxisome Proliferator-Activated Receptors: Nuclear Control of Metabolism*
1999 Standout
Synthesis of a Substance P Antagonist with a Somatostatin Scaffold: Factors Affecting Agonism/Antagonism at GPCRs and the Role of Pseudosymmetry
2000
The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity
1998 Standout
Activation of Peroxisome Proliferator-Activated Receptor γ Does Not Inhibit IL-6 or TNF-α Responses of Macrophages to Lipopolysaccharide In Vitro or In Vivo
2000
cDNA isolated from a human T-cell library encodes a member of the protein-tyrosine-phosphatase family.
1989 StandoutNobel
Peroxisome proliferator-activated receptor (PPAR)γ agonists for diabetes
2001
Role of Skeletal Muscle in Thiazolidinedione Insulin Sensitizer (PPARγ Agonist) Action
1998
Peroxisome Proliferator-Activated Receptors γ and α Mediate in Vivo Regulation of Uncoupling Protein (UCP-1, UCP-2, UCP-3) Gene Expression
1998
A Solid-Phase Approach to Mouse Melanocortin Receptor Agonists Derived from a Novel Thioether Cyclized Peptidomimetic Scaffold
2002 StandoutNobel
Identification of a Nuclear Receptor for Bile Acids
1999 StandoutScience
Role of Peroxisome Proliferator-Activated Receptor-γ in Maintenance of the Characteristics of Mature 3T3-L1 Adipocytes
2002
Acetoxymethyl esters of phosphates, enhancement of the permeability and potency of cAMP.
1993 StandoutNobel
Nuclear Receptors Have Distinct Affinities for Coactivators: Characterization by Fluorescence Resonance Energy Transfer
1998
The Metal−Ligand Bifunctional Catalysis: A Theoretical Study on the Ruthenium(II)-Catalyzed Hydrogen Transfer between Alcohols and Carbonyl Compounds
2000 StandoutNobel
Regional Differences in the Response of Human Pre-Adipocytes to PPARγ and RXRα Agonists
2002
Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas
2004 StandoutNobel
Mechanism of pervanadate stimulation and potentiation of insulin-activated glucose transport in rat adipocytes: dissociation from vanadate effect.
1993
Estrogen inhibits the vascular injury response in estrogen receptor β-deficient female mice
1999 StandoutNobel
Works of R Saperstein being referenced
A protein phosphotyrosine phosphatase distinct from alkaline phosphatase with activity against the insulin receptor
1988
Thiazolidinediones produce a conformational change in peroxisomal proliferator-activated receptor-gamma: binding and activation correlate with antidiabetic actions in db/db mice.
1996
The Insulin-Mimetic Effect of Vanadate Is Not Correlated with Insulin Receptor Tyrosine Kinase Activity Nor Phosphorylation in Mouse Diaphragmin Vivo
1989
Synthesis and hypoglycemic activity of substituted 8-(1-piperazinyl)imidazo[1,2-a]pyrazines
1992
Conformationally restricted bicyclic analogs of somatostatin.
1978
Glucose-dependent alterations of intracellular free calcium by glucagon-like peptide-1(7-36amide) in individual mouse β-cells
1994
Synthesis of New Peptides Based on Models of Receptor-Bound Conformation
1987