Citation Impact
Citing Papers
TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo
2010 StandoutNobel
MK-2206, an Allosteric Akt Inhibitor, Enhances Antitumor Efficacy by Standard Chemotherapeutic Agents or Molecular Targeted Drugs In vitro and In vivo
2010 Standout
AKT Inhibition Relieves Feedback Suppression of Receptor Tyrosine Kinase Expression and Activity
2011
A Visualizable Chain‐Terminating Inhibitor of Glycosaminoglycan Biosynthesis in Developing Zebrafish
2014 StandoutNobel
Feedback upregulation of HER3 (ErbB3) expression and activity attenuates antitumor effect of PI3K inhibitors
2011
Insights into the PI3-K-PKB-mTOR signalling pathway from small molecules
2008
Enhancing extracellular vesicle cargo loading and functional delivery by engineering protein-lipid interactions
2024 StandoutNobel
Expression and purification of active PKB kinase from Escherichia coli
2005
mTOR Signaling in Growth Control and Disease
2012 Standout
A view on drug resistance in cancer
2019 StandoutNature
AKT/PKB Signaling: Navigating Downstream
2007 Standout
Identification of Host-Targeted Small Molecules That Restrict Intracellular Mycobacterium tuberculosis Growth
2014
Drug discovery approaches targeting the PI3K/Akt pathway in cancer
2008
Akt-regulated pathways in prostate cancer
2005
Protease‐activated receptor‐induced Akt activation – regulation and possible function
2007
The deficiency of Akt1 is sufficient to suppress tumor development in Pten +/− mice
2006
The ground state of embryonic stem cell self-renewal
2008 StandoutNature
Gout
2009 Standout
Autophagy: Renovation of Cells and Tissues
2011 Standout
Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2
2009
Allosteric inhibitors of Bcr-abl–dependent cell proliferation
2006
Exploiting the PI3K/AKT Pathway for Cancer Drug Discovery
2005 Standout
mTOR Signaling in Growth, Metabolism, and Disease
2017 Standout
Killing time for cancer cells
2005
Evolving concepts of rheumatoid arthritis
2003 StandoutNature
Targeting cancer with small molecule kinase inhibitors
2008 Standout
The effect Akt2 deletion on tumor development in Pten+/− mice
2011
The ATP-gated P2X1 Receptor Plays a Pivotal Role in Activation of Aspirin-treated Platelets by Thrombin and Epinephrine
2008 StandoutNobel
The impact of microwave synthesis on drug discovery
2005
Modern Synthetic Methods for Copper‐Mediated C(aryl)O, C(aryl)N, and C(aryl)S Bond Formation
2003 Standout
Aspiration of normal or asymptomatic pathological joints for diagnosis and research: indications, technique and success rate
2008
M-Type Phospholipase A 2 Receptor as Target Antigen in Idiopathic Membranous Nephropathy
2009 Standout
Double-edged swords as cancer therapeutics: simultaneously targeting p53 and NF-κB pathways
2008
Methods in Mammalian Autophagy Research
2010 Standout
Role of a Novel PH-Kinase Domain Interface in PKB/Akt Regulation: Structural Mechanism for Allosteric Inhibition
2009
4E-BP1 Is a Key Effector of the Oncogenic Activation of the AKT and ERK Signaling Pathways that Integrates Their Function in Tumors
2010
RosettaLigand Docking with Full Ligand and Receptor Flexibility
2008 StandoutNobel
Rheumatoid arthritis
2001
An expanding role for mTOR in cancer
2005
Foxo1 directly regulates the transcription of recombination-activating genes during B cell development
2008
Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer
2017 StandoutNature
The Proportion of Regulatory T Cells in Patients with Rheumatoid Arthritis: A Meta-Analysis
2016 StandoutNobel
AKT/PKB Signaling: Navigating the Network
2017 Standout
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
2015 Standout
A General Strategy for Creating “Inactive-Conformation” Abl Inhibitors
2006
The PI3K Pathway in Human Disease
2017 Standout
Imatinib potentiates antitumor T cell responses in gastrointestinal stromal tumor through the inhibition of Ido
2011 StandoutNobel
Ras, PI(3)K and mTOR signalling controls tumour cell growth
2006 StandoutNature
PI3K/PTEN signaling in tumorigenesis and angiogenesis
2007
Microparticle Matrix Encoding of Beads
2010 StandoutNobel
Mesenchymal stem cells within tumour stroma promote breast cancer metastasis
2007 StandoutNature
Targeting the EGFR and the PKB pathway in cancer
2009
Monofluorination of Organic Compounds: 10 Years of Innovation
2015 Standout
Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents
2008
Iodine (III)-mediated one-pot synthesis of quinoxaline by tandem nucleophilic substitution and cyclisation
2011
Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)
2013 Standout
Enzymatic Formation of Adrenaline and Other Catechols from Monophenols
1963 StandoutScienceNobel
Coordinating Radiometals of Copper, Gallium, Indium, Yttrium, and Zirconium for PET and SPECT Imaging of Disease
2010 Standout
Benzo[b]thiophene as a template for substituted quinolines and tetrahydroquinolines
2005
Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing
1983 StandoutNature
Regulatory T Cells and Human Disease
2020 StandoutNobel
Improving Prospects for Targeting RAS
2015
Turnover and Synthesis of Norepinephrine in Experimental Hypertension in Rats
1969 StandoutNobel
The Autocratic Legacy of Early Statehood
2012
Only Akt1 Is Required for Proliferation, while Akt2 Promotes Cell Cycle Exit through p21 Binding
2006
Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas
2016 Standout
An ATP-Site On-Off Switch That Restricts Phosphatase Accessibility of Akt
2012
Physiological roles of PKB/Akt isoforms in development and disease
2007
Chromone: A Valid Scaffold in Medicinal Chemistry
2014 Standout
Iterative in Situ Click Chemistry Assembles a Branched Capture Agent and Allosteric Inhibitor for Akt1
2011 StandoutNobel
Microwave-Enhanced High-Speed Fluorous Synthesis
2006
Advances in the Chemistry of Tetrahydroquinolines
2011 Standout
Diverse, High-Quality Test Set for the Validation of Protein−Ligand Docking Performance
2007
Aryl−Aryl Bond Formation by Transition-Metal-Catalyzed Direct Arylation
2007 Standout
Multicomponent and one-pot synthesis of trisubstituted pyridines through a Pd-catalyzed cross-coupling/cross-coupling/cycloaddition sequence
2007
The turnover of noreoinephrine in the heart during experimental hypertension in rats
1968
Elemental Fluorine. Part 21.1 Direct Fluorination of Benzaldehyde Derivatives
2008
Focally regulated endothelial proliferation and cell death in human synovium.
1998
Comprehensive Survey of Combinatorial Library Synthesis: 2001
2002
Microwave-Assisted Synthesis in Water as Solvent
2007 Standout
Diastereoselective Allylation of Carbonyl Compounds and Imines: Application to the Synthesis of Natural Products
2013 Standout
T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR
2008
Comprehensive Survey of Combinatorial Library Synthesis: 2005
2006
Syntheses of new quinoline‐containing heterocyclic scaffolds using inter‐ and intramolecular Pd‐catalyzed amination
2009
Protein Lipidation: Occurrence, Mechanisms, Biological Functions, and Enabling Technologies
2018
Genetic legacy of state centralization in the Kuba Kingdom of the Democratic Republic of the Congo
2018 StandoutNobel
The Combinatorial Synthesis of Bicyclic Privileged Structures or Privileged Substructures
2003 Standout
Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1)
2010
Advances in Synthetic Applications of Hypervalent Iodine Compounds
2016 Standout
Chromatography of Some Phenolic Amines
1962 Nature
Bacterial Topoisomerase Inhibitors: Quinolone and Pyridone Antibacterial Agents
2005
Applications of Palladium-Catalyzed C–N Cross-Coupling Reactions
2016 Standout
Handicapping the Race to Develop Inhibitors of the Phosphoinositide 3-Kinase/Akt/Mammalian Target of Rapamycin Pathway
2006
The selectivity of protein kinase inhibitors: a further update
2007 Standout
The Evolution of Protein Kinase Inhibitors from Antagonists to Agonists of Cellular Signaling
2011
Application of Combinatorial Chemistry Science on Modern Drug Discovery
2008
Emerging Targets in Photopharmacology
2016 StandoutNobel
A Fluorogenic Trehalose Probe for Tracking Phagocytosed Mycobacterium tuberculosis
2020 StandoutNobel
Recombinant Production and Properties of Binding of the Full Set of Mouse Secreted Phospholipases A2to the Mouse M-Type Receptor
2007
Endomembrane PtdIns(3,4,5)P3 activates the PI3K/Akt pathway
2015
Synthesis and Applications of tert-Butanesulfinamide
2010
Enkephalin-like immunoreactivity in gland cells and nerve terminals of the adrenal medulla
1978
Akt Signaling and Cancer: Surviving but not Moving On
2006
Metal-Free Multicomponent Syntheses of Pyridines
2014 Standout
Works of R. Robinson being referenced
Discovery of 2,3,5-trisubstituted pyridine derivatives as potent Akt1 and Akt2 dual inhibitors
2005
Development of Pyridopyrimidines as Potent Akt1/2 Inhibitors
2008
Diaryl ether inhibitors of farnesyl-protein transferase
2001
An allosteric Akt inhibitor effectively blocks Akt signaling and tumor growth with only transient effects on glucose and insulin levels in vivo
2010
Rapid assembly of diverse and potent allosteric Akt inhibitors
2007
Development of potent, allosteric dual Akt1 and Akt2 inhibitors with improved physical properties and cell activity
2007
Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors
2004
Optimization of 2,3,5-trisubstituted pyridine derivatives as potent allosteric Akt1 and Akt2 inhibitors
2007
Allosteric inhibitors of Akt1 and Akt2: A naphthyridinone with efficacy in an A2780 tumor xenograft model
2008
Mechanism of action and antitumor activity of (S)-10-(2,6-dimethyl-4-pyridinyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyridol [1,2,3-de]-[1,4]benzothiazine-6-carboxylic acid (WIN 58161)
1995
Allosteric inhibitors of Akt1 and Akt2: Discovery of [1,2,4]triazolo[3,4-f][1,6]naphthyridines with potent and balanced activity
2008
Africa and the Victorians
1961
Urinary normetadrenaline excretion in essential hypertension
1967
Morphometric analysis of blood vessels in synovial membranes obtained from clinically affected and unaffected knee joints of patients with rheumatoid arthritis.
1991
Adrenal Activity in Subjects with Complete Transverse Lesions of the Spinal Cord
1958 Nature
Synthesis and biological evaluation of unnatural canthine alkaloids
2005
Dual Protein Farnesyltransferase−Geranylgeranyltransferase-I Inhibitors as Potential Cancer Chemotherapeutic Agents
2003
The antitumor activity of novel pyrazoloquinoline derivatives
1995
Urinary amines in phaeochromocytoma
1962
Tumor cell sensitization to apoptotic stimuli by selective inhibition of specific Akt/PKB family members
2005
Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors
2005