Standout Papers
Citation Impact
Citing Papers
Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins
1997
Comprehensive computational design of ordered peptide macrocycles
2017 StandoutScienceNobel
A "Silent" Polymorphism in the MDR 1 Gene Changes Substrate Specificity
2006 StandoutScience
Crystal Structure of Rhodopsin: A G Protein-Coupled Receptor
2000 StandoutScience
X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C
2011 StandoutNobel
Strategy for Dual-Analyte Luciferin Imaging: In Vivo Bioluminescence Detection of Hydrogen Peroxide and Caspase Activity in a Murine Model of Acute Inflammation
2013 StandoutNobel
Gender Disparity in Liver Cancer Due to Sex Differences in MyD88-Dependent IL-6 Production
2007 StandoutScience
The Role of Surfactants in the Reversal of Active Transport Mediated by Multidrug Resistance Proteins
2003
Mutation of Trp1254 in the Multispecific Organic Anion Transporter, Multidrug Resistance Protein 2 (MRP2) (ABCC2), Alters Substrate Specificity and Results in Loss of Methotrexate Transport Activity
2001
Multidrug resistance in cancer: role of ATP–dependent transporters
2002 Standout
Congenital Jaundice in Rats with a Mutation in a Multidrug Resistance-Associated Protein Gene
1996 Science
Chimerism of the Transplanted Heart
2002 Standout
Lipid traffic: floppy drives and a superhighway
2005
ATP-binding cassette transporter A1 (ABCA1) affects total body sterol metabolism
2001
Innate immune sensing and its roots: the story of endotoxin
2003 StandoutNobel
P-glycoprotein: from genomics to mechanism
2003
Positively Cooperative Sites for Drug Transport by P‐Glycoprotein with Distinct Drug Specificities
1997
Role of transport proteins in drug absorption, distribution and excretion
2001
Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs
1994 Standout
Inhibition of lysosomal acid sphingomyelinase by agents which reverse multidrug resistance
1995
Function of the htrB High Temperature Requirement Gene of Escherichia coli in the Acylation of Lipid A
1996
Kinetic Analysis of the Mechanism and Specificity of Protein-disulfide Isomerase Using Fluorescence-quenched Peptides
1998 StandoutNobel
Confronting Complexity: the Interlink of Phototransduction and Retinoid Metabolism in the Vertebrate Retina
2001
Hepatobiliary secretion of organic compounds; molecular mechanisms of membrane transport
1995
The C. elegans Cell Corpse Engulfment Gene ced-7 Encodes a Protein Similar to ABC Transporters
1998 StandoutNobel
What have we learnt thus far from mice with disrupted P-glycoprotein genes?
1996
BILE ACID TRANSPORT
1999
Insights into the Function of Rim Protein in Photoreceptors and Etiology of Stargardt's Disease from the Phenotype in abcr Knockout Mice
1999
Human Hepatocyte Transplantation: Worldwide Results
2006
INBORN ERRORS OF BILE ACID BIOSYNTHESIS AND TRANSPORT
1999
Characterization of Prenylcysteines That Interact with P-glycoprotein and Inhibit Drug Transport in Tumor Cells
1995
Function of Escherichia coli MsbA, an Essential ABC Family Transporter, in Lipid A and Phospholipid Biosynthesis
1998
Coordinated Transcription of Key Pathways in the Mouse by the Circadian Clock
2002 Standout
Cell Death
2004 Standout
Kinetics of Liver Repopulation after Bone Marrow Transplantation
2002
Mitochondria: In Sickness and in Health
2012 Standout
Eater, a Transmembrane Protein Mediating Phagocytosis of Bacterial Pathogens in Drosophila
2005 StandoutNobel
Interaction of the P-glycoprotein Multidrug Transporter with Peptides and Ionophores
1995
Targeted Disruption of the Nuclear Receptor FXR/BAR Impairs Bile Acid and Lipid Homeostasis
2000 Standout
Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs
2007 Standout
Nuclear factor-κB in cancer development and progression
2006 StandoutNature
Human Multidrug Resistance ABCB and ABCG Transporters: Participation in a Chemoimmunity Defense System
2006
GENETIC ANALYSIS OF THE MULTIDRUG TRANSPORTER
1995
The biology of the P-glycoproteins
1995
Functional interactions between the gut microbiota and host metabolism
2012 StandoutNature
P-glycoprotein—A mediator of multidrug resistance in tumour cells
1996
Immunity, Inflammation, and Cancer
2010 Standout
Function of the Escherichia coli msbB Gene, a Multicopy Suppressor of htrB Knockouts, in the Acylation of Lipid A
1997
MDR1 P-Glycoprotein Is a Lipid Translocase of Broad Specificity, While MDR3 P-Glycoprotein Specifically Translocates Phosphatidylcholine
1996
A gene encoding a P-type ATPase mutated in two forms of hereditary cholestasis
1998
The Human ATP-Binding Cassette (ABC) Transporter Superfamily
2001
Recognition of lipid antigens by T cells
2005
Identification of the haemoglobin scavenger receptor
2001 StandoutNature
P-glycoprotein Expression: Critical Determinant in the Response to Osteosarcoma Chemotherapy
1997
Inflammatory caspases are innate immune receptors for intracellular LPS
2014 StandoutNature
[36] Purification and reconstitution of human P-glycoprotein
1998
Competition of Hydrophobic Peptides, Cytotoxic Drugs, and Chemosensitizers on a Common P-glycoprotein Pharmacophore as Revealed by Its ATPase Activity
1996
Intestinal lymphatic drug transport: an update
2001
Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview
2003 Standout
The ABCs of drug transport in intestine and liver: efflux proteins limiting drug absorption and bioavailability
2003
Induced pluripotent stem cell–derived hepatocytes have the functional and proliferative capabilities needed for liver regeneration in mice
2010 StandoutNobel
CED-1 Is a Transmembrane Receptor that Mediates Cell Corpse Engulfment in C. elegans
2001 StandoutNobel
The human MDR3 P‐glycoprotein promotes translocation of phosphatidylcholine through the plasma membrane of fibroblasts from transgenic mice
1994
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
2015 Standout
ABC transporters in lipid transport
2000
NF-κB functions as a tumour promoter in inflammation-associated cancer
2004 StandoutNature
Phosphatidylcholine translocase: A physiological role for the mdr2 gene
1994
Cancer-related inflammation
2008 StandoutNature
Purification and reconstitution of functional human P-glycoprotein
1995
Synthetic hydrophobic peptides are substrates for P-glycoprotein and stimulate drug transport
1996
Atherosclerosis
2001 Standout
A mouse genetic model for familial cholestasis caused by ATP8B1 mutations reveals perturbed bile salt homeostasis but no impairment in bile secretion
2004
Extraction of Hoechst 33342 from the Cytoplasmic Leaflet of the Plasma Membrane by P‐Glycoprotein
1997
An Escherichia coli Mutant Defective in Lipid Export
2001
Hepatobiliary transport
2000
Flip-flop: The transmembrane translocation of lipids
1994
Severe Cholestasis Induced by Cholic Acid Feeding in Knockout Mice of Sister of P–Glycoprotein
2003
The Tangier disease gene product ABC1 controls the cellular apolipoprotein-mediated lipid removal pathway
1999
Small molecules that dramatically alter multidrug resistance phenotype by modulating the substrate specificity of P -glycoprotein
2001
Orally Absorbed Cyclic Peptides
2017
Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome
2006 StandoutScience
Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview
2012 Standout
Functional rafts in cell membranes
1997 StandoutNature
BIOCHEMICAL, CELLULAR, AND PHARMACOLOGICAL ASPECTS OF THE MULTIDRUG TRANSPORTER
1999 Standout
Nuclear Receptors and Lipid Physiology: Opening the X-Files
2001 StandoutScience
Targeted inactivation of sister of P-glycoprotein gene ( spgp ) in mice results in nonprogressive but persistent intrahepatic cholestasis
2001
MRP2, a human conjugate export pump, is present and transports fluo 3 into apical vacuoles of Hep G2 cells
2000
Functional expression of P-glycoproteins in secretory vesicles.
1994
The ATP binding cassette transporter ABC1, is required for the engulfment of corpses generated by apoptotic cell death.
1996
Mutations in the MDR 3 gene cause progressive familial intrahepatic cholestasis
1998
DAF-16 Target Genes That Control C. elegans Life-Span and Metabolism
2003 StandoutScienceNobel
The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex
2009 StandoutNature
Functions of Ceramide in Coordinating Cellular Responses to Stress
1996 StandoutScience
Mammalian ABC Transporters in Health and Disease
2002
Regulation of apoptosis by the circadian clock through NF-κB signaling
2011 StandoutNobel
Enforced P-glycoprotein pump function in murine bone marrow cells results in expansion of side population stem cells in vitro and repopulating cells in vivo
2000
THE ENGULFMENT PROCESS OF PROGRAMMED CELL DEATH INCAENORHABDITIS ELEGANS
2004 Nobel
The role of phospholipids in bile formation: what can we learn from animals and human disease?
2000
Review
1997
Studies of Human MDR1-MDR2 Chimeras Demonstrate the Functional Exchangeability of a Major Transmembrane Segment of the Multidrug Transporter and Phosphatidylcholine Flippase
1999
Genetic and Biochemical Analysis of Non-Vesicular Lipid Traffic
2009
Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding
2009 StandoutScience
A physiologic function for p-glycoprotein (MDR-1) during the migration of dendritic cells from skin via afferent lymphatic vessels
1998 StandoutNobel
Lipid A Modification Systems in Gram-Negative Bacteria
2007
Lipopolysaccharide Endotoxins
2002 Standout
Pathophysiologic Implications of Membrane Phospholipid Asymmetry in Blood Cells
1997
Effector Memory T Cells, Early Metastasis, and Survival in Colorectal Cancer
2005 Standout
PapA1 and PapA2 are acyltransferases essential for the biosynthesis of theMycobacterium tuberculosisvirulence factor Sulfolipid-1
2007 StandoutNobel
Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein
1997
Niemann-Pick C1 Like 1 Protein Is Critical for Intestinal Cholesterol Absorption
2004 StandoutScience
Interaction of prenylcysteine methyl esters with the multidrug resistance transporter.
1994
Mice with homozygous disruption of the mdr2 P-glycoprotein gene. A novel animal model for studies of nonsuppurative inflammatory cholangitis and hepatocarcinogenesis.
1994
Specific detection of multidrug resistance proteins MRP1, MRP2, MRP3, MRP5, and MDR3 P-glycoprotein with a panel of monoclonal antibodies.
2000
Taxol resistance mediated by transfection of the liver-specific sister gene of P-glycoprotein.
1998
Polymer Vesicles
2002 StandoutScience
Works of R. Ottenhoff being referenced
Increased Bioavailability of the Food-Derived Carcinogen 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in MRP2-Deficient Rats
2001
Regulation of biliary lipid secretion by mdr2 P-glycoprotein in the mouse.
1995
Homozygous disruption of the murine MDR2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease
1993 Standout
Correction of liver disease by hepatocyte transplantation in a mouse model of progressive familial intrahepatic cholestasis
2000
Class III P-glycoproteins mediate the formation of lipoprotein X in the mouse.
1998
Reduced plasma cholesterol and increased fecal sterol loss in multidrug resistance gene 2 P-glycoprotein-deficient mice☆☆☆
1998
Hepatocanalicular organic-anion transport is regulated by protein kinase C
1991
ATP-dependent efflux of GSSG and GS-conjugate from isolated rat hepatocytes
1990