Standout Papers
Citation Impact
Citing Papers
Inhibition of vascular endothelial growth factor with a sequence-specific hypoxia response element antagonist
2004 StandoutNobel
Epidermal growth factor receptor transcriptionally up-regulates vascular endothelial growth factor expression in human glioblastoma cells via a pathway involving phosphatidylinositol 3'-kinase and distinct from that induced by hypoxia.
2000
erb B-2 Is a Potent Oncogene When Overexpressed in NIH/3T3 Cells
1987 Science
Hallmarks of Cancer: The Next Generation
2011 Standout
High Levels of Biologically Active Vascular Endothelial Growth Factor (VEGF) are Produced by the Baculovirus Expression System
1992
Regulation of vascular permeability by vascular endothelial growth factors
2002
Vascular Endothelial Growth Factor is Expressed in Rat Corpus Luteum
1990
The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains
1988 StandoutScience
Biology of angiogenesis in tumors of the gastrointestinal tract
2003
Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
1992 StandoutNature
Pancreatic cancer
2004 Standout
Inflammation and cancer
2002 StandoutNature
Ras regulation of vascular endothelial growth factor and angiogenesis
2001
Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor
1992 Standout
Prognostic significance of angiogenesis in human pancreatic cancer
1999
The Mouse Gene for Vascular Endothelial Growth Factor
1996
Induction of neuropilin-1 and vascular endothelial growth factor by epidermal growth factor in human gastric cancer cells
2003
A Novel Type of Vascular Endothelial Growth Factor, VEGF-E (NZ-7 VEGF), Preferentially Utilizes KDR/Flk-1 Receptor and Carries a Potent Mitotic Activity without Heparin-binding Domain
1998
Localization of the sevenless protein, a putative receptor for positional information, in the eye imaginal disc of Drosophila
1987
Down-regulation of vascular endothelial growth factor in human colon carcinoma cell lines by antisense transfection decreases endothelial cell proliferation
1996
The association of k-ras gene mutation and vascular endothelial growth factor gene expression in pancreatic carcinoma
2001
Multilineage hematopoietic disorders induced by transplantation of bone marrow cells expressing the v-fms oncogene
1987
Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
1998 StandoutNatureNobel
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
1999 StandoutNatureNobel
Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties
1992 StandoutNobel
Myb DNA binding inhibited by phosphorylation at a site deleted during oncogenic activation
1990 StandoutNatureNobel
The Hallmarks of Cancer
2000 Standout
The biology of VEGF and its receptors
2003 Standout
Both v-Ha-Ras and v-Raf Stimulate Expression of the Vascular Endothelial Growth Factor in NIH 3T3 Cells
1995
Keratinocyte-Derived Vascular Permeability Factor (Vascular Endothelial Growth Factor) Is a Potent Mitogen for Dermal Microvascular Endothelial Cells
1995
Gene interactions affecting mechanosensory transduction in Caenorhabditis elegans
1994 StandoutNatureNobel
Effects of Vascular Endothelial Growth Factor on Hemodynamics and Cardiac Performance
1996
Hypoxia-induced Transcriptional Activation and Increased mRNA Stability of Vascular Endothelial Growth Factor in C6 Glioma Cells
1995
Aplysia CREB2 represses long-term facilitation: Relief of repression converts transient facilitation into long-term functional and structural change
1995 StandoutNobel
Oncogenes as inducers of tumor angiogenesis
1995
Microbial Stimulation Fully Differentiates Monocytes to DC-SIGN/CD209+ Dendritic Cells for Immune T Cell Areas
2010 StandoutNobel
Inducibility and negative autoregulation of CREM: An alternative promoter directs the expression of ICER, an early response repressor
1993
Regulated expression and phosphorylation of a possible mammalian cell-cycle control protein
1988 StandoutNatureNobel
The Carboxyl-terminal Domain(111–165) of Vascular Endothelial Growth Factor Is Critical for Its Mitogenic Potency
1996
Vascular permeability factor/vascular endothelial growth factor:A multifunctional angiogenic cytokine
1997
Inhibition of Vascular Endothelial Growth Factor (VEGF)-induced Endothelial Cell Proliferation by a Peptide Corresponding to the Exon 7-Encoded Domain of VEGF165
1997
Vascular endothelial growth factor and its receptors
1996
Expression of two angiogenic factors, vascular endothelial growth factor and platelet-derived endothelial cell growth factor in human pancreatic cancer, and its relationship to angiogenesis
1998
Tumor Induction of VEGF Promoter Activity in Stromal Cells
1998
Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis
2002
Molecular and biological properties of vascular endothelial growth factor
1999
Vascular Endothelial Growth Factor in Ocular Fluid of Patients with Diabetic Retinopathy and Other Retinal Disorders
1994 Standout
Structural requirements for dimerization, glycosylation, secretion, and biological function of VPF/VEGF
1995
Differential Binding of Vascular Endothelial Growth Factor B Splice and Proteolytic Isoforms to Neuropilin-1
1999
Vascular endothelial growth factor
1996
Identification of cellular proteins that can interact specifically with the T/ElA-binding region of the retinoblastoma gene product
1991 StandoutNobel
VEGF and the quest for tumour angiogenesis factors
2002
Characterization of Novel Vascular Endothelial Growth Factor (VEGF) Receptors on Tumor Cells That Bind VEGF165 via Its Exon 7-encoded Domain
1996
A fusion protein required for vesicle-mediated transport in both mammalian cells and yeast
1989 StandoutNatureNobel
Transcriptional Regulation of the Rat Vascular Endothelial Growth Factor Gene by Hypoxia
1995
Identification of a 190-kDa Vascular Endothelial Growth Factor 165 Cell Surface Binding Protein on a Human Glioma Cell Line
1997
FMRFamide reverses protein phosphorylation produced by 5-HT and cAMP in Aplysia sensory neurons
1989 StandoutNatureNobel
Differential Expression of Vascular Endothelial Growth Factor–A Isoforms at Different Stages of Melanoma Progression
2003
Molecular Mechanisms of Developmental and Tumor Angiogenesis
1994
The Drosophila gene torso encodes a putative receptor tyrosine kinase
1989 StandoutNatureNobel
VEGF145, a Secreted Vascular Endothelial Growth Factor Isoform That Binds to Extracellular Matrix
1997
HIF-1 Regulates Cytochrome Oxidase Subunits to Optimize Efficiency of Respiration in Hypoxic Cells
2007 StandoutNobel
Purification and Characterization of a Naturally Occurring Vascular Endothelial Growth Factor · Placenta Growth Factor Heterodimer
1995
Vascular endothelial growth factor
1993
Hypoxia and platelet‐derived growth factor‐BB synergistically upregulate the expression of vascular endothelial growth factor in vascular smooth muscle cells
1995
Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells
1989 Standout
The angiogenic switch in carcinogenesis
2009
C/EBP is an immediate-early gene required for the consolidation of long-term facilitation in Aplysia
1994 StandoutNobel
Vascular Endothelial Growth Factor Stimulates Tyrosine Phosphorylation and Recruitment to New Focal Adhesions of Focal Adhesion Kinase and Paxillin in Endothelial Cells
1997
Injection of the cAMP-responsive element into the nucleus of Aplysia sensory neurons blocks long-term facilitation
1990 StandoutNatureNobel
Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
1996 StandoutNature
Evidence for the existence of a novel pregnancy-associated soluble variant of the vascular endothelial growth factor receptor, Flt-1
1998
Disruption of c-mos causes parthenogenetic development of unfertilized mouse eggs
1994 StandoutNatureNobel
Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene
1996 StandoutNature
Tyrosine phosphorylation of the fission yeast cdc2+ protein kinase regulates entry into mitosis
1989 StandoutNatureNobel
Identification of Vascular Endothelial Growth Factor Determinants for Binding KDR and FLT-1 Receptors
1996
Detection of Vascular Endothelial Growth Factor Messenger RNA and Vascular Endothelial Growth Factor-like Activity in Proliferative Diabetic Retinopathy
1994
Prognostic value of vascular endothelial growth factor expression in colorectal cancer patients
2000
Universal control mechanism regulating onset of M-phase
1990 StandoutNatureNobel
mec-3, a homeobox-containing gene that specifies differentiation of the touch receptor neurons in C. elegans
1988 StandoutNobel
Neuropilin-1 Is Expressed by Endothelial and Tumor Cells as an Isoform-Specific Receptor for Vascular Endothelial Growth Factor
1998 Standout
Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo
1993 StandoutNature
Regulation of c-fosgene expression in hamster fibroblasts: initiation and elongation of transcription and mRNA degradation
1987
Regulation of Vascular Endothelial Growth Factor in Cardiac Myocytes
1995
Human kidney amiloride-binding protein: cDNA structure and functional expression.
1990
Possible Participation of Autocrine and Paracrine Vascular Endothelial Growth Factors in Hypoxia-induced Proliferation of Endothelial Cells and Pericytes
1995
Multiple protein-binding sites in the 5'-flanking region regulate c-fos expression.
1986
Isolation and characterization of a newly identified endothelial cell mitogen produced by AtT-20 cells.
1989
Vascular endothelial growth factor and its receptors
1994
Generation of Lymphohematopoietic Cells from Embryonic Stem Cells in Culture
1994 StandoutScienceNobel
Isolation and characterization of a vascular endothelial cell mitogen produced by pituitary-derived folliculo stellate cells.
1989
The long and the short of long–term memory—a molecular framework
1986 StandoutNatureNobel
The binding of vascular endothelial growth factor to its receptors is dependent on cell surface-associated heparin-like molecules.
1992
Macrophage lineage switching of murine early pre-B lymphoid cells expressing transduced fms genes.
1990
Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
1997 Standout
Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis.
1995 Standout
Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity.
1986 Standout
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.
1995 StandoutNobel
Transcriptional activation encoded by the v-fos gene.
1986
Vascular endothelial growth factor/vascular permeability factor expression in a mouse model of retinal neovascularization.
1995
Control of thymidine kinase mRNA during the cell cycle.
1987
Inducible binding of a factor to the c-fos enhancer
1986
Central role of p53 on regulation of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) expression in mammary carcinoma.
2001
β-Adrenergic Receptor Kinase: Primary Structure Delineates a Multigene Family
1989 StandoutScienceNobel
Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium.
1993
The Biology of Vascular Endothelial Growth Factor
1997 Standout
Vascular Permeability Factor/Vascular Endothelial Growth Factor: A Critical Cytokine in Tumor Angiogenesis and a Potential Target for Diagnosis and Therapy
2002
Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand.
1987
Cachectin: More Than a Tumor Necrosis Factor
1987 StandoutNobel
The fms -Like Tyrosine Kinase, a Receptor for Vascular Endothelial Growth Factor
1992 StandoutScience
Vascular endothelial growth factor receptor expression during embryogenesis and tissue repair suggests a role in endothelial differentiation and blood vessel growth.
1993
Features of the pp60v-src Carboxyl Terminus That Are Required for Transformation
1986
Controlling mRNA lifespan
1988 StandoutNatureNobel
Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors
1986 Nature
Similarities between the oxygen-sensing mechanisms regulating the expression of vascular endothelial growth factor and erythropoietin.
1994
Developmental expression of binding sites and messenger ribonucleic acid for vascular endothelial growth factor suggests a role for this protein in vasculogenesis and angiogenesis.
1993
Oncogenes and tumor angiogenesis: differential modes of vascular endothelial growth factor up-regulation in ras-transformed epithelial cells and fibroblasts.
2000
A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA
1985 StandoutNobel
Vascular Endothelial Growth Factor Is a Secreted Angiogenic Mitogen
1989 StandoutScience
Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor.
1993
Studies and Perspectives of Protein Kinase C
1986 StandoutScience
A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation
1986 Standout
Membrane association of a 36,000-dalton substrate for tyrosine phosphorylation in chicken embryo fibroblasts transformed by avian sarcoma viruses.
1983
Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms.
1992
Synthesis, Storage, and Release of Vascular Endothelial Growth Factor/Vascular Permeability Factor (VEGF/VPF) by Human Mast Cells: Implications for the Biological Significance of VEGF206
1998
The vascular endothelial growth factor (VEGF) isoforms: differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF.
1993
The Molecular Genetics of Cancer
1987 StandoutScienceNobel
Interaction Between the Rous Sarcoma Virus Transforming Protein and Two Cellular Phosphoproteins: Analysis of the Turnover and Distribution of This Complex
1983
Transient accumulation of c-fos RNA following serum stimulation requires a conserved 5′ element and c-fos 3′ sequences
1985
daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans
1997 StandoutScienceNobel
A short sequence in the p60src N terminus is required for p60src myristylation and membrane association and for cell transformation.
1984
Expression of vascular permeability factor (vascular endothelial growth factor) by epidermal keratinocytes during wound healing.
1992
Role of vascular endothelial growth factor in the stimulation of cellular invasion and signaling of breast cancer cells.
2001
Activation of Vascular Endothelial Growth Factor Gene Transcription by Hypoxia-Inducible Factor 1
1996 StandoutNobel
Down-regulation of c-myb gene expression is a prerequisite for erythropoietin-induced erythroid differentiation.
1988
Regulation of angiogenesis via vascular endothelial growth factor receptors.
2000
A Novel Putative Tyrosine Kinase Receptor Encoded by the eph Gene
1987 Science
Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation
1992 Standout
Thermolability of ubiquitin-activating enzyme from the mammalian cell cycle mutant ts85
1984 StandoutNobel
Angiogenesis in Endocrine Tumors
2003
Hypoxia Regulates Vascular Endothelial Growth Factor Gene Expression in Endothelial Cells
1995
Induction of the proto-oncogene fos by nerve growth factor.
1985
Potentiated Angiogenic Effect of Scatter Factor/Hepatocyte Growth Factor via Induction of Vascular Endothelial Growth Factor
1998
Increased microvascular permeability and endothelial fenestration induced by vascular endothelial growth factor
1995 Nobel
Vascular endothelial growth factor (VEGF) and its receptors
1999 Standout
VEGF and flt
1996
Role of the Vascular Endothelial Growth Factor Pathway in Tumor Growth and Angiogenesis
2004 Standout
Angiogenesis.
1992 Standout
Works of R. Mitchell being referenced
c-fos expression is neither sufficient nor obligatory for differentiation of monomyelocytes to macrophages
1986
Vascular endothelial growth factor: A new member of the platelet-derived growth factor gene family
1989
Structural alteration of viral homologue of receptor proto-oncogene fms at carboxyl terminus
1986 Nature
Expression of human basic fibroblast growth factor cDNA in baby hamster kidney-derived cells results in autonomous cell growth.
1988
Bovine Granulosa Cells Produce Basic Fibroblast Growth Factor*
1987
Rapid induction of the expression of proto-oncogene fos during human monocytic differentiation
1985
Pituitary follicular cells produce basic fibroblast growth factor.
1987
Addition of growth hormone secretion signal to basic fibroblast growth factor results in cell transformation and secretion of aberrant forms of the protein.
1988
The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing
1991 Standout
Association of pp60src and src protein kinase activity with the plasma membrane of nonpermissive and permissive avian sarcoma virus-infected cells
1980